후부요도 판막증 2례

유용덕,이창호,전윤수,이남규 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Posterial urethal valves represent the most common post-vesical obstructive malformation. One of the most credited pathological theories considers them an anomalous insertion of mesonephric duct into the cloca or incomplete involution of plicae colliculi. Urinary tract disorders that following posterior urethral valves include hydrouretheronephrosis and functional impairment of the entire urinary tract with consequent renal failure. Treatment of posterior urethral valves consists in their resection. In low-weight patients or in case of poor general condition, temporary external urinary bypass is feasible.

누두흉 환자에서 Nuss 금속막대 제거 전 · 후 폐 역학 변화

강규식,백남순,김천숙,안기량,권진형,김지은,유시현 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Nuss operation is one of the surgical procedure for pectus excavatum and it's method is the insertion of convex steel bar under the sternum through small bilateral thoracic incision. As the patients is growing, the thorax can be compressed gradually by steel bar. So Nuss bar needs to be removed two years after Nuss operation. This study was undertaken to assess the effect on the repiratory mechanics before and after the removal of the Nuss bar. Twenty patients with previous Nuss operation were allocated for the removal of Nuss bar. Lung mechanics (dynamic lung compliance, static lung compliance, and airway resistance), hemodynamic change (heart rate, systolic pressure, and diastolic pressure), and pulmonary gas exchange (arterial oxygen tension, arterial carbon dioxide tension, pulse oximeter saturation, and end tidal carbon dioxide tension) were measured before and after removal of Nuss bar. Respiratory mechanics (dynamic and static lung compliance, inspiratory airway resistance), pulmonary gas exchange and hemodynamic parameter were unchanged before and after the removal of Nuss bar. We concluded that lung mechanics were not changed before and after the removal of Nuss bar in the patients with pectus excavatum and the 95% patients were satisfied with operation.

페놀베타인 유도체합성(XI)

우성주,박예진,황순호,홍유화,김남재,김인종,김신규 慶熙大學校 1996 論文集 Vol.25 No.-

Tetrahydroberberine-13-one was treated with ethylchloroformate to give the C_8-N bond cleaved product 1. On the treatment with Lawesson's reagent (LAS), chloroketone 2 derived from the hydrolysis of 1 afforded the thioketone 3. On the other hand, spirotype-chloroketone 4 was transformed to diaziridine 8 by a reduction, chlorination and aziridine introduction. Also, spirotype-chlorothioketone 6 was obtained from chloroketone 4.

Fuzzy Simulation of a Multi-electronic Acupuncture System and Clip-type Pulsimeter Equipped with a Magnetic Sensing Hall Device

You-Sik Hong,Jin-Kyu Rhee,Han-Kyu Kim,Il-Ho Son,Woo-Sung Yoon,Nam-Kyu Lee,Do-Young Park,Keun-Ho Kim,Yong-Jin Kim,P. Khajidmaa,Sang-Suk Lee 한국자기학회 2014 Journal of Magnetics Vol.19 No.3

A portable clip-type pulsimeter equipped with a magnetic sensing Hall device has been developed to raise the accuracy of oriental disease diagnosis and therapy by convergence of magnetism and oriental medicine. To improve accuracy and reliability of conventional pulsimeter due to subjective analysis of the pulse wave and measuring position dependency of the arterial pulse sensor, the fuzzy algorithm was applied to analyze the strong- and weak-pulse wave symptom. Optimal time for electronic acupuncture was calculated using fuzzy rules and interference were drawn from objective data in view of pre-treatment. Moreover, the electrical characteristics of the pain parts that respond to acupuncture point were applied in view of post-treatment to propose the scientific pulse wave algorithm and simulation experiment.

