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Case Report : Recurrent Systemic Capillary Leak Syndrome Responding to the Corticosteroid Therapy
( Eun Jung Cho ),( In Hye Cha ),( Ki Chul Yoon ),( Dae In Lee ),( Tae Kyung Lim ),( Young Sun Kang ),( Dae Ryong Cha ),( Young Sik Kim ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.4
Systemic capillary leak syndrome (SCLS) is a rare devastating condition that is caused by unexplained marked capillary hyperpermeability, resulting in hypovolemic shock, hemoconcentration, and hypoproteinemia. Most patients have prodromal symptoms such as non-specific gastrointestinal symptoms, myalgia, or dizziness. In the current case, we observed the patient with recurrent SCLS show perivascular lymphocytic infiltration on skin biopsy and eosinophilic infiltrates on random biopsies from duodenum to colon. This finding might be due to distinct eosinophilic enterocolitis or secondary to SCLS. However, there has been rare data for the prevention of the recurrent attack of SCLS, although the mortality is high. Therefore, we report a case of frequently relapsing SCLS responding to the corticosteroid therapy.
RNA polymerase II carboxy-terminal domain with multipleconnections
Eun-Jung Cho 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.3
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of an evolutionarily conserved heptapeptide repeat (YSPTSPS). Over the past decade, there has been increasing attention on the role of the CTD in transcription regulation in the view of mRNA processing and chromatin remo-deling. This paper provides a brief overview of the recent progress in the dynamic changes in CTD phosphorylation and its role in integrating multiple nuclear events.
Clinical Characteristics and Outcomes of Septic Acute Kidney Injury in Critically 3 Patients
( Eun Jung Cho ),( In Hye Cha ),( Ki Chul Yoon ),( Hye Min Choi ),( Sang Kyung Jo ),( Won Yong Cho ),( Hyoung Kyu Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.3
Purpose: This study was to determine the clinical characteristics and outcomes of critically ill patients with septic acute kidney injury (AKI). Methods: We retrospectively collected data of patients with AKI who were ≥18 years of age and admitted to the intensive care unit (ICU) for ≥24 hours from April 2007 to December 2009, and compared the clinical characteristics and outcomes of patients with and without sepsis. Results: Of the 1,075 patients, 333 had AKI, as defined by the RIFLE criteria, and 134 of them had AKI with sepsis. Septic AKI had significantly higher SAPS II and SOFA scores, and required more mechanical ventilation and vasoactive drugs than non-septic AKI. Patients with septic AKI progressed more to the failure category of the RIFLE criteria. Patients with septic AKI had higher in-hospital mortality and required more RRT, compared to patients with non-septic AKI. Amongst survivors, patients with septic AKI were more likely to recover renal function. A higher SAPS II score and a greater requirement for vasoactive drugs and renal replacement therapy were independently associated with increased in-hospital mortality in septic AKI. Conclusion: Patients with septic AKI have a higher burden of illness with an increased risk of death, but renal function recovers better in survivors of septic AKI.
A Study of the Internal Structure of N+N Compounds
Eun Jung Cho,Byeongkil Ahn 언어과학회 2021 언어과학연구 Vol.- No.99
This paper addresses the issue of how the language user can interpret two-constituent compounds. After reviewing the previous studies regarding classifications, this study finds out that although the studies suggest several sets of semantic relations or syntactic structures, the criteria of the classifications are not clear, and the previous studies usually depend on our encyclopedic information to get the appropriate interpretation of two noun compounds, especially attributive-appositive compounds. In order to distinguish similar-looking N+N compounds from each other, this study explores relevant notions, such as autonomacy/dependency in a cognitive framework regarding the relation between the two elements in compounds. The same examples in noun-noun compounds in the previous studies can be analyzed and examined from this perspective. Finally, this study goes back to Lees’ (1960) classification on the syntactic aspects and tries to elaborate upon his proposal by employing the findings in this study.
