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( Yi Zhou ),( Minglong Cai ),( Yujun Sheng ),( Xuejun Zhang ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.1
Background: Psoriasis vulgaris is a chronic inflammatory skin disease which occur at any age. It can be clinically classified into two age-onset subtypes: early-onset psoriasis (EOP; <40 years) and late-onset psoriasis (LOP; ≥40 years). More evidence showed EOP and LOP have different genetic architecture, notably the risk allele human leukocyte antigen (HLA)-C*06:02 located within the major histocompatibility complex (MHC) region, which was reported to be the outstanding variant associated with EOP. However, genetic structure of EOP and LOP have not been fully elucidated. Objective: To investigated HLA genetic heterogeneity between EOP and LOP in China. Methods: We first calculated the MHC-based heritability of EOP and LOP respectively. Then, we conducted a large-scale, stratified analysis including 7,097 EOP, 1,337 LOP patients, and 9,906 healthy controls by using MHC target sequencing data from a previous study. Results: We observed that HLA alleles collectively explained a larger heritability of EOP (27.4%) than LOP (11.3%). Further association analysis identified three independent loci (HLA-C*01:02, p=6.70×10<sup>-8</sup>; HLA-A amino acid position 9, p=3.27×10<sup>-17</sup>; and HLA-A amino acid position 161, p=5.75×10<sup>-10</sup>) that confer specific susceptibility to EOP. Our data also confirmed HLA-C*06:02 as an independent psoriasis-associated variant, contributing a higher degree of risk to EOP than LOP. Moreover, case-case analysis confirmed that HLA-C*06:02-positive psoriasis patients have earlier onset. Conclusion: Our analysis indicating that different genetic background underlie the EOP and LOP. We believe these findings will serve to predict psoriasis risk in the future and facilitate clinical decision. (Ann Dermatol 33(1) 61∼67, 2021)
Mechanisms of thermally induced deflection of a long-span cable-stayed bridge
Yi Zhou,Limin Sun,Zhijian Peng 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.3
Variation of temperature is a primary environmental factor that affects the behavior of structures. Therefore, understanding the mechanisms of normal temperature-induced variations of structural behavior wouldhelp in distinguishing them from anomalies. In this study, we used the structural health monitoring data of theShanghai Yangtze River Bridge, a steel girder cable-stayed bridge, to investigate the mechanisms of thermallyinduced vertical deflection ( DT ) at mid-span of such bridges. The DT results from a multisource combination ofthermal expansion effects of the cable temperature (TCab ), girder temperature (TGir ), girder differential temperature(TDif ), and tower temperature (TTow ). It could be approximated by multiple linear superpositions under operationalconditions. The sensitivities of DT of the Shanghai Yangtze River Bridge to the above temperatures were in thefollowing order: TCab > TGir > TTow > TDif . However, the direction of the effect of TCab was observed to beopposite to that of the other three temperatures, and the magnitudes of the effects of TCab and TGir were found tobe almost one order greater than those of TDif and TTow . The mechanisms of the thermally induced verticaldeflection variation at mid-span of a cable-stayed bridge as well as the analytical methodology adoptedin this study could be applicable for other long-span cable-stayed bridges.
Roles of the complement system in alcohol-induced liver disease
Yi Zhou,Guandou Yuan,Fudi Zhong,Songqing He 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a rational and novel avenue to postpone and even reverse the progression of disease and simultaneously promote the repair of liver injury. In this mini-review, we briefly summarize the recent research progress, especially focusing on the role of complement and oxidative stress-induced transfer RNA-derived fragments, which might help us to better understand the pathogenesis of ALD and provide aid in the development of novel therapeutic strategies for ALD.
Yizhou Zhuang,Kun-Sheng Song,Said M. Easa,Yong-Qing Song 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.3
The reinforced concrete piles (RC) in integral abutment bridges (IABs) are challenging to meet the longitudinal deformation of bridges with significant lateral stiffness. The H-shaped steel (HS) piles are costly and prone to corrosion. This paper proposes a new form of pile comprised of HS and RC piles in series to meet the longitudinal deformation demand of IABs. Tests were conducted for one HS pile under reciprocating low-cycle pseudo-static test and two HS-RC stepped piles with different bending stiffness ratios of HS/RC (0.25 and 0.5) using the HS-RC pile test model,. The influence of the stiffness ratio on the mechanical behavior of stepped pile-soil was studied. The mechanical behavior of the stepped pile was also compared with single HS and RC piles. and the applicability of the m and p-y curve methods to the calculation of horizontal displacement of stepped pile is discussed. The results show that the elastic deformation range of the HS pile is 2 mm to 25 mm, and its horizontal deformation capacity and bearing capacity are excellent. As the stiffness ratio increases, the stepped pile-soil system's yield displacement and yield load increased. The stiffness ratio has no significant effect on the failure mode of the piles. The hysteretic ring of the stepped pile shows a squeezing shape at the initial loading stage, but becomes a full spindle in the later loading stage. The stepped pile shows an excellent energy consumption effect and a horizontal deformation ability, indicating it is suitable for IABs. The m method has better accuracy only up to 2 mm displacement, while the p-y curve method still has higher accuracy within 15 mm.
Effect of Cooling Rate on Magnetic Properties of Fe‑3.3 wt% Si Non‑oriented Electrical Steel
Yizhou Du,Ronald J. O’Malley,M. F. Buchely 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.12
In this paper, the effects of solidification cooling rate on the inclusion distribution, magnetic properties, and texture of 3.3wt% Si non-oriented steel with different carbon and sulfur (C&S) levels are measured and analyzed. Fast and slow cooledstrip samples produced using specially designed melt samplers were thermo-mechanically treated by hot rolling (HR), coldrolling (CR), and final annealing. The fully processed fast cooled sample (~ 1700 K/s) exhibited a smaller average grainsize compared to the sample produced with a low solidification cooling rate (~ 9 K/s). In addition, under each C&S level,smaller inclusions (in the range 0.15–1.0 μm) were observed in the high solidification cooling rate sample. Differences inCube {100}⟨001⟩, S{213}⟨364⟩, Brass{110}⟨112⟩, Goss{110}⟨001⟩, and Copper{112}⟨111⟩ texture were also documentedin the fully processed material. Under each C&S level, the sample with low solidification cooling rate had a lower core lossthan the high cooling rate sample.
Construction of A Class of Traceability Codes
마역단(Yizhou Ma),얀이얼(Yier Yan),이문호(Moon Ho Lee) 대한전기학회 2007 대한전기학회 학술대회 논문집 Vol.2007 No.4
In order to protect copyrighted materials, codes may be embedded in the content to trace the traitors. Traceability (TA) codes, as a kind of such codes, have been extensively studied in the intervening years for use as a piracy deterrent. In this correspondence, we proposed a method to construct a class of traceability codes and gave out some parameters results of such codes.