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Seol Hwa Park,Hye Ran Kim,Youl-Chang Baek,Chae Hwa Ryu,Sang Yun Ji,Jin Young Jeong,Minji Kim,Hyunjung Jung,Byeonghyeon Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
This study aimed to evaluate the effect of microwave-dried black soldier fly (Hermetia illucens) larvae meal (HILM) as a dietary protein source in broiler chicken diets on growth performance and health of broilers. A total of 126 male broilers were randomly allocated to three dietary treatments (six replicates of seven birds per group): a control diet (CON) of corn and soybean meal and two experimental diets in which soybean meal was replaced with 25% (25HILM) or 50% (50HILM) HILM. The broilers were slaughtered at the end of the study (35 d) to determine volatile fatty acid (VFA) profiles, and the length and weight of the small intestine. Blood samples were collected from 36 randomly selected birds (12 broilers per treatment) to determine serum parameters and hematological traits. Average daily gain, feed intake in the 50HILM group compared with the CON group. Serum low-density lipoprotein cholesterol was the lowest (P < 0.01) but triglyceride levels were the highest (P < 0.05) in the 50HILM group. The HILM diet-fed chickens had lower (P < 0.01) serum phosphorus level and creatine phosphokinase level was lower in 50HILM group than CON group. On the other hand, the 50HILM group showed higher (P < 0.05) monocyte and red blood cell distribution width-standard deviation. In conclusion, the dietary microwave-dried HILM positively influenced the VFAs and cholesterol levels; however, growth performance was negatively affected by malnutrition caused by low protein digestibility in the 50HILM group. The microwave-dried HILM is a valuable ingredient for broiler diets, with up to 25% substitution showing no detrimental effects on growth performance and health. However, further research is needed to solve this drawback by improving digestibility.
Osteopromotion With Synthetic Oligopeptide-Coated Bovine Bone Mineral In Vivo
Park, Jun-Beom,Lee, Jue-Yeon,Park, Ho-Nam,Seol, Yang-Jo,Park, Yoon-Jeong,Rhee, Sang-Hoon,Lee, Sang-Cheol,Kim, Kyoung-Hwa,Kim, Tae-Il,Lee, Yong-Moo,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Chung, Chong-Pyo Wiley (John WileySons) 2007 Journal of periodontology Vol.78 No.1
Shin, Seol Hwa,Park, Seok Soon,Lee, Kyoung Jin,Ju, Eun Jin,Park, Jin,Ko, Eun Jeong,Jung, Joohee,Kuroda, Shunich,Hong, Seung-Mo,Hwang, Jung Jin,Lee, Jung Shin,Song, Si Yeol,Jeong, Seong-Yun,Choi, Eun K Spandidos Publications 2017 ONCOLOGY REPORTS Vol.38 No.4
<P>The incidence of hepatocellular carcinoma (HCC) has continued to increase worldwide, and advanced HCC is difficult to treat using the currently available therapeutics. Chemoradiotherapy with cisplatin (cis-diamminedichloroplatinum, CDDP) is expected to confer a curative benefit on HCC patients; however, its application is limited due to side-effects such as acute nephrotoxicity as well as the conventionally limited application of chemoradiotherapy for HCC. For the practical application of this drug in the clinical setting, we formulated a novel drug carrier-comprising bio-nanocapsule (BNC) and liposomal CDDP (BNC-LP-CDDP) that recognizes the human liver and releases CDDP. BNC-LP-CDDP showed selectively high cytotoxicity for HCC cells, and markedly reduced the survival fractions of HCC when combined with ionizing radiation (IR) treatment in in vitro assays. In particular, the treatment of mice bearing human HCC with BNC-LP-CDDP and 3 Gy IR showed 95.68% growth inhibition, whereas IR treatment alone showed 65.6% growth inhibition. Moreover, BNC-LP-CDDP led to the withdrawal of CDDP-induced nephrotoxicity. These results indicate that BNC-LP-CDDP in combination with IR markedly enhanced the chemo-radiotherapeutic efficacy and eliminated CDDP induced nephrotoxicity, thus, suggesting the potential for its clinical application as human HCC therapy.</P>
Disrupted-in-schizophrenia 1 (DISC1) Regulates Dysbindin Function by Enhancing Its Stability
