허혈성 흰쥐 해마에서 NMDA수용체 아단위 NR2B와 세포골격단백질 MAP-2의 변화

정용욱,문일수,고복현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

전반적 저산소증(global ischemia) 과 불완전 국소허혈(incomplete focal ischemia)에서 신경세포의 NMDA수용체 아단위 2B와 세포골격단백질 MAP2의 변화를 알아보기 위하여 immunoblot방법과 면역 조직화학법으로 조사하여 다음과 같은 결과를 얻었다. 1. 해마신경세포의 연접이후치밀질(postsynaptic density, PSD) 를 이용한 NR2B, MAP2표현의 변화를 알아보면 저 산소증과 불완정 국소허혈에서 3일 후 감소 하다가 6일 후에는 점차 정상 수준으로 환원되었으며(저 산소증의 MAP2제외)반대편 해마의 경우 NR2B는 3일경과 후 표현이 감소 하다가 6일 후에는 정상 수준 이상으로 증가 하였으며 MAP2는 정상과 변화가 없었다. 2. 해마의 면역조직화학법에서 MAP2의 표현은 저 산소증과 동측의 불완전 국소허혈 부위의 CA1, CA3, DG 전체 지역에서 정상에 비해 3일 후 감소 하다가 6일 후 증가 하였다(허혈의 반대측 해마의 경우는 CA1에서 MAP2의 표현이 6일째 감소됨.) 이상의 관찰 결과를 종합 해볼때 해마 신경세포의 지연성 손상은 NMDA수용체 아단위 2B의 감소와 세포골격단백질 MAP2를 파괴하며 그 시기는 3일 이전에 일어나 6일경에는 회복하는 단계를 거치는 것으로 생각되며 정확한 회복 시기는 허혈의 정도에 따라 차이가 있을 것으로 생각된다. 또한 허혈 반대편 부위에서의 NR2B와 MAP2의 면역 반응성 감소는 허혈지역의 주변부위에서(penumbra)에서 나타나는 현상과 일치하였다. Changes of NR2B & MAP-2 expression in global and focal ischemia Department of Anatomy, School of Medicine, DongGuk University YONG WOOK JUNG M.D., IL SOO MOON Ph.D., BOK HYUN KO M.D Microtubule associated protein 2 (MAP-2) degradation by Ca2' - dependent proteases after NMDARs (NRs) activation has been postulated in delayed hippocampal neuronal damage.. Degradation of MAP-2 in rat brain after hypoxia and ischemia was investigated through immunoblot analyses and immunohistochemistry. In order to test the changes of each NR subunits (NR2B) and MAP2 in neuronal damage, we carried out in vivo experiments to see if there is selective changes of MAP-2 and NR2B in global hypoxia and focal left common carotid artery ligation.. We found that, in global ischemia, NR2B was down-regulated and recovered to normal level by 3 and 6 days while MAP-2 was unchanged by the same days compared to untreated hippocampus, and that similar changes regarding to NR2B and MAP-2 were observed at ipsilateral hippocampus in focal ischemia. In contralateral hippocampus, NR2B expression was decreased and MAP-2 expression was unchanged compared to untreated hippocampus. These results imply that NR2B and MAP2 expression are regulated on the degree of ischemic damage in delayed neuronal death and that, in focal ischemia, down-regulation of NR2B in contralateral hippocampus may be a similar effect which is seen in the peripheral zone (penumbra) of ischemic region.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

한국형 노인주거개발을 위한 이론적 고찰

박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.

