기계적 합금화에 의해 제조된 고규소 Al-Si 합금 나노 결정의 특성

이정일,김일호,홍태환,어순철,양계준,석현광,한만갑,최국선,김준수 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

High silicon Al-Si alloys with nanocrystalline structures have been produced by mechanical alloying process. Microstructural changes of the Al-Si alloys were investigated by scanning electron microscopy and the transmission electron microscopy. X-ray diffraction analysis was also made to characterize the lattice constant, crystallite size and misfit strain. It was found that the effective milling time by attrition milling was about 12hours for Al-70 wt%Si alloy system. The Al and Si crystallites were reduced to about 30 nm and 70 nm, respectively, by the mechanical alloying for more than 12hours. The misfit strains increased with milling time UD to 240 hours, and saturated to 5.73×10^(-3) for Al and Si crystallites, respectively.

연작업자들에서의 δ -aminolevulinic acid dehydratase 유전형질의 다형성이 신기능에 미치는 영향

안익수,황보영,김용배,리갑수,이성수,장봉기,함정오,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

δ-aminolevulinic acid hehydratase (ALAD) is a polymorphic enzyme that has two alleles, ALAD1 (ALAD1-1 as phenotype) and ALAD2 (ALAD1-2 or ALAD2-2 as phenotype). ALAD genotype has been reported to modify the toxicokinetics of lead. To investigate the influence of ALAD genotype polymorphism on renal function in lead workers, author studied 1022 male lead workers and 149 non lead workers in the same industries. For the cross-sectional renal function indices, blood urea nitrogen (BUN), serum creatinine, uric acid and total protein were selected. Blood lead and blood zinc protoporphyrin were also measured as indices of lead exposure. Information on weight, age, job duration, smoking & drinking history were collected. Following results are as follows: 1. Whereas the mean (standard deviation) of blood lead and blood ZPP of lead workers were 27.2±12.5 ㎍/㎗ and 57.7±37.8 ㎍/㎗, those of non-lead workers in the same premises were 14.9±6.5 ㎍/㎗ and 44.6± 15.8 ㎍/㎗ respectively. The difference of mean blood lead and blood ZPP between two groups were statistically significant. 2. Whereas the prevalence of the variant allele, ALAD2 in 1022 lead workers was 10.2 %, the prevalence of that in 149 non-lead workers was 7.4 %. But there was no difference of prevalence between two groups. 3. The mean±standard deviation of blood lead of subjects with ALAD1 was 25.5± 12.7 ㎍/㎗ and was slightly lower than that of subjects with ALAD2 (26.5±10.9 ㎍/㎗), and the mean±standard deviation of blood ZPP of subjects with ALAD1 was slightly higher than that of subjects with ALAD2 (56.7±37.3 ㎍/㎗ vs 48.9±18.6 ㎍/㎗). But the differences of blood lead and blood ZPP between two genotypes were not statistically significant. 4. There were no differences of cross-sectional renal function indices (BUN, serum creatinine, uric acid and total protein) either by lead workers and non-lead workers or two genotypes. 5. In multiple regression analysis of ALAD genotype on BUN after controlling for possible confounders (sex, weight, job duration, smoking and drinking status), the mean of BUN in ALAD2 subjects was 0.629 ㎎/㎗ lower than ALAD1 subjects with a weak statistical significance (p=0.07). But in logistic analysis of ALAD genotype on median value of BUN revcaled that subjects of ALAD2 genotype were 32% less likely to have median value or more of BUN than subjects of ALAD1 with odd ratio of 0.618 (95% confidence interval 0.411-0.920). 6. In multiple regression analysis of ALAD genotype on serum creatinine after controlling for possible confounders (sex, weight, job duration, smoking and drinking status), the mean of serum creatinine in ALAD2 subjects was 0.0271 ㎎/㎗ lower than ALAD1 subjects with statistical significance (p=0.02). On the other hand, in logistic analysis of ALAD genotype on median value of serum creatinine revealed that subjects of ALAD2 genotype were 30% less likely to have median value or more of scrum creatinine than subjects of ALAD1 with odd ratio of 0.700 (95% confidence interval 0.442-1.080). With the above results, it was found that the variant allcle, ALAD2 appeared to modify the association of lead and renal function and ALAD2 genotype may be supportive for the protective effect of lead.

