Effects of Oral and Transdermal Hormone Replacement Therapy on Lipid Profile and Lp(a) Level in Healthy Korean Menopausal Women

서지현 ( Ji Hyun Suh ),( Joo Han Kim ),( Kyung Ja Shin ),( Doo Seok Choi ),( Duk Su Bae ),( Byung Koo Yoon ) 대한산부인과학회 2002 대한산부인과학회 학술대회 Vol.88 No.-

한국 임신부에서 임신성 당뇨병을 진단하기 위한 75 gm 과 100 gm 경구당부하검사의 효율성 비교

서지현(Ji Hyun Suh),윤은혜(Eun Hae Yoon),김언아(Eon Ah Kim),김영주(Young Ju Kim),이경순(Kyung Soon Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

N/A Objective : The purpose of this study was to compare one-step 2 hour 75 gm oral glucose tolerance test (OGTT) proposed by the World Health Organization (WHO) with two-step 3 hour 100 gm OGTT of National Diabetes Data group (NDDG) criteria for determining gestational diabetes. Methods : Data for 111 pregnant Korean women who were diagnosed of gestational diabetes either by 75 gm OGTT or 100 gm OGTT and 100 normal controls were reviewed and analyzed retrospectively. The effectiveness of the two tests was determined by comparing the frequency of diabetes-related pregnance outcomes such as macrosomia, cesarean delivery, and preterm birth. Chi-square, Fisher's Exact test, and T-tests were used for statistical analysis. Results : Among 111 gestational diabetic women, 59 (53.2%) were diagnosed by WHO criteria of 75 gm OGTT and 52 (46.8%) were diagnosed by 100 gm OGTT of NDDG criteria. Frequency of macrosomia and cesarean section was higher in 75 gm test group than in 100 gm test group (12.3% vs 5.8% and 35.1% vs 21.2%, respectively), but the difference was statistically not significant. When compared to the control group, 75 gm test group reached statistical significance in having higher incidence of macrosomia (12.3% vs 3%, p<0.05) whereas 100gm test group did not. Conclusion : Efficacy of the diagnostic criteria of WHO was comparable to that of NDDG for diagnosing gestational diabetes. This suggests WHO's 75 gm OGTT to be an efficient diagnostic tool for gestational diabetes in Korean women

페그-인터페론과 리바비린 병합치료 중 발생한 간질성 페렴 및 범혈구 감소증

서지현 ( Ji Hyun Suh ),한성환 ( Sung Hwahn Hahn ),이지은 ( Ji Eun Lee ),한진형 ( Jin Hyung Han ),김경묵 ( Kyung Mook Kim ),김도형 ( Doh Hyung Kim ),김윤섭 ( Yon Seop Kim ),박재석 ( Jae Suk Park ),지영구 ( Young Koo Jee ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.1

The combination therapy of pegylated interferon and ribavirin is the mainstay of treatment for chronic hepatitis C patients. Anti-viral therapy is commonly associated with side effects such as headache, fever, myalgia, and arthralgia. However, anti-viral therapy can continue because these side effects are mostly mild and can be improved with supportive management. Anti-viral therapy should be stopped promptly if serious side effects, such as interstitial pneumonitis or hemolytic anemia occur, although those serious side effects are rare. There were a few case reports of interferon-related interstitial pneumonitis worldwide. In Korea, one atypical case report of interstitial pneumonitis has been reported, which followed the combination therapy of interferon-alpha and ribavirin in a patient with chronic hepatitis C. We present a case of interstitial pneumonitis and pancytopenia following the combination therapy of pegylated interferon and ribavirin in a patient with chronic hepatitis C.

젊은 여성에서 발생한 점액암종의 특징을 가진 원발성 대장 경성암 1예

서지현 ( Ji Hyun Suh ),신현덕 ( Hyun Deok Shin ),신정은 ( Jeong Eun Shin ),남궁환 ( Gung Hwan Nam ) 대한장연구학회 2011 Intestinal Research Vol.9 No.1

