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우진현 ( Jin Hyun Woo ),이경해 ( Kyung Hae Lee ),박용욱 ( Yong Wook Park ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.2
Objective: Mononeuritis multiplex is an extra-articular manifestation associated with rheumatoid arthritis. This study set out to investigate its clinical characteristics in Korea. Methods: Clinical characteristics and laboratory data were compared retrospectively by review of medical records between 12 patients with mononeuritis multiplex (case) and randomly selected 116 age-matched patients without mononeuritis multiplex in patients with rheumatoid arthritis (control). Results: Mean age of the case group was 51.8±8.4 years old with 7 males and 5 females which showed higher prevalence of male gender compared to the control group (p<0.05). There was no difference in mean duration of disease between two groups. Upper limbs, lower limbs and both upper and lower limbs were involved in 3, 7 and 2 patients, respectively. Major symptoms were tingling (66.6%), paresthesia (33.3%), pain (33.3%), foot drop (33.3%), or muscle weakness (16.7%). Skin ulceration was accompanied in 3 patients, but vasculitis of other organs was not found. Mean C-reactive protein level in the case group was 7.6±6.7 mg/dL, which was higher compared to 2.4±3.1 mg/dL in the control group (p<0.05). Rheumatoid factor was positive in 83.3% of the case, however positive rate and titer showed no significant difference with the control group. There was no difference in other extra-articular manifestations between two groups. Six patients were treated with glucocorticoid and immuno-suppressants and 6 patients with only glucocorticoid1 for 6.8±7.1 weeks. Symptoms improved after treatment in 10 patients but, it lasted in 2 patients. Conclusion: Rheumatoid arthritis associated mononeuritis multiplex was more prevalent in males with higher CRP levels, and responded well to medical intervention including glucocorticoid, and immunosuppressants.
진현식,박판우,Jin, Hyun-Sik,Park, Phan-Woo 한국정보교육학회 2003 정보교육학회논문지 Vol.7 No.3
프로그래밍 교육은 문제 분석 능력, 논리적 사고력, 절차적 문제 해결 방식을 습득하는데 매우 긍정적인 역할을 한다. 하지만 초등학생의 지적 성장 발달 단계에 맞도록 설계된 프로그래밍 학습용 웹 코스 웨어에 관한 연구는 드물며, 개발되었다고 하더라도 초등학생에게는 맞지 않은 높은 이론적 내용을 다루고 있어서 이해하기가 어렵고, 웹 상에서 직접 실습할 수 있는 환경을 제공하지 못한다. 이에 본 연구에서는 웹 기반 학습 설계 이론을 바탕으로 초등학생의 지적 성장 발달에 맞는 비주얼베이식 교육 시스템을 설계하고 구현하였다. 본 시스템에서는 학습자에게 웹 환경에서 비주얼베이식 프로그래밍의 기초와 기본 문법을 익힐 수 있도록 하며, 프로그램을 코딩하고 실행할 수 있도록 환경을 제공한다.
신장 조직 검사에서 사구체 면역침착을 보인 베게너 육아종증 1예
서영진 ( Young Jin Seo ),김윤정 ( Yoon Jung Kim ),문지미 ( Ji Mi Moon ),최혜윤 ( Hae Yoon Choi ),우진현 ( Jin Hyun Woo ),최성재 ( Seong Jae Choi ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),정운용 ( Woon Yong Jung ),송관규 ( G 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Rapidly progressive glomerulonephritis (RPGN) in Wegener`s granulomatosis patients typically has been characterized by pauci-immune glomerulonephritis (PIGN). In some patients, however, significant amount of glomerular immune deposits was detected and reported that they may have poor prognosis. A 30 year-old-female visited due to the skin rash of both lower extremities, arthralgia and nasal stiffness. She had sinusitis, lung opacity, and proteinuria. Serologic PR-3 ANCA was positive and histologic findings of nasal cavity and lung also showed necrotizing vasculitis and granuloma. Thus we could diagnose Wegener`s granulomatosis. However, gross hematuria developed and renal function worsened in spite of treatment with high dose prednisolone and oral cyclophosphamide. Therefore we performed a kidney biopsy. The kidney biopsy showed crescentic glomerulonephritis with Ig A deposition in the mesangium. We experienced a case of Wegener`s granulomatosis patient with significant IgA deposition in glomeruli. We report this case with brief review of the literature.