Co-transplantation of Human Mesenchymal Stem Cells Promotes Human CD34+ Cells Engraftment in a Dose-dependent Fashion in NOD/SCID Mice

Park, Seong-Kyu,Won, Jong-Ho,Kim, Hyun-Jung,Bae, Sang-Byung,Kim, Chan-Kyu,Lee, Kyu-Taeg,Lee, Nam-Su,Lee, You Kyoung,Jeong, Dae-Chul,Chung, Nak-Gyun,Kim, Hyun-Soo,Hong, Dae-Sik,Park, Hee-Sook The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.3

<P>Mesenchymal stem cells (MSCs) have recently been identified and characterized in humans. Moreover, MSC secrete cytokines that can support hematopoietic progenitor growth. In the present study, we evaluated whether the efficacy of hematopoietic stem cell transplantation is improved by their co-transplantation with MSC, and whether this is positively correlated with the dose of infused MSCs. Accordingly, irradiated NOD/SCID mice were transplanted with 1×10<SUP>5</SUP> human CD34+ cells in the presence or absence of culture expanded MSCs (1×10<SUP>6</SUP> or 5×10<SUP>6</SUP>). We evaluated human hematopoietic cell engraftment by flow cytometry and assessed MSC tissue distributions by fluorescence in situ hybridization. We found that CD45+ and CD34+ cell levels were significantly elevated in a dose-dependent manner in cotransplanted mice 4 weeks after transplantation. The engraftments of CD33+ and CD19+ cells also increased dose-dependently. However, the engraftment of CD3+ cells did not increase after co-transplantation with MSCs. Human Y chromosome+ cells were observed in multiple tissues and were more frequently observed in mice co-transplanted with 5×10<SUP>6</SUP> rather than 1×10<SUP>6</SUP> MSCs. These results suggest that MSCs are capable of enhancing hematopoietic cell engraftment and distribution in multiple organs in a dose-dependent fashion.</P>

延世大學生 2,378名을 對象으로 한 不正咬合頻度에 關한 硏究

劉永奎,金南一,李孝景 대한치과교정학회 1971 대한치과교정학회지 Vol.2 No.1

Since malocclusion affects a large segment of the population, it is by definition a public health problem. The etiology and treatment of malocclusions have been studied by clinicians; however epidemiologic aspects of the problem have been neglected. This study was undertaken using Angle's classification to obtain and to evaluate epidemiologic data on the prevalence of malocclusion in a group of 2,378 Yonsei University students, 17 to 23 years of age. All freshmen were selected, except for those students receiving orthodontic treatment and those few with too many missing teeth which prohibits classification by Angle's method. The following results were obtained: 1) Almost 91% of students had malocclusion of the teeth severe enough to require correction. 2) There was a statistically significant difference in malocclusion between males and females(93.66% malocclusion in males, 79.13% malocclusion in females). 3) Crowing was most prevalent in class I malocclusion. 4) There appeared to be a specific association between the number of lost first molars and Angle's classification. 5) In this study, more class II, Div.2 malocclusion appeared than in Massler's and Frankel's study of Caucasians, which used similar criteria. Class Ⅲ malocclusion was more prevalent than normal occlusion in the Korean students studied, but in Caucasians'normal occlusion was more prevalent.

Studies on the Switching Characteristics of Sol-Gel Derived Ferroelectric (Bi,La)4Ti3O12 Thin Films on Pt/Ti/SiO2/Si Structures

Nam-Yeal Lee,Byoung-Gon Yu,In-Kyu You,Kwang-Ho Kim,Kwi-Dong Kim,Sang-Ouk Ryu,Seong-Mok Cho,Soon Won Jung,윤성민,Woong-Chul Shin 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.51

The switching characteristics of sol-gel derived ferroelectric (Bi,La)4Ti3O12 (BLT) thin lm capacitors were investigated for nonvolatile ferroelectric random access memory (FeRAM) and onetransistor- type metal-ferroelectric-insulator-semiconductor eld eect transistor (MFIS-FET) applications. We could eectively modulate the electrical properties of the BLT thin lms by controlling their crystallographic orientations, which could be performed by changing RTA temperature conditions during the rst annealing process. We characterized the ferroelectric switching properties of the prepared BLT lms and obtained the important parameters describing their switching characteristics by using a double-pulse method. The results for switching time (ts) of the BLT lms with preferred c-axis orientations and (117) orientations were measured to be in the range from 108 ns to 220 ns and from 60 ns to 89 ns at applied voltages from 8 V to 5 V, respectively; the capacitor size was 200 200 m2. The ferroelectric switching event of c-axis-oriented BLT may be said to nish in a shorter time than that of (117)-oriented BLT. On the other hand, the dimensionality factors (n) of both BLT lms were observed to be in the range of about 1.9 2.1, regardless of the capacitor size and BLT orientation.

