http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
프로토 타입 조직등가비례계수기의 중입자가속기연구소의 135 MeV/u 탄소 이온에 대한 선형에너지 스펙트럼 측정
남욱원 ( Uk Won Nam ),이재진 ( Jae Jin Lee ),표정현 ( Jeong Hyun Pyo ),박원기 ( Won Kee Park ),문봉곤 ( Bong Kon Moon ),임창휘 ( Chang Hwy Lim2,),문명국 ( Myung Kook Moon ),하시시키다무라 ( Hisashi Kitamure ),신고고바야시 ( Shingo Kob 한국센서학회 2014 센서학회지 Vol.23 No.3
TEPC (Tissue Equivalent Proportional Counter) was usually used for high LET radiation dosimetry. We developed a prototype TEPC for micro-dosimetry in the range of 0.2~300 keV/μm. And, the simulated site diameter of the TEPC is 2 μm, of similar size to a cell nucleus. For purposes of characterization the response for high LET radiation of the TEPC has been investigated under 135MeV/u Carbon ions in HIMAC (Heavy Ion Medical Accelerator). We determined the gas multiplication factor and measured the lineal energy spectrum [yd(y)] of 135 MeV/u Carbon ions. The value of the gas multiplication factor was 315 at 700 V bias voltage. As a result of the experiment, we could more understand the performance of the TEPC for high LET (Linear Energy Transfer) radiation. And the procedure of high LET radiation dosimetry using TEPC is established.
Kim, Mee-Young,Kim, Ju-Hyun,Lee, Jeong-Uk,Lee, Lim-Kyu,Yang, Seung-Min,Jeon, Hye-Joo,Lee, Won-Deok,Noh, Ji-Woong,Lee, Tae-Hyun,Kwak, Taek-Yong,Kim, Bokyung,Kim, Junghwan The Society of Physical Therapy Science 2014 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.26 No.3
<P> [Purpose] Immobilization-induced atrophy is a general phenomenon caused by prolonged muscle disuse associated with orthopaedic conditions. However, changes in the phosphorylation of atrophy-related cofilin and LIM kinases are still poorly understood. In this study, we examined whether or not phosphorylation of cofilin and LIM kinases is altered in the skeletal muscles of rats after 3, 7, 14, and 21 days of cast immobilization. [Methods] We used two-dimensional gel electrophoresis, mass spectrometry, and western blotting to examine protein expression and phosphorylation in atrophied rat gastrocnemius muscles. [Results] The expression of the cofilin was detected in gastrocnemius muscle strips using proteomic analysis. Cast immobilization after 3, 7, 14, and 21 days significantly diminished the phosphorylation of cofilin and LIM kinases. [Conclusion] The present results suggest that cast immobilization-induced atrophy may be in part related to changes in the phosphorylation of cofilin and LIM kinases in rat skeletal muscles.</P>
( Jeong Uk Lim ),( Soo Han Kim ),( Hye Seon Kang ),( Sung Kyoung Kim ),( Ju Sang Kim ),( Jin Woo Kim ),( Seung Joon Kim ),( Chang Dong Yeo ),( Chang Min Choi ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose The present study evaluated the impact of prior radiotherapy (RT) on patients with advanced non-small cell lung cancer (NSCLC) receiving therapy with immune checkpoint inhibitors (ICIs), and further assessed the prognostic factors in patients receiving both RT and ICI. Method Patients diagnosed with NSCLC at the Catholic Medical Center and Asan Medical Center between January 2016 and October 2020 and who received immunotherapy were retrospectively reviewed. Result Among 240 patients, 57 patients did not receive prior RT, and 183 patients received RT prior to initiation of ICI treatment. The responder group showed a higher proportion of ICI-related AEs (16.9% vs. 5.7%, P=0.012). Poor Eastern Cooperative Oncology Group (ECOG) score, high PD-L1 expression, and ICI-related adverse events (AE) were significantly associated with progressionfree survival (PFS) (HR, 2.654; 95% CI, 1.484-4.749; P=0.001; HR, 0.645; 95% CI, 0.449-0.926, P=0.017; HR, 0.430; 95% CI, 0.229- 0.808; P=0.009, respectively). Among patients who received both RT and immunotherapy, poor ECOG status, squamous cell carcinoma, and ICI-related AE were significant factors associated with poor PFS (HR, 2.430; 95% CI, 1.464-4.034; P=0.001; HR, 0.667; 95% CI, 0.455-0.978, P=0.038; HR, 0.520; 95% CI, 0.284-0.953, P=0.034, respectively). Conclusion The present study showed that prior RT showed no significant independent association with primary outcomes in patients with advanced NSCLC receiving immunotherapy. In patients who received both RT and immunotherapy, clinical parameters, including ICI-related AEs, were independently predictive of PFS.
