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Isothermal Crystallization Behavior of PAR/PBT Composite Prepared by Island-in-a-sea Fiber Method
Yong, Da Kyoung,Jeon, Han Yong,Yoo, Jae Jung,Im, Jung Nam,Lee, Seung Goo 한국섬유공학회 2013 FIBERS AND POLYMERS Vol.14 No.12
The PAR fiber reinforced PBT composite was manufactured using the PAR/PBT island-in-a-sea fiber. The isothermal crystallization kinetics of the PAR/PBT composite and the neat PBT resin were investigated in the temperature range of $187-199^{\circ}C$. To calculate the Avrami parameters for analyzing the crystallization behavior, crystallization peaks were measured and analyzed in terms of the crystallization temperature and the inclusion of the PAR fiber. The crystallization rate of the PBT is faster than that of the PAR/PBT composite from the analysis of their relative crystallinity. Consequently, it is considered that the PAR fiber interrupted the crystal nucleation and growth of the PBT matrix. It can be confirmed with the crystallization half time and the crystalline morphologies at the chosen isothermal temperatures.
Yong-il Kim,Sin-Hee Han,Jae-yong Ji,Da-jeong Jeong,Young-sub Ahn,Seon-woo Cha,Seong-min Kim 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10
We divided the sample into four groups by temperature regimes and comparing the Lethal effect after exposure to high room temperatures for 50~58 days. After inoculating Cnidium officinale Makino with Tribolium castaneum Herbst, the storage insects of medicinal herbs, was 20 respectively. The results of treating cut Cninium officinale Makino are listed below. Survival rate of group A by exposure of 5 times at 35~36.5℃ is less than 7.5%. Survival rate of group C by exposure of 5 times at 35.5~39.5℃ and group D by exposure of 23day at 37~44℃ is less than 2.5%. Especially in the case of group D, we found that complete eradication of the insect is difficult despite exposure high temperature for a long time. Also most of the grinded Cninium officinale Makino has the same patten but group B by relatively treated low temperature has a significant difference in mortality. Insect mortality in cut Cninium officinale Makino by exposure at 35℃ and 39.5℃ is 7.5% and the insect mortality in grinded Cninium officinale Makino by exposure at 39. 5℃ is only 75%. The reason is estimated that heat conduction of grinded Cninium officinale Makino is slow and it was less shocked by heat because The final core temperature of medicinal herbs is relatively low about 0.5~2℃. This means that storage insect(Tribolium castaneum Herbst) can be suppressed at mid-high temperature if it is to be treated more than 50 days without problem of quality deterioration of medicinal herbs that can be caused by high temperature.
Yong-il Kim,Sin-Hee Han,Jae-yong Ji,Da-jeong Jeong,Young-sub Ahn,Seon-woo Cha 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10
Currently, the storage temperature of the production factory of medicinal herbs (hGMP) is about 5~ 12℃. This temperature is possible to suppress pest but can not kill the pests. For this reason, we need to lower the temperature during lethal time because the pest has often occurred inside the packaging of medicinal herbs in the distribution process in summer. In order to solve this problem, we have investigated the lethal time of the storage insect(Tribolium castaneum Herbst) After we froze medicinal herbs(Cnidium officinale Makino and Angelica gigas N. ) at approx. –70℃ and –15℃ respectively. We then investigated the change of bioactive components and exterior characteristics of medicinal herbs in order to determine whether there is a change of quality. The results were as follows. The lethal time of Tribolium castaneum Herbst is about 2 minutes if processed at approx. –70℃, while the other time is about 16 minutes at approx. –15℃. We investigated the change of quality after the treatment of the two medicinal herbs in the similar way but could not confirm the difference of color and brightness and the bioactive components on statistics. Through this research, it has been verified that the process of quick freezing for pest control can not affect the main quality of the medicinal herbs. Therefore this technology can be introduced in the manufacturing process of medicinal herbs through additional research.
Higher incidence of sperm granuloma in the epididymis of C57BL/6N mice
Do-Yong Park,Byoung-Seok Lee,Woo-Jin Kim,Wan-Jung Im,Ji-Seok Han,Heejin Park,Mi-Jin Yang,Jae-Woo Cho,Da Hee Kim,Su-Cheol Han,Yong-Bum Kim,Hwa-Young Son 한국실험동물학회 2018 Laboratory Animal Research Vol.34 No.1
C57BL/6N mice are inbred strains widely used in biomedical research. Hence, a large amount of basic data has been accumulated. However, in the field of histopathology, spontaneous data for relatively younger mice that are used more frequently are not yet abundant, in contrast to data for older mice and their neoplastic lesions. To acquire the essential background data required by various research and toxicological assessments, 120 mice of the C57BL/6N strain (10 and 13 weeks of age) were collected from two institutions (From Korea and Japan) and subjected to histopathological analyses of the major organs (liver, spleen, kidney, thymus, heart, testis, epididymis). The results showed significantly higher incidence of sperm granulomas in the epididymides (10-56%) of these mice, compared with that in other strains or species of lab animals. Upon closer inspection, oligospermia/clear cell hyperplasia, cellular debris, and tubular vacuolation were also observed in the epididymides with sperm granulomas. Moreover, diseased organs were significantly heavier than healthy ones. Immunohistochemical staining showed a significant increase in the chromatic figures of cysteine-dependent aspartate-directed proteases-3 (caspase-3) and cleaved-poly(ADP-ribose) polymerase (c-PARP), and damages to the tubule due to spontaneous apoptosis, which may have led to the sperms leaking out of the tubule, causing the granuloma. To conclude, spontaneous sperm granuloma can occur in 10- and 13-week-old C57BL/6N mice and may thus affect the results of various studies using these mice. Therefore, sperm granuloma in epididymis needs to be carefully considered as an important factor when design the study using C57BL/6N.
