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Box-Wilson 실험계획에 의한 연마용 인산일수소칼슘의 최적 제조조건 추구 및 안정화
이계주,곽손혁,서성수 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-
An abrasive, calcium hydrogen phosphate dihydrate (DCPD), was synthesized in a Box-Wilson experimental design by reactions between phosphoric acid and milk of lime, and calcium chloride and sodium phosphate solutions, and stabilized with TSPP and TMP. The optimum conditions for preparation of DCPD from phosphoric acid with milk of lime were such as: reaction temp.: 51.9℃. conc. of lime: 25.9%. conc. of phosphoric acd: 77.9%. drying temp.: 60.2℃ and final pH: 6.46. The physico-chemical and pharmaceutical properties of DCPD were showed as follows: glycerin absorption value(68 ㎖/100g), whiteness(99.5%), particle size(10.9㎚). pH(7.8), and set test(pass). XRD and SEM of DCPD indicated a monoclinic system crystallographically. N_2 adsorption isotherm curve by BET showed non porous type Ⅱ form. The micromeritic parameters of DCPD showed that surface area was 3.27~4.6 ㎠/g and pore volume. pore area and pore radius were negligible. The rheogram of the toothpaste containing DCPD showed pseudoplastic flow with yield value of 321, and thixotropic behavior forming hysteresis loop. These results meet the requirements as abrasive standard, and sythesized DCPD is expected as a good dental abrasive such as a high quality grade in practice.
Ji-Hyuk Kim(김지혁),Hwan Gu Kang,Pratima Adhikari,Chan Ho Kim,Ik Soo Jeon,Jong-Wan Lee,Gye-Woong Kim,Hack-Youn Kim,Woo Kyun Kim 한국가금학회 2015 한국가금학회 정기총회 및 학술발표회 Vol.2015 No.11
A total of 528 broiler chicks were randomly distributed to 11 dietary treatments to give 6 replications per treatment and distributed as 8 birds per pen. Feed and water were provided ad libitum with 24 h of lightning and total experimental days were 21. The diets were formulated to contain 23% CP and 3200 Kcal/kg ME. Essential AA and vitamin-mineral premix were formulated to meet or exceed minimum standard suggested by NRC (1994). Experimental diets were T1= NC, T2= PC, T3= NC+0.01% Plants extract, T4= NC+0.03% Plants extract, T5= NC+0.06% Plants extract, T6= NC+0.4% Organic acids, T7= NC+0.6% Organic acids, T8= NC+0.8% Organic acids, T9= NC+0.4% Prebiotics complex, T10=NC+0.6% Prebiotics complex, T11= NC+0.8% Prebiotics complex. Feed intake and Feed conversion ratio(FCR) were the lowest in 0.1% Plants extract treated group when compared to NC group. Body weight gain was not differ significantly among all treatments. Crypt depth in jejunum and ileum increased in Prebiotics complex groups when compared to other treatments.
프레팔시드 정(시사프리드 5 mg)에 대한 시사플 정의 생물학적 동등성
이계주,황성주,우종수,곽손혁,박종우,한정희,장혁,남진경,구선회 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.1
Bioequivalence of two cisapride tablets, test drug (Cisaple^ⓡ tablet: Hanmi Pharm Co., Ltd.) and reference drug (Prepulsid^ⓡ tablet: Janssen Pharm. Co., Ltd.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty two healthy male volunteers were divided randomly into two groups and administered the drug orally at the dose of 10 mg as cisapride in a 2 × 2 crossover study. There was a week washout period between administrations. Blood samples were taken at predetermined time intervals for 36 hr and the plasma concentration of cisapride was determined by a HPLC method. AUC_(0-36hr) (area under the plasma concentration-time curve from time zero to 36 hr), C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were estimated from the plasma drug concentrationtime data. Analysis of variance (ANOVA) revealed no difference in AUC-(0-36hr), C_(max) and T_(max) between two products. The apparent differences of these parameters between two products were less than 20% (i.e., 5.38, 6.17 and 0.00% for AUC_(0-36hr), C_(max) and T_(max), respectively). The powers (1-β) for AUC_(0-36hr), C_(max) and T_(max) were over 0.9. Minimal detectable differences (△) at α=0.05, 1-β=0.8 were less than 20% (i.e. 17.67, 14.84 and 19.72% for AUC_(0-36hr), C_(max) and T_(max), respectively). The 90% confidence intervals (δ) for these parameters were also within ±20% (i.e. -4.97 ≤ δ ≤ 15.73, -2.53 ≤ δ ≤ 14.86 and -11.55 ≤ δ ≤ 11.55 for AUC_(0-36hr), C_(max) and T_(max), respectively). These results satisfied the criteria of KFDA guidelines for bioequivalence, indicating the two tablets of cisapride were bioequivalent.