Adenocarcinoma is the most common pathologic diagnosis, representing >95% of colorectal cancers; mucinous adenocarcinoma (MA) accounts for 10-15% and SRC accounts for 0.1-2.4% of colorectal cancers. MA is defined as a tumor with ≥50% mucin. Patients with MAs have a poor prognosis, a higher proportion of peritoneal metastases, and present at a more advanced stage of disease. Linitis plastica involving the colon and rectum is usually a metastatic lesion from gastric cancer and other organs, such as the prostate, gallbladder, and breast. Primary linitis plastica of the colon is very rare. We managed a case of colon cancer occurring in a 19-year-old female with a histologic diagnosis of mucinous adenocarcinoma and morphologic features of linitis plastica. Herein we report a rare case of primary linitis plastica of the colon with a review of the literature. (Intest Res 2011;9:61-65)

폐경후 호르몬 대체요법 중 발생한 심부 정맥 혈전색전증 및 폐 색전증 1례

서지현(Ji Hyun Suh),유은희(Eun Hee Yoo),유민영(Min Young Yoo),유한기(Han Ki Yoo),유정현(Jung Hyun Yoo) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.2

N/A A 57 year-old woman who has been on postmenopausal hormone replacement therapy (HRT) for past three years was admitted with chest discomfort and painful swelling of right leg, Homan's sign of the affected leg was positive. Although chest X-ray revealed no abnormalities, multiple perfusion defects were noted on lung perfusion scan and multiple calcified granulomatous lesions were suggested on chest computed tomography (CT). Doppler sonography and magnetic resonance (MR) venography revealed signs of multiple deep venous thrombosis of right superficial femoral vein. Under the diagnosis of pulmonary embolism and deep vein thromboembolism, she was started on treatment with intravenous heparin followed by oral warfarin after immediate discontinuation of HRT. With no underlying thrombophilic risk factors, this patient was the first reported case of developing thromboembolism under the use of HRT in Korea.

주물 응고 수치해석 복원모델의 설계모델 매핑을 통한 몰입형 가시화

박지영 ( Ji Young Park ),서지현 ( Ji Hyun Suh ),김성희 ( Sung Hee Kim ),이선민 ( Seon Min Rhee ),김명희 ( Myoung Hee Kim ) 한국정보처리학회 2008 정보처리학회논문지 A Vol.15 No.3

본 연구에서는 설계모델과 주물 응고의 유한차분법 기반 해석결과를 결합하여 가시화하는 새로운 방법을 제안하고 VR 디스플레이를 도입하여 입체 가시화함으로써 보다 효과적인 분석작업 환경을 제공한다. 먼저 기존 해석 소프트웨어를 사용하여 얻어진 응고해석 결과를 사각형 메쉬모델로 복원하여 복원모델의 모든 정점의 색이 해당 위치의 온도수치를 표현하도록 한다. 다음으로 설계모델의 모든 정점에 대해 가장 가까운 복원모델의 정점을 탐색함으로써 두 모델을 대응하고 대응점의 색을 설계모델 정점에 지정한다. 이때 설계 모델은 최소의 정점으로 모델의 형상이 이루어져 있어 정점의 분포가 복원모델에 비해 균일하지 않으므로 특정 임계값을 설정하여 삼각형 변의 길이가 이보다 큰 경우 정점을 추가함으로써 형태를 유지하는 메쉬 분할을 수행한다. 구현된 시스템은 설계모델 상에서 응고해석 데이터를 가시화함으로써 사용자가 분석객체 세부영역의 정확한 기하정보를 파악할 수 있으며 VR 디스플레이를 통해 실감나는 작업환경을 제공함으로써 보다 빠르고 효과적으로 문제발생여부를 판단할 수 있다. In this research we present a novel method which combines and visualizes the design model and the FDM-based simulation result of solidification. Moreover we employ VR displays and visualize stereoscopic images to provide an effective analysis environment. First we reconstruct the solidification simulation result to a rectangular mesh model using a conventional simulation software. Then each point color of the reconstructed model represents a temperature value of its position. Next we map the two models by finding the nearest point of the reconstructed model for each point of the design model and then assign the point color of the design model as that of the reconstructed model. Before this mapping we apply mesh subdivision because the design model is composed of minimum number of points and that makes the point distribution of the design model not uniform compared with the reconstructed model. In this process the original shape is preserved in the manner that points are added to the mesh edge which length is longer than a predefined threshold value. The implemented system visualizes the solidification simulation data on the design model, which allows the user to understand the object geometry precisely. The immersive and realistic working environment constructed with use of VR display can support the user to discover the defect occurrence faster and more effectively.