Remote Cerebral and Cerebellar Hemorrhage after Massive Cerebrospinal Fluid Leakage

You, Sung-Hye,Son, Kyu-Ri,Lee, Nam-Joon,Suh, Jung-Keun The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.51 No.4

Dural tears can occur during spinal surgery and may lead to cerebrospinal fluid (CSF) leakage which is rarely involved in remote cerebellar hemorrhage. Only a few of cases of simultaneous cerebral and cerebellar hemorrhage have been reported in the English literature. We experienced a case of multiple remote cerebral and cerebellar hemorrhages in a 63-year-old man who exhibited no significant neurologic deficits after spinal surgery. Magnetic resonance imaging (MRI) performed 4 days after the surgery showed a large amount of CSF leakage in the lumbosacral space. The patient underwent the second surgery for primary repair of the dural defect, but complained of headache after dural repair surgery. Brain MRI taken 6 days after the dural repair surgery revealed multifocal remote intracerebral and cerebellar hemorrhages in the right temporal lobe and both cerebellar hemispheres. We recommend diagnostic imaging to secure early identification and treatment of this complication in order to prevent serious neurologic deficits.

대전ㆍ충청지역 초ㆍ중학교 급식의 당 함량 및 급식을 통한 당류의 섭취실태 연구

박유경(You-Gyoung Park),이은미(Eun-Mi Lee),김창수(Chang-Soo Kim),엄준호(Joon-Ho Eom),변정아(Jung-A Byun),선남규(Nam-Kyu Sun),이진하(Jin-Ha Lee),허옥순(Ok-Soon Heo) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.10

