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Decay constants of heavy meson of <sup>0−</sup> state in relativistic Salpeter method
Cvetič,, G.,Kim, C.S.,Wang, Guo-Li,Namgung, Wuk Elsevier 2004 Physics letters: B Vol.596 No.1
<P><B>Abstract</B></P><P>The decay constants of pseudoscalar heavy mesons of <SUP>0−</SUP> state are computed by means of the relativistic (instantaneous) Salpeter equation. We solved the full Salpeter equation without making any further approximation, such as ignoring the small component wave function. Therefore, our results for the decay constants include the complete relativistic contributions from the light and the heavy quarks. We obtain <SUB>F<SUB>Ds</SUB></SUB>≈248±27, <SUB>FD</SUB>≈230±25(<SUP>D0</SUP>,<SUP>D±</SUP>), <SUB>F<SUB>Bs</SUB></SUB>≈216±32, <SUB>FB</SUB>≈196±29(<SUP>B0</SUP>,<SUP>B±</SUP>), <SUB>F<SUB>Bc</SUB></SUB>≈322±42 and <SUB>F<SUB>ηc</SUB></SUB>≈292±25 MeV.</P>
Whale, Alexandra S.,Jones, Gerwyn M.,Pav161,ič,, Jernej,Dreo, Tanja,Redshaw, Nicholas,Akyü,rek, Sema,Akgö,z, Mü,slü,m,Divieto, Carla,Sassi, Maria Paola,He, Hua-Jun,Cole, Kennet American Association for Clinical Chemistry, Inc. 2018 Clinical chemistry Vol.64 No.9
<P><B>BACKGROUND:</B></P><P>Genetic testing of tumor tissue and circulating cell-free DNA for somatic variants guides patient treatment of many cancers. Such measurements will be fundamental in the future support of precision medicine. However, there are currently no primary reference measurement procedures available for nucleic acid quantification that would support translation of tests for circulating tumor DNA into routine use.</P><P><B>METHODS:</B></P><P>We assessed the accuracy of digital PCR (dPCR) for copy number quantification of a frequently occurring single-nucleotide variant in colorectal cancer (<I>KRAS</I> c.35G>A, p.Gly12Asp, from hereon termed G12D) by evaluating potential sources of uncertainty that influence dPCR measurement.</P><P><B>RESULTS:</B></P><P>Concentration values for samples of <I>KRAS</I> G12D and wild-type plasmid templates varied by <1.2-fold when measured using 5 different assays with varying detection chemistry (hydrolysis, scorpion probes, and intercalating dyes) and <1.3-fold with 4 commercial dPCR platforms. Measurement trueness of a selected dPCR assay and platform was validated by comparison with an orthogonal method (inductively coupled plasma mass spectrometry). The candidate dPCR reference measurement procedure showed linear quantification over a wide range of copies per reaction and high repeatability and interlaboratory reproducibility (CV, 2%–8% and 5%–10%, respectively).</P><P><B>CONCLUSIONS:</B></P><P>This work validates dPCR as an SI-traceable reference measurement procedure based on enumeration and demonstrates how it can be applied for assignment of copy number concentration and fractional abundance values to DNA reference materials in an aqueous solution. High-accuracy measurements using dPCR will support the implementation and traceable standardization of molecular diagnostic procedures needed for advancements in precision medicine.</P>
Search for a dark vector gauge boson decaying toπ+π−usingη→π+π−γdecays
Won, E.,Adachi, I.,Aihara, H.,Al Said, S.,Asner, D. M.,Aushev, T.,Ayad, R.,Badhrees, I.,Bakich, A. M.,Bansal, V.,Barberio, E.,Behera, P.,Bhuyan, B.,Biswal, J.,Bobrov, A.,Bozek, A.,Brač,ko, M., American Physical Society 2016 Physical Review D Vol.94 No.9
<P>We report a search for a dark vector gauge boson U' that couples to quarks in the decay chain D*(+) -> D-0 pi(+), D-0 -> K-S(0) eta, eta -> U'gamma, U' -> pi(+)pi- No signal is found and we set a mass-dependent limit on the baryonic fine structure constant of 10(-3)-10(-2) in the U' mass range of 290 to 520 MeV/c(2). This analysis is based on a data sample of 976 fb(-1) collected by the Belle experiment at the KEKB asymmetric-energy e(+)e(-) collider.</P>
Chang, P.,Abe, K.,Abe, K.,Abe, T.,Aihara, H.,Asano, Y.,Aulchenko, V.,Aushev, T.,Aziz, T.,Bahinipati, S.,Bakich, A.M.,Ban, Y.,Bay, A.,Bedny, I.,Bitenc, U.,Bizjak, I.,Bondar, A.,Bozek, A.,Brač,ko, Elsevier 2004 Physics letters: B Vol.599 No.3
