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Pei-Ju Chen,Keng-Chen Liang,Hui-Chen Lin,Ching-Liang Hsieh,Kuan-Pin Su,Mei-Chu Hung,Lee-Yan Sheen 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
This study adopted the forced-swimming paradigm to induce depressive symptoms in rats and evaluated the effects on learning and memory processing. Furthermore, the effects of the water extract of Gastrodia elata Bl., a well-known Chinese traditional medicine, on amnesia in rats subjected to the forced-swimming procedure were studied. Rats were subjected to the forced-swimming procedure, and the inhibitory avoidance task and Morris water maze were used to assess learning and memory performance. The acquisition of the two tasks was mostly impaired after the 15-minute forced-swimming procedure. Administration of the water extract of G. elata Bl. for 21 consecutive days at a dosage of 0.5 or 1.0 g/kg of body weight significantly improved retention in the inhibitory avoidance test, and the lower dose showed a better effect than the higher one and the antidepressant fluoxetine (18 mg/kg of body weight). In the Morris water maze, the lower dose of the water extract of G. elata Bl. significantly improved retention by shortening escape latency in the first test session and increasing the time in searching the target zone during the probe test. These findings suggest that water extracts of G. elata Bl. ameliorate the learning and memory deficits induced by forced swimming.
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Evaluation of Malignancy Risk of Ampullary Tumors Detected by Endoscopy Using 2-[18F]FDG PET/CT
Chuang Pei-Ju,Wang Hsiu-Po,Tien Yu-Wen,Chin Wei-Shan,Hsieh Min-Shu,Chen Chieh-Chang,Hong Tzu-Chan,Ko Chi-Lun,Wu Yen-Wen,Cheng Mei-Fang 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.3
Objective: We aimed to investigate whether 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) can aid in evaluating the risk of malignancy in ampullary tumors detected by endoscopy. Materials and Methods: This single-center retrospective cohort study analyzed 155 patients (79 male, 76 female; mean age, 65.7 ± 12.7 years) receiving 2-[18F]FDG PET/CT for endoscopy-detected ampullary tumors 5–87 days (median, 7 days) after the diagnostic endoscopy between June 2007 and December 2020. The final diagnosis was made based on histopathological findings. The PET imaging parameters were compared with clinical data and endoscopic features. A model to predict the risk of malignancy, based on PET, endoscopy, and clinical findings, was generated and validated using multivariable logistic regression analysis and an additional bootstrapping method. The final model was compared with standard endoscopy for the diagnosis of ampullary cancer using the DeLong test. Results: The mean tumor size was 17.1 ± 7.7 mm. Sixty-four (41.3%) tumors were benign, and 91 (58.7%) were malignant. Univariable analysis found that ampullary neoplasms with a blood-pool corrected peak standardized uptake value in earlyphase scan (SUVe) ≥ 1.7 were more likely to be malignant (odds ratio [OR], 16.06; 95% confidence interval [CI], 7.13–36.18; P < 0.001). Multivariable analysis identified the presence of jaundice (adjusted OR [aOR], 4.89; 95% CI, 1.80–13.33; P = 0.002), malignant traits in endoscopy (aOR, 6.80; 95% CI, 2.41–19.20; P < 0.001), SUVe ≥ 1.7 in PET (aOR, 5.43; 95% CI, 2.00–14.72; P < 0.001), and PET-detected nodal disease (aOR, 5.03; 95% CI, 1.16–21.86; P = 0.041) as independent predictors of malignancy. The model combining these four factors predicted ampullary cancers better than endoscopic diagnosis alone (area under the curve [AUC] and 95% CI: 0.925 [0.874–0.956] vs. 0.815 [0.732–0.873], P < 0.001). The model demonstrated an AUC of 0.921 (95% CI, 0.816–0.967) in candidates for endoscopic papillectomy. Conclusion: Adding 2-[18F]FDG PET/CT to endoscopy can improve the diagnosis of ampullary cancer and may help refine therapeutic decision-making, particularly when contemplating endoscopic papillectomy.
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吳佩如(WU Pei Ju) 한국외국어대학교 대만연구센터 2021 대만연구 Vol.- No.18
Yan Shu Xia (1982~) and Chen Yu-Hsuan (1985~) are two young female writers of the new generation writers in Taiwan. They are both inspirational in their stylish proses and short story writings, while Chen currently also endeavors to complete her third novel. This essay will analyze their writing strategies as young writers who were born in the post-80s generation. Yan Shu Xia (her real name is Liu Shu Zhen) received her doctorate from the Graduate Institute of Taiwanese Literature, National Cheng Chi University. Published White Horse Walking Through Dawn (2013) and Life of Nothingness (2018),Yan is now an assistant professor at the Department of Chinese Literature, Tunghai University. She has been awarded Lin Rong-San Literary award and Chiu-ko Literary award. Chen Yu Hsuan received her bachelor degree from the Dept. of Chinese Literature, National Taiwan Normal University. She received her M.A. degree from the Graduate Institute of Creative Writing and English Literature, Tunghua University. She has also been awarded Lin Rong-San Literary award, China Times Literary award, and Religion Literary Award. She has published short stories and co-authored her exchange writer journal at Vermont with He Jing-Yao in the collection: There is No Curry in Vermont: Remembering Days in Maverick Writing Studios (2016). Her two novels: Misfortune Man (2015) and It Never Snows in the South (2020) are tentatively entitled as the first two series of her “Trilogy of the South”. She is now teaching Chinese Literature at Changhua Senior high school. These two writers are both educators and their unique creative writing backgrounds grant them a type of “In-betweenness” which seems to cast their positions in the middle of two genres: Prose and Novel/Fiction. As most Taiwanese younger generation writers participated in exchange writing workshops and they have also travelled wildly, Yan and Chen’s works can be regarded as weaving their common routines as an ordinary woman and a writer who moves from one place to another. In this essay, I intend to discuss the particular feature of feminine writings in which they demonstrate their literariness in depicting daily movements in different living spaces. They travel in between their lives and writings, whereas their works redefine multiple writing themes without a specific itinerary in linear style. Their characteristics in writings challenges contemporary Taiwanese writers’ creative forms, shifting ideas into the unknown haunted lands with ghosts, bodies, spirits, and past memories.