Lee, Seol-Ae,Kim, Seong-Mo,Suh, Bo Kyoung,Sun, Hwa-Young,Park, Young-Un,Hong, Ji-Ho,Park, Cana,Nguyen, Minh Dang,Nagata, Koh-ichi,Yoo, Joo-Yeon,Park, Sang Ki American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.11
<P>Dysbindin and DISC1 are schizophrenia susceptibility factors playing roles in neuronal development. Here we show that the physical interaction between dysbindin and DISC1 is critical for the stability of dysbindin and for the process of neurite outgrowth. We found that DISC1 forms a complex with dysbindin and increases its stability in association with a reduction in ubiquitylation. Furthermore, knockdown of DISC1 or expression of a deletion mutant, DISC1 lacking amino acid residues 403–504 of DISC1 (DISC1<SUP>Δ403–504</SUP>), effectively decreased levels of endogenous dysbindin. Finally, the neurite outgrowth defect induced by knockdown of DISC1 was partially reversed by coexpression of dysbindin. Taken together, these results indicate that dysbindin and DISC1 form a physiologically functional complex that is essential for normal neurite outgrowth.</P>
Arthothelium punctatum (Arthoniaceae, Arthoniales), A New Lichen Species from South Korea
( Jung Shin Park ),( Sook-young Park ),( Chan-ho Park ),( Seol-hwa Jang ),( Jae-seoun Hur ) 한국균학회 2017 Mycobiology Vol.45 No.4
A total of 121 species of lichens belonging to the genus Arthothelium have been described to date, most of which have been found in tropical regions. Here, we describe the discovery of a novel Arthothelium species for the first time in South Korea. Until now, Arthothelium ruanum was the only Arthothelium species reported in South Korea. Among the 113 specimens collected in this study, we identified A. ruanum and a putative new species, Arthothelium punctatum (J. S. Park & J.-S. Hur, sp. nov.). The diagnostic characters of A. punctatum are as follows: apothecia punctate, shortly elongate to branched, small, 0.1-0.2 mm wide, hypothecium hyaline to pale brown and obovate to broadly ellipsoid, muriform ascospores, 29.5-44.6 × 12.2-18.2 μm. The new species was found in Mt. Seokbyeong at an altitude of 790 m on smooth bark. Upon phylogenic analysis, the putative new species, A. punctatum, was separated from other Arthothelium species although the specimens analyzed were clustered with Arthoniaceae in phylogenetic trees based on both the mitochondrial small subunit (mtSSU) sequence and combined mtSSU and nuclear ribosomal large subunit sequences. Our data clearly indicate that this species is a new species belonging to the family Arthoniaceae. To elucidate the taxonomic characteristics of the new species, we provide morphological descriptions and a distribution map.
Hee-Bok Park,Moon-Cheol Shin,Pil-Nam Seong,Nam-Young Kim,Jun-Kyu Son,Jae Hoon Woo,Seol Hwa Park,Sang-Min Shin,Nam Geon Park,In-Cheol Cho 한국수정란이식학회 2017 한국수정란이식학회 학술대회 Vol.2017 No.05
Alterations affecting the status of robustness and health can bring about physiological changes including hematological parameters in pigs. To identify quantitative trait loci (QTL) associated with 8 hematological phenotypes (one leukocyte trait, six erythrocyte traits, and one platelet trait), we performed a genome-wide association study using the Porcine SNP 60K BeadChip in an intercross population between Landrace and Korean native pigs. A total of 36,740 SNPs from 816 F2 offspring were analysed for each blood related traits after filtering by quality control. Data were analysed genome-wide rapid association using the mixed model and regression (GRAMMAR) approach. A total of 257 significant SNPs (P<1.36x10-6) on SSC3, 6, 8, 13, and 17 were detected for blood related traits in this study. Interestingly, the genomic region between 17.9 and 130 Mb on SSC8 was found to be significantly associated with RBC, MCV, and MCH. Our results include 5 significant SNPs within five candidate genes (KIT, IL15, TXK, ARAP2, and ERG) for hematopoiesis. Further validation of these identified SNPs could give valuable information for understanding the variation of hematological traits in swine.
Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration
Kim, Kyoung-Hwa,Jeong, Lim,Park, Ho-Nam,Shin, Seung-Yun,Park, Won-Ho,Lee, Sang-Chul,Kim, Tae-Il,Park, Yoon-Jeong,Seol, Yang-Jo,Lee, Yong-Moo,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Chung, Chong-Pyoung Elsevier 2005 Journal of biotechnology Vol.120 No.3
<P><B>Abstract</B></P><P>The favorable biological properties of silk fibroin (SF) nanofiber membrane make it a good candidate for clinical applications as a device in bone and periodontal regenerative therapy. The purpose of this study is to evaluate the biocompatibility of the SF nanofiber membrane, and to examine its effect on bone regeneration in a rabbit calvarial model.</P><P>To examine the biocompatibility of the electrospun SF membrane, we investigated cell proliferation, morphology, and differentiation. The bone regenerative efficacy of the membrane was evaluated in the calvarial defect of rabbits.</P><P>The cell numbers and osteocalcin production labels were significantly increased in accordance with culture period. Cells had a stellate shape and broad cytoplasmic extensions on the membrane. The cells showed activity of ALPase that was comparable to culture dishes, and were calcified similarly to culture dishes. In in vivo tests, a complete bony union across the defects was observed after 8 weeks. At 12 weeks, the defect had completely healed with new bone.</P><P>In conclusion, the SF nanofiber membrane was shown to possess good biocompatibility with enhanced bone regeneration and no evidence of any inflammatory reaction. These results strongly suggest that the SF membrane should be useful as a tool for guided bone regeneration.</P>
Hee-Bok Park,Moon-Cheol Shin,Pil-Nam Seong,Nam-Young Kim,Jun-Kyu Son,Jae Hoon Woo,Seol Hwa Park,Sang-Min Shin,Nam Geon Park,In-Cheol Cho 한국수정란이식학회 2017 한국수정란이식학회 학술대회 Vol.2017 No.05
Previously, we reported a quantitative trait locus (QTL) that affect total teat number (TTN) on pig chromosome 7 (SSC7) in a large F2 intercross population between Landrace and Korean native pigs. The aim of this study was to refine the QTL associated with TTN and to identify positional candidate gene(s) within the refined genomic region. TTN was recorded in 1,105 F2 progeny. All experimental animals were genotyped using 998 informative single nucleotide polymorphism (SNP) markers located on SSC7. A haplotype-based linkage and association analysis using the PHASEBOOK programme was applied to perform high-resolution QTL analysis. Additionally, linear mixed-effect models were used to assess the effect of a positional candidate gene on TTN and other economically important traits [i.e., thoracic vertebrae number (THO), carcass body length (CBL) and weight (CW), back fat thickness (BFT) and intramuscular fat content (IMF) in loin muscles]. Joint linkage and association analysis refined the critical region to a 1.07 Mb region that included a novel positional candidate gene, BRMS1L, that encodes the breast cancer metastasis-suppressor 1-like protein, which could possibly be implicated in normal mammary gland development. Significant association of an SNP marker (g.-1087 G>A) in the 5’-flanking region of BRMS1L with TTN (P=1.10x10-8), THO (P=5.80x10-4), and CBL (P=0.038) was observed. Based on these data, we propose BRMS1L as a positional candidate gene for TTN in pigs. After validation of the association in other independent populations and further functional studies, these results could be useful in optimizing breeding programmes that improve TTN and other economically important traits in swine