<i>In vitro</i> and <i>in vivo</i> evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition

Park, Dae Sung,Bae, In-Ho,Jeong, Myung Ho,Lim, Kyung Seob,Sim, Doo Sun,Hong, Young Joon,Lee, So-Youn,Jang, Eun Jae,Shim, Jae-Won,Park, Jun-Kyu,Lim, Han Chul,Kim, Han Byul Elsevier 2018 Materials Science and Engineering C Vol.91 No.-

<P><B>Abstract</B></P> <P>Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO<SUB>2</SUB>) and verify its efficacy by <I>in vitro</I> and <I>in vivo</I> assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO<SUB>2</SUB> stent, everolimus-eluting N-TiO<SUB>2</SUB> (N-TiO<SUB>2</SUB>-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO<SUB>2</SUB> film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO<SUB>2</SUB> deposition (37.0%). The platelet adhesion on the N-TiO<SUB>2</SUB> surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO<SUB>2</SUB>-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO<SUB>2</SUB>-EVL group compared to that in the BMS group. The results (BMS; 47.0 ± 11.00%, N-TiO<SUB>2</SUB>-EVL; 31.7 ± 10.50%, and EES; 29.1 ± 11.21%, <I>n</I> = 10, <I>p</I> < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO<SUB>2</SUB> deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-TiO<SUB>2</SUB> surfaces can help to reduce the platelet adhesion. </LI> <LI> In porcine model, N-TiO<SUB>2</SUB> everolimus decreased in-stent restenosis and fibrin deposition. </LI> </UL> </P>

In_0.5(Ga_1-xAl_x)_0.5P/GaAs 이중 이종접합 구조의 Contactless Electroreflectance에 관한 연구

김정화,조현준,배인호,Kim, Jeong-Hwa,Jo, Hyun-Jun,Bae, In-Ho 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.2

Metal-organic chemical vapour deposition (MOCVD)법으로 성장된 $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs 이중 이종접합 구조의 특성을 contactless electroreflectance (CER) 분광법으로 조사하였다. CER 측정은 변조전압($V_{ac}$), 온도 및 dc 바이어스 전압($V_{bias}$)의 함수로 수행하였다. 상온에서는 5개의 신호가 관측되었는데, 이 신호들은 각각 GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$ 및 $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ 전이에 관련된 것이다. CER 스펙트럼의 온도 의존성으로부터 Varshni 계수 및 평탄인 자를 구하였다. 그리고 인가전압에 따른 신호의 진폭은 순방향 바이어스 전압 인가시 점차로 감소하나, 역방향 바이어스 전압 인가시에는 반대의 경향을 보였다. We have investigated the contactless electroreflectance (CER) properties of $In_{0.5}(Ga_{1-x}Al_x)_{0.5}P$/GaAs double heterostructures grown by metal-organic chemical vapour deposition (MOCVD). The CER measurements on the sample were studied as a function of temperature, modulation voltage ($V_{ac}$), and dc bias voltage ($V_{bias}$). Five signals observed at room temperature are related to the GaAs, $In_{0.5}Ga_{0.5}P$, $In_{0.5}(Ga_{0.73}Al_{0.27})_{0.5}P$, $In_{0.5}(Ga_{0.5}Al_{0.5})_{0.5}P$, and $In_{0.5}(Ga_{0.2}Al_{0.8})_{0.5}P$ transitions, respectively. From the temperature dependence of CER spectrum, the Varshni coefficients and broadening parameters were determined and discussed. In addition, we found that the behavior of the CER amplitude for the reverse bias is larger than that of the forward.

본교 신입생의 자아개념 특성에 관한 연구

전인철 용인대학교 학생생활연구소 1993 학생생활연구 Vol.1 No.-

The purpose of the study is to investigate characteristics in self concept of the fresh-man in Youngin University, 1993. The study revealed conclusions as followings ; 1. Scores of freshmen are 5 points higher as compared with norm in sum of self-positiveness, self-identification, physical concept, and personality-concept, while total variability scores are 4 points lower in the above sections. This results reveal that the freshman in the University perceive themselves positive in physical concept and personality concept with high self-esteem whereas students in the 2nd, 3rd, and 3th year in school show self-defense and low consistency. 2. In the average scores of 14 factors, students in the school of physical education get higher scores in most of factors whereas those in the school of art and the school of natural science get lower scores. Getting high scores in self-behavior and physical self-seems to have close relations to the characteristics of the University which has developed with strong emphasis on sports science and martial arts. 3. Differences in 5 of 14 factors are revealed among 3 departments in the school of physical education, while few differences are revealed in the rest of schools. Results in detail were discussed in the study. And, finallly, implications and suggestions for further study are discussed.

