부검으로 확진된 알쯔하이머병 1예 : An Autopsy Report

한설희,이건국,양기화,장순환 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

While the clinical diagnostic accuracy of probable Alzheimer′s disease (AD) is 87-96% with a diagnostic sensitivity/specificity of 0 81-0 87, the unequivocal diagnosis of AD rests on histopathological evidence at brain autopsy and/or biopsy We report here a 92-year-old woman whose clinical presentation suggested a far advanced Alzheimer′s disease Formal neuropsychological evaluations were not applicable due to severe cognitive impairments With a relatively good general physical condition she could walk with aid during her last days no focal neurological signs were noted on a detailed examination Brain MRI revealed a diffuse cortical atrophy with a marked reduction in the hippocampal volume The brain obtained weighted 780g The cerebral hemispheres examined after fixation disclosed moderately severe atrophy in prefrontal and temporal lobes on coronal section, the hippocampus was likewise severely atrophied the lateral ventricles were moderately dilated On microscope examination, there were numerous senile plaques and neurofibrillary tangles in the neocortices. hippocampus and amyglada, compatible with advanced Alzheimer′s disease In summary we report the first Korean autopsy-proven case with advanced Alzheimer′s disease.

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

Successful treatment of Kimura’s disease with cyclosporine

( Seol Hwa Seong ),( Ji Yun Jang ),( Myeong Hyeon Yang ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, painless subcutaneous swellings and lymphadenopathy mainly involving the head and neck region can be seen. The histopathologic findings of KD show lymphoid follicular hyperplasia with germinal centers, massive eosinophilic infiltration often with the formation of abscess, varying degree of fibrosis, and vascular proliferation. Surgical excision, regional or systemic steroid therapy have formed the mainstay of the treatment, but the consensus on the optimal treatment is not well established. Cyclosporine also can be used and its therapeutic effects are related to the decrease in production of cytokines including IL-2, IL-4, IL-5, which inhibits T-cell proliferation. A 34-year-old female patient presented with localized pruritic solitary erythematous swollen patches on the right cheek. The lesions gradually grew up during last 18 months. Histopathologic findings showed dense lymphocytic follicular hyperplasia, stromal fibrosis, marked eosinophilic infiltration with flat epithelial cells of venules. On the basis of these clinical and histopathologic findings, the diagnosis of KD was made. The patient was treated with oral cyclosporine (200mg/day). A significant improvement in skin lesions was achieved after 20 weeks of treatment and maintained during follow-up period. Herein, we report a case of KD successfully treated with oral cyclosporine.

The Effect of the Water Extracts of Digestive Medicinal Plants on the Shelf-life of Pork Patties

Seol, Kuk-Hwan,Seol, Hyun-Chul,Prayad, Thirawong,Kim, Hyoun-Wook,Jang, Ae-Ra,Ham, Jun-Sang,Oh, Mi-Hwa,Kim, Dong-Hun,Lee, Moo-Ha Korean Society for Food Science of Animal Resource 2011 한국축산식품학회지 Vol.31 No.1

This study was performed to examine the possibility of water extracts of several digestive medicinal plants (DMPEs), such as Amomum tasoko, Alpinia oxyphylla, Citrus unshiu, and Myristica fragrans, as a natural antioxidant. Total phenol contents of each extract were expressed as gallic acid equibalents (GAE) and those were significantly different among A. tasoko ($39.87{\pm}5.77$ mg GAE/g), A. oxyphylla ($30.28{\pm}3.36$ mg GAE/g), C. unshiu ($28.13{\pm}5.01$ mg GAE/g) and M. fragrans ($6.36{\pm}0.30$ mg GAE/g) (p<0.05), and extract of A. tasoko showed significantly higher antioxidative effect than butylated hydroxyanisole (BHA) on linoleic acid peroxidation at 72 h after incubation (p<0.05). Addition of extracts in pork patties did not affect the pH value and total microbes during cold storage. However, thiobarbituric acid reative substances (TBARS) of treated patties were lower in dose dependant manner than that of control as storage period increased (except patties treated with C. unshiu extract), and patties treated with 0.5% A. tasoko extract showed no significant difference with patties treated with 0.5% BHA at day 7.

