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조소담 The English Linguistic Science Association of Kore 2001 English Linguistic Science Vol.7 No.-
The purpose of this study is to provide practical and desirable ways for the improvement of English textbook for elementary school students through textbook analysis. To achieve this purpose the following areas were studied. First, an analysis model of the elementary school English textbook was presented on the basis of the theoretical background. The model consists of four parts communicative aspect, language material, organizational system of textbook and teacher's guide. Second, 6 weehs of English lessons have been observed researching the usage of textbooks and a survey was conducted to elementary school English teachers regarding the above four parts. With the result of the analysis, observation, and survey ,the author suggests the improvenment measures of a elementarry school English textbook as follow : Firstly, the textbooks should present student-centered activities to improve the student's communicative competance . Futhermore, the activity must be developed in connection with the student's real lives. Secondly it is very important to secure teachers who are exclusively charged for elementary English education as soon as possible. Thirdly, the circumstance are created for the gradational class as soon as possible. To develop and maintain this effectively, it is necessary to make suffcient and various audio-visual materials for studying, lots of valuation methods. Conclusively, the English textbooks are extremely important in the circumstances of our English education. So I hope that the result of this study will be helpful to the author of English education. So I hope that the result of this study will be helpful to the author of English textbooks in writing good English textbooks and better English language education. Also, there should be a government administrative support for English education
So-Hyun Lee,Jae-Sung Ryu,Jin-Hyoung Cho,So-Dam Lee,Ju-Taek Lee,Da-Hyun Park,Seul-Yi Lee,Dong Hoon Kwak,Young-Kug Choo 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
Human adipose-derived stem cells (hADSCs) and dental pulp-derived stem cells (hDPSCs) have been considered alternative sources of adult stem cells because of their potential to trans-differentiate into multiple cell lineages. This study investigated the possible role of gangliosides in the osteoblast differentiation of hADSCs and hDPSCs. First, we investigated characterization of hADSCs and hDPSCs using FACS analysis. Mesenchymal stem cell specific markers, CD44 and CD105, were expressed but not hematopoetic markers, CD45 and CD117 in both of hADSCs and hDPSCs. High-performance thin-layer chromatography analysis showed that increased gangliosides were associated with differentiation of hADSCs and hDPSCs into osteoblasts. RT-PCR analysis confirmed that osteoblast specific genes, ALP, BMP-2, collagen were expressed in differentiated osteoblasts, however, the another osteoblast specific gene, osteocalcin, was not expressed. When hADSCs and hDPSCs were cultured under osteoblast- differentiation conditions, alkaline phosphatase (ALP) activity was increased in comparison to hADSCs and hDPSCs. Furthermore, specifically both ALP activity and ganglioside expression increased more in hDPSCs-derived osteoblasts than hADSCs-derived osteoblasts. These results suggest that gangliosides play a more important role in regulating the osteoblast-differentiation of hDPSCs compared to hADSCs.
So-Hyun Lee,Dong-Hoon Kwak,Hyung-Keun You,Beom-Su Kim,Kyung-A Hwang,Byoung-Boo Seo,Hwi-cheul Lee,Jae-Sung Ryu,So-Dam Lee,Ju-Taek Lee,Yoon-Ju Na,Su-Bin Lee,Kyu-Tae Chang,Young-Kug Choo 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1
Gangliosides, sialic acid-conjugated glycosphingolipids, are involved in cell proliferation and differentiation. This study investigated the possible role of gangliosides in the dopaminergic neuron-like cells of human mesenchymal stem cells (hMSCs). We have reported the in vitro conditions for inducing hMSCs into dopaminergic neuron-like cells. hMSCs were induced in vitro to become dopaminergic neuron-like cells in 12 days by using a cocktail that includes sonic hedgehog and fibroblast growth factors. First, we investigated the characterization of hMSCs through FACS analysis. The mesenchymal stem cell specific markers, CD44 and CD105, were expressed in hMSCs while the hematopoetic markers, CD45 and CD117 were not. The cells developed a neuronal morphology expressing the neuronal markers Map2 and βⅢtubulin. RT-PCR analysis revealed the expression of dopamine specific genes such as TH, Pitx3, Nurr1 and DA transporter. Immunocytochemistry showed that hMSCs expressed GM3, GM2, GD1a, GD3 and GT1b based on tyrosine hydroxylase (TH) expression. Specifically, a significant decrease in GM3 and GT1b expression was observed during dopaminergic neuron differentiation. These results suggest that ganglioside GT1b may play a role in the dopaminergic neuron differentiation and development process of hMSCs.
Differential Expression Patterns of Gangliosides in Micro-pig solid organs
So-Dam Lee,Dong-Hoon Kwak,Kyu-Tae Chang,Ji-Su Kim,Jae-Sung Ryu,Jin-Hyoung Cho,So-Hyun Lee,Ju-Taek Lee,Da-hyun Park,Seul-Yi Lee,Young-Choon Lee,Young-kug Choo 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
Ganglioside are ubiquitous membrane component in mammalian cells and suggested to play important roles in various cell functions such as cell-cell recognition, differentiation and transmembrane signaling. These compounds are localized in a glycosphingolipid-enriched microdomain on the cell surface and regulated by the glycosphingolipid composition. However, the role that gangliosides play in immune rejection response by xenotransplantation is not yet clearly understood. In this study, differential expression patterens of gangliosides of Micro-Pig solid organs, which are heart, kidney, liver, pancreas and spleen. We examined expression level of high-performance thin-layer chromatography (HPTLC) showed that all of solid organs contained GM3, GM2, GM1 and GD1a as major gangliosides. Especially, ganglioside GD1b expressed in liver and pancreas, not in heart, kidney and spleen. Also, GT1b expressed in liver, kidney and spleen, not in heart and pancreas. As a results suggest that differential expression patterens of gangliosides of Micro-Pig solid organs are related immune rejection response in xenotransplantation by biomarker.
( So Dam Hong ),( Hye Jeong Cho ),( Jae Kyoung Shin ),( Hee Jin Hong ),( Bo Hye Kim ),( So Young Chong ),( Do Youn Oh ),( Ji Su Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
The incidence of metastases to the thyroid gland demonstrates a 1% in unselected autopsy series to 25% in patients with widespread metastatic lesions. Most recurrent uterine cervical cancer patients have metastatic lesions in intra-pelvis and adjacent lymph node involvement, while a distant metastasis alone is extremely rare. We report a case of a 79-year-old woman with recurrent uterine cervical cancer, presenting thyroid mass without intra-pelvic recurrence four year after initial curative treatment. 4 years ago, the patient was diagnosed uterine cervical cancer (invasive squamous cell carcinoma, non-keratinizing type). She had undergone a course of concurrent chemoradiotherapy to the pelvis. She had lived without any other symptoms and evidence of recurrence for 4 years. Several weeks ago she had noticed foreign body sensation in throat, a palpable mass in the left side of her neck and a swelling in the region of the thyroid gland. Sono-guided biopsy of thyroid mass was performed and revealed metastatic squamous cell carcinoma, clinically from the uterine cervix. She had undergone total thyroidectomy and treated with 4 cycles of chemotherapy and radiotherapy. We conclude that patients who present swelling or palpable nodules in the thyroid side and have a history of a previous malignancy must be considered for metastatic disease although metastasis from the uterine cervical carcinoma to the thyroid gland is even rare.