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Lee, Yi Seul,Lee, Ha-Jin,Choi, Won San American Chemical Society 2014 Langmuir Vol.30 No.31
<P>AgBr nanostructures with unified shapes and sizes were prepared using simple polyelectrolyte (PE) coatings on various AgBr microstructures that were prepared by mixing silver precursors with hexadecyltrimethylammonium bromide (CTAB) under controlled conditions. The AgBr microstructures (plates, rods, and wires), regardless of initial structures or sizes, transformed into cubic AgBr nanoparticles (CNPs) after only three PE coatings. The electrostatic interactions between the PEs and the CTAB in the AgBr microstructures are the crucial factors that control the shapes and sizes of the AgBr microstructures. During the PE coating, the AgBr microstructures were transformed and rearranged into AgBr CNPs with favorable catalytic faces that enhanced the photocatalytic activity. The size- and shape-controlled AgBr CNPs showed excellent photocatalytic performance for the degradation of methylene orange (MO) dyes under visible-light irradiation without deterioration even after multiple uses.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-31/la502378z/production/images/medium/la-2014-02378z_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la502378z'>ACS Electronic Supporting Info</A></P>
Comprehensive review on synthesis and adsorption behaviors of graphene-based materials
Seul-Yi Lee,Soo-Jin Park 한국탄소학회 2012 Carbon Letters Vol.13 No.2
Graphene is the thinnest known materials in the universe and the strongest ever measured. Graphene has emerged as an exotic material of the 21st century and received world-wide attention due to its exceptional charge transport, thermal, optical, mechanical, and adsorptive properties. Recently, graphene and its derivatives are considered promising candidates as adsorbent for H2 storage, CO2 capture, etc. and as the sensors for detecting individual gas molecule. The main purpose of this review is to comprehensive the synthesis method of graphene and to brief the adsorption behaviors of graphene and its derivatives.
Seul-Yi Lee,Tuan Anh Vuong,Xianlan Wen,Hyeon-Ju Jeong,Hyun-Kyung So,Ilmin Kwon,Jong-Sun Kang,Hana Cho 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The sodium leak channel NALCN is a key player in establishing the resting membrane potential (RMP) in neurons andtransduces changes in extracellular Ca2+ concentration ([Ca2+]e) into increased neuronal excitability as thedownstream effector of calcium-sensing receptor (CaSR). Gain-of-function mutations in the human NALCN gene causeencephalopathy and severe intellectual disability. Thus, understanding the regulatory mechanisms of NALCN isimportant for both basic and translational research. This study reveals a novel mechanism for NALCN regulation byarginine methylation. Hippocampal dentate granule cells in protein arginine methyltransferase 7 (PRMT7)-deficientmice display a depolarization of the RMP, decreased threshold currents, and increased excitability compared to wildtypeneurons. Electrophysiological studies combined with molecular analysis indicate that enhanced NALCN activitiescontribute to hyperexcitability in PRMT7−/− neurons. PRMT7 depletion in HEK293T cells increases NALCN activity byshifting the dose-response curve of NALCN inhibition by [Ca2+]e without affecting NALCN protein levels. In vitromethylation studies show that PRMT7 methylates a highly conserved Arg1653 of the NALCN gene located in thecarboxy-terminal region that is implicated in CaSR-mediated regulation. A kinase-specific phosphorylation siteprediction program shows that the adjacent Ser1652 is a potential phosphorylation site. Consistently, our data fromsite-specific mutants and PKC inhibitors suggest that Arg1653 methylation might modulate Ser1652 phosphorylationmediated by CaSR/PKC-delta, leading to [Ca2+]e-mediated NALCN suppression. Collectively, these data suggest thatPRMT7 deficiency decreases NALCN methylation at Arg1653, which, in turn, decreases CaSR/PKC-mediated Ser1652phosphorylation, lifting NALCN inhibition, thereby enhancing neuronal excitability. Thus, PRMT7-mediated NALCNinhibition provides a potential target for the development of therapeutic tools for neurological diseases.
Seul-Yi Lee,Tuan Anh Vuong,Hyun-Kyung So,Hyun-Ji Kim,Yoo Bin Kim,Jong-Sun Kang,Ilmin Kwon,Hana Cho 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
HCN channels regulate excitability and rhythmicity in the hippocampal CA1 pyramidal cells. Perturbation in the HCN channel current (Ih) is associated with neuropsychiatric disorders, such as autism spectrum disorders. Recently, protein arginine methyltransferase 7 (PRMT7) was shown to be highly expressed in the hippocampus, including the CA1 region. However, the physiological function of PRMT7 in the CA1 neurons and the relationship to psychiatric disorders are unclear. Here we showed that PRMT7 knockout (KO) mice exhibit hyperactivity and deficits in social interaction. The firing frequency of the CA1 neurons in the PRMT7 KO mice was significantly higher than that in the wild-type (WT) mice. Compared with the WT CA1 neurons, the PRMT7 KO CA1 neurons showed a more hyperpolarized resting potential and a higher input resistance, which were occluded by the Ih-current inhibitor ZD7288; these findings were consistent with the decreased Ih and suggested the contribution of Ih-channel dysfunction to the PRMT7 KO phenotypes. The HCN1 protein level was decreased in the CA1 region of the PRMT7 KO mice in conjunction with a decrease in the expression of Shank3, which encodes a core scaffolding protein for HCN channel proteins. A brief application of the PRMT7 inhibitor DS437 did not reproduce the phenotype of the PRMT7 KO neurons, further indicating that PRMT7 regulates Ih by controlling the channel number rather than the open probability. Moreover, shRNA-mediated PRMT7 suppression reduced both the mRNA and protein levels of SHANK3, implying that PRMT7 deficiency might be responsible for the decrease in the HCN protein levels by altering Shank3 expression. These findings reveal a key role for PRMT7 in the regulation of HCN channel density in the CA1 pyramidal cells that may be amenable to pharmacological intervention for neuropsychiatric disorders.