식이 섬유가 대사 증후군과 아디포넥틴에 미치는 영향

이기종 ( Ki Jong Lee ),서지현 ( Ji Hyun Suh ),안영 ( Young Ahn ),하승혜 ( Sung Hae Ha ),박주상 ( Ju Sang Park ),장은정 ( Eun Jeong Jang ),박상종 ( Sang Jong Park ),김상중 ( Sang Jung Kim ),박상운 ( Sang Woon Park ),백현욱 ( Hyun 한국정맥경장영양학회 2011 한국정맥경장영양학회지 Vol.4 No.1

Purpose: In Korea, the prevalence of metabolic syndrome has increased. The relationship between metabolic syndrome, adiponectin, and dietary components is widely known. However, the relation between cytokine and dietary components is not yet well studied in Korea. Methods: Five hundred and ninety-six Korean adults between 30 and 59 years of age were recruited by advertisement to the Bundang Jesaeng General Hospital (BJGH), and those not taking regular medications and without diagnoses of fulminant disease were included. Data was collected on anthropometric measurements, diagnostic parameters for metabolic syndrome (MetS), and 3-day dietary intakes from individuals in the study. Results: Serum adiponectin level was positively correlated with serum HDL-cholesterol level and was negatively correlated with BMI, waist circumference, and systolic and diastolic blood pressure. Intake of dietary fiber was high in the high-adiponectin group. Conclusion: High-fiber diet and adiponectin can be helpful for improving metabolic syndrome. (JKSPEN 2011; 4(1):16-20)

한국교원교육학술지 연구 동향 분석 - 정권별 의미연결망 분석을 중심으로 -

문희원(Moon Hee Won),서지현(Suh Ji Hyun),김시은(Kim Si Eun),엄문영(Eom Moon Young) 한국교원교육학회 2020 한국교원교육연구 Vol.37 No.1

‘한국교원교육학회’는 한국의 교원 교육에 관한 연구 및 협의를 통해 그 개선과 발전을 도모하고자 설립되었으며, 「한국교원교육연구(이하 교원교육연구)」를 연 4회 발간하고 있다. 교육행정 연구의 발전을 위해 설립된 여러 학회 중 하나로서 해당 학회의 정체성을 보다 분명하게 차별화하기 위해서는 발간 중인 학술지의 연구 흐름을 살펴볼 필요가 있다. 이에 본 연구에서는 이전의 선행 연구에서 시도되었던 분석 준거들뿐만 아니라 ‘의미연결망 분석기법’을 적용한 새로운 관점으로 「교원교육연구」의 연구 동향을 분석하였다. 특히, 학술지를 정권 시기별로 나누어 분석하여 각 정권의 교육공약과 실제 한국교원교육학술지에서 다루어지는 연구 내용의 유사성 및 관련성을 추론해보고자 하였다. 분석결과, 「교원교육연구」의 연구들은 각 정권에서 중점적으로 이슈화되었던 교육 주제들을 일부 반영하는 것으로 나타났다. 또한, 최근 현장 교원의 연구 참여가 늘어나는 추세를 보였으며, 이에 따라 실제 현장의 문제를 이론적으로 분석하는 연구의 비중도 함께 늘고 있었다. 본 연구에서는 분석결과를 토대로 한국교원교육학회의 정체성 확립을 위한 제언을 하였다. The Journal of Korean Teacher Education is quarterly published by The Korean Society for the Study of Teacher Education(KSSTE), the research association founded for improvement of teacher education study. There are other institutions established for the similar aim, development of educational administration research. Therefore, it is crucial to differentiate the identity of KSSTE from others, and analyzing research trends of the journal allows us to clarify the identity. This study aimed to look back on the research trend of the journal, especially using semantic network analysis that is allowing new and broaden perspective in reviewing research trends. Furthermore, we analyzed research topics by the regime and reasoned inductively the relation between research topics and educational policies of each regime. The conclusion of the study is as follows. It seems that the research topics of the journal have reflected educational issues at each period, and the proportion of theoretical-practical research was also increasing as the participation rate of field teachers increased recently. Based on the results of this study, suggestions were made for establishing the identity of The Korean Society for the Study of Teacher Education(KSSTE).