S-424 : A patient of congenitally corrected transposition of the great arteries as a kidney donor
( Jeong Uk Lim ),( Youn Hee Lee ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Herein we present an unusual case of congenitally corrected transposition of great arteries(ccTGA) patient who has undergone successful nephrectomy for purpose of donating kidney to his distant cousin. A 48-yr-old man came to our hospital to donate his kidney and received preop evaluation. Echocardiography revealed corrected TGA, with aorta arising from morphologic RV and pulmonary artery arising from the morphologic LV, and morphologic RV`s ejection fraction checked 42%. Electrocardiography showed finding of complete AV block. After consulting with cardiology department, patient has undergone a nephrectomy. No complication has occurred during general anesthesia and postoperative care. An abnormal conduction system is common in ccTGA patients. If the patient with AV discordance and narrow-complex complete AV block has an adequate heart rate, insertion of the pacemaker is not obligatory. Our patient`s average heart rate was around 53 beats per minute, and series of electrocardiography showed finding of complete AV block with narrow QRS shape. No definite indication for pacemaker insertion was present for our patient. So it was possible to proceed with nephrectomy without further cardiac procedures. This case showed that kidney donation is possible for patients of ccTGA and complete AV block, if patient does not have indication for pacemaker insertion.
( Jeong Uk Lim ),( Deog Kyeom Kim ),( Myung Goo Lee ),( Yong-il Hwang ),( Kyeong-cheol Shin ),( Kwang Ho In ),( Sang Yeub Lee ),( Chin Kook Rhee ),( Kwang Ha Yoo ),( Hyoung Kyu Yoon ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.-
Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition characterized by the overlapping clinical features of asthma and COPD. To evaluate the appropriateness of different sets of ACO definition, we compared the clinical characteristics of the previously defined diagnostic criteria and the specialist opinion in this study. Methods: Patients enrolled in the KOrea COpd Subgroup Study (KOCOSS) were evaluated. Based on the questionnaire data, the patients were categorized into the ACO and non-ACO COPD groups according to the four sets of the diagnostic criteria. Results: In total 1,475 patients evaluated: 202 of 1,475 (13.6%), 32 of 1,475 (2.2%), 178 of 1,113 (16.0%), and 305 of 1,250 (24.4%) were categorized as ACO according to the modified Spanish Society of Pneumonology and Thoracic Surgery (SEPAR), American Thoracic Society (ATS) Roundtable, Global Initiative for Asthma (GINA)/Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, and the specialists diagnosis, respectively. The ACO group defined according to the GINA/GOLD criteria showed significantly higher St. George's Respiratory Questionnaire and COPD Assessment Test scores than the non-ACO COPD group. When the modified SEPAR definition was applied, the ACO group showed a significantly larger decrease in the forced expiratory volume in 1 second (FEV<sub>1</sub>, %). The ACO group defined by the ATS Roundtable showed significantly larger decrease in the forced vital capacity values compared to the non-ACO COPD group (-18.9% vs. -2.2%, p=0.007 and -412 mL vs. -17 mL, p=0.036). The ACO group diagnosed by the specialists showed a significantly larger decrease in the FEV<sub>1</sub> (%) compared to the non-ACO group (-5.4% vs. -0.2%, p=0.003). Conclusion: In this study, the prevalence and clinical characteristics of ACO varied depending on the diagnostic criteria applied. With the criteria which are relatively easy to use, defining ACO by the specialists diagnosis may be more practical in clinical applications.
( Jeong Uk Lim ),( In Sook Woo ),( Yun Hwa Jung ),( Jae Ho Byeon ),( Chan Kwon Park ),( Tae Jung Kim ),( Hyo Rim Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although erlotinib has been found to markedly improve progression free survival and quality of life, most patients who show an initial response eventually develop disease progression. Acquired resistance due to histologic transformation have been recognized as one of the resistance mechanisms. Methods: We present a 33 year old male lung cancer patient who showed acquired resistance to erlotinib after histologic transformation into LCNEC with literature review. Results: A 33-year-old male was admitted to our institution for headache and diplopia.Brain MRI revealed multiple metastatic masses in the brain. A left frontal craniotomy was performed to remove the mass and after pathologic evaluation, he was diagnosed with metastatic lung adenocarcinoma harboring a deletion in exon19 of EGFR gene. He underwent cyberknife surgery followed by two cycles of pemetrexed-cisplatin as fi rst line chemotherapy. However, follow up CT showed progressive disease. Second line treatment with erlotinib for two months showed a partial response at the lung nodules, mediastinal lymph nodes and kidney masses. After 10 months of treatment with erlotinib, the right lower paratracheal lymph node increased in size from 1 to 3 cm. A rebiopsy of the right paratracheal lymph node by mediastinoscopy showedtwo different types of cells: adenocarcinoma cells, as shown on initial pathology; and LCNEC cells, comprising 50% of the microscopic fi eld. The EGFR gene in the second biopsy specimen was not analyzed due to patient refusal. Despite receiving three cycles of etoposide-cisplatin (EP) chemotherapy, along with maintenance erlotinib to prevent disease fi are up from erlotinib discontinuation, the disease progressed Conclusions: we describe a patient with metastatic lung adenocarcinoma who experienced a histologic transformation to combined LCNEC and adenocarcinoma of the lung during treatment with erlotinib.