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Discriminant Metric Learning Approach for Face Verification
( Ju-chin Chen ),( Pei-hsun Wu ),( Jenn-jier James Lien ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.2
In this study, we propose a distance metric learning approach called discriminant metric learning (DML) for face verification, which addresses a binary-class problem for classifying whether or not two input images are of the same subject. The critical issue for solving this problem is determining the method to be used for measuring the distance between two images. Among various methods, the large margin nearest neighbor (LMNN) method is a state-of-the-art algorithm. However, to compensate the LMNN`s entangled data distribution due to high levels of appearance variations in unconstrained environments, DML`s goal is to penalize violations of the negative pair distance relationship, i.e., the images with different labels, while being integrated with LMNN to model the distance relation between positive pairs, i.e., the images with the same label. The likelihoods of the input images, estimated using DML and LMNN metrics, are then weighted and combined for further analysis. Additionally, rather than using the k-nearest neighbor (k-NN) classification mechanism, we propose a verification mechanism that measures the correlation of the class label distribution of neighbors to reduce the false negative rate of positive pairs. From the experimental results, we see that DML can modify the relation of negative pairs in the original LMNN space and compensate for LMNN`s performance on faces with large variances, such as pose and expression.
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Color Congruency between Text and Graphics Improves Reading Fluency and Comprehension
Pei-Chen, Wang,Tsuei-Ju, Hsieh,Da-Lun, Tang 한국색채학회 2017 AIC 2017 Jeju Vol.2017 No.10
In layout design, color helps not only to decorate but also to index important messages across texts. In this study, we used eye movement data and a reading comprehension test to examine how different color schemes could affect reading behavior when applied in various infographics composed graphics and corresponding explanation text. Three types of infographics were designed: a tour map, a data diagram and an explanatory graph. Each infographic was varied in four coloring schemes that used in highlighting important messages mutually in the texts and the graphics within a infographic. The messages appear in both graphic and the explanatory text were colored in gray scale (no color highlights), a single red color, multiple colors congruently highlight the text and graphics, and multiple colors incongruently highlight the text and graphics. Twenty participants were recruited for the tests. Two-way ANOVA and analyses indicated that different coloring schemes of highlights in text and graphics would impact the readers comprehending process, as well as use different coloring schemes in different information types.
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Pei Xu,Haibo Xiao,Qi Yang,Rui Hu,Lianyong Jiang,Rui Bi,Xueyan Jiang,Lei Wang,Ju Mei,Fangbao Ding,Jianbing Huang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in nonsmall-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.
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Wang Ju-Wei,Han Pei-Jie,Han Da-Yong,Zhou Sen,Li Kuan,He Peng-Yu,Zhen Pan,Yu Hui-Xin,Liang Zhen-Rong,Wang Xue-Wei,Bai Feng-Yan 한국미생물학회 2021 The journal of microbiology Vol.59 No.8
The amylolytic yeast Saccharomycopsis fibuligera is a predominant species in starters and the early fermentation stage of Chinese liquor (Baijiu). However, the genetic diversity of the species remains largely unknown. Here we sequenced the genomes of 97 S. fibuligera strains from different Chinese Baijiu companies. The genetic diversity and population structure of the strains were analyzed based on 1,133 orthologous genes and the whole genome single nucleotide polymorphisms (SNPs). Four main lineages were recognized. One lineage contains 60 Chinese strains which are exclusively homozygous with relatively small genome sizes (18.55–18.72 Mb) and low sequence diversity. The strains clustered in the other three lineages are heterozygous with larger genomes (21.85–23.72 Mb) and higher sequence diversity. The genomes of the homozygous strains showed nearly 100% coverage with the genome of the reference strain KPH12 and the sub-genome A of the hybrid strain KJJ81 at the above 98% sequence identity level. The genomes of the heterozygous strains showed nearly 80% coverage with both the sub-genome A and the whole genome of KJJ81, suggesting that the Chinese heterozygous strains are also hybrids with nearly 20% genomes from an unidentified source. Eighty-three genes were found to show significant copy number variation between different lineages. However, remarkable lineage specific variations in glucoamylase and α-amylase activities and growth profiles in different carbon sources and under different environmental conditions were not observed, though strains exhibiting relatively high glucoamylase activity were mainly found from the homozygous lineage.
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