<P><B>Abstract</B></P><P>We report the observation of <SUP>B0</SUP> decays to the <SUP>K+</SUP><SUP>π−</SUP><SUP>π0</SUP> final state using a data sample of 78 fb<SUP>−1</SUP> collected by the Belle detector at the KEKB <SUP>e+</SUP><SUP>e−</SUP> collider. With no assumptions about intermediate states in the decay, the branching fraction is measured to be (36.6−4.3+4.2±3.0)×<SUP>10−6</SUP>. We also search for <I>B</I> decays to intermediate two-body states with the same <SUP>K+</SUP><SUP>π−</SUP><SUP>π0</SUP> final state. Significant <I>B</I> signals are observed in the ρ<SUP>(770)−</SUP><SUP>K+</SUP> and <SUP>K*</SUP><SUP>(892)+</SUP><SUP>π−</SUP> channels, with branching fractions of (15.1−3.3−1.5−2.1+3.4+1.4+2.0)×<SUP>10−6</SUP> and (14.8−4.4−1.0−0.9+4.6+1.5+2.4)×<SUP>10−6</SUP>, respectively. The first error is statistical, the second is systematic and the third is due to the largest possible interference. Contributions from other possible two-body states will be discussed. No <I>CP</I> asymmetry is found in the inclusive <SUP>K+</SUP><SUP>π−</SUP><SUP>π0</SUP> or <SUP>ρ−</SUP><SUP>K+</SUP> modes, and we set 90% confidence level bounds on the asymmetry of −0.12<<SUB>ACP</SUB><0.26 and −0.18<<SUB>ACP</SUB><0.64, respectively.</P>
Evolution of microstructure and hardness in AZ31 alloy processed by high pressure torsion
Strá,ská,, Jitka,Janeč,ek, Milo161,Gubicza, Jen151,Kraj148,á,k, Tomá,161,Yoon, Eun Yoo,Kim, Hyoung Seop Elsevier 2015 Materials science & engineering. properties, micro Vol.625 No.-
<P><B>Abstract</B></P> <P>A commercial MgAlZn alloy (AZ31) was processed by high pressure torsion (HPT) at room temperature, resulting in an extreme microstructure refinement down to the grain size of 150–250nm. The microstructure evolution during HPT was investigated by transmission electron microscopy and X-ray diffraction line profile analysis. The microhardness was measured as a function of the distance from the center of the disk and the number of HPT revolutions. The detailed analysis of dislocation contrast factors in X-ray diffraction line profiles enables to determine the population of the different slip systems as a function of the imposed strain. The influence of microstructure and defect structure evolution on microhardness is discussed in detail.</P>
Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies
Madireddi, Shravan,Eun, So-Young,Lee, Seung-Woo,Nemč,ovič,ová,, Ivana,Mehta, Amit Kumar,Zajonc, Dirk M.,Nishi, Nozomu,Niki, Toshiro,Hirashima, Mitsuomi,Croft, Michael The Rockefeller University Press 2014 The Journal of experimental medicine Vol.211 No.7
<P>Biologics to TNF family receptors are prime candidates for therapy of immune disease. Whereas recent studies have highlighted a requirement for Fcγ receptors in enabling the activity of CD40, TRAILR, and GITR when engaged by antibodies, other TNFR molecules may be controlled by additional mechanisms. Antibodies to 4-1BB (CD137) are currently in clinical trials and can both augment immunity in cancer and promote regulatory T cells that inhibit autoimmune disease. We found that the action of agonist anti–4-1BB in suppressing autoimmune and allergic inflammation was completely dependent on Galectin-9 (Gal-9). Gal-9 directly bound to 4-1BB, in a site distinct from the binding site of antibodies and the natural ligand of 4-1BB, and Gal-9 facilitated 4-1BB aggregation, signaling, and functional activity in T cells, dendritic cells, and natural killer cells. Conservation of the Gal-9 interaction in humans has important implications for effective clinical targeting of 4-1BB and possibly other TNFR superfamily molecules.</P>
Measurements of branching fractions ofτlepton decays with one or moreKS0
Ryu, S.,Adachi, I.,Aihara, H.,Asner, D. M.,Aulchenko, V.,Aushev, T.,Bakich, A. M.,Bala, A.,Bhuyan, B.,Bobrov, A.,Bondar, A.,Bonvicini, G.,Bozek, A.,Brač,ko, M.,Browder, T. E.,c,ervenkov, D. American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.7
Observation ofB0→pp¯K*0with a LargeK*0Polarization
Chen, J.-H.,Wang, M.-Z.,Adachi, I.,Aihara, H.,Arinstein, K.,Aulchenko, V.,Aushev, T.,Bakich, A. M.,Balagura, V.,Barberio, E.,Bay, A.,Bedny, I.,Belous, K.,Bitenc, U.,Bondar, A.,Bozek, A.,Brač,ko, American Physical Society 2008 Physical review letters Vol.100 No.25
<P>Using a 492 fb{-1} data sample collected near the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e{+}e{-} collider, we observe the decay B{0}-->ppK*0 with a branching fraction of (1.18{-0.25}{+0.29}(stat)+/-0.11(syst))x10{-6}. We study the decay dynamics of B{0}-->ppK*0 and compare with B{+}-->ppK*+. The K*0 meson is found to be almost 100% polarized (with a fraction of (101+/-13+/-3)% in the helicity zero state), while the K*+ meson has a (32+/-17+/-9)% fraction in the helicity zero state. The direct CP asymmetries for B{0}-->ppK*0 and B{+}-->ppK*+ are measured to be -0.08+/-0.20+/-0.02 and -0.01+/-0.19+/-0.02, respectively. In addition, we report improved measurements of the branching fractions B(B{+}-->ppK*+)=(3.38{-0.60}{+0.73}+/-0.39)x10{-6} and B(B{0}-->ppK{0})=(2.51{-0.29}{+0.35}+/-0.21)x10{-6}, which supersede our previous measurements.</P>