( Jeong Uk Lim ),( Chang Dong Yeo ),( Hye Seon Kang ),( Ju Sang Kim ),( Chan Kwon Park ),( Jin Woo Kim ),( Seung Joon Kim ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose While association between systemic inflammation and disease progression is suggested, we assessed potential predictability of early changes in neutrophil to lymphocyte ratio (NLR) and derived NLR (dNLR) in NSCLC under ICI. Method Among a multicenter cohort of lung cancer, patients with advanced (stage IIIB-IV) NSCLC who were under ICI between January 2016 and December 2019 were enrolled from six university hospitals. Complete blood count was measured just before 1st cycle of ICI and 2nd cycle of ICI. Differences in NLR, and dNLR were measured. When the increase in NLR was equal or more than 1, the patients were classified into the “NLR increase group” if otherwise, they were classified in to the “NLR non-increase group.” Likewise, when the increase in dNLR was equal or more than 1, the patients were classified into the “dNLR increase group”, if not, they were classified into the “dNLR non-increase group”. Results Total of 89 patients were selected for evaluation. Median progression free survival (PFS) was significantly longer for the NLR non-increase group when compared to the NLR increase group (9.5 vs 2.6 months, P<0.001). Derived NLR increase group showed significantly shorter median PFS when compared to the dNLR non-increase group (4.2 vs 9.2 months, P=0.001) (Figure). Using cox regression hazard model, association with PFS was analyzed. In the model 1, in which NLR increase was entered, increase ≥ 1 in NLR showed significant association (HR=3.007, 95% CI =1.610-5.617, P=0.001). In the model 2, in which dNLR increase was entered in the multivariate analysis, increase ≥ 1 in dNLR showed significant association (HR=2.601, 95% CI=1.331-5.079, P=0.005) (Table). Conclusion While early change in dNLR and NLR were shown to have prognostic value in patients undergoing immunotherapy, using multiple measurement points, they can be more accurate and comprehensive biomarkers in predicting ICI response.
( Jeong Uk Lim ),( Hye Seon Kang ),( Ah Young Shin ),( Chang Dong Yeo ),( Chan Kwon Park ),( Sang Haak Lee ),( Seung Joon Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Local treatment (LT) such as radiotherapy and metastasectomy on metastatic sites can improve outcomes in oligometastatic NSCLC patients. Patients with single extrathoracic metastatic lesion are more likely to benefit from local therapy. In this study, we evaluated the efficacy of LT in NSCLC patients with a single extrathoracic metastatic lesion. Methods Data were obtained from the Korean Association for Lung Cancer Registry (KALC-R), a database created using a retrospective sampling survey by the Korean Central Cancer Registry (KCCR) and the Lung Cancer Registration Committee. Results A total of 787 NSCLC patients with a single extrathoracic metastatic lesion were evaluated. Regarding the LT modality, 17 (2.2%) patients underwent metastasectomy and 297 (37.7%) underwent radiotherapy. In the multivariate analysis for overall survival (OS), age, female sex, poor performance score, squamous histologic subtype, LT, and initial treatment modality showed significant associations. Regarding LT, groups that underwent curative LT showed significantly associated with better OS compared to groups that did not undergo LT (P=0.011, HR 0.448, 95% CI: 0.242-0.829). In the multivariate analysis of patients who underwent LT, poor performance score, initial treatment modality, and T stage were independently associated with poor OS. Compared to the T1 stage, T3 stage showed an HR of 2.470 (95% CI: 1.309-4.663; P=0.005) and T4 stage showed an HR of 2.063 (95% CI: 1.093-3.904; P=0.026). Conclusion In NSCLC with a single extrathoracic metastatic lesion, LT, especially for curative purposes, has an independent association with improved OS. Moreover, among the patients who received LT, factors such as T stage, poor performance score, and initial treatment modality were significantly associated with OS.