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Study of the Ultimate Load Capacity of K-Type Tube-Gusset Plate Connections
Yan-Zhong Ju,Jia-Yang Li,De-Hong Wang,Jun-Feng Bai 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.2
In order to investigate the ultimate load capacity of K-type tube-gusset plate connections with stiff ened plate, the static tests of fi ve full-scale specimens were conducted in this study. The results indicate that the end stiff ened plate is critical for improving the load capacity of the connections. In addition, the parametric nonlinear fi nite element analysis of the K-type tube-gusset plate specimens was performed with account of such non-dimensional parameters as chord diameter-to-thickness ratio ( γ ), plate width-to-chord diameter ratio ( α ), plate thickness-to-chord thickness ratio ( 1 ), stiff ened plate thickness ( t d ), and nominal-to-yield stress ratio ( η ). The above analysis implies that the ultimate load capacity decreases with the increment of γ and increases with the increment of α and 1 , while it is only slightly aff ected by the stiff ened plate thickness. Compare the results of the fi nite element analysis with assessment by design guides existing. Based on the former results, an equation for estimating the load capacity of K-type tube-stiff ened gusset plate is proposed.
Density Functional Study of Deoxycytidine Radicals In Irradiated DNA
Yan-ju Ji,Feng-xiang Wang,Yang Jiao 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.-
Density functional theory is used to study the energetics and geometries of deoxycytidine radicals which are formed by removal of hydrogen from ve carbon atoms through irradiation. The C0 1 and C0 4 centered radicals (C0 1 and C0 4) are more energetically favored than the others. To investigate the cytosine release, a potential energy surface scan is performed to break the N1-glycosidic bond (N1-C0 1 bond). The result indicates that the activation energy needed for the N1-glycosidic bond breaking in every one of the deoxycytidine radicals is much lower than that in the parent deoxycytidine. The discussion shows that in irradiated molecular DNA, the C0 4 site is the most favored site for H abstraction; hence, there is C0 4-centered radical formation, subsequently leading to base release. This conclusion is in agreement with the experimental results. Density functional theory is used to study the energetics and geometries of deoxycytidine radicals which are formed by removal of hydrogen from ve carbon atoms through irradiation. The C0 1 and C0 4 centered radicals (C0 1 and C0 4) are more energetically favored than the others. To investigate the cytosine release, a potential energy surface scan is performed to break the N1-glycosidic bond (N1-C0 1 bond). The result indicates that the activation energy needed for the N1-glycosidic bond breaking in every one of the deoxycytidine radicals is much lower than that in the parent deoxycytidine. The discussion shows that in irradiated molecular DNA, the C0 4 site is the most favored site for H abstraction; hence, there is C0 4-centered radical formation, subsequently leading to base release. This conclusion is in agreement with the experimental results.
A Parallel Fast Sort Algorithm for Mass 3D Point Clouds of Irregular Model
Liu Yan-ju,Zhang Hong-lie,Tao Bai-rui,Li Cheng 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.6
According to mass point clouds without explicit topology relation, a parallel fast sort algorithm is proposed in this paper. Morton order is introduced and used to merge one-dimensional data. The mass point clouds of irregular model are generated corresponding address code named Morton code and these points are stored in the octree structure chain. And then a parallel fast sort algorithm based on Euclidean distance is used to sort by CPU and GPU. The k-Nearest Neighbors of point can be located in the chain. The experiment results show that much time is saved and k-Nearest Neighbors of point can be searched directly. This algorithm is simpler than those complex sort methods used on the whole point clouds.
( Hong Yan Li ),( Hyung Min Jeong ),( You Hee Choi ),( Ju Hee Kim ),( Joong Kook Choi ),( Chang Yeol Yeo ),( Hye Gwang Jeong ),( Tae Cheon Jeong ),( Chang Ju Chun ),( Kwang Youl Lee ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
Protein kinase A (PKA), a serine/threonine kinase, regulates bone formation, and enhances Bone morphogenetic protein (BMP)-induced osteoblast differentiation. However, the mechanisms of how PKA controls the cellular response to BMP are not well known. We investigated the effects of modulating PKA activity during BMP2-induced osteoblast differentiation, and found that PKA regulates the function of Dlx3. Dlx] plays crucial roles in osteoblast differentiation and it is expressed in most skeletal elements during development. We found that PKA activation increases BMP2-induced expression of Dlx3 protein, and enhances the protein stability, DNA binding, and transcriptional activity of Dlx3. In addition, PKA activation induces the phosphorylation of Dlx3 at consensus PKA phosphorylation target site(s). Lastly, substitution of serine 10 in Dlx3 to alanine significantly reduces, if not completely abolishes, the phosphorylation of Dlx3 and the regulation ofDlx3 function by PKA. These results suggest that Dlx3 is a novel target ofPKA, and that PKA mediates BMP signaling during osteoblast differentiation, at least in part, by phosphorylating Dlx3 and modulating the protein stability and function ofDlx3. J. Cell. Biochem. 115: 2004-2011, 2014. ⓒ 2014 Wiley Periodicals, Inc.
( Hong Yan Li ),( Hyung Min Jeong ),( You Hee Choi ),( Ju Hee Kim ),( Joong Kook Choi ),( Chang Yeol Yeo ),( Hye Gwang Jeong ),( Tae Cheon Jeong ),( Chang Ju Chun ),( Kwang Youl Lee ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Protein kinase A(PKA),a serine/threonin kinase, regulates bone formation,and enhances Bone morphogenetic protein(BMP)-induced osteoblast differentiation.However.the mechanisms of how PKA controls the cellular response to BMP are not well known.We innestigated the effects of modulating PKA activity during BMP2-induced osteoblast differentiation.and found that PKA regulates the function of Dlx3. DLx3 plays crucial roles in osteoblast diferentiation and it is expressed in most skeletal elements during development.We found that PKA activation increases BMP2-induced exprseeion of Dlx3 protein. and enhances the protein stability, DNA binding, and transcriptional activity of Dlx3. In addition. PKA activation induces the phosphorylation of Dlx3 at consensus PKA phosphorylation target site(s). Lastly, substitution of serine 10 in Dlx3 to alanine significantly reduces, if not completely abolistes, the phosphorylation of Dlx3 and the regulation of Dlx3 function by PKA. These results suggest ehat Dlx3 is a novel targer of PKA, and that PKA ,mediates BMP signaling during osteoblast differentiation,at least in part,by phosphorylating Dlx3 and modulating the protein stability and function ofDlx3.J.Cell.Biochem.115:2004-2011,2014.ⓒ2014 Wiley periodicals,lnc.