Box-Wilson 실험계획에 의한 연마용 인산일수소칼슘의 최적 제조조건 추구 및 안정화
이계주,곽손혁,서성수 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3
An abrasive, calcium hydrogen phosphate dihydrate (DCPD), was synthesized in a Box-Wilson experimental design by reactions between phosphoric acid and milk of lime, and calcium chloride and sodium phosphate solutions, and stabilized with TSPP and TMP. The optimum conditions for preparation of DCPD from phosphoric acid with milk of lime were such as: reaction temp.: 51.9℃, conc. of lime: 25.9%, conc. of phosphoric acd: 77.9%, drying temp.; 60.2℃ and final pH: 6.46. The physico-chemical and pharmaceutical properties of DCPD were showed as follows: glycerin absorption value(68㎖/100g), whiteness(99.5%), particle size(10.9nm), pH(7.8), and set test(pass). XRD and SEM of DCPD indicated a monoclinic system crystallographically. N₂ adsorption isotherm curve by BET showed non porous type II form. The micromeritic parameters of DCPD showed that surface area was 3.27∼4.6㎠/g and pore volume, pore area and pore radius were negligible. The rheogram of the toothpaste containing DCPD showed pseudoplastic flow with yield value of 321, and thixotropic behavior forming hysteresis loop. These results meet the requirements as abrasive standard, and sythesized DCPD is expected as a good dental abrasive such as a high quality grade in practice.
Smart geophysical characterization of particulate materials in a laboratory
Kwon, Tae-Hyuk,Cho, Gye-Chun Techno-Press 2005 Smart Structures and Systems, An International Jou Vol.1 No.2
Elastic and electromagnetic waves can be used to gather important information about particulate materials. To facilitate smart geophysical characterization of particulate materials, their fundamental properties are discussed and experimental procedures are presented for both elastic and electromagnetic waves. The first application is related to the characterization of particulate materials using shear waves, concentrating on changes in effective stress during consolidation, multi-phase phenomena with relation to capillarity, and microscale characteristics of particles. The second application involves electromagnetic waves, focusing on stratigraphy detection in layered soils, estimation of void ratio and its spatial distribution, and conduction in unsaturated soils. Experimental results suggest that shear waves allow studying particle contact phenomena and the evolution of interparticle forces, while electromagnetic waves give insight into the characteristics of the fluid phase and its spatial distribution.
가금의 살모넬라 제어를 위한 사료의 이화학적 처리와 사료첨가제의 활용
김지혁(Ji-Hyuk Kim),김학연(Hack-Youn Kim),김봉기(Bong-Ki Kim),김계웅(Gye-Woong Kim) 한국가금학회 2018 韓國家禽學會誌 Vol.45 No.1
Salmonella infections in livestock industry cause various problems such as worsening animal welfare and productivity, damaging consumer confidence in the food safety of animal products. Chicken meat and eggs are known as major source of pathogen causing human foodborne infections. Therefore food safety concerns have prompted the poultry producers and governments to introduce the strategy and regulation to control these pathogens. Salmonella can persist for long periods of time in a wide range of spaces including feed bin, feed processing facilities, poultry farm, slaughterhouse, processing plants, etc. For the effective and constant Salmonella control, combination of pre-harvest, harvest and post-harvest measures should be considered comprehensively. The control measures would be most effective at farm level where the contamination initiates. Transmission of pathogen from feed origin to the live poultry and finally to the products was proven already. To control bacteria in the feed ingredients and formula feed, thermal processing, irradiation or chemical treatment may be applied. Chemical treatments to inhibit Salmonella in the feed involve the use of products containing organic acids, formaldehyde, or a combination of such compounds. However, recontamination which might occur during storage and transport process and/or by other various factors should always be under control and eliminated. Feed additives used to control Salmonella in birds’ gastrointestinal track can be of various types, including prebiotics, probiotics, organic acids and bacteriophages. Although their mode of action varies, they ultimately inhibit the colonization of Salmonella in the gut and improve the performance of birds. This review describes the strategies that could be adapted to the management of feedstuffs and the use of feed additives in pre-harvest stage to control Salmonella contamination in poultry farming.