중년 여성의 에어로빅댄스와 헬스운동 참여에 따른 신체조성, 골밀도, 비특이적 운동효과에 대한 비교분석

전종귀,박인순 충남대학교 체육과학연구소 2006 體育科學硏究誌 Vol.23 No.1

This study performed to compare the body composition, bone mineral density and non specificity exercise effect following to the types of exercise program. Exercise program were divided to three types as aerobic-dance, health exercise, and general women. The subjects recruited for this study were 45 middle-aged women composed of 15 aerobics-dancers and 15 health exercisers who participated in regular exercise more than 1~2 years, and 15 non-exercisers. The subjects were methods in some variables influencing body composition and femoral bone mineral density by DTX-200. Non specificity exercise effect a survey instrument modified by the researcher and based on the Psychological Well-being index. The statistical methods utilized in this study were one way ANOVA and Sheffe test was used. The .05 level was in established in significance. The findings of this study were as follow; 1. In the characteristics of body compositions, health group was significantly lower than non-exercise group in body weight, total body fat, % fat and body mass index and lower than aerobic-dance group. Not significantly different among three groups in lean body mass. 2. In the femoral bone density, aerobic-dance and health groups were not significantly different among three groups in non-exercise group, and not different at all regions in non-exercise group between dominant and non-dominant formula. 3. In the characteristics of non specificity exercise effect, aerobic-dance group was significantly higher than health group and non-exercise group in the body, mind, nerves.

고형배지의 종류가 수경재배 멜론의 품종별 과실의 생육과 품질에 미치는 영향

전하준,황진규,김인규,손미자 대구대학교 생명과학연구소 2004 생명과학연구 Vol.3 No.1

In order to examine how growth substances influence to fruit growth and its quality, we cultivated 3 different kinds of melons which grown in hydroponic system into 3 different types of growth substances, such as perlite, perlite/rock wool and rock wool/perlite. In this experiment, “Siroi Kagayaki”, showed no significant difference in fruit weight and its diameter in any of growth substances, but higher in plant height in perlite/rock wool than Perlite. In case of “TS-1806”, there were no significant differences in soluble solids, fruit weight and diameter in all the substances. However, it showed longer in fruit length in rock wool / perlite than that in perlite/ rock wool. In addition, the soluble solids in placenta and flesh were higher in perlite than those in rock wool/perlite.

톡소포자충 감염마우스의 Cytokine 및 Heat shock protein 생산 분석

노형준,최인욱,신대환,이영하 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

T. gondii frequently causes severe congenital defects and life-threatening disease in immunocompromised individuals. Cytokines. nitric oxide (NO) and heat shock proteins (HSP) are important to control the parasite multiplication and host resistance. However. there were only fen reports about HSP70 in toxoplasmosis. Moreover. we do not know the cytokines and HSP70 production in case of NO inhibition. Therefore. this study was performed to analyze the production of NO. HSP70 and cytokines after adminstration of aminoguanidine (AMG. suppressor of NO production) in mice infected with T. gondii. BALB/c and C57BL/6 mice were injected with either 5 brain cysts of Me49 strain of T. gondii or 50㎍ of AMG for 2 weeks every day. and then mice were sacrificed at day 4. 7. 14 and 28. HSP70 production in the brain and spleen of both mice strains mere decreased after treatment with AMG. however Toxoplasma-infected ones were significantly increased. HSP70 production of Infection/AMG-treated group of C57BL/7mice was significantly decreased in comparison to Infection group. Whereas Infection/AMG-treated group of BALB/c mice showed similar HSP70 production compared to Infection group. After T. gondii infection. the IFN-γ and TNF-α mRNA expression in the brain and spleen was significantly increased in BALB/c or C57BL/6 mice. IFN-γ mRNA expression in the brain and spleen of Infection/AMG-treated BALB/c mice were not significant differences compared to those of infected ones. however there were significant differences in the spleen of C57BL/6 mice. TNF-α mRNA expression in the spleen of Infection/AMG-treated BALB/c or C57BL/6 mice were significantly decreased in comparison to those of infected ones. Taken together. HSP70. IFN-γ and TNF-α production were significantly increased in Toxoplasma-infected BALB/c and C57L/6 mice. After treatment with NO inhibitor in infected C57BL/6 mice, the production of HSP70 and IFN-γ were significantly decreased. whereas BALB/c mice were not significant differences of HSP70 and IFN-γ production between Infection and Infection/AMG-treated group.