인삼투여가 체력 및 체중감량에 미치는 영향

이명복,김창규,박성순,김귀봉,이상구,김현덕 국민대학교 스포츠과학연구소 1985 스포츠科學硏究所論叢 Vol.4 No.-

The purpose of the study was to investigate and find the metabolic and strength response to the effects of Gin Seng intake on weight reduction in Wrestlers. Ten subjects experienced five to eight years fro were used for the study. They are attending at university and engaging in wrestling program. The subjects were divided into experimental and control groups. Five exeprimental group was supplemented Korean Gin Seng with the amounts of 600g for eight weeks. The pre-post test methods was conducted. The metabolic test using the Ergo-Oxyscreen (Jager co. German) were obtained during the ergometer bicycle tests. The subjects were seated on the bicycle for two minutes after two minutes resting period, and pedalled with 60rpm at the beginning with free loading for two minutes, and increased the 0.5KP load every one minute. The exercise on the bicycle was continued until the subjects were exhausted. The metabolic data such as weight, MV(minute ventilation)., BF(breathing frequency), Heart rate, Vo_2ml kg/min., and Time. were calculated automatically and printed out the data every minute. The grip and back strength tests were obtained using the dynamometer (T.KK. Japan), and leg strength(180/sec, 30/sec.), power, isometric maximal strength, and endurance were measured through Cybex-Ⅱ system. After pre-test, exprimental group was begin to intake Gin-Seng for eight weeks, and control was start to reduce their body weight. As the results of the study, conclusion to be drawn as follows; 1. There were no significant difference between before weight reduction and after weight

서울말의 리듬과 억양

이현복 서울대학교 어학연구소 1974 語學硏究 Vol.10 No.2

時變磁界 測定用 센서에 관한 硏究

이복희,백용현,박형기,정승수,전덕규 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

한국의 산업구조변화요인과 경제자립화분석

성태현,한복상 慶南大學校 産業經營硏究所 1990 産業經營 Vol.13 No.-

歷節風의 病因病機와 鍼灸治療에 關한 文獻的 考察

劉複鍾,金基鉉 대전대학교 한의학연구소 2000 한의학연구소 논문집 Vol.9 No.1

The Literatural Study on the classification of cause and the effect of Acupuncture and Moxibustion treatment for Youk Jeol Poung was studied from the viewpoint of therapeutic acupuncture and moxibustion effect. And the results were as follows: 1.Youk Jeol Poung is similar to Tong Bi, Ju Bi. Haeng Bi, Tong Poung. 2.The symptoms of Youk Jeol Poung are pain and weakness, difficulty of flexion, swelling and pain, severe pain etc., at night pain is more severe. 3.The cause, mechanism of Youk Jeol Poung is as follow, due to penetration of the wind, cold, moisture, uder situation of whole body is pain. 4.The main treatment is invigorate vital energy and blood, expel wind-evil, promote diuresis, eliminating phlegm, promote blood circulation, cold, heat -clearing. 5.The basal meridian of acupuncture and moxibustion treatment were the channels of Su Jok Sam Yang.

국어사전에서의 발음표시

이현복 서울대학교 어학연구소 1987 語學硏究 Vol.23 No.1

The Korean spelling system, which is in principle morphologically oriented, is not necessarily a reliable and consistent guide to the standard pronunciation of Korean. For example, it does not show the difference in vowel length which is phonologically significant, as in the pair of words /mal/ 'horse', /ma:l/ 'language'. Hence the need for representing pronunciation in Korean dictionaries. However it may be fair to say that the need for marking the pronunciation of Korean words has been neither seriously felt nor adequately met in most dictionaries published in Korea. The writer strongly feels that pronunciation should be adequately marked in all Korean dictionaries according to the following principles: 1) The Korean alphabet should be adopted to represent the standard pronunciation since it will be easier to read than the IPA or other phonetic symbols for Korean readers. 2) A Phonemic transcription is preferred to a Phonetic one to guarantee optimal 'readability'. 3) The Linear Writing System is preferred to the Block Writing System since it helps represent the pronunciation more accurately. 4) The features of pronunciation to be represented in dictionaries are: a) Vowel length, b) lenis-fortis distinction, c) consonant insertion, d) stress and rhythmic feature, etc.

10주간의 행동요법이 비만 초등학생의 혈중지질 성분에 미치는 영향

김현준,김태운,박태곤,박찬호,예정복 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this study was to verify the effect of behavioral modification therapy among elementary students by comparing and analysing serum lipid between the experimental group and the control group on obese children. For this study, 44 obese children(boys: above 25% of % fat, girls: above 30% of % fat) between 11 and 12 years old S elementary school in Busan city were engaged in and were divided into two groups, each group consisting twenty two children an experimental group for behavioral modification therapy and a control group without any kind of obesity management program......