야간자율학습 미참여 고등학생의 방과후 시간 활용 및 학업성취도 분석

정설미(Jeong, Seol Mi),나은선(Eun Sun Na),김영롱(Young Rong Kim),서지현(Ji-Hyun Suh),송채윤(Chae Yoon Song),정동욱(Jeong, Dong Wook) 한국교육학회 2020 敎育學硏究 Vol.58 No.3

본 연구는 한국교육고용패널조사Ⅱ의 2016~2017년 데이터를 활용하여 중등교육정책 환경의 변화에따라 지속적으로 증가하고 있는 야간자율학습 미참여 고등학생에 대해 분석하였다. 이에 정책이 의도한효과와 의도하지 않은 효과로 각각 야간자율학습 미참여 학생의 방과후 시간 활용과 학업성취도 변화를분석하였다. 야간자율학습 미참여 학생의 방과후 시간 활용을 패널토빗모형을 활용하여 분석한 결과, 야간자율학습 미참여 학생의 자율학습시간은 약 2.68시간 유의하게 감소하고, 여가시간은 1.91시간만큼 유의하게 증가하는 것으로 나타나 정책이 의도한 바와 같이 학생의 학습 부담이 감소한 것으로 긍정적인평가를 할 수 있다. 그러나 교외 사교육 시간은 오히려 증가했다는 점에서 풍선효과가 다소 우려되는 결과이다. 다음으로 야간자율학습 미참여가 학생의 학업성취도에 미치는 영향을 경향점수매칭을 활용하여분석한 결과, 야간자율학습 미참여 학생의 종합내신등급이 약 0.15~0.33등급만큼 유의하게 하락하는 것으로 나타났다. 특히, 교외 사교육비 투자 분위별 집단에 따른 차별적 효과를 분석한 결과, 야간자율학습미참여에 따른 학업성취도 하락 현상은 사교육비 투자 중·하위 집단에서만 나타났다. 이에 학생의 학습선택권은 보장되어야 마땅하나, 동시에 내실화된 야간자율학습 대체 프로그램과 저소득층 학생 방과후지원 방안 등이 마련되어야 함을 제언하는 바이다. This study analyzed the increasing number of students who do not participate in night-time self-study in the educational policy changes by using the 2016~2017 data from KEEP II. We analyzed non-participatory students after-school time utilization as an intended effect and followed by analyzing their academic performance as an unintended effect. The analysis of after-school time utilization with the panel tobit model showed that educational policy changes significantly reduce students academic burden as intended. However, increasing private tutoring hours shows that the balloon effect could be on some concerns. Next, the analysis with propensity score matching shows that non-participation of night-time self-study has a significant negative effect on students academic performance. Specifically, the effects differ depending on private education investment; only middleand lower- private education investment groups showed a decline in academic performance. Therefore, we suggest that enriched alternatives such as additional programs should be provided to students from low-income families.

임신성 고혈압 한국인 환자에서 C677T Methylenetetrahydrofolate reductase 유전자 변이 , 호모시스테인 , 지질성분의 감수성 연구

안정자(Jung Ja Ahn),윤은혜(Eun Hye Yoon),서지현(Ji Hyun Suh),김영주(Young Ju Kim),이경순(Kyung Soon Lee),하은희(Eun Hee Ha) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

N/A Objective : The purpose was to test the hypothesis that the common missense mutation of 5,10-methylenetetrahydrofolate reductase(MTHFR) is more prevalent among preeclamptic women compared with control and also was to determine whether homocysteine and other lipid profile is changed in pregnant women with preeclampsia. Methods : We measured plasma homocysteine, cholesterol, HDL, LDL, triglyceride, apoprotein B, vitamin B12, and folate in 48 pregnant women without preeclampsia and 22 women with preeclampsia. And the MTHFR genotype was determined with a polymerase chain reaction/restriction fragment length polymorphism method. Results were analyzed with aX2 contingency table and T-test. Results : The prevalence of the MTHFR C677T mutation was not significantly different between the population studied. There was no significant difference in the level of plasma homocysteine, cholesterol, HDL, LDL, triglyceride, apoprotein B, and folate between controls and preeclamptic women. Furthermore, there was a significant difference in the level of plasma vitamin B12 between the population studied. Conclusion : These data suggest that the MTHFR C677T mutation is not a risk factor for preeclampsia in this population. Plasma homocysteine, cholesterol, HDL, LDL, triglyceride, apoprotein B, and folate level are not elevated in preeclamptic women. However, the plasma vitamin B12 level is elevated in preeclamptic women. Further studies are necessary to determine why the plasma vitamin B12 level is elevated in preelamptic women although they did not have vitamin drug.