공군사관생도의 심폐능력에 따른 심리 · 생리요인 비교

김인기(In-ki Kim),김건희(Gun-hee Kim),송성우(Sung-woo Song),최가람(Ga-ram Choi),엄장원(Jang-won Eom),곽재준(Jae-jun Kwak),유영남(Young-nam You),정덕화(Deok-hwa Jeong),강지훈(Ji-hun Kang) 육군사관학교 화랑대연구소 2019 한국군사학논집 Vol.75 No.2

The purpose of this study was to analyze the differences in psychological and physiological factors between groups by classifying groups based on the 3km running record of fourth grade Air Force Academy cadets. Among the top 46 Air Force Academy cadets who wanted to participate in the study, the study conducted an open survey of the top 13 and the bottom 15 who wanted to provide the data prior to the study. The subjects of the experiment and in-depth interview were studied by a total of 18 people, 9 of each upper and lower members who wished to participate in the study. Psychological factors were structured through inductive content analysis of data extracted from in-depth interviews, and physiological factors were conducted to verify differences between groups of body composition and cardiopulmonary function. The psychological factors of the upper and lower groups were found to be general areas of performance strategy, achievement motivation, emotional response, military spirit, situation perception, and basic physical strength. In the detailed areas, the subjects were also examined in 15 areas including physical fitness indicators, confidence, condition control, task orientation, and positive self-perception. As a result of comparison between upper and lower groups, the upper group was 2.2 times higher than the lower group and the lower group was 1.7 times higher than the upper group in the military spirit and performance strategy of the general area response rate. In general area response, the ratio of mental strength and confidence was different in the general area of military spirit. In addition, the upper group in the achievement motivation showed a high percentage of task tendency at 47%, while the lower group showed a high rate of zero motivation at 50%. In the emotional response, the upper group showed an equal ratio, while the lower group showed an 81% ratio of negative emotions. In the overall response by sub-region, the negative emotions of the subgroup were high at 28%. In the body composition, BFM showed a statistically significant difference between upper and lower groups, and Weight, FFM, and SMM did not show any significant difference between groups. In cardiopulmonary capacity, VO2max showed a statistically significant difference between upper and lower groups, and VE and LT did not show significant differences between groups.

품종별 감꽃 동결건조 분말의 유효성분 분석

김준한 ( Jun Han Kim ),박석희 ( Seok Hee Park ),문혜경 ( Hye Gyeong Mun ),이인선 ( In Seon Lee ),김종국 ( Jong Kuk Kim ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2006 한국식품저장유통학회지 Vol.13 No.6