忠淸南北道에 捿息하는 翼手類(Chiroptera)의 地理的 分布

孫成源,吳甲守,李守一,李政勳 경남대학교 환경문제연구소 1991 환경연구 Vol.13 No.-

The geographical distribution of Ch'ungch'□ngnam-buk-do chiropteran fauna has not been investigated throughout systematically. In the present study, 216 specimens of Ch'ungch'□ngnam-buk-do bats fauna were collected at 45 localities in city and districts during the period from February 1980 to August 1990. The results are as follows : The species of collecting bats during this period were Rhinolopus ferrumequinum korai, Myotis garcilis, Myotis ikonnikovi, Myotis formosus tsuensis, Myotis daubentoni ussuriensis, Myotis macrodactylus, Pipistrellus abramus, Pipistrellus coreensis, Miniopterus schreibersii fuliginosus, Murina leucogaster intermedia. Therefore, the recent chiropteran fauna in habited in Ch'ungch'□ngnam-buk-do were found as 13 species, which belongs to 6 genera, 2 families, including 3 species of Myotis nattereri bombinus, Eptesicus nilssoni parvus and E. serotinus brachydigitus reported by Kim(1969) and Mori(1928a). The habitats of 2 species of P. coreensis and M. l. intermedia were discorved for the first time in Ch'ungch'□ngnam-buk-do.

새로운 연노출의 효과지표로서의 혈장 δ-aminolevulinic acid 측정의 유용성

이금원,황보영,김용배,리갑수,이성수,장봉기,함정오,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

To evaluate the usefulness of the measurement of plasma δ - aminolevulinic acid (ALAP) as a new effect indicator of lead exposure, the association of ALAP with blood lead, DMSA chelatable lead and bone lead with a special emphasis of genetic interaction of ALAD polymorphism was studied with 419 lead exposed workers and 85 non-lead exposed workers. Lead workers were recruited from storage battery industries, secondary smelting industries and other lead using industries and non-lead workers selected from electronic refrigerator manufacturing industry. Blood lead, DMSA chelatable lead and bone lead were chosen for parameters of lead exposure. Plasma and urinary ALA were selected for the effect parameter of lead intoxication. Information for age, smoking, drinking habit and body mass index were also obtained. Job duration for lead workers was also collected. The overall prevalence of the variant allele, ALAD type 1-2 or 2-2(ALAD2) in lead exposed workers was 10.0% (42 out of 419 lead workers) which was not differed from control workers (9.4% : 8 out of 85). The means blood lead and DMSA chelatable lead of lead workers with ALAD 1(ALAD type 1-1) were lower than those of lead workers with ALAD2, but the differences were not statistically significant. On the other hand, the mean of tibia lead of lead workers with ALADI was higher than that of lead workers with ALAD2, but the difference was not statistically significant. DMSA chelatable lead showed highest correlation with log transformed plasma ALA(LALAP)(r=0.682) and blood lead and tibia lead had r=0.650, r=0,402 correlation coefficient with LALAP respectively On the other hand. log transformed urinary ALA(LALAU) had lower correlation coefficient with all three parameters of lead exposure than LALAP. The equation of robustic simple linear regression of blood lead on LALAP was LALAP=2.0439+0.0165PbB in ALADI lead workers and LALAP=2.031+0.0121PbB in ALAD2 lead workers. ALAD genotype in the multiple regression analysis of blood lead with LALAP after adjusting for possible confounders(sex, ago, BMI, smoking and drinking status and job duration) showed significant main effect on LALAP resulting lower LALAP in ALAD2 lead workers than ALADI lead workers. On the other hand, effect modification of ALAD genotype was observed in the multiple regression analysis of tibia lead with LALAP after adjusting for possible confounders, but there was no significant effect of ALAD genotype in the multiple regression analysis of DMSA chelatable lead with LALAP after covariate adjustment. With above results, plasma ALA was found to be a useful effect parameter of lead exposure compared with urinary ALA. It was also observed that ALAD polymorphism made significant effect on the association of blood and tibia lead with ALAP. Thc lower plasma ALA in ALAD2 lead workers suggested supportive effect of ALAD2 in lead exposure.

풍력발전기 소음평가

정성수(Sung Soo Jung),전병수(Byung Soo Jeon),서재갑(Jae Gap Seo),이용봉(Yong Bong Lee) 한국소음진동공학회 2014 한국소음진동공학회 학술대회논문집 Vol.2014 No.10

Wind turbine industry is the most developing field among other renewable energy industry. As expanding wind farms, noise is the big problem to solve. This study is about wind turbine noise measuring method based on IEC 61400-11. Sound pressure levels, 1/3-octave band levels, and low frequency sound pressure levels of a 3 MW wind turbine were measured and analyzed.