A Study on the Segmented Elements of Neologisms
( Eun Jung Cho ) 현대영미어문학회 2018 현대영미어문학회 춘계학술대회 발표논문집 Vol.2018 No.-
This study discusses how to classify a certain type of word formation such as that of hamburger series and focuses on the identity of the segmented elements of the newly-coined word series. The type of hamburger series includes -burger series, -holic series, -gate series, and so on. Regarding this kind of word formation, there are not unified accounts and there are mainly three approaches: Some argue the (un)bound morphemes which serve as a new word generator should be treated as blend splinters, others argue they should be treated as pseudo affixes, and still others argue that they should be treated as combining forms. This study discusses the three approaches and argues that the emergent (un)bound morphemes should be treated as combining forms and the word formation involving the elements should be regarded as compounding, or neoclassical compounding. This suggestion can explain this certain type of word formation in a unified way.
Eun-Jung Cho,Ae Ran Choi,Ji Hyeong Ryu,So Jeong Yun,Eun-Jee Oh 대한임상검사정도관리협회 2020 Journal of Laboratory Medicine And Quality Assuran Vol.42 No.4
As a diagnostic immunology program of the Korean Association of External Quality Assessment Service, two trials were organized to assess the external quality of hepatitis serology in 2018 and 2019. The hepatitis serology program consisted of 10 test items. For this, we delivered four kinds of pooled sera specimens to 1,068 and 1,076 institutions for external proficiency testing in 2018 and 2019, respectively. Out of the participating laboratories, 1,041 (97.5%) and 1,046 (97.9%) responded in the first and second trials of 2018, respectively. In the first and second trials of 2019, 1,058 (98.3%) and 1,057 (98.2%) participating laboratories responded. The most commonly tested items were hepatitis B surface antigen (HBsAg), followed by antibodies against hepatitis B surface antigen (anti-HBs), anti-hepatitis C virus (anti- HCV), hepatitis B envelope antigen (HBeAg), antibodies to hepatitis B envelope antigen, anti-hepatitis A virus, and antibodies to hepatitis B core antigen. The most frequently used methods for detecting viral markers were chemiluminescence immunoassay and electrochemiluminescence immunoassay. In 2019, the use of immunochromatography assay (ICA) kits for HBsAg and anti-HBs detection increased. Some ICAs showed falsenegative results for HBeAg and anti-HCV due to low sensitivity. Improved pooled sera production reduced the HBeAg false-positive rate due to the matrix effect. The quality of viral hepatitis testing should be continuously improved through participation in the survey.
Eun Jung Cho,Myoung Soo Park,Sahng Seop Kim,Gun Kang,Sunga Choi,이유란,장석종,Kwon Ho Lee,이상도,박진봉,전병화 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6
Ulmus davidiana var. japonica Rehder (Urticales: Ulmaceae) (UD) is a tree widespread in northeast Asia. It is traditionally used for anticancer and anti-inflammatory therapy. The present study investigated the effect of an ethanol extract of UD on vascular tension and its underlying mechanism in rats. The dried root bark of UD was ground and extracted with 80% ethanol. The prepared UD extract was used in further analysis. The effect of UD on the cell viability, vasoreactivity and hemodynamics were investigated using propidium iodide staining in cultured cells, isometric tension recording and blood pressure analysis, respectively. Low dose of UD (10∼100μg/ml) did not affect endothelial cell viability, but high dose of UD reduced cell viability. UD induced vasorelaxation in the range of 0.1∼10μg/ml with an ED50 value of 2μg/ml. UD-induced vasorelaxation was completely abolished by removal of the endothelium or by pre-treatment with L-NAME, an inhibitor of nitric oxide synthase. UD inhibited calcium influx induced by phenylephrine and high K+ and also completely abolished the effect of L-NAME. Intravenous injection of UD extracts (10∼100 mg/kg) decreased arterial and ventricular pressure in a dose-dependent manner. Moreover, UD extracts reduced the ventricular contractility (+dP/dt) in anesthetized rats. However, UD-induced hypotensive actions were minimized in L-NAME-treated rats. Taken together, out results showed that UD induced vasorelaxation and has antihypertensive properties, which may be due the activation of nitric oxide synthase in endothelium.