영상의 영역 분할과 이중선형 보간행렬을 이용한 멀티모달 의료 영상의 정합

김양욱,박준,Kim, Yang-Wook,Park, Jun 대한의용생체공학회 2009 의공학회지 Vol.30 No.1

Transforms including translation and rotation are required for registering two or more images. In medical applications, different registration methods have been applied depending on the structures: for rigid bodies such as bone structures, affine transformation was widely used. In most previous research, a single transform was used for registering the whole images, which resulted in low registration accuracy especially when the degree of deformation was high between two images. In this paper, a novel registration method is introduced which is based image sub-division and bilinear interpolation of transformations. The proposed method enhanced the registration accuracy by 40% comparing with Trimmed ICP for registering color and MRI images.

투석 : 국내 혈액투석여과요법의 현황

김양욱 ( Yang Wook Kim ),신기호 ( Ki Ho Shin ),문광백 ( Kwang Baek Moon ),신석균 ( Sug Kyun Shin ),김현철 ( Hyun Chul Kim ) 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1

부산항 신항 배후단지 입주업체 특성별 생산성 비교연구

김양욱(Yang-Wook Kim),차재웅(Jae-Ung Cha),김율성(Yul-Seong Kim) 한국항해항만학회 2020 한국항해항만학회지 Vol.44 No.6

우리나라는 항만의 기능 다각화 및 부가가치 창출을 목표로 국내 주요 무역항에 항만배후단지를 단계적으로 개발해왔다. 그러나 이러한 목표를 달성하기 위한 배후단지 입주업체 선정기준에 관한 연구는 아직 부족한 실정이다. 본 연구는 부산항 신항 배후단지를 대상으로 입주업체 특성별 생산성을 비교분석하여 입주업체 선정기준 마련에 기여하고자 하였다. 분석을 위해 67개 업체들의 최근 3년(2017-2019)간 운영실적 자료를 수집하여 단일요소생산성을 측정하였다. 그 결과, 물류업은 물동량, 제조업은 매출액 측면의 생산성에 강점이 있는 것으로 나타났다. 또한, 상대적으로 개장시기가 빨랐던 북컨테이너 배후단지가 웅동 배후단지에 비해 전반적인 생산성이 높았다. 마지막으로 외국인과 시설·설비 투자규모에 따른 생산성의 경우 전반적으로 투자규모가 평균 미만인 업체들이 평균 이상인 업체들보다 생산성이 높은 것으로 분석되어 부정적인 상관관계를 보였다. 따라서 항만배후단지의 생산성 및 경쟁력을 강화하기 위해서는 입주업체들의 고용 및 화물 창출 능력을 제고할 수 있는 제도적·법률적 보완과 신규 입주업체 선정기준의 재확립이 필요하다고 판단된다. Korea has gradually been developing port distriparks in major domestic trade ports to diversify their function and create added-value. New tenant companies are needed to help achieve these goals, but no research has been done on selection criteria. To provide such criteria, this study conducted a comparative analysis of the productivity of tenant companies in Busan New Port Distripark based on their characteristics. SFP (single-factor productivity) was measured using the operational data of 67 companies in the distripark over the past - three years (2017-2019). The results indicate that the logistics business and the manufacturing business have strengths in cargo volume productivity and in sales productivity respectively. Also, Northern distripark, a relatively older facility, was found to be more productive than Ung-dong distripark. Finally, the effect of investment—both foreign and in FAC/EQ (facility and equipment)—on productivity showed an inverse relationship with productivity, with the companies with under-average investments being more productive than those whose investments were above average. Therefore, to enhance the productivity and competitiveness of port distriparks, tenant companies must be subject to supplemented system and law for increasing employment and cargo volume, and reestablished selection criteria.

소아 신장이식 후 성장에 대한 평가

이지웅,김정수,김양욱,김영훈,윤영철,정우영,Lee, Ji-Woong,Kim, Jung-Soo,Kim, Yang-Wook,Kim, Young-Hoon,Yoon, Young-Chul,Chung, Woo-Yeong 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2

Purpose : We aim to identify the clinical and demographic characteristics in children who underwent renal transplantation(RTx) and to evaluate the influence on growth of RTx in children. Methods : We reviewed 17 medical records of chronic renal failure patients who underwent RTx from April 1992 and June 2004 at Busan Paik Hospital. Age and sex distribution, cause of disease, donor analysis, patient and graft survival rate, and the status of growth after RTx were analysed by retrospective study. Results : Eighteen RTx were performed in 17 patients(8 boys, 9 girls). The mean age at the time of RTx was $15.8{\pm}3.5$ years and the mean duration of dialysis therapy before RTx was $22.4{\pm}18.0$ months. The 1 year and 5 year patient survival rate were each 100%, and the 1 year and 5 year graft survival rate were 88%, 36% respectively. The most common cause of graft failure was chronic rejection. The mean final height of male patients was $162.8{\pm}10.0$ cm(143.0-172.5 cm) and of female patients was $154.5{\pm}12.1$ cm(135.8-160.0 cm). The mean height standard deviation score(Ht SDS) increased after RTx from -1.95 to -1.53 but the increment rate was not statistically significant. Similar changes were noted in individual patient analysis. Also there was no significant difference between the living-related donors and cadaveric donors. Conclusion : Our data shows that even successful RTx rarely results in full growth rehabilitation. To overcome retarded growth in children with chronic renal failure, appropriate combined management of metabolic and nutritional problems, correction of anemia, proper use of recombinant growth hormone therapy, early renal transplantation and shortening of the duration of dialysis would be necessary.