본 연구에서는 대전과 충남북 지역에서 지역별로 8개의 학교를 선정하고 각 학교당 4주간의 급식을 수거하여 842개 메뉴의 당 함량을 분석하였고, 수거된 급식메뉴에 대해 초등학교 2학년과 5학년, 중학교 2학년 남녀학생의 급식섭취량을 직접 측정하여 급식을 통한 2,806건의 당 섭취량을 산출함으로써 해당학교 및 지역의 당 섭취 특성을 대표할 수 있는 자료를 확보하였다. Fructose, glucose, sucrose, maltose, lactose의 함량 합으로 구한 총 당류의 함량은 가공식품에서와 달리 학교별로 임의의 조리법에 의해 조리된 음식이므로 그 범위가 넓게 나타났다. 주식류의 당 함량은 급식 100 g당 평균 0.20 g, 부식류는 2.08 g, 후식류는 5.13 g으로 과일음료와 유제품, 과일 등을 포함한 후식류의 당 함량이 다른 군에 비해 훨씬 높은 것으로 나타났으며, 부식류 중에서는 소스류와 조림류의 당 함량이 높았다. 급식메뉴 중 가장 많은 양을 섭취하는 음식은 일품식류, 음료 및 차류, 탕 및 전골류, 찌개류 순이었으며, 주스나 식혜와 같은 음료는 정해진 규격이 있어 다른 부식류에 비해 섭취량이 높게 나타났다. 부식류중에서는 국 종류를 제외하면 30~50 g 범위에서 찜류, 튀김류, 볶음류, 부침류, 조림류, 구이류 순으로 많이 섭취하였으나 무침ㆍ나물류와 김치류는 각각 13 g, 10 g만을 섭취하였다. 급식메뉴 중 후식류, 특히 음료 및 차류, 유제품류섭취로 인한 당 섭취량이 가장 많았으며 이들 식품은 당 함량도 높고 규격화된 중량으로 인해 섭취량도 많았기 때문이다. 일품식류는 낮은 당 함량에 비해 급식섭취량이 많아 후식류 다음으로 당 섭취에 크게 기여하였으며, 부식류에서도 조림류에 비해 당 함량이 낮은 튀김류의 급식섭취량이 많으므로 튀김류로 인한 당 섭취량이 조림류로 인한 것보다 높게 나타났다. 급식 한 끼니를 통한 당 섭취량은 평균 4.22 g으로, 학년이 높을수록 급식섭취량과 함께 끼니당 당의 섭취량도 많아 중학생이 5.31 g, 초등학생이 4.03 g을 섭취하였으며, 성별이나 수거시기에 의한 차이는 크지 않았다. 학교급식을 통한 한 끼니의 당 섭취량은 열량섭취량을 기준으로 정한 한국인총 당류 섭취기준이나 한국인영양조사 결과의 하루 총 당류섭취량의 10분의 1 이하 수준으로, 한 끼니 해당량으로서도 높지 않은 것으로 판단된다. 다만 과일주스, 식혜 등의 음료나 요구르트 등의 당 함량이 높은 식품이 제공되거나 이러한후식류가 일품식류와 함께 제공되어 한 끼니당 당의 섭취량이 높은 급식일이 없도록 하는 데에는 관심을 가질 필요가 있을 것으로 판단된다. Korean government will set up the nationwide food safety system with strict control of hazardous nutrients like sugar, fatty acids and sodium as well as advanced nutrition education system. In addition, almost one hundred percent of school food service rate forced the government to consider more effective ways to upgrade the nutritional status of school meals. The object of our study was to provide the data on content and consumption of sugar in school meal for the nationwide project. For this purpose, we surveyed the sugar content of 842 school meal menus and their intake level for 154 days in 8 schools in Daejeon and Chungcheong Province. Sugar contents, the sum of the quantity of 5 sugars commonly detected in food, were analysed with HPLC-RID (Refractive Index Detector). Sugar intakes were calculated by multiplying the intake of each menu to the sugar content of that menu. The sugar content was highest in the desserts, which include fruit juices, dairy products and fruits. Sugar content of side dish was high in sauces and braised foods. Sugar intake from one dish is high in beverage and dairy product, and one dish meals contribute greatly to sugar intake because of their large amount of meal intake. The average lunch meal intakes of second grade and fifth grade elementary school students were 244 g/meal and 304 g/meal, respectively. The meal intake of middle school student was 401 g/meal. The average sugar intake from one day school lunch was 4.22 g (4.03 g on elementary and 5.31 g on middle school student), which is less than 10% of daily sugar reference value for Koreans. The result of this study provides exact data of sugar intake pattern based on the content of sugar which is matched directly to the meals consumed by the students.

Presence of a bi-directional S phase-specific transcription regulatory element in the promoter shared by testis-specific TH2A and TH2B histone genes

Huh, Nam-Eung,Hwang, Inhwan,Lim, Kyu,You, Kwan-Hee,Chae, Chi-Bom 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

During mammalian spermatogenesis, somatic histones are replaced by testis-specific variants. The synthesis of the variants occurs primarily in the germ cells undergoing meiosis in the absence of DNA replication. We have cloned the genes encoding rat somatic and testis-specific H2A (TH2A) histones. The two genes share 300 bp of 5; upstream region with respective H2B genes: somatic H2A with somatic H2B and testis-specific TH2A with testis-specific TH2B gene. The deduced amino acid sequences show that H2A and TH2A histones have eight amino acid differences in the first half of the molecules and three consecutive changes in the C-terminal region. TH2A gene is expressed only in testis. Although synthesis of TH2A and TH2B histones is independent of DNA replication and insensitive to inhibitors of DNA synthesis in testis, the regulatory region shared by the two genes contain a bi-directional S phase-specific transcription regulatory element. In addition, TH2A gene, like TH2B gene, contains the consensus sequence element in the 3' non-coding region which is involved in the S phase-specific stabilization of histone mRNA.