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권순환 ( Soon-hwan Kwon ),이수진 ( Sujin Lee ),강대연 ( Daeyoun Kang ),최지선 ( Jisun Choi ),장제윤 ( Jeyoun Jang ) 국군의무사령부 2018 대한군진의학학술지 Vol.49 No.1
Objectives; Hantavax is not yet improved due to absence of prospective randomized controlled study. The analysis of neutralizing antibody is known to the method of guessing of protectiveness of vaccine. To investigate the effectiveness of Hantavax more correctly. we were carried out immunogenicity studies before and after vaccination with Hantavax. Methods; The new solider of 17 and 20 division of Korean army are enrolled in this study. 246 blood samples collected before vaccination and 3 and 6 month after vaccine inoculation. Before and after vaccination, hantaanvirus antibodies in the serum were analyzed by ELISA, IFA, and PRNT in the collected serum. Results; The result of the vaccination status, 246 enrolled persons were able to confirm the vaccination status. In the basic vaccination, second vaccination inoculated at 1 to 3 month intervals from first shot and booster vaccination was inoculated after 7 to 11 months from second vaccination. 20% of persons are vaccinated only once in the training center. According to the results, in the group that was boosted at 7 months after basic vaccination, 37.5% from ELISA and 53.33% from IFA were detected the hantaanvirus antibodies at 6 months after the boosting. The group that was boosted at 11 months after basic vaccination was able to confirm the antibody retention by 75% in EISA and 100% in IFA at 6 months after the boosting. Conclusions; We found problems with vaccination and management of vaccine in the army. It is very important to vaccinate at the correct vaccination guideline. To find this study confirmed that the interval of hantavax vaccination was very important for the vaccine efficacy.
( Jae-hoon Ko ),( Hyeong-taek Woo ),( Hong Sang Oh ),( Song Mi Moon ),( Joon Young Choi ),( Jeong Uk Lim ),( Donghoon Kim ),( Junsu Byun ),( Soon-hwan Kwon ),( Daeyoun Kang ),( Jung Yeon Heo ),( Kyong 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1
Background/Aims: Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter. Methods: To evaluate the epidemiologic characteristics of HAdV-ARI in the Korean military, we analyzed respiratory virus polymerase chain reaction (RV-PCR) results, pneumonia surveillance results, and severe HAdV cases from all 14 Korean military hospitals from January 2013 to May 2018 and compared these data with nationwide RV surveillance data for the civilian population. Results: A total of 14,630 RV-PCRs was performed at military hospitals. HAdV (45.4%) was the most frequently detected RV, followed by human rhinovirus (12.3%) and influenza virus (6.3%). The percentage of the military positive for HAdV was significantly greater than the percentage of civilians positive for HAdV throughout the study period, with a large outbreak occurring during the winter to spring of 2014 to 2015. The outbreak continued until the end of the study, and non-seasonal detections increased over time. The reported number of pneumonia patients also increased during the outbreak. Case fatality rate was 0.075% overall but 15.6% in patients with respiratory failure. The proportion of severe patients did not change significantly during the study period. Conclusions: A large HAdV outbreak is currently ongoing in the Korean military, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.
The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study
Hyeji Kwon,Song Hwa Chae,Hyo Jin Jung,Hyeon Min Shin,O-Hyun Ban,Jungwoo Yang,Jung Ha Kim,Ji Eun Jeong,Hae Myung Jeon,Yong Won Kang,Chan Kum Park,Daeyoun David Won,Jong Kyun Lee 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.5
Purpose: Microbiota manipulation through selected probiotics may be a promising tool to prevent cancer development as well as onset, to improve clinical efficacy for cancer treatments. The purpose of this study was to evaluate change in microbiota composition after-probiotics supplementation and assessed the efficacy of probiotics in improving quality of life (QOL) in postoperative cancer patients. Methods: Stool samples were collected from 30 cancer patients from February to October 2020 before (group I) and after (group II) 8 weeks of probiotics supplementation. We performed 16S ribosomal RNA gene sequencing to evaluate differences in gut microbiota between groups by comparing gut microbiota diversity, overall composition, and taxonomic signature abundance. The health-related QOL was evaluated through the EORTC Quality of life Questionnaire Core 30 questionnaire. Results: Statistically significant differences were noted in group II; increase of Shannon and Simpson index (P = 0.004 and P = 0.001), decrease of Bacteroidetes and Fusobacteria at the phylum level (P = 0.032 and P = 0.014, retrospectively), increased of beneficial bacteria such as Weissella (0.096% vs. 0.361%, P < 0.004), Lactococcus (0.023% vs. 0.16%, P < 0.001), and Catenibacterium (0.0% vs. 0.005%, P < 0.042) at the genus level. There was a significant improvement in sleep disturbance (P = 0.039) in group II. Conclusion: Gut microbiota in cancer patients can be manipulated by specific probiotic strains, result in an altered microbiota. Microbiota modulation by probiotics can be considered as part of a supplement that helps to increase gut microbiota diversity and improve QOL in cancer patients after surgery.