연부조직육종의 수술후 방사선 치료결과

김연실(Yeon Shil Kim),장홍석(Hong Seok Jang),윤세철(Sei Chul Yoon),유미령(Mi Ryeong Ryu),강기문(Ki Moon Kang),정수미(Su Mi Chung),김훈교(Hoon Kyo Kim),강용구(Yong Koo Kang) 대한방사선종양학회 1998 Radiation Oncology Journal Vol.16 No.4

목 적 : 최근들어 연부 조직 육종의 치료방법이 광범위 구획절제에서 사지기능을 보존하는 제한적 수술과 방사선/항암화학요법의 다병용치료로 변환되고 있으며 광범위 수술과 유사한 치료성적을 거두고 있다. 저자들은 수술후 방사선 치료를 시행한 연부 조직 육종 환자를 대상으로 치료 결과 및 실패 양상을 알아보고 관련된 예후 인자를 분석하여 수술 후 방사선치료의 역할을 알아보고자 하였다. 대상 및 방법 : 대상환자는 1983년부터 1994년까지 치료한 60명이었고 모두 추적관찰이 가능했으며 평균 추적기간은 50개월이었다. 원발병소는 상·하지가 35례(58%)로 가장 많았고 체간 12례(20%), 두경부 7례(12%)였으며 병리학적 유형에 따른 구분은 악성섬유구종 14례(23%),지방육종이 10례(17%), 악성신경섬유종 7례(12%) 등 이었다. 전체환자중 6례를 제외하고는 조직학적등급의 분석이 가능했고 grade I, II, III가 각각 27례(45%), 3례(5%), 24례(40%)였다. 수술적 절제는 19례(32%)에서 광범위절제, 36례(60%)에서 변연절제, 5례(8%)에서 국소절제를 시행하였다. 방사선치료선량은 28.8- 80Gy였고 25례에서 방사선치료와 함께 항암화학 요법을 병용하였다. 결 과 : 최종분석 시 실패 양상은 국소재발이 20례(25%), 원격전이 7례(12%), 국소재발과 원격전이를 동반한 경우가 14례(23%)였다. 원격전이한 환자는 구제치료와 상관 없이 모두 사망하였고 국소재발한 환자중 5명이 구제치료에 성공하여 무병생존하였다. 전체환자의 2년 및 5년 국소제어률은 68.0%와 48.7%로 비교적 저조한 결과를 보였다. 국소제어율에 영향을 미친 예후인자는 조직학적 유형, AJCC 병기, 조직학적 등급, 수술의 범위, 수술절연 침범 유무 및 잔존종양 정도, 림프절 전이 유무(p <0.05)였다. 전체 환자의 5년 생존률과 5년 무병생존률은 각각 60.4%, 36.6%였고 평균 생존기간은 89개월이었다. 단변량 분석에 의한 생존률에 영향을 미친 예후인자로는 조직학적 유형, AJCC 병기, 림프절 전이 유무, 조직학적 등급, 수술절연 침범 유무와 잔존 종양 정도 였다. 결 론 : 결론적으로 본 연구 결과 연부 조직 육종에서 제한적 수술과 수술 후 방사선치료로 비록 저조한 국소제어률을 보였으나 사지 절단 혹은 광범위 구획절제와 비교시 유사한 생존률을 얻었다. Purpose : The major goal of the therapy in the soft tissue sarcoma is to control both local and distant tumor. However, the technique of obtaining local control has changed significantly over the past few decades from more aggressive surgery to combined therapy including conservative surgery and radiation and/or chemotherapy. We retrospectively analyzed the treatment results of the postoperative radiation therapy of soft tissue sarcoma and its prognostic factor. Materials and Methods : Between March 1983 and June 1994, 60 patients with soft tissue sarcoma were treated with surgery and postoperative radiation therapy at Kang-Nam St. Mary's hospital. Complete follow up was possible for all patints with median follow up duration 50 months (range 6 - 162 months). There were 28 male and 32 female patients. Their age ranged from 6 to 83 with a median of 44 years. Extremity (58%) was the most frequent site of occurrence followed by trunk (20%) and head and neck (12%). Histologically malignant fibrous histiocytoma (23%), liposarcoma (17%), malignant schwannoma (12%) constitute 52% of the patients. Daily radiation therapy designed to treat all areas at a risk for tumor spread upto dose of 4500-5000 cGy. A shrinking field technique was then used and total 55-65 Gy was delivered to tumor bed. Twenty-five patients (42%) received chemotherapy with various regimen in the postoperative period. Results : Total 4 1 patients failed either with local recurrence or with distant metastasis. There were 29 patients(48%) of local recurrence. Four patients (7%) developed simultaneous local recurrence and distant metastasis and 8 patients (13%) developed only distant metastasis. Local recurrence rate was rather higher than of other reported series. This study included patients of gross residual, recurrent cases after previous operation, trunk and head and neck prima ry. This feature is like ly explanation for the decreased loca l control rate . Five of 29 patients who fa iled only loca lly were salvaged by re- excis ion and/or re- irradiation and rema ined free of disease . Factors affecting loca l control include histologic type , grade, stage , extent of operation and surgica l ma rgin involvement, lymph node metastas is (p <0.05). All 21 patients who fa iled distantly are dead with progress ive disease at the time of this report. Our overall survival results are similar to those of larger series . Actuarial 5 year overall survival and disease fresurvival were 60.4 %, 36.6% respectively. Grade, stage (being close association with grade), residual disease (negative ma rgin, microscopic, gross) were significant as a predictor of survival in our series (p <0.05). Conclusion : Combined surgery and postoperative radiation therapy obtained 5 year survival rate comparable to that of radical surgery.