The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis

Jung, Sun-Do,Park, Yoon-Kyung,Shin, Jung-Hoon,Lee, Hyun-Ji,Kim, Soo-Young,Lee, Gap-Ryol,Park, Se-Ho Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.8

TGF-${\beta}$-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from $CD1d^{+/-}$ or $CD1d^{-/-}$ mice, unlike $CD1d^{+/-}$ APCs, $CD1d^{-/-}$ Tol-APCs failed to suppress CIA. More specifically, $CD1d^{-/-}$ Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.

저주파 소음 수용성 연구

정성수(Jung Sung Soo),이용봉(Lee Yong Bong),전병수(Jeon Byeong Su),서재갑(Suh Jae Gap) 한국소음진동공학회 2011 한국소음진동공학회 학술대회논문집 Vol.2011 No.4

흉추부 경막외에 발생한 골수의 형질세포종 : 증례 보고 Case Report

문수현,박정율,박윤관,정흥섭,서중근,이훈갑 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.10

Spinal cord compression associated with plasma cell neoplasm is observed always in the patients suffering from the multiple myeloma or solitary plasmacytoma that occur in the marrow of the spine. Authers report a rare case of extramedullary plasmacytoma forming a mass in the epidural space of the thoracic spine. In 70 year old woman with paraplegia, MRI of the thoracic spine indicated a presence of epidural mass at the 2nd to 8th thoracic vertebrae. There was no abnormal bony changes in the spine on plain X-ray and MFU. Total removal of the epidural mass was performed by posterior approach. Histopathologic examination including immunohistochemical stain showed the plasma cell neoplasm producing IgM and kappa light chain. Cancer workup after operation including bone marrow study and whole body simple radiologic studies supported the diagnosis of extramedullary plasmacytoma.

리모트 펌프 광증폭기를 이용한 무중계 거리 확장

류갑열(Gap Youl Lyu),이상수(Sang Soo Lee),김향균(Hyang Kyun Kim),이창희(Chang-Hee Lee),한정희(Jung Hee Han) 대한전자공학회 1995 대한전자공학회 학술대회 Vol.1995 No.6

산업용 전기집진 장비에서의 오존(O3)발생에 대한 산업기준 필요성과 저감방안 연구

김영수(Young-Soo Kim),황준호(Jun-Ho Hwang),유홍수(Hong-Soo Yoo),임형길(Hyung-Gil Im),김정훈(Jung-Hoon Kim),심재석(Jae-Seok Sim),최갑봉(Gap-Bong Choi) 한국철도학회 2016 한국철도학회 학술발표대회논문집 Vol.2016 No.10

미세먼지(PM10)와 초미세먼지(PM2.5)에 대한 사회적 관심이 높아지면서 대중의 이용률이 높은 다중 이용시설 에서는 다양한 저감 대책과 측정기술이 적용되고 있다. 특히 국내외 미세먼지 관리대상 시설의 공조 설비에 유지관리 효율이 높은 전기집진장비(Electrostatic Precipitator, EP)의 사용비중이 늘어나고 있으나, 이에 따른 표준화된 오존 측정절차나 정확한 관리기준이 미흡한 상태이다. 본 논문에서는 현재 주로 사용되고 있는 부코로나(negative corona, 이하 NC)방식의 전기 집진장비에 대한 오존 발생 현황을 분석하고, 밀폐된 공간 혹은 지하 터널에서의 전기 집진설비 사용으로 발생한 오존의 표준화된 측정방법과 기준치 설정 필요성 및 효율적인 저감 방안을 모색코자 한다. Increasing social interest in the fine dust (PM10) and ultra-fine dust (PM2.5), the utilization rate is high multiple use facilities of the masses, various reduction measures and measurement techniques have been applied. In particular, the efficiency of the maintenance on air conditioning equipment of the managed facilities at home and abroad of the fine dust is increasing the proportion of high electrostatic precipitator (Electrostatic Precipitator, EP). But, Standardized ozone measurement procedures and accurate management criteria associated with this is an unsatisfactory state. In this paper, to analyze current, mainly being used are part corona (negative corona, following NC) ozone generation status of the system of electrostatic precipitator. Also Attempting to seek a sealed necessity of setting standardized measurement methods and reference values of ozone generated by the use of electrostatic precipitator in space or underground tunnels and effective reduction measures.