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사람 말초혈액 단핵세포에서 흰털오가피 열매 추출물에 의한 Th1/Th2 Cytokine 분비조절
유수연,노빛나,박원봉,Lyu, Su-Yun,Noh, Bin-Na,Park, Won-Bong 대한약학회 2008 약학회지 Vol.52 No.1
Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL-2, L-12, $IFN-{\gamma}$ and $TNF-{\alpha}$) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th-1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.
자외선이 조사된 사람피부 섬유아세포에서 흰털오가피 잎추출물의 항산화작용
신애향,유수연,노빛나,김자인,김옥경,박원봉,Shin, Ai-Hyang,Lyu, Su-Yun,Noh, Bin-Na,Kim, Ja-In,Kim, Ok-Kyoung,Park, Won-Bong 대한약학회 2007 약학회지 Vol.51 No.4
We investigated antioxidative activity of the water and ethanol extracts of leaves of Acanthopanax divaricatus var. albeofructus in human dermal fibroblast (HDFs) irradiated by UVA. The irradiation of UVA did not affect the cell viability of HDFs. The antioxidative activity of the extract was investigated by xylenol orange, TBARS (thiobarbituric acid reactive substances) and antioxidant enzyme assay. Both extracts showed H202 scavenging activity and inhibited lipid peroxidation in HDF cells irradiated by UVA. The extracts also recovered enzyme activity in the same cells.