감 품종별(도근조생, 고종시, 갑주백목, 차랑, 월하시, 상주둥시)로 감꽃을 개화기에 채취하여 동결건조 분말화한 감꽃분말에 함유된 유효성분을 분석, 비교하였다. 조지방 함량은 도근조생이 57.26%로 가장 높은 값을 보였으며, 유리당 조성은 fructose가 95~310 mg%, glucose는 75~281 mg%, sucrose가 7~28 mg%의 함유량을 나타내었고, 유기산 중 malic acid가 갑주백목(6월4일)에 225 mg%로 가장 많았고, tartaric acid도 189 mg%로 가장 많았다. 유리아미노산 중 hydroxy-L-proline은 월하시에 25.33 mg%, L-citrulline은 상주둥시(5월28일)가 58.83 mg%, L-threonine은 상주둥시(5월28일)가 11.88 mg%로 가장 많았다. 페놀산으로 caffeic acid는 갑주백목(6윌4일)이 1946 μg/100 g, phydroxybenzoic acid는 상주둥시(5월29일)가 417.8 μg/100 g, protocatechuic acid는 갑주백목(6월1일)이 181.1 μg/l00 g으로 가장 많았다. 따라서 감꽃에도 감이나 감잎에 못지않게 유용한 식품성분들과 기능성 성분들이 다량 함유되어 있어 새로운 식품 및 기능성 신소재로서의 가치가 매우 높다고 할 수 있다. This study was carried out to analyze useful components in freeze-dried persimmon flower powder made from six cultivars. The cultivars were Dogunjosang, Kojongsi, Kabjubaekmok, Chalang, Weolhasi and SangjuDungsi. Powder of persimmon flower was prepared by milling after freeze drying at -70℃. Crude lipid was the highest in Dogunjosang (57.26%). Major free sugars of the persimmon flowers were fructose (95~310 mg%), glucose (75~281 mg%)and sucrose (7~28 mg%). Major organic acids were malic acid (225 mg% in Kabjubaekmok (Jun. 4th)) and tartaric acid (189 mg% in Kabjubaekmok (Jun. 4th)). Predominant free amino acids were hydroxy-L-proline(25.33 mg% in Weolhasi), L-citrulline (58.83 mg% in SangjuDungsi (May 28th)) and L-threonine (11.88 mg% in SangjuDungsi (May 28th)). Major phenolic compounds in the persimmon flowers were caffeic acid (1,946 μg/100g in Kabjubaekmok (Jun. 4th)), p-hydroxybenzoic acid(418 μg/100g in SangjuDungsi (May 29th)) and protocatechuic acid(181 μg/100g in Kabjubaekmok(Jun. 1st)). The results suggest that persimmon flowers be potential materials as useful food ingredients.

러시아 전위예술(Russian Avant-garde)이 무대미술에 미친 영향에 관한 연구

김인준 한국연극교육학회 2002 연극교육연구 Vol.7 No.-

Russian contribution to the modern movement in art and architecture and theatre. Malevich, Tatlin are now given their full stature, and the Constructivist movement which they founded is shown to have been a powerful influence on the continental movements between the wars, particulary the Bauhaus. From the aesthetic point of view, the story tells of historic experiments and discoveries. But its greatest interest, perhaps, lies in its account of a attempt to integrate art with society-an attempt that was pursued with passionate idealism through the revolutionary years which gave the movement's protagonists such a unique opportunity. In its short-lived heyday, music, drama, poetry, and all the industrial arts were embraced in an experiment which attacked at the root the problems which still concern the artist today. Tatlin regarded his artistic career as a single goal-oriented programmed made up of a series of increasingly complicated tasks, and he expected others to look upon it the same way. He regarded himself as having a special mission in the artistic scene of his country, which gave him an exceptional historical responsibility. At the beginning of his career he was interested in figurative painting and the theatre. The ensuing period was characterized by abstract works of art, painterly reliefs and counter-reliefs, which bordered on painting and sculpture, then he turned to architecture, and created the design for the 'Monument to the Third International'. This was followed by a long spell in industrial design, which ended with the construction of a flying apparatus. In the final period of his life he worked as a set designer and painted and drew again in the traditional way. According to Tatlin the task of the artist is to 'invent' new form and the task of the engineer is to provide its technical realization. The conception of architectural planning as 'painting+engineering-architecture' will later become(to use a modern term)the principle of industrial design. For Tatlin this conception meant Consturctivism. Malevich was consistently working out his own individual style. The subject of peasant labours was most important for him at that period. Though the picture is essentially cubist, Malevich superimposes and distorts forms in a peculiar improvizational style. Whereas the task of the futurist is to break up form and thus express duration of motion in space, Malevich aims more at revealing the ideational content, which is uncovered in the dynamic juxtapositions that appear puzzling in their irrelevance. Malevich's "pictorial alogisms", the given work included, introduce the viewer to the world "behind the looking glass" where it is the absurd and not the commensensical that is seen by the artist as a synonym of free creativity and the only way towards intuitive comprehension of the hidden essence of things and phenomena. The "Suprematisms" are among his earlier paintings dating back to the 1910s. They familiarize the viewer with the artist's best known period motivated by his original idea of attaining the "supreme" superpersonal essence of art. Malevich uses a minimum of the pictorial means. The compositions are the dynamic conjugations of coloured geometrical shapes-plane, square sna cross. These constructions float in the space of the background which epitomizes the infinity of the universe. There is no indication of top or bottom and no reference to reality. The painter uses a purely symbolic language, thus asserting his dream to create" the universal language of art". The attempts to identify with the universe and to find a means expressing perception of infinite space led Malevich to rely on advances in psychology of human sensory perception and studies on the emotional impact of color. This enabled him to achieve a brilliant synthesis of science and art and to merry cold calculation and free flight of fancy, creating new forms for fresh insights.

