Effectiveness of alendronate as an adjunct to scaling and root planing in the treatment of periodontitis: a meta-analysis of randomized controlled clinical trials

Jin Chen,Qian Chen,Bo Hu,Yunji Wang,Jinlin Song 대한치주과학회 2016 Journal of Periodontal & Implant Science Vol.46 No.6

Purpose: Alendronate has been proposed as a local and systemic drug treatment used as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. However, its effectiveness has yet to be conclusively established. The purpose of the present meta-analysis was to assess the effectiveness of SRP with alendronate on periodontitis compared to SRP alone. Methods: Five electronic databases were used by 2 independent reviewers to identify relevant articles from the earliest records up to September 2016. Randomized controlled trials (RCTs) comparing SRP with alendronate to SRP with placebo in the treatment of periodontitis were included. The outcome measures were changes in bone defect fill, probing depth (PD), and clinical attachment level (CAL) from baseline to 6 months. A fixed-effect or random-effect model was used to pool the extracted data, as appropriate. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using the Cochrane χ2 and I2 tests. Results: After the selection process, 8 articles were included in the meta-analysis. Compared with SRP alone, the adjunctive mean benefits of locally delivered alendronate were 38.25% for bone defect fill increase (95% CI=33.05%–43.45%; P<0.001; I2=94.0%), 2.29 mm for PD reduction (95% CI=2.07–2.52 mm; P<0.001; I2=0.0%) and 1.92 mm for CAL gain (95% CI=1.55–2.30 mm; P<0.001; I2=66.0%). In addition, systemically administered alendronate with SRP significantly reduced PD by 0.36 mm (95% CI=0.18–0.55 mm; P<0.001; I2=0.0%) and increased CAL by 0.39 mm (95% CI=0.11–0.68 mm; P=0.006; I2=6.0%). Conclusions: The collective evidence regarding the adjunctive use of alendronate locally and systemically with SRP indicates that the combined treatment can improve the efficacy of non-surgical periodontal therapy on increasing CAL and bone defect fill and reducing PD. However, precautions must be exercised in interpreting these results, and multicenter studies evaluating this specific application should be carried out.

DEVELOPMENTS OF NEW FEATURE EXTRACTION METHODS IN MACHINERY FAULT DIAGNOSIS

Jin CHEN 한국소음진동공학회 2008 한국소음진동공학회 국제학술대회논문집 Vol.2008 No.7

Mechanism optimal design of backhoe hydraulic excavator working device based on digging paths

Jin Chen,Fei Qing,Xiaoping Pang 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.1

In order to solve the problem that hydraulic excavator in the real working process cannot meet the design requirements and reveals insufficientdigging force, a new method on mechanism optimal design of backhoe hydraulic excavator working device based on diggingpaths is introduced and discussed in this paper. Considering the characteristics of consecutive digging process of hydraulic excavator, adigging path is composed of bucket digging trajectories and arm digging trajectories. The feasible working region is divided into a seriesof uniform paths according to the working position of boom. The practical digging performance of excavator is evaluated based on thedigging force parameters under combined work condition of the discrete points on the digging paths. It is turned out that the method ismore accurate to analyze excavator's real-world digging performance via the analysis of some practical cases. Based on the new diggingperformance analysis method, the optimization mathematical model is built to ensure the digging force under combined work conditionand the average digging force of every operating path as big as possible. The layout design of hinge position on the working device isoptimized through genetic algorithm. The optimization result shows that a certain model of an excavator's maximum digging force on thecustomary digging paths is improved by 10% and the average digging force is improved by 4% after the optimization on the workingdevice of the excavator with weak digging force.

