항암제 젬시타빈의 경구용 제제 개발을 위한 전략수립

임지호,황지숙,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

마이크로니들의 형태 및 적용방법이 약물의 피부 투과에 미치는 영향

임지호,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

The purpose of this study is to develop the microneedle using biodegradable and biocompatible polymer and to pioneer the new route of drug delivery through the research to apply the most desirable administration form of small molecules, peptides, proteins, genes, biological products including vaccines. Various biocompatible microneedles were manufactured. To apply drug to microneedle, drug formulation using ethylene vinyl acetate patch or polyacryl acid gel was developed. Drug permeation into rat skin based on the application method of patch or gel with microneedle was studied using Franz diffusion cell system. In vitro drug permeation results showed that the permeation by the application of hollow microneedle was not increased compared with solid microneedle. When G60 or G60*2 microneedle was used, the permeated amount of calcein was increased compared to when solid microneedle was used. The permeated amount of lidocaine HCl in 12 hr was increased when microneedle was used was increased. Skin irritation followed by microneedle showed there was little difference in the decrease of redness after microneedle application based on application time.

정신분열병 환자의 유ㆍ소아기 발달 및 소아 청소년기의 병전 사회 적응에 대한 연구

문지현,우행원,김영철,연규월,김종원,임원정 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 주요 정신 질환 가운데 하나인 정신분열병은 병의 증상이 나타나기 훨씬 이전인 유아기 및 소아기 때부터 앉기, 서기, 걷기, 말하기, 대소변 가리기 등의 발달 양상과 언어 기능, 운동 기능 등의 양상에서 차이가 나며, 소아 청소년기의 적응 정도도 좋지 않다고 알려져 왔다. 본 연구에서는 대조군과 정신분열병환자군의 발병 전 과거 발달 과정과 병전 적응 정도를 비교하여 그 차이를 알아보고자 하였다. 방 법: 연구 대상은 이대부속 동대문병원 정신과에 입원하였던 환자들 중 정신과 진단 편람 제4판 진단 기준에 의거하여 정신분열병으로 진단 받은 환자군 56명(남자 26명, 여자 30명)과 대조군 51명(남자 25명, 여자 26명)이었다. 연구 방법은 환자와 환자 가족과의 직접 면담 및 병록지 검토를 통해 유아기 발달 과정의 주요 이정표 획득 시기, 소아기의 언어 기능과 운동 기능을 평가하였고, Lewis의 산과적 합병증 척도를 이용하여 출산 합병증을 평가하였으며, 병전 사회 적응 척도를 이용하여 소아 청소년기의 병전 적응 정도를 평가하였다. 사춘기 이차 성징 획득에 관한 정보는 Tanner stage에 기초하여 수집하였다. 결 과: 1) 출산시의 산과적 합병증은 환자군과 대조군에서 유의한 차이가 없었다. 유아기 발달 과정 상 환자군에서 처음 앉은 시기, 걸음마를 시작한 시기, 처음 문장을 말한 시기가 대조군에 비해 유의하게 지연되었다(p<0.05). 2) 소아기 발달 과정을 보면 언어 발달상의 문제는 환자군에서 유의하게 많았으나(p<0.05). 운동 기능 장애의 빈도는 두 군 사이에 차이가 없었다. 읽고 쓰기 시작한 연령은 환자군에서 지연되었다(p<0.05). 환자군에서 언어 기능 장애 및 운동 기능 장애의 빈도는 성별간의 차이를 보이지 않았다. 3) 소아기의 병전 적응 정도는 환자군에서 대조군에 비해 좋지 않은 편이었으나 유의하지 않았다(p=0.06). 반면 청소년기의 적응 정도는 환자군이 유의하게 좋지 않았다(p<0.05). 소아기와 청소년기 동안의 병전 적응 정도를 사회성 영역과 학업 영역으로 나누어 보았을 때 두 영역 모두 환자군에서 유의하게 좋지 않은 것으로 나타났다(p<0.05). 환자군에서 발병 연령이 빠를수록 병전 적응 정도가 좋지 않은 경향이 있었으나 통계적 유의성에는 이르지 못했다(Spearman`s coeff=-0.27, p=0.07). 4) 성별에 따라 살펴보았을 때 남자 환자가 여자 환자보다 학업 영역에서 좋지 않은 적응 정도를 보였다(p<0.05). Tanner Stage에 기초한 이차 성징의 발현은 두 군 사이에 차이가 없었다. 결 론: 이상의 결과를 종합하면, 환자군에서 유아기 발달 과정상 처음 앉는 시기와 걸음마를 시작한 시기 등의 운동 발달 영역과 처음 문장을 말한 시기 등 인지 발달 영역이 대조군에 비해 지연되며, 소아기의 언어 발달 과정에 문제가 있는 경우가 많았고, 읽고 쓰기 시작한 연령이 늦어지며, 발병 전 청소년기의 적응 정도가 대조군에 비하여 좋지 않았다. Objectives: Schizophrenia, one of the major mental illnesses, shows abnormal developmental patterns such as delayed developmental milestones, impaired language and motor function, and poor premorbid social adjustment long before the onset of clinical symptoms of illness. In this study, we tried to find out developmental patterns and premorbid adjustment during childhood and adolescence in schizophrenic patients. Methods: The subjects were 56 inpatients(26 male patients and 30 female patients) who met the diagnostic criteria for schizophrenia by DSM-Ⅳ and 52 healthy control subjects(25 male patients and 26 female patients). Interview with subjects and their families and the review of medical records were done to assess sociodemographic factors, timing of developmental milestones, language and motor function of childhood, and timing of sexual maturational events. Obstetrical Complication Scale of Lewis was used to get information on the subjects prenatal and perinatal history, and Premorbid Social Adjustment Scale(PSAS) to assess premorbid adjustment. Results: 1) There were no significant differences in the rates of obstetrical complications. The developmental milestones during infancy such as sitting, walking, age of first sentence were significantly delayed in the schizophrenics than in the controls(p<0.05). 2) Disturbances of speech and language development were significantly more common in the schizophrenics than in the controls(p<0.05), but there were no significant differences in the rates of disturbance in motor development. Mean ages of reading and writing were significantly delayed in schizophrenics than in the controls(p<0.05). No significant differences were found between males and females for either language disturbance or motor disturbance in the schizophrenics. 3) During adolescence, premorbid adjustment was poorer in schizophrenic patients(p<0.05). The schizophrenic patients scored significantly worse than the controls on both sociability and schooling domains(p<0.05). There was a trend for correlation between poor premorbid functioning and early age of onset, but it failed to achieve statistical significance(Spearman`s coeff=-0.27, p=0.07). 4) Male schizophrenic subjects showed poorer premorbid functioning on schooling domain than female schizophrenic subjects(p<0.05). No significant difference was recognized in timing of sexual maturational events between schizophrenics and controls. Conclusion: In summary, the schizophrenics were significantly delayed in infantile developmental milestones, impaired in development of language, delayed mean age of reading and writing, and showed poorer premorbid social adjustment than the controls.