한국인 류마티스관절염 환자에서 항CCP항체와 류마티스인자의 진단정확성에 대한 메타분석연구
이영호 ( Young Ho Lee ),우진현 ( Jin Hyun Woo ),최성재 ( Seong Jae Choi ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.1
목적: 한국인 류마티스관절염 환자에서 항CCP항체와 류마티스인자의 민감도와 특이도, 진단정확성에 대해 연구하였다. 방법: 문헌검색은 Medline과 Koreamed, 대한류마티스학회지를 이용하였고 논문들의 참고문헌도 조사하였다. Random-effects 모델을 이용하여 메타분석을 시행하였으며 항CCP항체와 류마티스인자의 민감도, 특이도, positive와 negative likelihood ratios (PLR, NLR), diagnostic odds ratio (DOR)와 summary receiver-operating characteristic curve (SROC 커브)를 구하였다. 결과: 항CCP항체와 류마티스인자의 민감도와 특이도를 연구한 7개의 논문의 류마티스관절염환자 1,041명과 대조군 970명이 메타분석에 포함되었다. 항CCP항체의 민감도와 특이도, PLR, NLR, DOR은 76.7% (95% confidence interval [CI] 74.0∼79.2), 95.1% (93.8∼96.3), 14.837 (11.567∼19.031), 0.244 (0.202∼0.294)과 59.235 (43.806∼80.097)이었고 류마티스인자의 수치는 78.2% (0.756∼0.807), 80.5% (78.1∼82,6), 3.687 (3.027∼4.492), 0.298 (0.218∼0.406)과 12.915 (8.427∼19.771)이었다. 항CCP항체의 area under the curve (AUC)와 Q* index는 0.9453과 0.8842이었고 류마티스인자의 수치들은 0,8583과 0.7891이었다. 항CCP항체는 류마티스인자와 비교하여 특이도와 PLR, DOR, AUC, Q* index가 높았으며 민감도와 NLR은 유사하였다. 항CCP항체와 류마티스인자가 모두 양성인 경우 특이도와 AUC가 류마티스인자에 비해 현저히 증가하였다(특이도 96.5% vs. 80.5%, AUC 0.9864 vs. 0.8583). 결론: 한국인에서 항CCP항체는 류마티스인자와 비슷한 민감도를 보이나 특이도와 진단 정확성은 더 높았고 항CCP항체와 류마티스인자를 같이 검사하는 경우 항CCP항체나 류마티스인자보다 진단정확성이 증가하여 한국인 류마티스관절염 진단에 유용할 것으로 보인다.
남승주 ( Seung Joo Nam ),우진현 ( Jin Hyun Woo ),최성재 ( Seong Jae Choi ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ),이영호 ( Young Ho Lee ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.2
Wegener`s granulomatosis is multi-systemic disease characterized by granulomatous necrotizing vasculitis and it usually affects upper and lower respiratory tracts. Cutaneous manifestation as an initial presentation is unusual and comprises about 15% of cases. The most frequent skin lesions are palpable purpura, papules, ulcerations, vesicles, subcutaneous nodules, necrotizing ulcerations. We report a patient with Wegener`s granulomatosis who presents as a pyoderma gangrenosum.
한국인 류마티스 혈관염과 안지오텐신 전환효소 유전자 삽입/결손 다형성
이경해 ( Kyung Hae Lee ),우진현 ( Jin Hyun Woo ),김숙경 ( Sook Kyoung Kim ),박용욱 ( Yong Wook Park ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),배상철 ( Sang Cheol Bae ),유대현 ( 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Objective: Rheumatoid arthritis has various extra-articular manifestations including rheumatoid vasculitis. Angiotensin converting enzyme (ACE) gene shows insertion/deletion polymorphism and has II, ID, DD genotypes. ACE gene is related with vasoconstriction and endothelial dysfunction in cardiovascular disease. This study was undertaken to determine the association between ACE gene polymorphism and rheumatoid vasculitis. Methods: Twenty-nine patients were collected as rheumatoid vasculitis group. DNA was isolated from blood samples collected from 114 Korean rheumatoid arthritis patients meeting American College of rheumatology 1987 revised criteria, and 114 healthy control group. Genotyping for the angiotensin converting enzyme gene insertion/deletion polymorphism was performed by polymerase chain reaction method. Results: As vasculitis manifestation, 15 patients showed neuropathy, 13 showed scleritis, 3 showed skin rash. In rheumatoid vasculitis group, II, ID and DD polymorphism was seen in 8 (27.6%), 15 (51.7%), 6 (20.7%) patients respectively and 39 (34.2%), 57 (50.0%), and 18 (15.8%) in normal controls. There was no skewing of ACE I/D polymorphism in compared with normal group. In rheumatoid arthritis control group, II, ID and DD polymorphism was seen in 37 (32.5%), 64 (56.1%), and 13 (11.4%) patients. Among rheumatoid arthritis patient, there was no significant difference between patient with vasculitis and without vasculitis. Conclusion: Our results showed that genetic polymorphisms of angiotensin converting enzyme insertion/deletion gene has no association with the susceptibility to rheumatoid vasculitis.