Effects of Different Atmosphere on Electrochemical Performance of Hard Carbon Electrode in Sodium Ion Battery

Ziqiang Xu,Jinchen Chen,Mengqiang Wu,Cheng Chen,Yaochen Song,Yuesheng Wang 대한금속·재료학회 2019 ELECTRONIC MATERIALS LETTERS Vol.15 No.4

Hard carbon is deemed to be a most promising anode materials for sodium—ion batteries (SIBs), while, the issues of lowcapacity and low initial coulombic efficiency still exist limiting the development of SIBs. Although high temperature carbonizationof biomass materials under nitrogen or argon atmosphere is a common method for preparation of hard carbon,there are few reports about the effects of different protective atmospheres on propriety of hard carbon. In this article, hornet’snest (HN) is used to prepare hard carbon under nitrogen and argon. At a suitable carbonization temperature (1200 °C and1400 °C), the hard carbon under argon possesses lower specific surface area (25–50 cm−3 g−1), but higher initial coulombefficiency (4–6%) and higher capacity retention (3–6%). Thus, it is inferred that high—performance hard carbon can beobtained under argon atmosphere. Our research about the effect of sintering atmosphere on material properties is expectedto provide a reference for the synthetization of hard carbon by high temperature carbonization.

Achieving Distributed Consensus in Networked Flexible-joint Manipulator Systems via Energy-shaping Scheme

Bin Zheng,Jin Zhou,Jinchen Ji,Zhonghua Miao 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.7

This paper deals with the distributed consensus problem for networked flexible-joint manipulator systems which are formulated by underactuated Euler-Lagrange (EL) dynamics. Based on the energy-shaping scheme of passivity-based control (PBC) with interconnection and damping assignment, a novel decentralized controller is proposed to solve the leaderless and the leader-follower consensus problems. The main feature of the present work is the systematical integration of the energy of the systems composed of underactuated and actuated components and the energy of the controller as a total energy. Then the total energy is formulated as a suitable Lyapunov function to solve distributed consensus problems for the networked underactuated EL systems. The proposed consensus scheme without the need of velocity measurement possesses a relatively simple structure and good robustness. It is shown that interconnection pattern and damping assignment of the PBC are two key factors to affect the cooperative behavior of networked flexible-joint manipulator systems, which will be used to regulate or improve the cooperative performance of networked flexible-joint manipulator systems in practice. Finally, two numerical examples of networked six flexible-joint manipulator systems are presented to validate the correctness of the proposed algorithms.

Model of the onset of liquid entrainment in large branch T-junction with the consideration of surface tension

Liu, Ping,Shen, Geyu,Li, Xiaoyu,Gao, Jinchen,Meng, Zhaoming Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.3

The T-junction exists widely in industrial engineering, especially in nuclear power plants, which plays an important part in nuclear power reactor thermal-hydraulics. However, the existing prediction models of the liquid entrainment are mainly based on the small branches or small breaks while there are a few researches for large branches (d/D > 0.2). Referring to the classical models about the onset of liquid entrainment of the T-junction, most of previous models regard liquid as ideal working fluid and ignore surface tension. This paper aims to study the effect of surface tension on the liquid entrainment, and develops an improved model based on the reasonable assumption. The establishment of new model employs the methods of force analysis, dimensional analysis. Besides, the dimensionless Weber number is adopted innovatively into the model to show the effect of surface tension. What is more, in order to validate the new model, three kinds of working fluids with different surface tensions are creatively adopted in the experiments: water, silicone oil and ethyl alcohol. The final results show that surface tension has a nonnegligible effect on the onset of liquid entrainment in large branch T-junction. The new model is well matched with the experimental data.

Consensus of Multiple Euler-Lagrange Systems Using One Euler- Lagrange System’s Velocity Measurements

Shan Cheng,Li Yu,Dongmei Zhang,Jinchen Ji 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1

This brief paper studies the stationary consensus of multiple Euler-Lagrange systems with nonlinear protocols. Two consensus protocols are given to guarantee that positions and velocities of multiple Euler-Lagrangesystems reach consensus. Proposed protocols need only the relative position measurements and the velocity measurementsof one Euler-Lagrange system. Finally, numerical simulations are given to illustrate the theoreticalresults.