장 정결 후 발생한 정상 신기능에서의 고마그네슘혈증

김태홍 ( Taehong Kim ),김태형 ( Tae Hyung Kim ),이원혁 ( Won Hyuk Lee ),이유진 ( Yoo Jin Lee ),박시형 ( Sihyung Park ),박봉수 ( Bong Soo Park ),김양욱 ( Yang Wook Kim ) 대한내과학회 2016 대한내과학회지 Vol.91 No.3

대장 내시경 검사에서 장 정결은 필수적인 조건이며, 이를 위해선 장 정결제가 반드시 필요하고 정결제는 각기 다른 특성을 지니고 있다. 따라서 정상 신기능을 가진 환자라도 대장 내시경의 목적 및 환자의 증상에 따라 장 정결제 선택에 주의를 해야 할 것으로 생각된다. Most reported cases of hypermagnesemia are related to laxative abuse and impaired renal function, while hypermagnesemia is uncommon without iatrogenic magnesium administration and decreased renal function. Magnesium-containing bowel-cleansing agents are widely used before colonoscopy, usually without complications. However, we experienced a case of symptomatic hypermagnesemia with normal renal function after using a bowel-cleansing agent. A 74-year-old man with normal renal function complained of lethargy and motor weakness after taking a bowel-cleansing agent containing 14 grams of magnesium before a colonoscopy for hematochezia. His magnesium level was 12 mg/dL. Fluid stasis in the gut due to colonic obstruction might have caused the hypermagnesemia. He was treated successfully with a bowel enema and intravenous calcium. We should be cautious when prescribing drugs for colonoscopy if colonic obstruction is suspected. (Korean J Med 2016;91:306-310)

증례 : 신장 ; 막성사구체신염과 동반된 폐포단백증 1예

박봉수 ( Bong Soo Park ),김양욱 ( Yang Wook Kim ),김현국 ( Hyun Kuk Kim ),노태훈 ( Tae Hoon No ),서민교 ( Ming Yo Seo ),김연미 ( Yeon Mee Kim ),진규복 ( Kyu Bok Jin ) 대한내과학회 2014 대한내과학회지 Vol.87 No.2

막성사구체신염 및 폐포단백증의 발생에는 자가면역 기전이 중요한 역할을 하는 것으로 알려져 있다. 우연히 동시에 두 질환이 발생하였는지 혹은 공통된 자가항체를 가지는지는 명확하지 않다. 이에 대한 더 많은 증례보고와 추가적인 연구가 필요할 것으로 생각된다. Membranous glomerulonephritis is one of the most common causes of nephrotic syndrome in adults. Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which abnormal accumulation of surfactant occurs within the alveoli. We describe a 61-year-old man with concurrent membranous glomerulonephritis and PAP, which is very rare; both are pathophysiologically related to an abnormal immune response. A patient came to hospital with leg edema but no respiratory symptoms. Chest X-ray and CT showed classical PAP findings, which are ground-glass opacities with interlobular septal thickening, in both lung fields. A bubbly whitish secretion retrieved via broncho-alveolar lavage showed neutrophils and lymphocytes as well as Periodic acid-Schiff-positive proteinaceous materials. A kidney biopsy revealed findings of membranous glomerulonephritis with irregular subepithelial deposits by electron microscopy. At 1 year after diagnosis, the membranous glomerulonephritis was well under control with steroids and mycophenolate mofetil but PAP became aggravated gradually and whole-lung lavage was needed. (Korean J Med 2014;87:215-218)

비외상성 횡문근융해증의 임상적 고찰

강선우 ( Sun Woo Kang ),김양욱 ( Yang Wook Kim ),김영훈 ( Yeung Hoon Kim ) 대한내과학회 2004 대한내과학회지 Vol.67 No.5

증강현실을 이용한 직관적인 제품 디자인 방법

진윤석(Yoon-Suk Jin),김양욱(Yang-Wook Kim),김보미(Bo-Mi Kim),박준(Jun Park),이상국(Sang-Goog Lee) 한국정보기술학회 2009 한국정보기술학회논문지 Vol.7 No.4

Designers often create 3D virtual models and evaluate design results through display devices such as a monitor. Comparing with traditional design processes where almost every step is performed manually, designers may reduce effort, time, and expense using CAD tools. However, replacing traditional materials and mock-ups with 3D CAD systems, designers are faced with the intangibility problem, unable to physically interact with test products in early stages of design process. In this paper, we introduced an Augmented Reality based Rapid Prototyping method that enables designers to grasp, touch, and interact with the design products. Using this method, users may assemble a product mockup, and observe and interact with the augmented design product by changing colors, textures, and UI layers. Users are also allowed to manipulate through touching the UI buttons.

