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( Brigida Barberio ),( Edoardo Vincenzo Savarino ),( Timothy Card ),( Cristina Canova ),( Francesco Baldisser ),( Alessandro Gubbiotti ),( Davide Massimi ),( Matteo Ghisa ),( Fabiana Zingone ) 대한장연구학회 2022 Intestinal Research Vol.20 No.1
Background/Aims: Current literature is lacking in studies comparing the incidence of adverse events (AEs) in patients with inflammatory bowel diseases (IBD) treated with adalimumab (ADA) or vedolizumab (VDZ) in a real-life scenario. Therefore, our primary aim was to compare the AEs occurring in patients taking ADA to those of patients taking VDZ. Methods: In this single center study, data on AEs from IBD patients who underwent treatment with ADA and VDZ were retrospectively collected. AE rates per 100 person-years were calculated. A Cox regression model was used to estimate the hazard ratios of the AEs between the 2 drugs. Results: A total of 16 ADA patients (17.2%) and 11 VDZ patients (7.6%) had AEs causing drug interruption during the study period (P=0.02). Most of the AEs were noninfectious extraintestinal events (50% in ADA and 54.5% in VDZ) while infections accounted for 31.2% of the AEs in patients treated with ADA and 27.3% in those treated with VDZ. The incidence rate of AEs causing withdrawal of therapy was 13.2 per 100 person-years for ADA and 5.3 per 100 person-years for VDZ, corresponding to a 76% lower risk in patients in VDZ. Considering the first year of treatment, we observed 34 subjects treated with ADA (36.5%) having at least 1 AEs and 57 (39.3%) among those taking VDZ (P=0.67). Conclusions: VDZ has a lower incidence rate of AEs causing withdrawal of treatment compared to ADA but a similar risk of AEs not causing drug interruption. Real-life head-to-head studies are still necessary to further explore the safety profile of these drugs. (Intest Res 2022;20:114-123)
Measurement of|Vub|from Inclusive Charmless SemileptonicBDecays
Urquijo, P.,Barberio, E.,Adachi, I.,Aihara, H.,Arinstein, K.,Bakich, A. M.,Belous, K.,Bhardwaj, V.,Bischofberger, M.,Bozek, A.,Brač,ko, M.,Browder, T. E.,Chao, Y.,Chen, A.,Cheon, B. G.,Chistov, R American Physical Society 2010 Physical review letters Vol.104 No.2
<P>We present the partial branching fraction for inclusive charmless semileptonic B decays and the corresponding value of the Cabibbo-Kobayashi-Maskawa matrix element vertical bar V-ub vertical bar, using a multivariate analysis method to access similar to 90% of the B -> X(u)l nu phase space. This approach dramatically reduces the theoretical uncertainties from the b-quark mass and nonperturbative QCD compared to all previous inclusive measurements. The results are based on a sample of 657 X 10(6) B (B) over bar pairs collected with the Belle detector. We find that Delta B(B -> X(u)l nu; p(l)*(B) > 1.0 GeV/c) = 1.963X(1 +/- 0.088(stat) +/- 0.081(syst)) X 10(-3). Corresponding values of vertical bar V-ub vertical bar are extracted using several theoretical calculations.</P>
The Lyon Consensus: Does It Differ From the Previous Ones?
( Matteo Ghisa ),( Brigida Barberio ),( Vincenzo Savarino ),( Elisa Marabotto ),( Mentore Ribolsi ),( Giorgia Bodini ),( Fabiana Zingone ),( Marzio Frazzoni ),( Edoardo Savarino ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.3
Gastroesophageal reflux disease (GERD) is a complex disorder with heterogeneous symptoms and a multifaceted pathogenetic basis, which prevent a simple diagnostic algorithm or any categorical classification. Clinical history, questionnaires and response to proton pump inhibitor (PPI) therapy are insufficient tools to make a conclusive diagnosis of GERD and further investigations are frequently required. The Lyon Consensus goes beyond the previous classifications and defines endoscopic and functional parameters able to establish the presence of GERD. Evidences for reflux include high-grade erosive esophagitis, Barrett’s esophagus, and peptic strictures at endoscopy as well as esophageal acid exposure time > 6% on pH-metry or combined pH-impedance monitoring. Even if a normal endoscopy does not exclude GERD, its combination with distal acid exposure time < 4% on off-PPI pH-impedance monitoring provides sufficient evidence refuting this diagnosis. Reflux-symptom association on pH-monitoring provides supportive evidence for reflux-triggered symptoms and may predict a better treatment outcome, when present. Also recommendations to perform pH-impedance “on” or “off” PPI are well depicted. When endoscopy and pH-metry or combined pH-impedance monitoring are inconclusive, adjunctive evidence from biopsy findings (eg, microscopic esophagitis), high-resolution manometry (ie, ineffective esophagogastric barrier and esophageal body hypomotility), and novel impedance metrics, such as mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index, can contribute to better identify patients with GERD. Definition of individual patient phenotype, based on the level of refluxate exposure, mechanism of reflux, efficacy of clearance, underlying anatomy of the esophagogastric junction, and clinical presentation, will lead to manage GERD patients with a tailored approach chosen among different types of therapy. (J Neurogastroenterol Motil 2020;26:311-321)