Systemic Lupus Erythematosus를 동반한 Multiple sclerosis

이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.

아동이 지각한 가족관계 및 정서조절능력이 친구 간 갈등해결전략에 미치는 영향

하지원,김광웅 숙명여자대학교 아동연구소 2005 兒童硏究 Vol.18 No.1

The purpose of this study is to examine the influence of family relation and emotional regulation on conflict resolution strategies in children's friendship which influences on children's social adaptation and development. Also, this study tests the independent effect of emotional regulation, find out the important of emotional regulation, and promotes its growth and change positively. Results of this study are as follows. First, there were some differences in the conflict resolution strategies according to child's personal factors (sex, number of sibling, birth other and household's monthly income). In the conflict resolution strategies, girls used more dominating strategy. Also it was shown that the more household's monthly income used the more compromising-integrating strategies. Second, in research of the effect of children's recognized family relation on conflict resolution strategies their friendship, cohesion, one of the family relation subscales, has a positive influence on conflict resolution strategies and especially it predicted compromising-integrating strategies the most significantly. Also, expressiveness influenced only compromising-integrating strategies and conflict subscale influenced only dominating strategies. Third, in research of the effect of children's emotional regulation on conflict resolution strategies in children's friendship, emotional regulation has a positive influence on conflict resolution strategies except for other-regulation that influence dominating strategies. Especially in the cases of each subscale, self-regulation influenced avoiding and dominating strategies more, and other-regulation influenced compromising-integrating and obliging strategies more. Fourth, in research of effect of children's recognized family relation and emotional regulation on conflict resolution strategies in children's friendship, emotional regulation without family relation showed as independent effect. Especially it predicted compromising-integration strategies, that is the most effective solution for conflict situation, the most significantly.

채소류의 조리방법별 비타민 C의 잔존량 비교분석 시험

김지나;홍정연;신원선 한양대학교 2009 韓國 生活 科學 硏究 Vol.28 No.2

In this study, using three different cooking facilities(Vitamin+, conventional non-electric steamer, boiling jar), the effect of cooking method on the degradation of vitamin C will be investigated. Three cooking methods were applied to examine their effects on vitamin C residue. For each batch, 5 vegetables and dumpling were steamed by using Vitamin+, 6 conventionally steamed, 6 boiled and 6 remains raw as a control group. For cabbage, broccoli, spinach, bean sprout, vegetable dumpling and potato, the retention values of vitamin C were 53.30%, 73.07%, 69.48%, 83.93%, 84.17% and 12.53% respectively, when cooked by Vitamin+. On the contrast, the retention was 40.05%, 39.34%, 50.09%, 73.24%, 55.63% and 8.85% respectively, when cooked by conventional steam jar. When the vegetables were boiled for 10 min, the retention was 21.83%, 59.43%, 22.08%, 18.24%, 37.28% and 7.38% respectively. Thus, vitamin C retention in vegetables and processed food(dumpling) cooked by Vitamin+ was significantly higher than cooked by other cooking methods. This implies that Vitamin+ steaming can minimize the vitamin C loss for various vegetables and, even processed food during cooking.