IL-10 and TNF-α level changes in Oviduct and Endometrium at the Preimplantation Period in Sows
Da-Yeon Jeon(전다연),Soo-Jin Sa(사수진),Hyun-Ju Park(박현주),Hyun-Ju Jin(진현주),Jo-Eun Kim(김조은),Ye-Jin Min(민예진),Yo-Han Choi(최요한),Yong-Dae Jeong(정용대),Jo-Eun Kim(정학재) 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.11
수정란이 착상하는 동안 모체의 생식 기관에서 면역 세포 군집의 변화가 발생하며 이는 임신 과정의 핵심이다. 착상 전·후 기간동안 T 림프구를 포함한 면역 세포는 이식 초기에 생식 기관으로 불러들여지며, T 림프구 중 보조T세포인 Th1과 Th2 사이의 균형은 착상의 성공에 중요한 영향을 미친다. 본 연구에서는 돼지 수정란 착상 전 모체의 난관(OVI), 자궁내막 (ENDO), 자궁 점막층 (UML)에서 Th1, Th2의 균형을 확인하고자 종양괴사인자-알파 (TNF-α)와 인터루킨-10 (IL-10)의 농도를 효소결합 면역흡착 분석법 (ELISA)을 이용해 분석하였다. IL-10의 경우 7일차에 OVI, ENDO, UML에 유의한 차이가 있었으나 (p < 0.01), TNF-α의 경우 모두 유의한 차이가 없었다. IL-10:TNF-α 비율은 OVI에서만 7일째에 유의한 차이가 나타났다 (p < 0.05). 본 연구의 결과는 착상 전 생식 기관별 염증-항염증 기전의 변화를 통해 모체의 생식계가 배아를 수용하는 과정의 일부를 뒷받침할 수 있다. After implantation, dramatic shifts in immune cell populations occur in the maternal reproductive tract, and these changes are key to the implantation and pregnancy process in sows. Immune cells, including T lymphocytes, are recruited during the early implantation period, and an accurate balance between Th1 and Th2 is essential for successful implantation. In this study, the concentration of TNF-α (tumor necrosis factor-alpha) and IL-10 (interleukin-10) in early pregnancy were investigated using an enzyme-linked immunosorbent assay (ELISA) to determine Th1/Th2 ratios in oviduct (OVI), endometrium (ENDO), and the uterine mucosal layer (UML) before implantation. Significant differences in IL-10 levels were observed in OVI, ENDO, and UML tissues on day 7 post-implantation (p < 0.01), whereas TNF-α levels were no different. As regards IL-10 and TNF-α ratios, a significant difference was found on day 2 in OVI tissues (p < 0.05). The result of this study supports the notion that the maternal reproductive system accepts the embryo through changes in preimplantation reproductive system-specific pro-/anti-inflammatory mechanisms.
Han, Chan Su,Lee, Tae Hyeon,Kim, Gwang Mook,Lee, Da Yun,Cho, Yong Soo The Korean Ceramic Society 2016 한국세라믹학회지 Vol.53 No.2
Various piezoelectric nanostructures have been extensively studied for competitive energy harvesting applications. Here, GaN nanowires grown by a nonconventional magnetic field-assisted chemical vapor deposition process were investigated to characterize the piezoelectric energy harvesting characteristics. As a controlling parameter, only the growth time was changed from 15 min to 90 min to obtain different crystallinity and morphology of the nanowires. Energy harvesting characteristics were found to depend largely on the growth time. A longer growth time tended to lead to an increased output current, which is reasonable when considering the enhanced charge potentials and crystallinity. A maximum output current of ~14.1 nA was obtained for the 90 min-processed nanowires.
( Da Hyun Lee ),( Buhyun Lee ),( Jeong Su Park ),( Yu Seol Lee ),( Jin Hee Kim ),( Yejin Cho ),( Yoonjung Jo ),( Hyun-seok Kim ),( Yong-ho Lee ),( Ki Taek Nam ),( Soo Han Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.3
Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt2) is an NAD<sup>+</sup>-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesis, as well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries. [BMB Reports 2019; 52(3): 190-195]