[論文] 마이크로 콤퓨터를 이용한 차량용 엔진 제어에 관한 기초 연구

강기문(Ki Moon Kang),전병실(Byoung Sil Chon),황준택(Jun Teak Hwang) 한국자동차공학회 1985 오토저널 Vol.7 No.3

In order to control ignition advance angle,this system is designed with Z-80 CPU, CTC(Counter Timer Circuit), PIO (Parallel Input Output), A/D Converter and Memory, etc.<br/> Serial pulses from speed sensor and analog voltage from pressure sensor are converted to digital data.<br/> In order to reduce the error of ignition advance angle output, the reference of ignition advance angle output is set 56.25 before TDC (Top Dead Center).<br/> The table of ignition advance angle and program which have a main routine and subroutines are writtern into ROM(1K-byte),<br/> The experimental result of this system is correspondent to the theoretical values of proposed ignition advance angle table.<br/> This system can be utilized to any other type of 4 cylinder vehicles for advance angle control by changing software.

합성 제올라이트를 이용한 해수중의 N, P 제거

강기문 ( Ki Moon Kang ),이성우 ( Sung Woo Lee ),임준혁 ( Jun Heok Lim ) 한국공업화학회 2007 응용화학 Vol.11 No.2

水平 Bridgman法에 의한 GaAs 單結晶 成長 및 Wetting에 관한 研究

姜錤文(Ki-Moon Kang),洪鳳植(Bong-Sik Hong),韓秉誠(Byoung-Sung Han),溫東萬(Dong-Man On) 대한전기학회 1986 전기학회논문지 Vol.35 No.1

메탄의 건조 개질을 위한 코어/쉘 구조를 가진 니켈 촉매의 촉매활성 연구

강기문(Ki Moon Kang),김효원(Hyo Won Kim),곽호영(Ho Young Kwak) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

Supported nickel catalysts with core/shell structure of Ni/Al₂O₃ synthesized under the multi-bubble sonoluminescence (MBSL) conditions were tested for dry reforming of methane (DRM) to produce hydrogen and carbon monoxide. The supported Ni catalyst made of 10% Ni loading on Al₂O₃ which performed best in the steam reforming of methane (97 % at 750 ℃) and in the partial oxidation of methane (96 % at 800 ℃) showed also good performance in the dry reforming of methane. The supported Ni catalysts Ni/Al₂O₃ yielded 92% methane conversion and 95 % CO₂ conversion at a reaction temperature of 800℃ with molar ratio CH₄/CO₂=1 ,which are close to the thermodynamic equilibrium values, and showed excellent thermal stability for the first 150 h.

유럽의 발효육제품 기술 개발 동향

송민석,강기문,박종세,유근주,정동순,사공헌구,최지훈,Song, Min Seok,Kang, Ki Moon,Park, Jong Se,Ryu, Geun Joo,Jeong, Dong Soon,Sagong, Hun Gu,Choi, Ji Hun 한국축산식품학회 2017 축산식품과학과 산업 Vol.6 No.1

웨이퍼 표면의 Si₃N₄ 파티클 제거를 위한 초임계 이산화탄소 세정

김용훈,최해원,강기문,안톤커랴킨,임권택,Kim, Yong Hun,Choi, Hae Won,Kang, Ki Moon,Karakin, Anton,Lim, Kwon Teak 한국청정기술학회 2018 청정기술 Vol.24 No.3

본 연구에서는 초임계 이산화탄소와 공용매 첨가물을 이용하여 실리콘 웨이퍼 표면의 $Si_3N_4$ 파티클을 제거하는 기술을 조사하였다. 우선, 몇 가지 계면활성제와 첨가제에 관한 초임계 이산화탄소 용해도 및 파티클 분산성 평가를 통하여 초임계 공정에 대한 적합성을 확인하였다. 다양한 변수를 조정하여 파티클 세정 실험을 진행하여 최적의 제거 조건을 확립하였다. 실험에 사용된 계면활성제는 파티클 제거 효과가 떨어졌으며, 실험 후 이차 오염물이 형성됨을 확인하였다. 반면 trimethyl phosphate는 IPA공용매와 미량의 HF와 혼합된 세정 첨가제로서 초임계 이산화탄소에 5 wt%로 포함한 유체로 온도 $50^{\circ}C$, 압력 2000 psi에서 $15mL\;min^{-1}$의 유속으로 4분 간 세정한 결과, 85%의 파티클 제거 효율을 나타내었다. In this study, the removal of $Si_3N_4$ particles from the surface of a silicon wafer was investigated by using supercritical carbon dioxide, the IPA co-solvent and cleaning additive chemicals. First, the solubility of several surfactants and binders in supercritical carbon dioxide solubility and particle dispersibility in the binders were evaluated in order to confirm their suitability for the supercritical cleaning process. Particle removal experiments were carried out with adjusting various process parameters and reaction conditions. The surfactants used in the experiment showed little particle removal effect, producing secondary contamination on the surface of wafers. On the other hand, 5 wt% (with respect to $scCO_2$) of the cleaning additive mixture of trimethyl phosphate, IPA, and trace HF resulted in 85% of particle removal efficiency after $scCO_2$ flowing for 4 minutes at $50^{\circ}C$, 2000 psi, and the flow rate of $15mL\;min^{-1}$.

