人事管理의 環境要因으로서의 最低賃金制에 關한 硏究

辛承國,權純七 龍仁大學校 1990 용인대학교 논문집 Vol.6 No.-

The purpose of this study is to explain minimum wage system as a personnel environment. In the course of Korea's industrialization, minimum wage problem now comes into existence as a primary challenge. So the Minimum Wage Law in Korea was promulgated on December 31, 1986 and has been effective since January 1, 1988. In this study, the influence of the minimum wage system on the personnel management considered as a fact in point of system. However, it is natural that the minimum wage system enhances the level of wage from the standpoint of the employer. To cope with this situation in personnel management more effectively, this study will suggest some effective solutions as follows. 1. Personnel departments must provide employees with training for increase of labor productivity. 2. Personnel departments should improve the wages and salary system of business. 3. Personnel departments should improve the relations between labor and management. And other personnel functions should be inproved in connection with above functions.

느릅나무 뿌리껍질 성분의 유방염균에 대한 항균효과

신성진,윤민호,권순경,최우영 충남대학교 농업과학연구소 1999 농업과학연구 Vol.26 No.1

젖소 유방염 병원균에 대한 느릅나무 뿌리껍질(楡白皮)의 항균활성을 검토하기 위하여 용매분획별로 시험한 결과 일반적으로 chloroform 분획이 가장 효과적이었고 butanol 및 물분획의 활성은 낮았다. 유방염균을 Fleish extract broth에서 액체 배양할 경우에 chloroform 분획을 첨가하면 생육이 억제되었으며 특히 Staphylococcus aureus 및 Streptococcus sp. No. 12는 초기생육이 현저하게 저해되는 경향을 나타내었다. Hoechst 제약의 표준방법에 의한 MIC 시험에서도 유사한 결과를 얻었다. 또한 건조한 느릅나무의 뿌리껍질 100g을 물로 추출하여 겉보기 점도 77.5 cP, 최대흡수 파장 440㎚의 황갈색 수용성 점질물 4.500㎖를 회수할수 있었다. 이를 정제 건조한 무게는 32~35g이었으며, 탄수화물 함량이 61.0±1.0%, 단백질 8.0±0.2%로서 다당이 주성분이었다. 이상의 실험결과를 통해 유백피의 용매 추출분획물은 항균활성을 나타내는 성분으로, 그리고 수용성 점질물은 흡수성과 점성이 높은 다당류로서 염증 부위에 수렴작용을 나타내는 성분으로 결론지을 수 있었다. The methanolic extracts from the elm (Ulmus davidiana var japonica) root barks which have been known as an oriental medicine Eubackpie for the treatment of edema, ulcer and inflammation were examined for their bacteriocidal effects on mastitis pathogens of milk cows. The growth of the pathogenic bacteria such as Staphylococcus aureus and Streptococcus sp. No. 12 was markedly inhibited by the chloroform fraction among the extracts, and these antibacterial activities were also supported by MIC test. Water-soluble mucilage was obtained from the root barks with a yield of 36.8∼40.2% bf dry weight basis. This substance appeared to be a kind of polysaccharide with 61.0±1.0% carbohydrate content, and to have hygroscopic and astringent properties due to its high viscosity and water absorption.

합성 알릴티오피리다진 유도체의 Carbon Tetrachloride 유발 간독성에 대한 보호효과

신혜순,권순경 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1

In order to evaluate the protective effects of five allylthiopyridazine derivatives, synthetic four 3-alkoxy-6-allylthiopyridazines and 3-chloro-6-allylthiopyridazine, on carbon tetrachloride-induced hepatotoxicity, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase were measured in rats. The activites of serum aminotransferase after carbon tetrachloride-treatment were markedly increased than normal control but those levels were decreased by the pretreatment of five allylthiopyridazine derivatives. 3-Methoxy and 3-ethoxy-6-allylthiopyridazine showed remarkable protective effects at the oral dose of 50㎎/㎏, respectively.

잠재성 소염진통작용이 있는 Hydantoin-3-Acetic Acids 및 그 유도체 합성

권순경,박명숙,신영식 德成女子大學校 藥學硏究所 1991 藥學論文誌 Vol.2 No.1

Through the Bucherer-Bergs method, new 5-alkylthio (sulfonyl)-methyl-p-x-phenylhydantoins were prepared. Hydantoin-3-acetates were synthesized by the reaction of the hydantoins and ethyl chloroacetate and through the subsequent hydrolysis of the 3-acetates with dilute sodium hydroxide hydantoin-3-acetic acids were obtained. These products are expected to exhibit antiinflammatory and analgetic activities.

