폐광산지역 토양 식생복원 과정 내 토양특성 및 미생물 군집 변화 분석

박민정,윤민호,남인현,Park, Min-Jeong,Yoon, Min-Ho,Nam, In-Hyun 한국지하수토양환경학회 2015 지하수토양환경 Vol.20 No.3

Mine soil contamination by high levels of metal ions that prevents the successful vegetation poses a serious problem. In the study presented here, we used the microbial biocatalyst of urease producing bacterium Sporosarcina pasteurii or plant extract based BioNeutro-GEM (BNG) agent. The ability of the biocatalysts to bioremediate contaminated soil from abandoned mine was examined by solid-state composting vegetation under field conditions. Treatment of mine soil with the 2 biocatalysts for 5 months resulted in pH increase and electric conductivity reduction compared to untreated control. Further analyses revealed that the microbial catalysts also promoted the root and shoot growth to the untreated control during the vegetation treatments. After the Sporosarcina pasteurii or plant extract based BNG treatment, the microbial community change was monitored by culture-independent pyrosequencing. These results demonstrate that the microbial biocatalysts could potentially be used in the soil bioremediation from mine-impacted area.

우리나라 에코세대의 자살생각과 관련요인: 2012년도 한국의료패널 자료를 이용하여

박민정,Park, Min Jeong 한국가정간호학회 2016 가정간호학회지 Vol.23 No.1

Purpose: This study investigated the factors associated with suicidal ideation in the Korean Echo Generation using 2012 Korea Health Panel Data. Methods: The 2012 Korea Health Panel Data were collected from February 2012 to July 2012 and included 2,303 people who responded to a question asking whether they had experienced suicidal ideation. The data were analyzed by chi-square and multiple logistic regression test using SPSS 22.0. Results: The rate of suicidal ideation was 4.2% in the Echo Generation. Factors associated with suicidal ideation in the Echo Generation revealed that the following variables increased the rate of suicidal ideation: sex(odd ratio: 2.39, CI: 1.39-4.09), education(odd ratio: 1.95, CI: 1.08-3.52), depression(odd ratio: 12.06, CI: 6.92-21.03), frustrating experience(odd ratio: 2.52, CI: 1.22-5.20), anxiety about the future(odd ratio: 14.58, CI: 3.20-66.41), self-rated health status(odd ratio: 2.39, CI: 1.39-4.09 and odd ratio: 6.41, CI 2.87-14.33). Conclusion: This study provides a preliminary examination of the factors associated with suicidal ideation in the Echo Generation. A more careful examination may be warranted.

한양방치료를 병행한 안성 대상포진 환자 치험 1례

박민정,양정윤,김수현,조기호,문상관,권승원,정우상,Park, Min-jeong,Yang, Jung-yun,Kim, Soo-hyun,Cho, Ki-ho,Moon, Sang-kwan,Kwon, Seung-won,Jung, Woo-sang 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.2

A case of a 72-year-old Korean male with herpes zoster ophthalmicus revealed. He was treated with Korean-Western cooperative treatment. We used the Numeric Rating Scale (NRS) to evaluate forehead and eye pain. Pain was improved after the administration of Korean medical treatments and disappeared after eight days. Korean-Western cooperative treatment may be effective in treating acute herpes zoster ophthalmicus.

갈색 느티만가닥버섯 추출물의 부위별 항산화 활성

박민정,유찬열,조수정,Park, Min Jeong,Yu, Chan Yeol,Cho, Soo Jeong 한국버섯학회 2021 한국버섯학회지 Vol.19 No.4

