내시경적 절제로 진단된 폴립 형태의 심재성 낭종성 위염 2예

허종현,조영화,성용완,유재훈,구동영,김갑식,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Gastritis cystica profunda (GCP) is a disease characterized by hyperplastic and significant extension of cystic dilatation of the gastric mucous glands, which results in a cystic lesion in gastric submucosa. It often occurs on the part of gastroenterostomy, but can be found in the stomach without any previous surgery. GCP has variable gross finding including solitary polyps, diffuse ones, submucosal tumors, and rare giant gastric mucosal fold. It is difficult to tell GCP from a cancerous lesion by gross finding that the disease demands a necessary tissue biopsy, though GCP is commonly showed as a benign in the progress. We report a case of GCP in polypoid types diagnosed by endoscopic polypectomy.

종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과

노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암공동연구소 2005 암공동연구소 업적집 Vol.4 No.

Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)

종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과

노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-

Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)

직무스트레스가 직무 만족도에 미치는 영향

박정현,노동연 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study purposes the influence of job stress upon job satisfaction demonstratively. I set up the employees of sports centers in Seoul and Gyeonggi Province as population and took 300 employees in 13 sports centers using a stratified cluster random sampling. The actually used data were 278 workers except 22 employees who were judged to respond unfaithfully or to leave out some of the surveyed questions. I made a conclusion as follows through statistical analyses including correlation analysis and regression analysis. Related to the influence of job stress of upon job satisfaction, there was a statistical significance at the level of 5 percent in all factors including job characteristics, roles, relationship, rewarding system, and organizational characteristics, and the factors of job stress show the depiction of 21.1%(R² =.211) on job satisfaction.

내시경적 밴드 결찰술로 치료한 출혈을 동반한 위 혈관이형성증 1예

김갑식,허종현,성용완,조영화,구동영,유재훈,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Gastric angiodysplasia is vascular ectasia in mucosa and submucosa of the gastric wall. It is an uncommon cause of upper gastrointesinal hemorrhage that may occur in the stomach or duodenum. There are many kinds of endoscopic treatments, such as argon plasma coagulation, electrocoagulation, heat probe, and submucosal injection of hypertonic saline mixed with epinephrine for gastric angiodysplasia. However, these treatment methods are associated with high rate of rebleeding. In order to avoid the recurrence, endoscopic band ligation has recently been used as an alternative method for endoscopic treatment of gastric angiodysplasia. We encountered a case of gastric angiodysplasia that presented with overt bleeding and anemia, and was successfully treated with endoscopic band ligation.

인천지역 TDI 노출 작업자에서 직업성천식 유병율

김형렬,김철우,홍윤철,전형준,김치년,김현수,이지나,신주연,고동희,노재훈 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.2

목적 : TDI는 직업성천식을 일으키는 대표적인 물질로 알려져 있다. 과거 TDI에 노출된 작업자들의 천식 발생률을 5~6%가량 보고하였고, 국내에서도 2-20%에 이르는 유병율을 보고한바 있다. 작업환경이 많이 개선되고, 노출량이 감소된 최근에도 TDI에 의한 직업성천식에 대한 보고가 많이 이루어지고 있어, 이에 대한 적극적인 조사와 진단과정을 통해 유병율을 구하고 질병발생의 변화양상을 파악해 보고자 하였다. 방법 : 인천지역에서 특수건강진단을 수행하는 2개 기관의 TDI 노출 근로자 400여명 중, 사업장의 규모가 50인 이상이며 사업주가 연구진행을 허락한 사업장에서 근무하는 근로자 중 직접적으로 TDI에 노출되는 작업에 종사하는 근로자 170명을 연구대상으로 하였다. 이들에 대해 설문지와 산업의학의사의 면담을 통한 작업관련성 평가를 근거로 정밀대상자를 선정하고 이들에 대해 메타콜린 유발시험, TDI 유발시험 등을 수행하여 직업성천식을 확인하였다. 결과 : 설문조사 결과 11명이 직업과 관련하여 천식증상을 보이는 것으로 나타났고(6.9%), 이중 7명에서 메타콜린 유발검사 양성소견을 보였다. TDI에 의한 특이유발시험 결과 1명에서 양성반응이 나타나, 이 집단에서 TDI에 의한 직업성천식의 유병율은 0.58%였다. 결론 : 과거 국내연구에서 TDI에 의한 직업성천식의 유병율이 2~20%에 이르렀던 데 비해, 본 연구에서는 0.58%로 나타났다. 이는 국외 논문에서도 나타나는 경향으로 작업장 노출량 감소로 점차 발생률이 감소하는 양상을 보이고 있다. 그러나 이미 증상이 나타난 근로자들이 부서를 옮기거나, 직장을 그만둠으로 인해 그 유병율이 과소평가되었을 가능성도 있다고 판단된다. Objecdives: This study was carried out to estimate the prevalence of isocyanate-induced occupational asthma in toluene diisocyanate (TDI) exposed workers. Methods: We examined 170 workers who had been directly exposed to TDI through a medical questionnaire, physical examination, and pulmonary function test. Based on screening examination, workers with suspected occupational asthma were selected for further evaluation such as methacholine and TDI challenge tests. Results: Eleven (6.9%) among 170 workers complained of symptoms of occupational asthma. and 7 among these 11 symptomatic workers showed positive responses to the methacholine challenge test (4.1 %). One spray painter was confirmed as having the TDI induced occupational asthma following a positive response to TDI challenge test. Conclusions: The prevalence of TDI-induced asthma was at 0.58% was lower than that for former studies (2-20%). Improved workplace environment, lower level of TDI exposure compared to the past, and the healthy workers effect may have contributed to this low rate of asthma prevalence in workers with TDI exposure.