짧은 균열의 피로성장거동에 대한 연구

최용식,한지원 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2

The short fatigue crack growth behavior of notched specimens was studied with various stress ranges. Crack closure and crack growth experiments were performed on Al alloy 5052-H38. Computer --aided unloading elastic compliance method was employed to measure the closure of short fatigue cracks. The growth rate of short fatigue cracks decelerated with increasing crack length at first, and then accelerated or became non-propagating depending on the applied stress range. Similar deceleration was observed when the growth rate was correlated with the stress intensity factor range △K. But the growth rate of short fatigue cracks could be well represented in terms of the effective stress intensity factor range △Keff. The relation between the crack growth rate and the effective stress intensity factor range for short cracks was identical to that obtained for long cracks.

小型 Solar Pond 內에 鹽度變化에 따른 溫度와 密度樣相에 관한 實驗的 硏究

朴伊東,徐志源 成均館大學校 科學技術硏究所 1986 論文集 Vol.37 No.2

A salt-gradient solar pond is a body of saline water which performsas a collector of solar energy and long-term thermal storage system. Salt-gradient solar ponds usually consist of three direct zones: an upper convective zone, a nonconvective gradient zone and a bottom convective zone. The increased density in non-convective-layer, as a result of salt concentration, counterbalance the decrease in density due to thermal expansion caused by solar heating and thus prevents convective circulation. For this purpose, experimental apparatus was made, and temperature, density brine in test pond were measured by pycnometer that was moving vertically. The testing situations and states for data taken were as follows: The test pond is of 0.5m wide, 0.5m high, 1.0m long, 7.1cm of suction height of diffuser above the tank bottom, 1.8cm of discharge height of diffuser above the tank bottom, 0.3 cm of slot size of sunction diffuser, 1.0 cm of slot size of discharge diffuser, 47 cm of diffuser slot length, heating method of circulation of hot water(75℃) through hot water tank, the extraction method of circulation storage brine into a heat exchanger external to the pond. In small test solar pond, confirmed the typical three zone which showed up in real solar pond. The results obtained are as follows: 1. When the salt concentration was constant and flow rate of extration hot brine increased, the density and temperature of storage zone tended to decrease and the temperature of upper convective layer tended to decrease respectively. But the density of upper convective layer tended to increase slowly. 2. The content of salt resulted in the salinity variation had a great influence on typical three zone, then the temperature and density of each layer changed directly. 3. They, that is density and temperature profile, stability governing parameter (Richardson number, Froude number) and visual observation, made use of confirming the height of interface, but the absolute value of it accorded with one another perfectly, tended to be closely according to the high salinity. In this experiment the interface stability level was identitied at a level 18.7 cm or so above the test tank bottom. 4. Optimal operating condition in the test pond as follows: 10% of salt concentration, 0.05 ㎥/h of flow rate of extraction hot brine.

Nuss 방법에 의한 소아 오목가슴 수술 후 정맥 통증자가조절법을 사용한 Fentanyl 과 Fentanyl-Ketorolac의 진통효과 비교

안기량,서은정,김천숙,강규식,유시현,정진헌,정지원 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

..

Anti-oxidant and immune enhancement effects of Artemisia argyi H. fermented with lactic acid bacteria

Ji Yun Lee,Ji Hyun Kim,Ji Myung Choi,Hyemee Kim,Weon Taek Seo,Eun Ju Cho,Hyun Young Kim 한국응용생명화학회 2023 Journal of Applied Biological Chemistry (J. Appl. Vol.66 No.-

This study investigated the antioxidant and immune enhancement activities of Artemisia argyi H. fermented by Lactobacillus plantarum. The fermented A. argyi H. ethanol extract increased scavenging activities of 1,1-diphenyl-2- picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6- sulfonic acid) (ABTS+), hydroxyl (·OH), and superoxide (O2 -) radicals. Particularly, the ethanol extract of fermented A. argyi H. exhibited higher ·OH and O2  radical scavenging activities, compared with DPPH and ABTS+ radical scavenging activities. To evaluate the immune enhancement effects of the fermented A. argyi H., mice were fed a normal diet supplemented the fermented A. argyi H. at concentrations of 1%, 2%, and 5%, respectively. The supplementation of fermented A. argyi H. dose-dependently increased splenocyte proliferation. In addition, mice fed with 5% fermented A. argyi H. showed enhanced proliferation of T-cells and B-cells, along with increased levels of interferon-γ, interleukin-10, and tumor necrosis factor-α, compared to the normal group. Furthermore, mice fed with fermented A. argyi H. exhibited an increase in prominent probiotics such as Akkermansia muciniphila and Lactobacillus in gut microbiota, compared to the normal group. This study suggests that fermented A. argyi H. with Lactobacillus plantarum could be used as a dietary antioxidant and immune enhancement agent.