본 연구에서는 기능성 식의약품 소재로써 갈색 느티만가닥버섯(Hypsizygus marmoreus)의 이용 가능성을 조사하기 위해 갈색 느티만가닥버섯의 부위별, 추출 용매별 항산화 활성을 조사하였다. 열수 추출물 갓과 대의 총 폴리페놀 함량은 17.15±0.19 mg GAE/g과 7.37±0.16 mg GAE/g이었으며 에탄올 추출물 갓과 대의 총 폴리페놀 함량은 각각 10.23±0.14 mg GAE/g과 3.76.±0.19 mg GAE/g으로 에탄올 추출물에 비해 열수 추출물의 폴리페놀 함량이 높게 나타났고 대에 비해 갓의 폴리페놀 함량이 높게 나타났다. 또한 갈색 느티만가닥버섯 추출물의 DPPH, ABTS, ORAC 지수, 환원력도 10 mg/ml의 농도에서 에탄올 추출물에 비해 열수 추출물에서 높게 나타났고 대에 비해 갓에서 높게 나타났으며 흰색 느티만가닥버섯에 비해 갈색 느티만가닥버섯의 총 폴리페놀 함량, DPPH, ORAC 지수, 환원력이 높은 것으로 나타났다. 추출물의 세포독성은 WST-1 assay (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulphonate)를 이용하여 열수 추출물의 처리 농도에 따른 대식세포주 RAW 264.7의 세포 생존율로 확인하였으며 갈색 느티만가닥버섯 열수 추출물 처리구에서 대식세포주 RAW 264.7의 세포 생존율이 증가하였기 때문에 세포독성은 없는 것으로 판단된다. 이상의 결과를 종합하면, 느티만가닥버섯은 품종에 따라 항산화 활성에 차이가 있고, 갈색 느티만가닥버섯은 다른 버섯보다 항산화 활성이 높기 때문에 기능성 식의약품 소재로서 이용 가능성이 있다고 판단된다. This study was carried out to evaluate potential of Hypsizygus marmoreus (brown cultivar) as a functional food and drug materials. H. marmoreus were divided into pileus and stipe and extracted in hot water and 80% ethanol. The total polyphenol content was highest in the hot water extracts (pileus 17.15±0.19 mg of GAE g, stipe 7.37±0.16 mg of GAE/g) and pileus compared to the ethanol extracts (pileus 10.23±0.14 mg of GAE/g, stipe 3.76.±0.19 mg of GAE/g) and stipe. Also, hot water extracts of pileus from H. marmoreus (brown cultivar) was more effective DPPH, ABTS, ORAC value, reducing power than ethanol extracts and stipe extracts. The pileus and stipe extracts were confirmed to be non-cytotoxic in the mouse macrophage cell line RAW 264.7 determined by WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulphonate) assay. Overall, extracts of H. marmoreus (brown cultivar) was higher antioxidant activity than other mushrooms, and no cytotoxicity. Therefore, H. marmoreus (brown cultivar) showed potential as a functional food and drug materials. The brown cultivar of H. marmoreus have higher antioxidant activity than white cultivar, H. marmoreus seem to have different antioxidant activity depending on the cultivar.

마이크로데이터 공표를 위한 통계적 노출제어 방법론 고찰

박민정,김항준,Park, Min-Jeong,Kim, Hang J. 한국통계학회 2016 응용통계연구 Vol.29 No.6

학술 연구나 정책 입안 등을 위한 심층적 자료 활용의 확대는 동시에 개별 정보 노출에 대한 염려도 증가시킨다. 때문에 최근 이십여 년 간 통계적 노출제어(정보보호) 분야에서 많은 논문들이 발표되었다. 본 논문은 그러한 연구 내용들을 정리하여 국내 통계인들과 기관들에게 소개하고자 한다. 주요 내용으로 국소통합이나 잡음추가와 같은 전통적인 매스킹 기법 뿐만 아니라, 온라인 자료 분석 시스템에서의 정보보호 처리, 차등정보보호를 통한 노출제어 및 재현자료를 활용한 정보보호 대안 모색에 대해 다룬다. 또한 각각의 주제에 대한 방법론 소개와 함께 활용 사례 및 장단점을 논의하였다. 본 논문이 실제적인 통계적 노출제어 문제를 고민하는 통계인들에게 도움이 되기를 바란다. The increasing demand from researchers and policy makers for microdata has also increased related privacy and security concerns. During the past two decades, a large volume of literature on statistical disclosure control (SDC) has been published in international journals. This review paper introduces relatively recent SDC approaches to the communities of Korean statisticians and statistical agencies. In addition to the traditional masking techniques (such as microaggregation and noise addition), we introduce an online analytic system, differential privacy, and synthetic data. For each approach, the application example (with pros and cons, as well as methodology) is highlighted, so that the paper can assist statical agencies that seek a practical SDC approach.