FPGA를 이용한 전파천문용 디지털 필터 설계에 관한 기본연구

정구영,노덕규,오세진,염재환,강용우,이창훈,정현수,김광동,Jung, Gu-Young,Roh, Duk-Gyoo,Oh, Se-Jin,Yeom, Jae-Hwan,Kang, Yong-Woo,Lee, Chang-Hoon,Chung, Hyun0Soo,Kim, Kwang-Dong 한국융합신호처리학회 2008 융합신호처리학회 논문지 (JISPS) Vol.9 No.1

본 논문에서는 전파천문용으로 사용하기 위한 대칭형 디지털 필터 코어의 설계를 제안한다. 본 논문에서는 Xilinx사의 Virtex-4 SX55 모델의 FPGA칩을 기반으로 한국우주전파관측망(Korean VLBI Network; KVN)의 자료획득시스템에서 요구하는 FIR 필터 코어의 기능을 VHDL 코드로 설계하였다. 본 논문에서 설계한 디지털 필터는 디지털 필터계수를 공유하여 시스템의 효율을 증대시킨 대칭형 구조(Symmetric Structure)를 갖는다. 대칭구조의 디지털 필터(Symmetric FIR Filter Unit; SFFU)는 제한된 시스템 클록을 이용하여 데이터의 처리를 효과적으로 수행하기 위해 병렬처리 방법을 사용한다. 따라서 본 논문에서는 SFFU의 효율적인 설계를 위해 전체적인 IP core의 합성 및 실험에는 통합 합성 소프트웨어 ISE Foundation을 사용하였으며, GUI 환경이 뛰어난 core generator를 활용하였다. 설계한 디지털 필터 코어의 합성 결과, 최대 동작 주파수는 260MHz를 약간 상회하는 수준까지 달성하였으며, 슬라이스, LUT 등의 리소스 사용량은 40% 이하임을 확인하였다 또한 Mentor Graphics사의 Modelsim 6.la 버전을 이용하여 SFFU(Symmetric FIR Filter Unit)의 시뮬레이션을 수행한 결과, 오류 없이 작동하는 것을 확인하였다. SFFU의 기능을 확인하기 위하여 추가적으로 Matlab을 이용하여 의사 신호를 이용한 시뮬레이션을 수행하였다. 시뮬레이션과 설계한 디지털 FIR 필터의 비교실험결과에서 FIR 필터의 기능을 수행하고 있음을 확인할 수 있어 본 논문에서 FPGA와 VHDL을 이용하여 설계한 대칭구조의 디지털 FIR 필터의 유효성을 확인할 수 있었다. In this paper, we would like to propose the design of symmetric digital filter core in order to use in the radio astronomy. The function of FIR filter core would be designed by VHDL code required at the Data Acquisition System (DAS) of Korean VLBI Network (KVN) based on the FPGA chip of Vertex-4 SX55 model of Xilinx company. The designed digital filter has the symmetric structure to increase the effectiveness of system by sharing the digital filter coefficient. The SFFU(Symmetric FIR Filter Unit) use the parallel processing method to perform the data processing efficiently by using the constrained system clock. In this paper, therefore, for the effective design of SFFU, the Unified Synthesis software ISE Foundation and Core Generator which has excellent GUI environment were used to overall IP core synthesis and experiments. Through the synthesis results of digital filter core, we verified the resource usage is less than 40% such as Slice LUT and achieved the maximum operation frequency is more than 260MHz. We also confirmed the SFFU would be well operated without error according to the SFFU simulation result using the Modelsim 6.1a of Mentor Graphics Company. To verify the function of SFFU, we carried out the additional simulation experiments using the pseudo signal to the Matlab software. From the comparison experimental results of simulation and the designed digital FIR filter, we confirmed the FIR filter was well performed with filter's basic function. So we verified the effectiveness of the designed FIR digital filter with symmetric structure using FPGA and VHDL.

Enhancement of magnetic properties of sintered Nd-Fe-B magnet with grain boundary diffusion process of Tb-Al-Cu

Dong Hyun Lee,Seong Chan Kim,Juyoung Baek,Sangchul Lee,Donghwan Kim,Sang Hyub Lee,Dalhyun Do,Jong Wook Roh,Dong Hwan Kim,Jeongmin Kim 한국자기학회 2023 한국자기학회 학술연구발표회 논문개요집 Vol.33 No.1

Purification and Promoter Binding Assay of XylR , which is a Regulatory Protein for xylA Gene in Escherichia coli

Dong Hyun Roh,Gil Jae Joo,In Koo Rhee 한국응용생명화학회(구 한국농화학회) 1996 한국응용생명화학회 학술발표회 Vol.1996 No.2

Comparison of Effects Between Modified Vertical Roll Sling and Bobath Roll Sling in Hemiplegic Shoulder Subluxation

( Dong Hyun Kim ),( Tack Hoon Kim ),( Jung Suk Roh ),( Heon Seock Cynn ),( Houng Sik Choi ),( Dong Sik Oh ) 한국전문물리치료학회 2008 한국전문물리치료학회지 Vol.15 No.4