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Allylisothiocyanate 첨가가 Aflatoxin 생성 곰팡이 대사산물의 생합성에 미치는 영향
강성조,여명재,이은일,송재영,정덕화 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.1
The effects of allylisothiocyanate on the biosynthesis of various fungus metabolites such as sterigrnatocystin, lipid, protein, citrate RNA and AMP from the culture of Aspergillius parasiticus R-716 were investigated. The content of sterigmatocystin, the precursor of aflatoxin, was lower in the culture added with 50ppm allylisothiocyanate after 48 hours, however was rather higher after 144 hours compared to that of the control. The addition of allylisothiocyanate resulted in the increase of lipid, protein, RNA in mycelium and the content of citrate in the media, but the amount of AMP was low.
윤명숙,김미혜,엄예선,이은주 한국 정신보건 사회사업학회 1995 정신보건과 사회사업 Vol.2 No.-
Couple therapy has been recognized as an effective way to treat alcoholism. However, research by the authors indicate there are no couple therapy porgrams currently in the Korean psychiatric setting. The purpose of this study is to develop an effective program to aid in the recovery alcoholics and their spouses. This program is specifically designed for the couples of hospitalized alcoholics. The program consists of 10 sessions, the first four held with gender specific groups, the final five as co-joint couple sessions. The groups will meet 2 times weekly with five monthly after care follow ups. The program is divided into 3 phases ; The first phase deals with the symptoms of alcoholism and its impact on relationships with in 1st-2nd sessions. The second phase treats the issues of co-dependency and the recovery process with in 3th-4th sessions. In the final phase, conflict resolution, communication, anger control, and stress management skills are developed with in 5th-9th sessions. In the final session of the last phase, all 3 phases are integrated and summarized. At this point the group sessions are terminated, five follow up after care sessions are scheduled, to be conducted on a monthly bases. These sessions are designed to help the couple with unresolved issues, assist with implementation of their after care plan, and to monitor the couples progress with in a life of sobriety. The methods of implementing the program are centered on the cognitive behavioral approach, utilizing lectures, group discussion, role play and feedback sessions.
Viral Etiology of Acute Exacerbations of Bronchiectasis: A Retrospective Single-center Study
( Yea Eun Park ),( Heungsup Sung ),( Yeon-mok Oh ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose Bacterial infections are well known factors underlying acute exacerbations in bronchiectasis. However, virus infections may also contribute to acute exacerbations. We aimed to assess the rate of viral infection in acute exacerbation of bronchiectasis and the associated clinical factors. Method We retrospectively reviewed the electronic medical records of patients who presented to the emergency department or the respiratory care inpatient unit at a tertiary referral center in South Korea (2015-2019) and underwent diagnostic testing for bacterial and viral pathogens. All patients were diagnosed with bronchiectasis by chest computerized tomography and were prescribed antibiotics for minimum 3 days for managing the deteriorating symptoms. Result Viral pathogens were detected in 204 of 801 patients enrolled in our study (25.5%). The most common viral pathogen isolated was influenza virus A (24.5%), followed by rhinovirus (22.7%), influenza virus B (10.2%), respiratory syncytial virus B (8.8%), and human metapneumovirus (6.0%). In a total of 148 patients, viral but not bacterial pathogen was detected, while no pathogens were found in 451 exacerbated patients. Multivariable analysis revealed that female sex (adjusted OR, 1.608; 95% CI, 1.094- 2.363; P = 0.016), chronic heart disease as a comorbidity (adjusted OR, 1.723; 95% CI, 1.096-2.708; P = 0.018) were positively associated with viral etiology of acute exacerbation in bronchiectasis patients, while the presence of radiographic infiltration (adjusted OR, 0.612; 95% CI, 0.395-0.948; P = 0.028) was negatively associated. Conclusion Respiratory viruses were identified in approximately 25% of the acute exacerbations observed among patients with bronchiectasis; influenza and rhinovirus were detected in >50% cases. More attention to viruses as a causative pathogen for acute deteriorating symptoms in patients with bronchiectasis is warranted.