이지안(Ji An Lee),박상현(Sang Hyun Park),류형욱(Hyung Uk Ryu),이승기(Seung Gi Lee),정설영(Seol Yeong Jeong),우진현(Jin Hyun Woo) 한국정보기술학회 2022 Proceedings of KIIT Conference Vol.2022 No.12
비대면 시대가 도래함에 따라 온라인에서 필요한 물품을 주문하는 e-커머스 시장이 확대되고 있다. 그러나 오픈마켓을 운영하는 기업의 재고관리 시스템은 여전히 구시대적인 방식에 머물러 있어 산업 전체의 효율성에 악영향을 미치고 있다. 본 연구에서는 오픈마켓 데이터 연계 및 직관적인 UI 기반의 기업형 창고 관리 솔루션을 개발하고, 이를 통해 기존 재고 관리 솔루션의 한계를 극복하고자 했다. 세부적으로는 실제 창고환경과 유사한 데이터를 시스템 내에 연동하고, 오픈마켓 데이터를 이용한 효과적인 배치 작업을 설계함으로써 발주부터 배송이 완료되기까지 재고의 상태를 실시간으로 추적 가능한 실용적 창고관리 시스템 모델을 설계하고자 했다. With the advent of the non-face-to-face era, the e-commerce market for ordering necessary items online is expanding. However, the warehouse management system of companies selling goods in the open market remains outdated, adversely affecting the efficiency of the entire industry. In this study, we developed a warehouse management system that supports linkage of open market order information and an intuitive UI for users. And through this, we tried to overcome the limitations of the existing warehouse management system. In detail, by implementing a data structure similar to the actual warehouse environment in the system and designing effective deployment method using open market data, we tried to design a practical warehouse management system model that can track the status of inventory in real time from order to delivery completion.
인간 대식세포에서 1,25(OH)2D3에 의한 CYP24 유전자 발현에 있어 MAPK의 역할
지종대 ( Jong Dae Ji ),이빛나라 ( Bit Na Ra Lee ),김태환 ( Tae Hwan Kim ),우진현 ( JIn Hyun Woo ),최성재 ( Sung Jae Choi ),이영호 ( Young Ho Lee ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3
Objective: Several important roles of 1,25(OH)2D3 have been recognized in the immune system. The availability of 1,25(OH)2D3 at the cellular level is significantly influenced by the relative abundance of enzymes to synthesize (CYP27B1) and catabolize (CYP24) 1,25(OH)2D3. In this study, we examined the effect of 1,25(OH)2D3 on the expression of the CYP24 gene and the role of MAPK for the induction of CYP24 by 1,25(OH)2D3 in activated human macrophages. Methods: For obtaining human activated macrophages, we treated U937 cells with PMA and we cultured these cells for 24 hours to adhere. After 24 hours treatment with PMA, the differentiated cells were washed with phosphate buffered saline (PBS), and then they were used for examining the effect of 1,25(OH)2D3 on the expression of the CYP24 gene. The mRNA expressions of the vitamin-D3 inducible genes were measured by real-time PCR, and the change of the protein expression by 1,25(OH)2D3 was measured by immunoblotting. Results: 1,25(OH)2D3 significantly induced the expression of CYP24 in the U937 cells and the 1,25(OH)2D3-induced expression of CYP24 was strongly augmented in the PMA-differentiated U937 cells. The 1,25(OH)2D3-induced expression of CYP24 was mediated by Erk1/2 and p38 MAPKs. Parallel to the induced expression of CYP24, 1,25(OH)2D3 induced the expression and phosphorylation of the CCAAT enhancer-binding protein (C/EBPβ). Conclusion: In this study, we found that 1,25(OH)2D3 inducedthe expression of CYP24 via activation of MAPKs. These results suggest that MAPK inhibitors may be useful for the treatment of inflammatory conditions, in which active vitamin D3 can be used as the therapeutic molecule, by increasing the availability of 1,25(OH)2D3.