Long Term Outcomes and Prognostic Factors of N₀ Stage Nasopharyngeal Carcinoma: a Single Institutional Experience with 610 Patients

Sun, Jian-Da,Chen, Chuang-Zhen,Chen, Jian-Zhou,Li, Dong-Sheng,Chen, Zhi-Jian,Zhou, Ming-Zhen,Li, De-Rui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Treatment responses of $N_0$ stage nasopharyngeal carcinoma were firstly analyzed comprehensively to evaluate long term outcomes of patients and identify prognostic factors. A total of 610 patients with $N_0$ NPC, undergoing definitive radiotherapy to their primary lesion and prophylactic radiation to upper neck, were reviewed retrospectively. Concomitant chemotherapy was administrated to 65 out of the 610. Survival rates of the patients were calculated using the Kaplan-Meier method and compared by log-rank test. Prognostic factors were identified by the Cox regression model. The study revealed the 5-year and 10-year overall, disease-free, disease-specific, local failure-free, regional failure-free, locoregional failure-free and distant metastasis-free survival rates to be 78.7% and 66.8%, 68.8% and 55.8%, 79.9% and 70.4%, 81.2% and 72.5%, 95.8% and 91.8%, 78.3% and 68.5%, 88.5% and 85.5%, respectively. There were 192 patients experiencing failure (31.5%) after radiotherapy or chemoradiotherapy. Of these, local recurrence, regional relapse and distant metastases as the first event of failure occurred in 100 (100/610, 16.4%), 15(15/610, 2.5%) and 52 (52/610, 8.5%), respectively. Multivariate analysis showed that T stage was the only independent prognostic factor for patients with $N_0$ NPC (P=0.000). Late T stage (P=0.000), male (P=0.039) and anemia (P=0.007) were independently unfavorable factors predicting disease-free survival. After treatment, satisfactory outcome wasgenerally achieved in patients with $N_0$ NPC. Local recurrence represented the predominant mode of treatment failure, while T stage was the only independent prognostic factor for overall survival. Late T stage, male gender, and anemia independently predicted lower possibility of the disease-free survival.

Dispersion Compensation of 10 Gb/s Optical Transmitted 100km in the G652 Optical Fiber

Jian Guo Yu,Chong Xiu Yu,Da Siung Hsu 한국통신학회 1997 OPTOELECTRONICS & COMMUNICATIONS CONFERENCE Vol.2 No.1

Eddy-Current Calculation of Solid Components in Fractional Slot Axial Flux Permanent Magnet Synchronous Machines

Jian Li,Da-Woon Choi,Chang-Hum Cho,Dae-Hyun Koo,Yun-Hyun Cho IEEE 2011 IEEE transactions on magnetics Vol.47 No.10

<P>This paper investigates eddy-current in an axial flux permanent magnet (AFPM) machine, which consist of the segmented stator teeth and concentrated winding, with one inner rotor and double stators. Analytical methods was developed to calculate the eddy-current loss of PMs and other solid components, including effect of winding harmonics and permeance variation due to slot opening. Eddy-current losses were analyzed by time-stepping three dimensional finite element analysis (3D FEA) in two rotor models, when magnets are insulated or noninsulated. A prototype machine was manufactured based on analysis results, and was tested as a generator. It is found that rotor stainless PM holder should be used in order to reduce eddy-currents and insulation of PMs further reduces eddy-current losses.</P>

Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression

Da Zhou,Yuan-Wen Chen,Ze-Hua Zhao,Rui-Xu Yang,Feng-Zhi Xin,Xiao-Lin Liu,Qin Pan,Huiping Zhou,Jian-Gao Fan 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways. GLP-1 receptor (GLP-1R) agonists have significant therapeutic effects on non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. However, clinical studies indicated that GLP-1 treatment had little effect on hepatic steatosis in some NAFLD patients, suggesting that GLP-1 resistance may occur in these patients. It is wellknown that the gut metabolite sodium butyrate (NaB) could promote GLP-1 secretion from intestinal L cells. However, it is unclear whether NaB improves hepatic GLP-1 responsiveness in NAFLD. In the current study, we showed that the serum GLP-1 levels of NAFLD patients were similar to those of normal controls, but hepatic GLP-1R expression was significantly downregulated in NAFLD patients. Similarly, in the NAFLD mouse model, mice fed with a high-fat diet showed reduced hepatic GLP-1R expression, which was reversed by NaB treatment and accompanied by markedly alleviated liver steatosis. In addition, NaB treatment also upregulated the hepatic p-AMPK/p-ACC and insulin receptor/ insulin receptor substrate-1 expression levels. Furthermore, NaB-enhanced GLP-1R expression in HepG2 cells by inhibiting histone deacetylase-2 independent of GPR43/GPR109a. These results indicate that NaB is able to prevent the progression of NAFL to NASH via promoting hepatic GLP-1R expression. NaB is a GLP-1 sensitizer and represents a potential therapeutic adjuvant to prevent NAFL progression to NASH.