Yea Eun Lee,Jin-Joo Hue,Ki-Nam Lee,Sang Yoon Nam,Byeongwoo Ahn,Young Won Yun,Jae-Hwang Jeong,Beom Jun Lee 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Iron is essential for life and has numerous biochemical roles. Phytic acid (PA) has been recognized as a natural antioxidant by its chelating properties and reducing the catalytic activities of many divalent transition metals. We investigated the effect of PA on the formation of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in dietary iron-deficient F344 rats. After acclimation for one week, six-week old F344 male rats were fed with the AIN-93G purified diet (normal diet) or an iron-deficient diet (3 ppm Fe, only 10% vs control diet) for 8 weeks. PA (0.5% or 2% PA in water) was given for drink throughout the experimental period. Animals were treated subcutaneously with AOM (15 ㎎/㎏) twice (1<SUP>st</SUP> and 2<SUP>nd</SUP> week of the experiment) to induce colonic ACF. After sacrifice, the colonic mucosa were examined for the total numbers of aberrant crypt (AC) and ACF after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. Iron-deficient diet induced an anemic status of rats as indicated by significantly low values in RBC count, hemoglobin, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin, compared with the AOMtreated control (P<0.01). However, treatments of PA increased these values. Treatment with 2% PA significantly increased the numbers of both ACF/colon and AC/colon in iron deficient rats, compared with the respective control (P<0.05). The number of large ACF (≥4 AC/ACF), which had been suggested to possess a greater tumorogenic potential than small ACF (≤3 AC/ACF), was significantly enhanced by treatment with 2% PA (P<0.05). These results suggest that PA may promote colon carcinogenesis in irondeficient status in rats.
Yea Eun Kim,Seok Ran Yeom,Yu Jeong Jeon 위기관리 이론과 실천 2019 Crisisonomy Vol.15 No.10
각종 재난 및 다수사상자 사고 발생 시 현장의료대응을 위하여 2016년부터 각 보건소에서는 「재난응 급의료비상대응매뉴얼」에 근거하여 보건소 신속대응반을 조직·운영하고 있다. 본 연구는 국가재난 대응체계 내 보건소 신속대응반의 운영 및 활동근거를 파악하고, 실제 활동사례 및 재난의료실무자 면담을 통해 이들의 역할을 분석하고 고찰하고자 시도되었다. 보건소 신속대응반은 국가재난안전관 리체계 내 긴급구조통제단의 응급의료반으로서, 2018년 8월 기준 전국 249개(468팀, 총 2,557명)이 다. 의료인 및 행정지원 인력으로 구성되며, 재난 현장에서의 역할은 초기 환자 분류, 의료자원조달 및 분배, 환자 이송, 현장응급의료지원, 언론 대응 및 의사소통 등이다. 보건소 신속대응반이 보다 체계적으로 국가안전관리체계 내에서 활동하기 위해서는 재난에 있어 공공보건의 역할에 대한 재정 립과 보건소 신속대응반 활동에 대한 법·제도적 뒷받침, 역량 강화를 위한 개인적, 조직적 차원에서 의 노력이 요구되며 이들을 대상으로 한 실증적 연구가 추후에 수행되어야 함을 제언한다. In South Korea, Public Health Disaster Response Team (PHDRT) has been organized by every Community Health Center since 2016. When a disaster or accident with heavy casualties is expected to occur, PHDRT is dispatched. This study shed light on the role of PHDRT within the Korean National Disaster Response System by analyzing the related law and regulations, their activities, and interviews with disaster medical professionals. PHDRT is the part of the national disaster management system in Korea, organized under the Framework Act on the Management of Disasters and Safety. As of 2018, there was a total of 468 teams and 2,557 members, mostly consisting of physicians, nurses and administrators. The roles of PHDRT in disaster medical response include early triage, medical resource planning, patient transportation, support of on-site emergency care, and media relations and communications. To facilitate the activities of PHDRT, their roles need to be well defined and supported by legal and institutional frameworks, along with individual and organizational efforts to strengthen capacity.
용매 첨가제의 용해도 계수가 공액고분자의 자기조립 거동에 미치는 영향
권은혜 ( Eun Hye Kwon ),이정익 ( Jeong Ik Lee ),박소영 ( So Young Park ),함예은 ( Yea Eun Hahm ),박영돈 ( Yeong Don Park ) 한국공업화학회 2020 공업화학전망 Vol.23 No.5
유기전자소자는 용액공정을 통한 대량생산이 가능하기 때문에 기존 무기전자소자에 비해 제조비용이 저렴하고 대면적 생산이 가능하며, 유기분자의 본연 특징으로 인해 유연하고 가벼운 소자를 구현할 수 있다. 그러나 무기반도체에 비하여 현저히 낮은 전하이동도 특성은 유기전자소자의 상용화에 걸림돌이 되고 있다. 따라서 공액고분자의 결정화도, 모폴로지, 분자배향 최적화를 통한 자기조립 박막 제조는 전하이동을 원활히 하기 때문에 유기전자소자의 개발에 필수적이다. 본 기고에서는 유기전자소자의 활성층으로 사용되는 공액고분자의 자기조립을 유도하기 위한 다양한 특성을 갖는 용매 첨가제의 효과에 대해서 알아보고, 특히 첨가제의 용해도 계수가 공액고분자의 자기조립 거동에 미치는 영향에 대해 자세히 논의하고자 한다.