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박건주,하정상,이준,도현철,박승권,서상덕,기병수,김진국 영남대학교 의과대학 1996 Yeungnam University Journal of Medicine Vol.13 No.1
1985년 8월부터 1996년 1월까지 중증근무력증으로 진단받은 환자 52례에 대한 임상적 고찰을 통하여 다음과 같은 결론을 얻었다. 1. 전체 환자 중 남자가 19례(35.8%), 여자가 33례(64.2%)이넜고 11세에서 20세 사이가 12례(23%)로 가장 높은 빈도를 보였다. 2. 환자의 초기증상으로는 안검하수, 복시 등의 안구증상이 37례(71.2%)로 가장 많았고 modified Osserman의 분류에 따라서도 가장 증상이 가볍고 약물치료에 잘 반응하는 1군이 36례(69.3%)로 가장 많았다. 3. 환자가 호소하는 증상의 비특이성과 회복과 재발을 거듭하는 질병의 특성으로 인해 발병이후 진단될 때까지의 시간은 비교적 오래 걸렸고 1년이상 경과하며 진단된 경우도 16례(30.8%)나 되었다. 4. 자가면역질환이 7.6%에서 동반되었는데 갑상선기능 항진증이 2례(3.8), 인슐린의존형 당뇨 2례(3.8%)였고 종격동 전산화 단층촬영소견에서 흉선의 비대가 의심되었던 환자는 6례(11.5%), 흉선종이 발견 되었던 경우는 3례였다. 5. 환자의 치료는 대부분 항콜린에스테라제나 부신피질호르몬을 병용하는 내과적 치료를 하였으며 약물의 치료에 반응이 미비하거나 악화되는 경우 혹은 종격동 전산화 단층촬영상에서 흉선의 이상 소견이 보인 경우에 2례(3.9%)에서는 흉선절제술이, 1례(1.9%)에서는 혈장여과요법이 추가 되었고 흉선절제술과 혈장여과요법이 같이 병합 치료된 경우도 3례(5.9%)있었다. 6. 전체 환자중 2명에서 자연치유의 경과를 보였으며 이들은 모두 1군이였다. 그리고 흉선절제술과 부신피질 호르몬 투여로 완치된 예가 1례있었다. The authors experienced 52 patients with myasthenia gravis who were diagnosed at the Department of Neurology, Yeungnam University Hospital from August 1985 to January 1996. The following results were obtained through diagnostic evaluation and treatment. 1. The ratio of male to female was 1:1.7 and the most prevalent age group was second decade. 2. The most common initial presentation symptom was ocular(71.2%) and the peak incidence group was stage I(69.3%) according to the modified Osserman's classification. 3. In 16 patients(30.8%), it took more than a year to diagnose due to symptoms which were relapsed and remitting. 4. Of 52 patients, 2 cases were associated with thyroid disease(3.8%) and 2 with insulin-dependent diabetes mellitus(3.8%). 5. All of those who received anticholinesterase and corticosteroid therapy were improved with the exception of 5 cases which were improved after thymectomy and/or plasmapheresis. 6. Spontaneous remission was occured in 2 cases(3.8%) of ocular myasthenia gravis. And 1 case of group II was cured through thymectomy and long-term corticosteroid therapy.
측정오차와 외란을 고려한 유도전동기의 강인한 속도제어에 관한 연구
蔡英茂,尹炳道,金燦起,鄭憲主 충주대 산업과학기술연구소 1995 産業科學論文集 Vol.3 No.-
It is difficult to control industrial drive systems because of load disturbance, parameter variation and measurement noise. So a theorem is required to have robustness for the measurement noise and disturbance. This paper is among the researches of solving these problems. Sliding mode state observer is robust for measurement noise, modeling-error and load disturbance. The pole of sliding mode state observer can be placed at (0,0) in Z-plane for fast response. This method is, namely, deadbeat control. One side, sliding mode state observer output is discontinuous on a switching hyperplance, that causes harmful effects such as current harmonics and speed oscillation. In this paper, also the reducing method of the chattering of sliding mode state observer output is proposed. In this paper, the method of designing a robust sliding mode state observer taking account of the ability of disturbance and noise attenuation is proposed. Also, the proposed control system is digitally implemented with TMS320C31.