경제활동인구조사 자료를 위한 다중대체 방식 연구

박민정,배윤종,김정연,Park, Min-Jeong,Bae, Yoonjong,Kim, Joungyoun 한국통계학회 2021 응용통계연구 Vol.34 No.5

경제활동인구조사는 고용 관련 통계를 생성하는 국가조사로서, 국민의 경활상태(취업/실업/비경활)를 파악하는 것이 주요 목적이다. 정확한 통계를 내기 위해 무응답률을 낮추는 것이 중요하고, 이미 발생한 무응답을 보완하기 위한 방법으로 무응답 대체가 가능하다. 경제활동인구조사는 응답 방식이 순차적 흐름을 따라가기 때문에 구조적인 무응답이 존재한다. 또한 전체 가구원내 무응답 항목이 하나라도 있으면 해당 가족 구성원 전체를 무응답 처리하기에 최종 자료에는 항목 무응답이 아닌 단위 무응답만 존재한다는 특징이 있다. 본 연구에서는 구조적 무응답 이해 및 연계자료를 통한 과거 자료의 활용 등을 통해 기존의 방법보다 효과적인 무응답 대체 모형을 제시하고자 한다. 대체 모형의 성능을 일치도/비일치도를 기반으로 평가한다. 이를 위해, 2019년 11월 경제활동인구조사 자료를 기반으로 모의실험을 실시한다. 총 59,996명의 응답자 중 일부를 랜덤하게 선택한 뒤, 경활상태를 판정하는데 결정적인 설명변수 6개와 경활상태를 무응답 처리한다. 기존 무응답 대체 모형에서 사용하였던 설명 변수 이외에 산업변수와 종사상지위 변수를 추가함으로써 모형을 개선한다. 이는 과거자료의 연계 및 활용을 가정한 것으로, 기존의 모형모다 성능이 향상되는 것을 확인한다. 또한, 경활상태별 무응답자 수에 대한 다양한 시나리오를 고려한다. The Korean Economically Active Population Survey (KEAPS) is a national survey that produces employment-related statistics. The main purpose of the survey is to find out the economic activity status (employed/ unemployed/ non-employed) of the people. KEAPS has a unique characteristics caused by the survey method. In this study, through understanding of structural non-response and utilization of past data, we would like to present an improved imputation model. The performance of the proposed model is compared with the existing model through simulation. The performance of the imputation models is evaluated based on the degree of mathing/nonmatching rates. For this, we employ the KEAPS data in November 2019. For the randomly selected ones among the total 59,996 respondents, the six explanatory variables, which are critical in determining the economic activity states, are treated as non-response. The proposed model includes industry variable and job status variable in addition to the explanatory variables used in the precedent research. This is based on the linkage and utilization of past data. The simulation results confirm that the proposed model with additional variables outperforms the existing model in the precedent research. In addition, we consider various scenarios for the number of non-responders by the economic activity status.

불면을 호소하는 Lewy's body dementia 환자 치험 1례

박민정,이미림,김경묵,조기호,문상관,권승원,정우상,Park, Min-jeong,Lee, Mi-rim,Kim, Gyeong-muk,Cho, Ki-ho,Moon, Sang-kwan,Kwon, Seung-won,Jung, Woo-sang 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

The patient was a 69-year-old Korean male with Lewy's body dementia and insomnia. He was treated with acupuncture and a herbal medicine, Ukan-san. To evaluate insomnia, the patient's total sleeping time was recorded. The patient's sleeping time increased after the administration of the Korean medicine treatments. Treatment with Korean medicine may be effective in treating insomnia in cases of Lewy's body dementia.

The Effect of Topiramate on Hippocampal Neuronal Death and Expression of Glutamate Receptor in Kainate-induced Status Epilepticus Model

박민정,하세운,배혜란,김상호,Park Min-Jeong,Ha Se-Un,Bae Hae-Rahn,Kim Sang-Ho Korean Society of Life Science 2005 생명과학회지 Vol.15 No.3