Lee, Ye-Seul,Lee, In-Seon,Kim, Song-Yi,Lee, Hyangsook,Park, Hi-Joon,Lee, Hyejung,Kim, Sung-Hoon,Chae, Younbyoung THE BRITISH MEDICAL ACUPUNCTURE SOCIETY 2015 ACUPUNCTURE IN MEDICINE Vol.33 No.2
<P><B>Objectives</B></P><P>The utilisation of healthcare services is the result of a complex decision-making process with different determinants. This study aims to identify the determinants of the utilisation of acupuncture treatment using Andersen's behavioural model and quality of life.</P><P><B>Methods</B></P><P>In this study we reviewed Korean Health Panel data, a nationally representative set of data, and analysed the utilisation of outpatient acupuncture services during 2011. A two-part model, which included predisposing, enabling and need factors of Andersen's behavioural model in model 1 and the additional factor of health-related quality of life (HRQOL, EQ-5D Korean index) in model 2, was analysed by logistic analysis to identify determinants of acupuncture service usage among subjects who visited traditional Korean medical clinics.</P><P><B>Results</B></P><P>The higher frequency of acupuncture service usage among patients who visited traditional Korean medical clinics was associated with gender, age, number of chronic diseases, physical disabilities and HRQOL of the subjects.</P><P><B>Conclusions</B></P><P>This study shows that the important determinants of the frequency of acupuncture treatment utilisation are gender, age, number of chronic diseases and the presence of physical disabilities. Our findings contribute to understanding the characteristics of patients who use acupuncture treatment and may be used as a basic resource for related policy making by government officials and medical professionals.</P>
Effect of temperature on activated carbon nanotubes for hydrogen storage behaviors
Lee, Seul-Yi,Park, Soo-Jin Elsevier 2010 International journal of hydrogen energy Vol.35 No.13
<P><B>Abstract</B></P><P>In this work, activated multi-walled carbon nanotubes (Acti-MWNTs) with well-developed pore structures, a highly specific surface area, and higher hydrogen adsorption capacities due to CO<SUB>2</SUB> activation were prepared. The activation was performed at activation temperatures in the range of 500–1100 °C. The microstructure and crystallinity of the Acti-MWNTs were evaluated with a transmission electron microscope (TEM) and an FT-Raman spectrometer, respectively. The textural properties of the Acti-MWNTs were investigated by using a nitrogen gas sorption analyzer at 77 K. The hydrogen storage capacities of the Acti-MWNTs were investigated by BEL-HP at 298 K/100 bar. The hydrogen storage capacities of the Acti-MWNTs were enhanced to 0.78 wt.% by increasing activation temperatures to 900 °C, which resulted in the formation of a defective structure in the Acti-MWNTs. This result indicated that the CO<SUB>2</SUB> activation was one of the most effective methods to develop the textural properties, as well as to enhance the hydrogen storage capacities of MWNTs.</P>
Lee, Seul Ji,Yi, TacGhee,Ahn, Soo Hyun,Lim, Dong Kyu,Kim, Si-na,Lee, Hyun-Joo,Cho, Yun-Kyoung,Lim, Jae-Yol,Sung, Jong-Hyuk,Yun, Jeong-Ho,Lim, Johan,Song, Sun U.,Kwon, Sung Won Elsevier 2018 Analytica Chimica Acta Vol.1024 No.-
<P><B>Abstract</B></P> <P>Mesenchymal stem cells (MSCs) are a promising therapeutic option for cell-based therapy due to their immunomodulatory and regenerative properties. They can be isolated from various adult tissues, including bone marrow, fat, dental tissue, and glandular tissue. Although they share common characteristics, little is known about the biological differences between MSC populations derived from different tissues. In this study, we used MS to compare the endogenous metabolite level in the human MSCs originating from the bone marrow, adipose tissue, periodontal ligaments, and salivary glands. Using an optimized metabolomics technique, we verified that human MSCs exhibit differences in the endogenous metabolite level depending on their source material, while the multivariate analysis showed that 5 lysophosphatidylcholines and 3 lysophosphatidylethanolamines can serve as markers for the discrimination between MSC sources and may be related to differences in their differentiation capacity. These results may significantly contribute to further mechanistic studies on the MSCs and provide novel insights into the properties and optimal usage of MSCs from different tissues.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Endogenous metabolite level of human mesenchymal stem cells (MSCs) was evaluated. </LI> <LI> MSCs from different tissue sources were compared. </LI> <LI> Metabolic markers to distinguish MSCs by source tissue were identified. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>