Numerical simulations on hot cracking of rock

Jian Kang,Yang-Sheng ZHAO,Da-hai Zhang 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-

Using random non-homogeneous the solid-head coupled mathematics model and FEM, For example of granite, changing of thermal dilatability and thermal conduction with uniform distributing, Weibull distributing, study on the changing process on hot cracking of rock it is pointed that the relationship between thermal cracking and random distributing, the relationship between thermal cracking and probability distribution mother relationship between thermal cracking and time t, the changing law of temperature and probability distribution and time.

Two new benzylisoquinoline alkaloids from Thalictrum foliolosum and their antioxidant and in vitro antiproliferative properties

Da-Hong Li,Jia Guo,Wen Bin,Nan Zhao,Kai-bo Wang,Jian-yong Li,Zhan-Lin Li,Hui-Ming Hua 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7

Two novel rare chloro-containing benzylisoquinolinealkaloids, thalfoliolosumines A (1) and B (2),along with eight known isoquinoline alkaloids (3–10) wereisolated from the whole plant of Thalictrum foliolosum. The structures of these compounds were elucidated byspectral analyses, including 1D and 2D NMR (COSY,HSQC, HMBC and NOESY) experiments. The antiproliferativeeffects of all the isolated compounds were evaluatedby MTT method against MCF-7, PC-3, and U937cells, and trypan blue method against HL-60 cells. Newcompounds 1 and 2 exhibited moderate in vitro antiproliferativeactivity against MCF-7, PC-3, and HL-60 cells,and good inhibitory effects against U937 cells with IC50values of 7.50 and 6.97 μM, respectively. Compounds 7and 10 showed the strongest in vitro antiproliferative withIC50 values of 0.93 and 1.69 lM against HL-60 cell line. The antioxidant properties were also measured, bisbenzyltetrahydroisoquinolinealkaloids 3–6 showed the strongestantioxidant activities in ABTS assay.

Robust Nonlinear Feedback Control of a Chaotic Permanent-magnet Synchronous Motor with a Load Torque Disturbance

Jian Hu,Long Liu,Da-wei Ma 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.12

The permanent-magnet synchronous motor (PMSM) system, which is a nonlinear dynamic system,will demonstrate a variety of chaotic phenomena when its parameters or external inputs fallinto a certain area, which will lead to a deterioration of its performance. Thus, chaos should besuppressed or eliminated. In this paper, the property of equilibrium points is analyzed, and thecondition for the occurrence of a Hopf bifurcation in a PMSM system is given based on a mathematicalmodel of the PMSM system with a bifurcation diagram, a Lyapunov exponent map and phaseplane diagrams given. After the drawbacks of the existing control methods have been analyzed, arobust nonlinear feedback controller is designed to control the chaos in the PMSM system with aload torque disturbance. The object is to eliminate the chaos and to drive the system speed to adesired value, Numerical simulation proves the validity of this control method.

The game of safety behaviors among different departments of the nuclear power plants

Da Yuan,Hanqing Wang,Jian Wu 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.3

To study the developments and variations of unsafe behaviors in nuclear power plants thus reduce thepossibility of human-related accidents, this paper, based on the Game Theory, focused on the changes inbenefits of the Department of Management, Operational and Emergency in a nuclear power plant, andestablished the expected revenue functions of these departments. Additionally, the preventive measuresof unsafe behaviors in nuclear power plants were also presented in terms of these 3 departments. Resultsshowed that the violations of the Operation Department (OD) and the Emergency Department (ED) werenot only relevant with the factors such as their own risks, costs, and the responsibility-sharing due toaccidents, but also affected by the safety investments from the Management Department (MD). Furthermore, results also showed that the accident-induced responsibility-sharing of both the OD andthe ED would rise, if the MD increased the investments in safety. As a result, the probability of violationbehaviors of these 3 departments would be attenuated consciously, which would reduce the unsafebehaviors in the nuclear power plants significantly

Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation

Yu Jian,Li Wen,Hou Guo-jun,Sun Da-peng,Yang Yuan,Yuan Sheng-xian,Dai Zhi-hui,Yin Hao-zan,Sun Shu-han,Huang Gang,Zhou Wei-ping,Yang Fu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from the third exon of transcript NM_001098801 of the FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with HBV-related HCC. Furthermore, cFAM210A reduced the proliferation, stemness, and tumorigenicity of HCC cells. Mechanistically, HBx increased the N6-methyladenosine (m6A) level of cFAM210A by promoting the expression of RBM15 (an m6A methyltransferase), thus inducing the degradation of cFAM210A via the YTHDF2-HRSP12-RNase P/MRP pathway. cFAM210A bound to YBX1 and inhibited its phosphorylation, suppressing its transactivation function toward MET. These findings suggest the important role of circular RNAs in HBx-induced hepatocarcinogenesis and identify cFAM210A a potential target in the prevention and treatment of HBV-related HCC.

Incidence and Risk Factors of the Caudal Screw Loosening after Pelvic Fixation for Adult Spinal Deformity: A Systematic Review and Meta-analysis

Zhao Jian,Nie Zheng,Zhou Jiangjun,Liao Dongfa,Liu Da 대한척추외과학회 2024 Asian Spine Journal Vol.18 No.1

The purpose of this study was to assess the factors affecting caudal screw loosening after spinopelvic fixation for adult patients with spinal deformity. This meta-analysis calculated the weighted mean difference (WMD) and odds ratio (OR) using Review Manager ver. 5.3 (RevMan; Cochrane, London, UK). The loosening group was older than the control group (WMD, 2.17; 95% confidence interval [CI], 0.48–3.87; <i>p</i>=0.01). The S2 alar-iliac (S2AI) could prevent the caudal screw from loosening (OR, 0.43; 95% CI, 0.20–0.94; <i>p</i>=0.03). However, gender distribution (<i>p</i>=0.36), the number of fusion segments (<i>p</i>=0.24), rod breakage (<i>p</i>=0.97), T-score (<i>p</i>=0.10), and proximal junctional kyphosis (<i>p</i>=0.75) demonstrated no difference. Preoperatively, only pelvic incidence (PI) in the loosening group was higher (WMD, 5.08; 95% CI, 2.71–7.45; <i>p</i><0.01), while thoracic kyphosis (<i>p</i>=0.09), lumbar lordosis (LL) (<i>p</i>=0.69), pelvic tilt (PT) (<i>p</i>=0.31), pelvic incidence minus lumbar lordosis (PI–LL) (<i>p</i>=0.35), sagittal vertical axis (SVA) (<i>p</i>=0.27), and T1 pelvic angle (TPA) demonstrated no difference (<i>p</i>=0.10). PI–LL (WMD, 6.05; 95% CI, 0.96–11.14; <i>p</i>=0.02), PT (WMD, 4.12; 95% CI, 0.99–7.26; <i>p</i>=0.01), TPA (WMD, 4.72; 95% CI, 2.35–7.09; <i>p</i><0.01), and SVA (WMD, 13.35; 95% CI, 2.83–3.87; <i>p</i>=0.001) were higher in the screw loosening group immediately postoperatively. However, TK (<i>p</i>=0.24) and LL (<i>p</i>=0.44) demonstrated no difference. TPA (WMD, 8.38; 95% CI, 3.30–13.47; <i>p</i><0.01), PT (WMD, 6.01; 95% CI, 1.47–10.55; <i>p</i>=0.01), and SVA (WMD, 23.13; 95% CI, 12.06–34.21; <i>p</i><0.01) were higher in the screw loosening group at the final follow-up. However, PI–LL (<i>p</i>=0.17) demonstrated no significant difference. Elderly individuals were more susceptible to the caudal screw loosening, and the S2AI screw might better reduce the caudal screw loosening rate than the iliac screws. The lumbar lordosis and sagittal alignment should be reconstructed properly to prevent the caudal screw from loosening. Measures to block sagittal alignment deterioration could also prevent the caudal screw from loosening.