Transient heat transfer and crust evolution during debris bed melting process in the hypothetical severe accident of HPR1000

Lv Chao,Li Gen,Gao Jinchen,Wang Jinshi,Yan Junjie 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.8

In the late in-vessel phase of a nuclear reactor severe accident, the internal heat transfer and crust evolution during the debris bed melting process have important effects on the thermal load distribution along the vessel wall, and further affect the reactor pressure vessel (RPV) failure mode and the state of melt during leakage. This study coupled the phase change model and large eddy simulation to investigate the variations of the temperature, melt liquid fraction, crust and heat flux distributions during the debris bed melting process in the hypothetical severe accident of HPR1000. The results indicated that the heat flow towards the vessel wall and upper surface were similar at the beginning stage of debris melting, but the upward heat flow increased significantly as the development of the molten pool. The maximum heat flux towards the vessel wall reached 0.4 MW/m2 . The thickness of lower crust decreased as the debris melting. It was much thicker at the bottom region with the azimuthal angle below 20 and decreased rapidly at the azimuthal angle around 20e50. The maximum and minimum thicknesses were 2 and 90 mm, respectively. By contrast, the distribution of upper crust was uniform and reached stable state much earlier than the lower crust, with the thickness of about 10 mm. Moreover, the sensitivity analysis of initial condition indicated that as the decrease of time interval from reactor scram to debris bed driedout, the maximum debris temperature and melt fraction became larger, the lower crust thickness became thinner, but the upper crust had no significant change. The sensitivity analysis of in-vessel retention (IVR) strategies indicated that the passive and active external reactor vessel cooling (ERVC) had little effect on the internal heat transfer and crust evolution. In the case not considering the internal reactor vessel cooling (IRVC), the upper crust was not obvious

Consensus of Second-order Multi-agent Systems with Directed Networks Using Relative Position Measurements Only

Shan Cheng,Han Dong,Li Yu,Dongmei Zhang,Jinchen Ji 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.1

This brief paper studies the consensus problem of second-order multi-agent systems when the agents’ velocitymeasurements are unavailable. Firstly, two simple consensus protocols which do not need velocity measurementsof the agents are derived to guarantee that the multi-agent systems achieve consensus in directed networks. Secondly, a key constant which is determined by the complex eigenvalue of the nonsymmetric Laplacian matrix andan explicit expression of the consensus state are respectively developed based on matrix theory. The obtained resultsshow that all the agents can reach consensus if the feedback parameter is bigger than the key constant. Thirdly,the theoretical analysis shows that the followers can track the position and velocity of the leader provided that theleader has a directed path to all other followers and the feedback parameter is bigger enough. Finally, numericalsimulations are given to illustrate the effectiveness of the proposed protocols.

BRAF-Activated Long Noncoding RNA Modulates Papillary Thyroid Carcinoma Cell Proliferation through Regulating Thyroid Stimulating Hormone Receptor

Haitao Zheng,Meng Wang,Lixin Jiang,Haidi Chu,Jinchen Hu,Jinyao Ning,Baoyuan Li,Dong Wang,Jie Xu 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Purpose The importance of long noncoding RNAs (lncRNAs) in tumorigenesis has recently been demonstrated. However, the role of lncRNAs in development of thyroid cancer remains largely unknown. Materials and Methods Using quantitative reverse transcription polymerase chain reaction, expression of three lncRNAs, including BRAF-activated long noncoding RNA (BANCR), papillary thyroid cancer susceptibility candidate 3 (PTCSC3), and noncoding RNA associated with mitogen-activated protein kinase pathway and growth arrest (NAMA), was investigated in the current study. Results Of the three lncRNAs (BANCR, PTCSC3, and NAMA), expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. In addition, BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. Conclusion These findings indicate that BANCR may contribute to the tumorigenesis of PTC through regulation of cyclin D1 and TSHR.