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RISS 인기검색어
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- 저자 : Whale, Alexandra S. (검색결과 3 건)
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Whale, Alexandra S.,Jones, Gerwyn M.,Pavš,ič,, Jernej,Dreo, Tanja,Redshaw, Nicholas,Akyü,rek, Sema,Akgö,z, Mü,slü,m,Divieto, Carla,Sassi, Maria Paola,He, Hua-Jun,Cole, Kennet American Association for Clinical Chemistry, Inc. 2018 Clinical chemistry Vol.64 No.9
<P><B>BACKGROUND:</B></P><P>Genetic testing of tumor tissue and circulating cell-free DNA for somatic variants guides patient treatment of many cancers. Such measurements will be fundamental in the future support of precision medicine. However, there are currently no primary reference measurement procedures available for nucleic acid quantification that would support translation of tests for circulating tumor DNA into routine use.</P><P><B>METHODS:</B></P><P>We assessed the accuracy of digital PCR (dPCR) for copy number quantification of a frequently occurring single-nucleotide variant in colorectal cancer (<I>KRAS</I> c.35G>A, p.Gly12Asp, from hereon termed G12D) by evaluating potential sources of uncertainty that influence dPCR measurement.</P><P><B>RESULTS:</B></P><P>Concentration values for samples of <I>KRAS</I> G12D and wild-type plasmid templates varied by <1.2-fold when measured using 5 different assays with varying detection chemistry (hydrolysis, scorpion probes, and intercalating dyes) and <1.3-fold with 4 commercial dPCR platforms. Measurement trueness of a selected dPCR assay and platform was validated by comparison with an orthogonal method (inductively coupled plasma mass spectrometry). The candidate dPCR reference measurement procedure showed linear quantification over a wide range of copies per reaction and high repeatability and interlaboratory reproducibility (CV, 2%–8% and 5%–10%, respectively).</P><P><B>CONCLUSIONS:</B></P><P>This work validates dPCR as an SI-traceable reference measurement procedure based on enumeration and demonstrates how it can be applied for assignment of copy number concentration and fractional abundance values to DNA reference materials in an aqueous solution. High-accuracy measurements using dPCR will support the implementation and traceable standardization of molecular diagnostic procedures needed for advancements in precision medicine.</P>
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일반논문 : 해석소통의 교과서 구현 양상에 대한 비판적 고찰
이인화 ( In Whalee ) 한국어교육학회(구 한국국어교육연구학회) 2014 국어교육 Vol.0 No.146
This study aims to survey the Korean language textbooks and curriculums that reflected interpretive communication and to seek a direction of interpretive communication education. An analysis of the Korean language textbooks and curriculums shows that ⑴ in 1st~3rd curriculum period, monophonic interpretive communication is emphasized, ⑵ in 4th curriculum period, interpretive communication is diminished, ⑶ in 5th~6th curriculum period, noticing differences present in interpretive communication, and ⑷ in 7th~2007 curriculum period, interpretive communication as meaning transaction is oriented. In spite of development of the perspective of interpretive communication education, it is not sufficiently complete. In the majority of cases, interpretation(or communication) afford the means of communication(or interpretation). The interpretive communication is a method of interpretation and interpretation itself in one. Therefore when educating interpretive communication, ‘one experience’ should be offered.
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Macro Model and Sense Amplifier for a MRAM
Ji-HyunKim,Jung-WhaLee,Seung-JunLee,HyungsoonShin 한국물리학회 2002 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.41 No.6
For the simulation of the architecture for a magnetoresistive random access memory (MRAM) based on GMR (giant magnetoresistance) and a MTJ (magnetic tunnel junction) cell having a hysteretic characteristics, a macro model showing this hysteresis is required. Also, a new sense amplier is needed for the MRAM because the cell is destroyed at high voltages. Thus, this work presents a macro model and a sensing circuit for a MRAM. The macro model is realized by using a six-terminal subcircuit, which emulates the hysteretic nature of MRAM cell, and read/write simulations are possible. A current-source bit-line-clamped sense amplier maintains a low voltage on the bit line during the full VDD sensing, so it is suitable for sensing the MRAM cell.
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