Measurement ofe+e−→Ds(*)+Ds(*)−cross sections near threshold using initial-state radiation
Pakhlova, G.,Adachi, I.,Aihara, H.,Arinstein, K.,Aushev, T.,Aziz, T.,Bakich, A. M.,Balagura, V.,Barberio, E.,Bay, A.,Belous, K.,Bhardwaj, V.,Bhuyan, B.,Bondar, A.,Bozek, A.,Brač,ko, M.,Browder, T American Physical Society 2011 PHYSICAL REVIEW D - Vol.83 No.1
Belle Collaboration,Vinokurova, A.,Kuzmin, A.,Eidelman, S.,Arinstein, K.,Aulchenko, V.,Aushev, T.,Bakich, A.M.,Balagura, V.,Barberio, E.,Belous, K.,Bhardwaj, V.,Bondar, A.,Bozek, A.,Bracko, M.,Brodzic North-Holland Pub. Co 2011 Physics letters: B Vol.706 No.2
We report the results of a study of B<SUP>+/-</SUP>→K<SUP>+/-</SUP>η<SUB>c</SUB> and B<SUP>+/-</SUP>→K<SUP>+/-</SUP>η<SUB>c</SUB>(2S) decays followed by η<SUB>c</SUB> and η<SUB>c</SUB>(2S) decays to (K<SUB>S</SUB>Kπ)<SUP>0</SUP>. The results are obtained from a data sample containing 535 million BB@?-meson pairs collected by the Belle experiment at the KEKB e<SUP>+</SUP>e<SUP>-</SUP> collider. We measure the products of the branching fractions B(B<SUP>+/-</SUP>→K<SUP>+/-</SUP>η<SUB>c</SUB>)B(η<SUB>c</SUB>→K<SUB>S</SUB>K<SUP>+/-</SUP>π<SUP>@?</SUP>)=(26.7+/-1.4(stat)<SUB>-2.6</SUB><SUP>+2.9</SUP>(syst)+/-4.9(model))x10<SUP>-6</SUP> and B(B<SUP>+/-</SUP>→K<SUP>+/-</SUP>η<SUB>c</SUB>(2S))B(η<SUB>c</SUB>(2S)→K<SUB>S</SUB>K<SUP>+/-</SUP>π<SUP>@?</SUP>)=(3.4<SUB>-1.5</SUB><SUP>+2.2</SUP>(stat+model)<SUB>-0.4</SUB><SUP>+0.5</SUP>(syst))x10<SUP>-6</SUP>. Interference with the non-resonant component leads to significant model uncertainty in the measurement of these product branching fractions. Our analysis accounts for this interference and allows the model uncertainty to be reduced. We also obtain the following charmonia masses and widths: M(η<SUB>c</SUB>)=(2985.4+/-1.5(stat)<SUB>-2.0</SUB><SUP>+0.5</SUP>(syst)) MeV/c<SUP>2</SUP>, Γ(η<SUB>c</SUB>)=(35.1+/-3.1(stat)<SUB>-1.6</SUB><SUP>+1.0</SUP>(syst)) MeV/c<SUP>2</SUP>, M(η<SUB>c</SUB>(2S))=(3636.1<SUB>-4.2</SUB><SUP>+3.9</SUP>(stat+model)<SUB>-2.0</SUB><SUP>+0.7</SUP>(syst)) MeV/c<SUP>2</SUP>, Γ(η<SUB>c</SUB>(2S))=(6.6<SUB>-5.1</SUB><SUP>+8.4</SUP>(stat+model)<SUB>-0.9</SUB><SUP>+2.6</SUP>(syst)) MeV/c<SUP>2</SUP>.
Search forD0−D¯0mixing using semileptonic decays at Belle
Bitenc, U.,Abe, K.,Abe, K.,Adachi, I.,Aihara, H.,Asano, Y.,Aushev, T.,Bahinipati, S.,Banerjee, S.,Barberio, E.,Barbero, M.,Bedny, I.,Bizjak, I.,Blyth, S.,Bondar, A.,Bozek, A.,Brač,ko, M.,Brodzick American Physical Society 2005 PHYSICAL REVIEW D - Vol.72 No.7
Belle-II VXD radiation monitoring and beam abort with sCVD diamond sensors
Adamczyk, K.,Aihara, H.,Angelini, C.,Aziz, T.,Babu, V.,Bacher, S.,Bahinipati, S.,Barberio, E.,Baroncelli, T.,Basith, A.K.,Batignani, G.,Bauer, A.,Behera, P.K.,Bergauer, T.,Bettarini, S.,Bhuyan, B.,Bil Elsevier 2016 Nuclear instruments & methods in physics research. Vol.824 No.-
<P><B>Abstract</B></P> <P>The Belle-II VerteX Detector (VXD) has been designed to improve the performances with respect to Belle and to cope with an unprecedented luminosity of 8 × <SUP> 10 35 </SUP> <SUP> cm − 2 </SUP> <SUP> s − 1 </SUP> achievable by the SuperKEKB. Special care is needed to monitor both the radiation dose accumulated throughout the life of the experiment and the instantaneous radiation rate, in order to be able to promptly react to sudden spikes for the purpose of protecting the detectors. A radiation monitoring and beam abort system based on single-crystal diamond sensors is now under an active development for the VXD. The sensors will be placed in several key positions in the vicinity of the interaction region. The severe space limitations require a challenging remote readout of the sensors.</P>
Measurement of thee+e−→D0D*−π+cross section using initial-state radiation
Pakhlova, G.,Aihara, H.,Arinstein, K.,Aushev, T.,Bakich, A. M.,Balagura, V.,Barberio, E.,Bay, A.,Belous, K.,Bhardwaj, V.,Bischofberger, M.,Bondar, A.,Bozek, A.,Brač,ko, M.,Browder, T. E.,Chang, P American Physical Society 2009 PHYSICAL REVIEW D - Vol.80 No.9