김교창,최병주,김도영,정준영 충북대학교 농업과학기술연구소 1993 農業科學硏究 Vol.10 No.2
The conclusion from experiments in the characteristic of yeast strain for selecting the appropriate yeast strain according to the variation of wort plato was as follows ; 1.CB8l, CB175 and CB89 yeast strain showed 73.3%, 72.6% and 73.0% in its limit fermentation, respectively. CB89 yeast strain showed the good result of 46.3% in the fermentation power test, also CB8l and CB175 yeast strains showed 33.1% and 24.0%, respectively. 2.In the yeast cell size CB8l, CB175 and CB89 yeast strain showed 8.4㎛, 8.8㎛ and 8.0㎛, respectively, and in the flocculation test those sedimentation content showed 0.6ml, 0.4ml and 8.5 ml, respectively after 10 minutes. CB89 yeast strain with high flocculation showed on appropriate result for brewing yeast. 3.Measured reducing sugar of each yeast after a day were observed as follows; CB8l, CB175 and CB89 yeast stain used up 33.3%, 42.6%, 61.1% of reducing sugar , respectively. 4.In ending fermentation, V. D. K(Vicinal Diketones) content and suspension yeast cell number of CB8l yeast strain showed 0.51-0.65ppm and 20-32×106cells/ml, respectively. Those of CB175 yeast strain showed 0.42-0.48ppm and 12-20×106cells/ml, respectively. CB89 yeast strain showed 0.58-0.69ppm and 34×106 cells/ml. 5.In ending fermentation, alcohol content of CB89 yeast was produced 4.55% and 5.05% was higher than that of CB8l and CB175 yeast. 6.CB89 yeast strain also showed about 300% of yeast recovery rate and 5.2% of dead cell rate which were good results.
열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
Moon, Byung-Ju,Son, Yeong-Jun,Lee, Jae-Pil,Kim, Choul-Seung,Song, Ju-Hee,Kim, Hyun-Ju,Kim, Jae-Woo,Kim, Do-Hoon,Park, Hyean-Cheal The Korean Society of Plant Pathology 2002 Plant Pathology Journal Vol.18 No.1
Resistance of perilla varieties to Botrytis cinerea LVF12 was evaluated, while antagonistic bacteria were selected and tested for their efficacy towards biological control of gray mold rot caused by B. cinerea. Among 11 perilla varieties tested for disease resistance, Milyang variety showed some degree of resistance, while the rest of varieties showed no resistance. Among 250 bacterial isolates collected from perilla loaves and rhizosphere of perilla plants, six isolates showed high levels of inhibitory effect on mycelial growth and conidial germination of B. cinerea in in vitro test. Using the pot test in growth chambers these isolates showed high levels of disease suppression, with Nl isolate showing 95.3% of control value and N4 isolate showing 90.8% of control value. Further test was performed to evaluate the two isolates ability for disease prevention and/or disease therapy, and results showed almost 100% of control vague. Isolates Nl and N4 were identified as Bacillus licheniformis and 5. megatepium, respectively, according to Bergey's manual, API 20E and 50CHB test kit, and Transmission electron microscope.
Gene Cloning and Characterization of MdeA, a Novel Multidrug Efflux Pump in Streptococcus mutans
( Do Kyun Kim ),( Kyoung Hoon Kim ),( Eun Ji Cho ),( Seoung Je Joo ),( Jung Min Chung ),( Byoung Yil Son ),( Jong Hwa Yum ),( Young Man Kim ),( Hyun Ju Kwon ),( Byung Woo Kim ),( Tae Hoon Kim ),( Eun 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.3
Multidrug resistance, especially multidrug efflux mechanisms that extrude structurally unrelated cytotoxic compounds from the cell by multidrug transporters, is a serious problem and one of the main reasons for the failure of therapeutic treatment of infections by pathogenic microorganisms as well as of cancer cells. Streptococcus mutans is considered one of the primary causative agents of dental caries and periodontal disease, which comprise the most common oral diseases. A fragment of chromosomal DNA from S. mutans KCTC3065 was cloned using Escherichia coli KAM32 as host cells lacking major multidrug efflux pumps. Although E. coli KAM32 cells were very sensitive to many antimicrobial agents, the transformed cells harboring a recombinant plasmid became resistant to several structurally unrelated antimicrobial agents such as tetracycline, kanamycin, rhodamin 6G, ampicillin, acriflavine, ethidium bromide, and tetraphenylphosphonium chloride. This suggested that the cloned DNA fragment carries a gene encoding a multidrug efflux pump. Among 49 of the multidrug-resistant transformants, we report the functional gene cloning and characterization of the function of one multidrug efflux pump, namely MdeA from S. mutans, which was expressed in E. coli KAM32. Judging from the structural and biochemical properties, we concluded that MdeA is the first cloned and characterized multidrug efflux pump using the proton motive force as the energy for efflux drugs.
( Do Kyun Kim ),( Yu Ri Jang ),( Kyoung Hoon Kim ),( Mi Nan Lee ),( A Ra Kim ),( Eun Ji Jo ),( Tae Hwan Byun ),( Eun Tak Jeong ),( Hyun Ju Kwon ),( Byung Woo Kim ),( Eun Woo Lee ) 한국수산과학회(구 한국수산학회) 2011 Fisheries and Aquatic Sciences Vol.14 No.3
An agar-degrading enzyme-producing strain was isolated from seawater. The isolate was identified as Microbulbifer sp. SD-1 by 16S rRNA sequencing analysis. The optimal pH and temperature for growth were 6.0 and 30°C, respectively, and growth was possible at pH 9.0 and 60°C. The isolate required 5% NaCl for optimal growth and showed 45% growth activity without NaCl. Agar concentrations of 0-0.4% in the medium did not affect growth. Thin-layer chromatography analysis revealed that this strain could degrade agar into a monosaccharide and oligosaccharide, which may have industrial applications.