Effects of dietary microwave-dried black soldier fly (Hermetia illucensr) larvae meal on growth performance and health in broilers

Seol Hwa Park,Hye Ran Kim,Youl-Chang Baek,Chae Hwa Ryu,Sang Yun Ji,Jin Young Jeong,Minji Kim,Hyunjung Jung,Byeonghyeon Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

This study aimed to evaluate the effect of microwave-dried black soldier fly (Hermetia illucens) larvae meal (HILM) as a dietary protein source in broiler chicken diets on growth performance and health of broilers. A total of 126 male broilers were randomly allocated to three dietary treatments (six replicates of seven birds per group): a control diet (CON) of corn and soybean meal and two experimental diets in which soybean meal was replaced with 25% (25HILM) or 50% (50HILM) HILM. The broilers were slaughtered at the end of the study (35 d) to determine volatile fatty acid (VFA) profiles, and the length and weight of the small intestine. Blood samples were collected from 36 randomly selected birds (12 broilers per treatment) to determine serum parameters and hematological traits. Average daily gain, feed intake in the 50HILM group compared with the CON group. Serum low-density lipoprotein cholesterol was the lowest (P < 0.01) but triglyceride levels were the highest (P < 0.05) in the 50HILM group. The HILM diet-fed chickens had lower (P < 0.01) serum phosphorus level and creatine phosphokinase level was lower in 50HILM group than CON group. On the other hand, the 50HILM group showed higher (P < 0.05) monocyte and red blood cell distribution width-standard deviation. In conclusion, the dietary microwave-dried HILM positively influenced the VFAs and cholesterol levels; however, growth performance was negatively affected by malnutrition caused by low protein digestibility in the 50HILM group. The microwave-dried HILM is a valuable ingredient for broiler diets, with up to 25% substitution showing no detrimental effects on growth performance and health. However, further research is needed to solve this drawback by improving digestibility.

Epidemiology and clinical outcomes of 151 patients with mycosis fungoides at the Kosin University Gospel Hospital: retrospective 27-year review

( Seol Hwa Seong ),( Do Ik Kwon ),( Ji Yun Jang ),( Jong Bin Park ),( Kee Suck Suh ),( Min Soo Jang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma with a variety of clinicopathological features. A single center-based large scale study with long-term follow up in Korea has not been reported. Objectives: To investigate epidemiologic features and clinical outcomes of MF patients at the authors’ hospital over a 27-year period. Methods: This is a pilot study conducted on 151 patients diagnosed as MF, from 1991 to 2018, with the retrospective review. Results: Of 151 patients, 62.9% were male and 37.1% female. The mean age at the diagnosis was 44.2 years (range, 5-82). The mean duration of symptoms was 50.4 months (range, 0.25-360). The mean follow-up duration was 57.6 months (range, 2-251). Common subtypes were classic MF (45.0%), mycosis fungoides palmaris et plantaris (MFPP) (23.8%), and folliculotropic MF (7.9%). In early-stage MF (IA-IIA) of 143 patients (94.7%), the 10-year overall survival (OS) was 93.6%. In advancedstage MF (IIB-IVB) of eight patients (5.3%), the 10-year OS was 23.4%. Complete remission (CR) and disease progression were found in 63.6% and 4.6% of the patients. The recurrence after CR was observed in 33 patients (21.9%) and the mean recurrence free-duration was 24.1 months (range, 1-118). Conclusion: Clinical outcomes generally paralleled the previous reports with favorable prognosis in the earlystage MF. Recurrence was not uncommon, largely due to greater prevalence of MFPP.

Localized mycosis fungoides that predominantly affects knuckles of hands

( Seol Hwa Seong ),( Jang Hwan Jung ),( Do Ik Kwon ),( Kang Hoon Lee ),( Jong Bin Park ),( Kee Suck Suh ),( Min Soo Jang ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Mycosis fungoides palmaris et plantaris (MFPP) is a variant of mycosis fungoides (MF) that localized on the palms and soles, which often spreads to the dorsal aspect of hands, fingers, and feet. However, it is argumentative to classify localized MF that mainly affects knuckles of hands, with or without involvement of palms, as MFFP. Further, it can be overlooked as chronic hand eczema unless a biopsy is performed. Objectives: To investigate the clinicopathologic features of localized MF that mainly affects the dorsal aspect of hands. Methods: This study was conducted on nine patients diagnosed clinicopathologically MF, and who presented discrete eczematous lesions predominantly on the dorsal aspect of hands. Results: The mean age at the diagnosis was 47.6 years (range, 38-59). The mean duration of the disease was 46.7 months (range, 12-120). Knuckles were the most common site of involvement shown in all nine patients, followed by the volar side of fingers shown in six patients. Five patients reported an occupational history with frequent minor injuries on the hands. During 78.5 months of the mean follow-up, none of the patients had progressive disease. While most histopathologic findings were similar to that of classic MF, spongiosis was more pronounced in our patients. Conclusion: We suppose that trauma may play a role in the development of localized MF, and a high index of suspicion is needed for this diagnostic challenge.