혈액 투석막에 따른 말초 혈액 단핵세포의 Interleukin 1 , Iterleukin 6 , Tumor necrosis Factor 생산능에 관한 연구

김영훈(Yeong Hoon Kim),임대건(Dae Geon Lim),조현대(Hyun Dae Cho),김양욱(Yang Wook Kim),박원도(Won Do Park),안재형(Jae Hyung Ahn),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.6

N/A Objectives: In order to evaluate the role of these cytokines in biological response induced by blood interaction with hemodialysis membranes. Methodes: We have investigated the IL-1, TNF and IL-6 concentrations in the supernatant of 24-hours cultured peripheral blood mononuclear cells (PBMC) without(spontaneous group) or with broken cuprophan or P1VMA membranes in 9 chronic hemodialyzed patients and 8 healthy controls. The blood samples were drawn before dialysis using following criteria: (a) in last dialytic treatment with PMMA membranes(HDEl), (b) after two weeks of dialytic treatment wih cuprophan membranes(HDE2), Results: In the both of patient group(HDE1 and HDE2) and controls production of IL-l, TNF and IL-6 of PBMC stimulated with cuprophan or PMMA membrane particles was increased compared to those of spontaneous group. IL-1 production of HDE1 stimulated PMMA(99.31±30.15fmol/ml) was significantly higher compared to that of cuprophan(48.43±11.29fmol/ml), TNF production of HDE2 with cuprophan(114.86±38.5lfmoVml) was significantly high compared to that of spontaneous group(52.42±29.94fmol/ml). IL-6 production of HDE2(646.70±103.84fmol/ml) was significantly high compared to that of spontaneous group(385.88±87.03fmoVml). Comparing cytokine production of PBMC, there was a significant correlation between IL-1 and IL-6(r=0.78), IL- 1 and TNF(r=0.78) and TNF and IL-6(r=0,76). Conclusion: Our results show that the interaction of cuprophan or PMMA membranes with blood increase the production of IL-1, TNF and IL-6. We suggest that in patients undergoing routine hemodialysis PBMC are primed by exposure to chronic stimulation.

신장이식 환자에서 Rifampin과 Cyclosporine의 약동학적 상호작용

손지홍,윤영란,김경아,박지영,차인준,김양욱,김영훈,신재국,Shon, Ji-Hong,Yoon, Young-Ran,Kim, Kyoung-Ah,Park, Ji-Young,Cha, In-June,Kim, Yang-Wook,Kim, Young-Hoon,Shin, Jae-Gook 대한임상약리학회 2000 臨床藥理學會誌 Vol.8 No.1

Background: We present a case whose plasma cyclosporine concentrations were markedly decreased after adding antituberculosis medications. To assess the effect of rifampin on this pharmacokinetic interaction, we evaluated the pharmacokinetic changes of cyclosporine in kidney-transplanted patients with tuberculosis before and after withdrawing rifampin. Methods : Two separate full pharmacokinetic studies of cyclosporine were performed in four kidney recipients with tuberculosis before and one month after withdrawing rifampin from antituberculosis medications. Multiple blood samples were repeatedly drawn after morning oral dose of cyclosporine, and cyclosporine concentrations were determined by HPLC method. Pharmacokinetic parameters were estimated from noncompartmental method using $WinNonlin{\circledR}$ Results : After withdrawing rifampin, changing patterns of all pharmacokinetic parameters were consistent in all 4 subjects. Corrected Cmax and AUC estimated on the same 100mg dose basis were significantly increased from $291.1{\pm}54.1$ ng/ml to $950.7{\pm}174.7$ ng/ml and from $1483.1{\pm}92.0$ ng/ml ${\cdot}$ h to $6047.2{\pm}666.6$ ng /ml ${\cdot}$ hr, respectively (p<O.Ol). Total oral clearance (Cl/F) estimated during administration of rifampin ($19.8{\pm}3.5$ L/kg) was decreased to $6.0{\pm}0.9$ L/kg after withdrawing rifampin. However, the prolongation of halflife was not statistically significant $(6.1{\pm}1.7 hour vs)$ $10.6{\pm}1.1)$. Conclusions : These results strongly suggest that rifampin markedly decrease the plasma concentration of cyclosporine coadministered through pharmacokinetic interaction, and careful dose readjustment should be considered from frequent monitoring of plasma cyclosporine concentrations in patients taking both cyclosporine and antituberculosis medications including rifampin.