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Flurbiprofen 함유 키토산 제제가 치은 섬유아세포에 미치는 영향
정종평,박윤정,이승진,유인철,최상묵 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6
The main goal of periodontal regeneration is to be achieved by epithelial exclusion, periodontal ligament cell activation or alveolar bone regeneration. The purpose of this study was to investigate on the physico-chemical and biological characteristics of biodegradable chitosan beads. Chitosan beads were fabricated by ionic gelation with sodium tripolyphosphate and they had the size in 300㎛ diameter. As therapeutic agent, flurbiprofen was incorporated into the beads by 10, 20% loading contents. The release of drugs from the chitosan beads was measured in vitro. Also, biological activity tests of flurbiprofen loaded chitosan beads including cytotoxicity test, ihhibition of IL-1β production, suppression to PGE_2 production, collagenase inhibition test, the ability of total protein synthesis, and tissue response were evaluated. The amount of flurbiprofen released from chitosan was 33-50% during 7 days. Minimal cytotoxicity was observed in chitosan beads. Flurbiprofen released from chitosan beads significantly suppressed the IL-1β production of monocyte, PGE_2 production and markedly inhibited collagenase activity. Meanwhile, flurbiprofen released from this system showed increased ability for protein synthesis. Throughout 4-week implantation period, no significant inflammatory cell infiltrated around chitosan bead and also fibroblast like cell types at the beads-tissue interface were revealed with gradual degradation of implanted chitosan beads. From these results, it was suggested that flurbiprofen loaded chitosan beads can be effectively useful for biocompatible local delivery system in periodontal regeneration.
林忠默 건국대학교 1993 대학원 학술논문집 Vol.37 No.-
The objective of this study is to build a new optimal service rate for situation in which, During the stockout, time-proportional backorder cost and fixed penalty cost per unit lost With partial backorders. A mathematical example is used to illustrate this mathematical model. We know as follows through this study 1.As the demend increase, optimal shortage rate decrease. 2.As optimal shortage rate decrease, optimal service rate increase. 3.As demend increase, optimal service rate increase. Therefore, the new model developed in this study represents the real nature of Inventory systems.
하석호,김정묵,육종철 대한방사선 방어학회 1991 방사선방어학회지 Vol.16 No.2
외삽형 전리함을 사용하여 90Sr+90Y(1.65mCi) 베타선원에 대해 교정점 30cm 거리에서 조직표면의 흡수선량을 측정하였다. 이때 흡수선량 측정에 영향을 주는 유효단면적, 입사창 감쇠율, 극성효과, 이온 재결합율 등의 보정인자를 분석하였다. 이들 인자를 보정한 후의 조직표면의 흡수선량은 1.4939μGy/sec(±2.9%)로 평가되었다. Beta ray(90Sr+90Y) absorbed dose at tissue surface was measured from the distance of 30cm by use of extrapolation chamber. In the measurement, following factors were considered : effective area of collecting electrode, polarity effect, ion recombination and window attenuation. The measured absorbed dose rate at tissue surface was 1.4939μGy/sec with ±2.9%.
지평국,박종묵,노성기 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.2
수중의 방사능을 측정하기 위한 전처리과정으로서 이온교환농축법과 증발건조법을 서로 비교하였다. 시료를 증발건조법으로 처리하였을 때 방사성물질의 손실율은 이온교환농축법에 비해 20% 정도 많았다. 또, 1리터의 시료를 처리하는데 소요되는 증발시간은 70℃에서 증발시킨 경우 약20시간이었으나 이온교환농축법으로 같은 양의 시료를 처리하는데 소요된 시간은 약6시간이었다. 따라서 이온교환농축법이 증발건조법에 의해 효과적이며 특히 수중의 저준위 방사성물질 측정에 적합한 것으로 나타났다. An ion-exchange method for the detection of radioactivity in water using ion-exchange resion in concentrating radioactive nuclides was compared with an evaporation method. The loss of the radioactive materials in the sample treated by the ion-exchange method was less by about 20% than that by the evaporation method. In addition, the evaporation method needed about 20 hours for evaporating one liter of the sample at 70℃, while the ion-exchange method spent 6 hours to adsorb and desorbs the same amount of the sample on the resion. Consequently, the ion-exchange method is more effective than the evaporation method for the treatment of the radioactively contaminated water and is especially suitable for detecting the low-level radioactivity in water.
이종무(Chong-Moo Lee),최현택(Hyun-Taek Choi),김기훈(Kihun Kim),이판묵(Pan-Mook Lee),정인식(In-Shik Jung),서영우(Young-Woo Seo),한상철(Sang Chul-Han),구법모(Beob-Mo Gu) 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6
MOERI has developed a mine disposal vehicle (MDV) under an ACTD (Advanced Concept Technology Demonstrations) project supported by DAPA (Defense Acquisition Program Administration). The vehicle's required top speed is over 7kts for a measure against high currents in the sea near Korean Peninsular. To fulfil the various sophisticated requirements the vehicle carries battery and uses three types of communication channel with surface control unit. Even it can autonomously return to given point without external control. In this paper the vehicle system will be introduced and the principal test results carried out through a year will be shown.