Distinction of bowenoid papulosis, seborrheic keratosis and condyloma acuminatum in genital area with dermoscopic features and human papilloma virus related entities

( Seol Hwa Seong ),( Do Ik Kwon ),( Ji Yun Jang ),( Jong Bin Park ),( Kee Suck Suh ),( Min Soo Jang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Making a clear diagnosis of bowenoid papulosis (BP), seborrheic keratosis (SK) and condyloma acuminatum (CA) in genital area can be difficult. Skin biopsy can be helpful but its invasiveness and low cost-effectiveness provoke to seek other diagnostic methods. Objectives: To investigate distinctive dermoscopic features and human papillomavirus (HPV) related entities that can differentiate BP, SK, and CA. Methods: Dermoscopic patterns and real-time polymerase chain reaction (PCR) to detect HPV were evaluated in 44 biopsy specimens. 10, 13, and 21 specimens of them were histologically confirmed as BP, SK, and CA. Results: The most common site of occurrence was penile shaft in BP, inguinal area in SK and equally penile shaft or inguinal area in CA. Dermoscopic features tend to be different showing structureless pattern (80%) with glomerular vessels (70%) in BP, cobblestone pattern (46%) without specific visible vessels (69%) in SK, and exophytic papillary structures (86%) with high vascularity including hairpin, glomerular, and comma-like vessels (71%, 57%, and 52%, respectively) in CA. Detection rate of HPV in PCR was 90% in BP, 61.5% in SK, and 100% in CA. Commonly found subtype was HPV 16 in BP (46.2%), SK (60.0%), and HPV 6 in CA (42.9%). Conclusion: Dermoscopy can be useful for differential diagnosis of BP, SK, and CA. High-risk HPV was predominant in BP, SK and low-risk HPV in CA implying distinctive HPV related entities.

Metastatic pancreatic cancer mimicking keratoacanthoma: Dermoscopic features

( Seol Hwa Seong ),( Ji Yun Jang ),( Jong Bin Park ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Cutaneous metastasis of internal malignancy is a rare phenomenon that accounts for less than 5% of the patients with cancer and can be confused with benign skin disorders. A 47-year-old male suffering from the pancreatic cancer presented with a well-defined, erythematous coin sized solitary tumor with central ulceration on the face, clinically similar to a keratoacanthoma (KA). On dermoscopy, the ulcerated central amorphous area surrounded by white structureless area and white circles on the erythematous to orange colored background were seen. Polymorphous vascular patterns were asymmetrically distributed with densely aligned, linear serpentine vessels, dotted vessels, and arborizing vessels. The hairpin vessel, a well-known dermoscopic feature of KA, was not seen. Histologic findings showed atypical hyperchromatic cells densely involving the dermis and subcutaneous tissue, transepidermal elimination, and uninvolved epidermis separated from underlying tumor cell infiltration by Grenz zone. Moderately differentiated neoplastic glands and tumor cells showing the ‘Indian file’ arrangment were seen. In the immunohistochemical staining, CA19-9, CK19, and CK7 were positive, whereas, CK20 were negative. On the basis of dermoscopic and histologic findings, the diagnosis of metastatic pancreatic cancer was made. Herein, we report a case of metastatic pancreatic cancer mimicking KA for which the dermoscopy was used as a helpful diagnostic tool.

Unusual clinicohistopathologic features of cutaneous nontuberculous mycobacterial infection caused by Mycobacterium marinum

( Seol Hwa Seong ),( Ji Yun Jang ),( Jong Bin Park ),( Min Soo Jang ),( Kee Suck Suh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Nontuberculous mycobacteria (NTM), which rarely cause cutaneous lesions, are a heterogeneous group of acid-fast bacilli other than Mycobacterium tuberculosis and Mycobacterium leprae. Among the cutaneous NTM infections, Mycobacterium marinum is the most common pathogen and its clinical manifestation can be variable. A 74-year-old woman presented with diffuse tender erythematous to yellow cellulitis-like patches on the left arm along the discrete papules on the left flank. Histopathologic findings showed caseating granuloma that distinctly had central necrosis with a palisaded lymphohistiocytic infiltration and multinucleated giant cells in the upper dermis. Non-caseating granulomas, nonspecific mixed cell infiltration in the deep dermis, and abscesses in the subcutaneous tissue were seen. Cultures for the NTM and sequencing of the polymerase chain reaction confirmed M. marinum infection. Retrospectively, acid-fast bacilli were found in the Ziehl-Neelsen stain. On the basis of histopathologic, microbiologic, and molecular findings, the diagnosis of cutaneous NTM infection caused by M. marinum was made. Among the variable clinicohistopathologic features of cutaneous NTM infection, cellulitis-like appearance is rarely observed and caseating granuloma surrounded by palisading lymphohistiocytic infiltration is not common. Herein, we report a case of unusual clinicohistopathologic features of cutaneous NTM infection caused by M. marinum.