대학생의 노인복지에 대한 인식도

차병준,김무룡,김기열,차경미,김귀희,김현실,서인선,임상규,이순자,위광복,남철현 慶山大學校 保健福祉硏究所 1999 保健福祉硏究 Vol.2 No.-

The purpose of this study is to grasp the change of consciousness of young people in order to seek new approach of policy for aged era. 1,200 students attending collages and universities in three small or medium sized cities were inquired for 2 months, from October 1 to November 30, 1996. The result is as follows. 1. The characteristic of the respondents of this survey is that they include 72.1% of women, 40.4% of people aged between 20 to 21, and 49.1% of people who do not have any religion. Those who are from big cities and those who are form farming villages or fishing village occupy equally 40.2%, those who reside in that cities for a long period 49.0%, and those who live with their family 60.9%. 2. The family feature of the subject is that 31.5% of them are those whose father is the age of 55 and more than 55, 10% of them are those whose mothers age is so, 33.1% of them have 5 family members, 29.5% of them have the family income of 1,000,000 to 1,490,000 won, 83.9% of them are from middle class, 47.7% of them are the people whose grand parents have passed away, 70.4% of them live apart from their grand parents, and 60.9% of them are second child. 3. 64.0% of males, 70% of respondents who are aged over 24, 58.1% of respondents who are from rural communities, 62.4% of respondents who live in rural area, and 58.3% of respondents who live alone, prefer to live with grand parents, marked higher rate than other groups. The groups whose father and mother are the age of more than 55 marked higher rate of 55.9% and 58% each than any other groups(p<0.05). The groups whose family member is less than three, whose grand parents both have passed away in middle class, who live with their grand parents, and who are second children, give more positive answers than any other groups. 4. Those who are older, who are buddhists, who are from rural area or live in rural area, whose family is small, whose family income is small, who are from lower class and whose grand parents are still alive, shows preference to support their parents after marriage. 5. Females(89.4%), those who are from small or medium sized cities(89%), who live with their family(85.6%), whose father is the age of 55 and more than 55, whose mother is the age of 54 and less than 54, whose family member is 6, who are from middle class, whose grandparents are still alive and who are the eldest child in their family, give more response that they prefer to live apart from their children in their old age than any other groups. 6. What elderly people need most right now is past time(42.3%), and the respondents whose age is 20 to 21, who are buddhists, who are from middle sized cities and live alone, whose parents are the age of more than 55, who have small family income, who live with their grand parents and who are second children show higher level than any other groups. 7. 76.8% of respondents answer that they do not need their parent's fortune, marked still higher rate than the opposite answer. Those who are older, who are buddhists, who are from big cities, who reside in rural area, who live alone and have smaller family, who are in bad family economic conditions and who live with grand parents present higher rate of positive response. 8. 59.3% of respondents reply that they think about death from time to time, and those who are female, who are in the age of 20 to 21, who are christian, who live with their family, whose siblings or other family members offer their education expenses show higher rate than any other groups. 9. 92.3% of respondents answer that the budget for welfare facility for elderly people is very small. The younger the respondents are and the worse economic condition they have among those who live in big cities, the more answered that. 10. 50% of respondents think social security should provide for their old age, and 42.8% of them believe they themselves provide against it. The respondence that social security ought provide for it appeared more among those whose age are over 24, who are female, who reside in rural area, who are christian, who are in bad economic condition, and who ever used medical institutions in recent one month, marked higher level than other groups. 11. The adequate time of retirement is 59.97±5.60 for public officers, the highest and 59.28±6.35 for teachers, the next. 12. 35.2% of respondents reply that the adequate budget for the old age after their retirement at the age of 60 is 220 million won, showed the highest level of respondence. 13. The factors which affect on the old people in the charged welfare facilities are sex(p<0.01), the type of housing(p<0.05) and whole family income(p<0.05). 14. The factors which affect on remarriage are sex(p<0.05) and religion(p<0.05). For varying old population and expanded welfare service for them, government and relevant authority should give more attention to secure the budget, establish effective plans to expand various program and the facilities for elderly people in order that elderly people spend the rest of life time more happily and more fruitfully. To do that, each college and university should open Health courses, and educate and inform about health and welfare.