해저에서 TNT 폭발에 의한 파이어볼의 팽창과 이에 따른 충격파 전파

곽호영(Ho-Young Kwak),강기문(Ki-Moon Kang),고일곤(Ilgon Ko) 대한기계학회 2011 大韓機械學會論文集B Vol.35 No.7

지금껏 TNT 폭발에 의한 피해를 계산하는 방법에는 몇 가지 실험에 의한 모델이 제안되었다. 본 논문에서는 fire-ball 중심에서 가스가 단열이라는 가정하에 연속방정식, 오일러 및 에너지 방정식에 대한 해석적 해를 얻어 TNT 가 폭발 후 팽창하는 fire-ball 에 대한 시간에 따른 반경의 변화를 얻었다. 급격히 팽창하는 fire-ball 에 의한 충격파의 전파는 Kirkwood-Bethe 가정에 의해 구하였다. 해저에서 TNT 가 폭발하게 되면 fire-ball 이 생성, 팽창해 기포로 거동하게 된다. 이 기포의 주기와 최대반경에 대한 계산값을 실험 값과 비교한 결과 계산 값은 실험 값과 잘 일치 하였다. Until now, several empirical models for assessing the damage due to TNT explosions have been proposed. A set of analytical solutions for the time-dependent radius of an expanding fire-ball after detonation of TNT was obtained by solving the continuity, Euler (momentum), and energy equations with a “polytrope” assumption at the fire-ball center. The shock waves developed from the rapid expansion of a fire-ball under water were obtained by using the KirkwoodBBethe hypothesis. The calculated period of bubble oscillation and the maximum radius of the bubble resulting from the fire-ball due to a violent underwater TNT explosion were in good agreement with the experimental data.

해수의 전기 분해 반응에 있어서의 극전환을 이용한 파울링 현상 제거

이성우 ( Sung Won Lee ),강기문 ( Ki Moon Kang ),이제근 ( Je Keun Lee ),이경학 ( Kyoung Hag Lee ),박현정 ( Hyun Jung Park ),임준혁 ( Jun Heok Lim ) 한국공업화학회 2008 응용화학 Vol.12 No.1

시중 판매되는 발효소시지의 이화학적 및 관능적 특성 연구

사공헌구(Hun Gu Sagong),강기문(Ki Moon Kang),박종세(Jong Se Park),정동순(Dong Soon Jeong),문병석(Byoung Seok Moon),황한준(Han Joon Hwang),유현희(Hyun Hee Yu),최지훈(Ji Hun Choi) 한국식품조리과학회 2017 한국식품조리과학회지 Vol.33 No.4

Purpose: This study was carried out to evaluate the quality characteristics of fermented sausages on the domestic market and to use as a basis data for the development of fermented sausages suitable for domestic consumers. Methods: Out of 13 commercial fermented sausages, four best-selling commercial fermented sausages were chosen. Selected fermented sausages (Romano salami, Iberico salchichon, Italian salami, and Chorizo salami) were analyzed for their physicochemical characteristics (proximate analysis, salinity, pH, water activity, thiobarbituric acid value, volatile basic nitrogen) and counts of lactic acid bacteria. Results: According to the results, water contents and pH were 28.25-40.70% and 4.9-5.1, respectively. Water activity and saltiness were 0.79-0.88 and 2.01-3.96%, respectively. Thiobarbituric acid (TBA) value and volatile basic nitrogen (VBN) were 1.95-3.18 mg/kg and 2.31-3.54 mg%, respectively. Counts of lactic acid bacteria were around 4.3×10<SUP>7</SUP>-1.6×10<SUP>8</SUP> CFU/g. Moreover, the four isolated bacteria were identified as lactic acid bacteria (Lactobacillus plantarum) and color fixing bacteria (Staphylococcus carnosus). For the sensory properties, all products received favorable evaluations due to high-class appearance, common flavor and taste. Conclusion: Fermented sausages on the domestic market had various flavors and qualities due to the different characteristics of materials, fermentation conditions, fat particle size, and so on. Therefore, we need to develop fermented sausages appropriate for Korean consumers by optimizing parameters such as pH and moisture content.