Cyclooxygenase-2 저해제로서의 benzothiazine 유도체 합성과 항염작용 평가

신혜순,박명숙,권순경 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

The antiinflammatory mechanism of NSAIDs is attributed to the reduction of prostaglandin synthesis by the direct inhibition of cyclooxygenase. Inhibition of prostaglandin production in organs such as stomach and kidney can result in gastric lesions, nephrotoxicity and increased bleeding. In this study, newly designed COX-2 inhibitors, synthesized 1,2-benzothiazine derivatives, were screened in vitro for selectivity of COX-1 and COX-2 inhibition properties. Lead compounds in the structure-activity relationship were studied to synthesize new highly selective COX-2 inhibitors. To determine inhibitory effect of COX-2, synthesized 1,2-benzothiazine derivatives were screened with accumulation of prostaglandin by lipopolysaccharide (LPS) in aspirin-treated macrophages and murine macropharge cell. Some of synthesized 1,2-benzothiazine derivatives were shown to be effective as selective COX-2 inhibitory activity. Others exhibited a preferential inhibition of COX-2, although some COX-1 inhibitory activity was still present. As a conclusion, simple monomer derivatives were more active than dimer derivatives. Substitution of halogen (Br, Cl) on the benzothiazine nucleus slightly enhanced inhibition activity.

1,2-벤조디아진-3-카복서마이드 유도체 합성 및 진통작용

권순경,송윤신,장은성,이명숙 德成女子大學校 藥學硏究所 1997 藥學論文誌 Vol.8 No.1

Seven new 7-H(or bromo)-4-hydroxy-2H(or methyl)-N-(5-aralkyl-3-aminohydantoinyl) -1,2-benzothiazine-3-carboxamide-1,1-dioxide derivatives were synthesized through the condensation of 7-H(or bromo)-4-hydroxy-2H(or methyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 5-substituted-3-aminohydantoins. The analgesic activities of the synthesized compounds were investigated by Randall-Selitto assay. Most compounds exhibited lower activities but compound 6 and 7 showed higher analgesic activities than piroxicam.

상악골과 비사골동에 이환된 백악질 골화성 섬유종(cemento-ssifying fibroma)의 치험례

권대현,김신유,남정순,구명숙,이봉서,권대근,김종배 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

The cemento-ossifying fibroma is a benign fibro-osseous tumor that may behave in an aggressive pattern. Although found predominantly in the mandible, most of these unusual tumors may arise in the maxilla and paranasal sinuses. Especially these lesion in the maxilla and sinuses behave more aggressively and are more prone to recur compared to mandibular counterparts. Therefore, more radical approach may be recommended than expectant observation or curettage in the initial management of this neoplasm. This is a case report of cemento-ossifying fibroma extended to maxillary sinus and naso-ethmoidal area treated by wide surgical excision after repeated conservative treatments.

Alatoxin B_1으로 유발시킨 급·만성독성에 대한 합성 3-Alkoxy-6-allylthiopyridazine 유도체의 간보호효과

신혜순,권순경 德成女子大學校 2003 德成女大論文集 Vol.32 No.-

3-Alkoxy-6-allylthiopyridazine derivatives were synthesized and their hepatoprotective activities were studied by Aflatoxin B_1 administration. Male Sprague-Dawley rat were pretreated with 3-alkoxy-6-allylthiopyridazine derivatives at the daily oral doses of 50 ㎎/㎏ for 10 consecutive days, and during this period single dose(3.0 ㎎/㎏, i.p.) or three repeated doeses(1.0 ㎎/㎏, i.p.) of Aflatoxin B_1 injected. In the experimental result, the ratio of the liver to body weights of rats in the AFB_1-treated and control group was no different. Pretreatment with the 3-alkoxy-6-allylthiopyridazine derivatives, K6, K8, K16, K17 and K18, inhibited the body weight reduction induced by AFB_1 administration. The effect of five 3-alkoxy-6-allylthiopyridazine derivatives completely decreases in AFB_1-induced elevation of ALT and AST activities, respectively.

地域社會開發事業의 意義와 그展望에 對한 小考

崔錦紅,李順愛,吳信姬,池亭順 梨花女子大學校 師範大學 社會生活科 1961 綠友硏究論集 Vol.- No.3

Aflatoxin B_(1)으로 유발시킨 급·만성독성에 대한 합성 3-Alkoxy-6-allylthiopyridazine 유도체의 간보호효과

신혜순,권순경 德成女子大學校 藥學硏究所 2003 藥學論文誌 Vol.14 No.1

3-Alkoxy-6-allylthiopyridazine derivatives were synthesized and their hepatoprotective activities were studied by Aflatoxin B_(1) administration. Male Sprague-Dawley rat were pretreated with 3-alkoxy-6-allylthiopyridazine derivatives at the daily oral doses of 50mg/kg for 10 consecutive days, and during this period single dose (3.0mg/kg, i.p.) or three repeated doeses (1.0mg/kg, i.p.) of Aflatoxin B_(1) injected. In the experimental result, the ratio of the liver to body weights of rats in the AFB_(1)-treated and control group was no different. Pretreatment with the 3-alkoxy-6-allylthiopyridazine, K6, K8, K16, K17 and K18, inhibited the body weight reduction induced by AFB_(1) administration. The effect of five 3-Alkoxy-6-allylthiopyridazine derivatives completely decrease in AFB_(1)-induced elevation of ALT and AST activities, respectively.