신경흥분독성과 간질발작발현은 glutamate 수용체활성과 연관이 있다고 알려져 있다. a-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA), kainate 수용체에 대한 glutamate 활성을 포함하는 다양한 기전을 가진 항전간제인 Topiramate는 신경보호작용을 가진다는 증거가 제시되어 Topiramate가 간질발작 후 해마의 glutamate 수용체 발현에 미치는 효과를 관찰하였다. 흰쥐에 kainate를 복강 내 주사하여 간질중첩증을 유발시킨 후 Topiramate를 1주일 주사하였다 Apop tag in situ detection kit를 이용하여 세포손상을 관찰한 결과 kainate 유발 간질중첩증 1주일 후 해마의 CA1, CA3에서 심각한 세포사를 보였으나, Topiramte 처리 군에서는 세포사가 현저히 감소하였다. 간질중첩증 이후 NMDA 수용체 아형 1,2a, 2b 발현이 현저히 증가했으나 Topiramate 처치에 의해 NMDA수용체의 발현에는 뚜렷한 변화가 없었다. AMPA수용체에서는 GluR1이 간질중첩증 이후 현저히 상향 조정되었고 GluR2는 현저히 하향조정 되었다 Topiramate 1주일 처리 시 간질중첩증으로 인해 변화된 CluR1과 GluR2의 발현이 역전되었다. 결론적으로 Topiramate는 간질중침증에 의한 CluR1/CluR2 발현비의 증가로 유발되는 흥분성 신경세포사를 억제시킴으로써 신경보호작용이 있는 것으로 보인다. Excitotoxicity and epileptogenesis have often been associated with glutamate receptor activation. Accumulating evidences indicates that topiramate (TPM), an antiepileptic drug with multiple mechanisms of action has neuroprotective activity. We explored the neuroprotective effect of TPM on the status epilepticus (SE)-induced hippocampal neuronal death. After development of SE by kainite injection (15 mg/Kg), rats were treated with TPM (10mg/kg) for 1 week. The neuronal death was detected by Apop tag in situ detection kit, and the expression levels of glutamate receptors were semi-quantitatively analyzed by immunoblot. Kainate-induced SE caused a significant neuronal death and cell loss in CAI and CA3 regions of hippocampus at 1 week. However, treatment of TPM for 1 week after SE markedly reduced hippocampal neuronal death. The expression of N-methyl-D-aspartate (NMDA) receptor subunit 1, was increased by SE, but was not affected by 1 week treatment of TPM. The expressions of NMDA receptor subunit 2a and 2b were not changed by either SE or TPM. As for ${\alpha}-amino-3-hydroxy-5-methyl-4-isoxazole-propionate$ (AMPA) glutamate receptors (GluR), kainate-induced SE markedly up-regulated GluR1 expression but down-regulated GluR2 expression, leading to increased formation of $Ca^{2+}$ permeable GluR2- lacking AMPA receptors. TPM administration for 1 week attenuated SE-induced expression of both the up-regulation of GluR1 and down-regulation of GluR2, reversing the ratio of GluR1/GluR2 to the control value. In conclusion, TPM protects neuronal cell death against glutamate induced excitotoxicity in kainate-induced SE model, supporting the potential of TPM as a neuroprotective agent.

회전근개 부분파열 환자에 대한 한의학적 치료 증례보고

박민정 ( Min Jung Park ),민선정 ( Seon Jeong Min ),유경곤 ( Kyung Gon You ),염승룡 ( Seung Ryong Yeam ),권영달 ( Young Dal Kwon ),김성하 ( Sung Ha Kim ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.2

Objectives :This study was performed to report the effect of the conservative oriental medical treatment in the patient with rotator cuff partial tear. Methods :37 year old man lifting heavy package repeatedly was diagnosed with supraspinatus and subscapularis tendon partial tear on left shoulder magnetic resonance imaging(MRI). This patient underwent severe left shoulder pain and range of motion(ROM) limitation. We treated him by acupuncture, a bee venom injection, a herbal medicine, cupping and moxa treatment, physical therapy from January 28th 2011 to April 2nd 2011. Within this treatment period of time, we measured visual analogue scale(VAS), ROM and physical examination changes. Results :After these treatments, shoulder ROM and physical examination recovered signifcantly and static VAS score changed 9 to 0, kinetic VAS score changed 10 to 0.5. Conclusions :In this study, oriental medical treatment was effective in the patient with partial tear of rotator cuff. But this treatment tends to take a long time, so patients with severe pain may give up conservative treatment and choose an operation in a short period of time. Thus, if the more various case studies are reported, patients will follow conservative oriental treatment with confidence.

CNN 모델 기반의 공유 전동킥보드 주차 판단 시스템 구현

박민정 ( Min-jeong Park ),황성업 ( Sung-up Hwang ),김나희 ( Na-hee Kim ),서승현 ( Seung-hyun Seo ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.1