Antispasmodic Effects of Junsibaekchul-San In Vivo and In vitro

Hur, Jin-Il,Byun, Joon-Seok,Kim, Dae-Jun The Physiological Society of Korean Medicine and T 2010 동의생리병리학회지 Vol.24 No.1

In Vivo and In vitro antispasmodic effects of Jun-Si-Baek-Chul-San, a Traditional Korean Polyherbal Medicineconsisted of 7 types of herbs were observed in the present study. To clarify the effects of Jun-Si-Baek-Chul-San, on accelerating small intestinal movement induced by the stimulation of cholinergic neurotransmission, we evaluated the effects of Jun-Si-Baek-Chul-San on In vivo carbachol (an acetylcholinergic agent)-accelerated mice small intestinal transit and on In vitro contractions induced by low-frequency electrostimulation, KCl, histamine or acetylcholine using isolated guinea pig ileum. To induce the acceleration of mice small intestinal transit, Carbachol 1 mg/kg was once subcutaneously dosed 15min before last administration of the test drugs. In the present study, Jun-Si-Baek-Chul-San 500, 250 and 125 mg/kg or domperidone 20 mg/kg were orally pretreated on the carbachol-accelerated mice small intestinal transit once a day for 7 days and the small intestinal transit rateof activated charcoal powder were monitored. In vitro assays, Jun-Si-Baek-Chul-San1, 0.1, 0.01 and 0.001 mg/ml or domperidone $2{\times}10^{-5}M$ were treated 10min before ileal contraction was induced by filed stimulation, acetylcholine, KCl and histamine, and the % changes of contractions were observed compared to the treatment of inducer alone. In spontaneous contraction, the % changes of contractions were observed compared to treatment of vehicle alone at 10min after Jun-Si-Baek-Chul-San or domperidone treatment. The efficacy of Jun-Si-Baek-Chul-San was compared to those of domperidone. High concentration, 1 mg/ml of Jun-Si-Baek-Chul-San was found to decrease the spontaneous contraction of the isolated guinea-pig ileum. In addition, Jun-Si-Baek-Chul-San decrease contractions induced by electrostimulation, acetylcholine, histamine and KCl in the isolated guinea-pig ileum. In addition, Jun-Si-Baek-Chul-San effectively inhibited the accelerated small intestinal movement induced by carbachol stimulation of cholinergic neurotransmission in In vivo. Based on the results, although the exact molecular or action mechanism and which herbs or compound in Jun-Si-Baek-Chul-San are responsible for actions, it was concluded that Jun-Si-Baek-Chul-San normalization in the accelerated intestinal motility might be interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilization of calcium ions required for smooth muscle contraction non-specificly. Therefore, it is expected that Jun-Si-Baek-Chul-San will be promising as a prescription of clinical treatment of digestive tract disorders such as accelerated the motility of intestine, diarrhea or intestinal painful contractions.

광범위 외측 접근법으로 수술한 종골 골절의 술 후 조기 합병증

변영수,조영호,박준우,이진석,김지환 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적 : 광범위 외측 접근법으로 수술한 종골 골절에서 술 후 조기 합병증들을 분석하고 창상 합병증에 대한 위험 요인들을 알아보았다. 대상 및 방법 : 1990년 7월부터 2003년 2월까지 광범위 외측 접근법으로 수술한 종골 골절 104명, 116예를 대상으로 하였다. 환자들의 병록지에서 술 후 조기에 발생한 합병증들을 조사하여 분석하였으며, 창상 합병증의 위험을 증가시키는 요인들을 알아보기 위해 예견되는 변수들에 대하여 통계학적 분석을 하였다. 결과 : 감염이 14예 (12.0%)에서 발생하였으며, 10예 (8.6%)는 표재 감염이었고 4예 (3.4%)는 삼부 감염으로 수술적 치료가 필요하였다. 피부 괴사가 8예 (6.9%)에서 발생하였으며, 6예 (5.2%)는 수술창 변역부의 피부 괴사였고 2예 (1.7%)는 피판 괴사로 수술적 치료가 필요하였다. 비복신경 손상이 7예 (6.0%)에서 발생하였으나 부가적인 치료 없이 회복되었다. 통계학적 분석 결과 개방성 골절 군(p=0.003)과 수술시간이 90분 이상 연장된 군 (p=0.049)에서 창상 합병증의 발생률이 유의하게 높았다. 결론 : 광범위 외측 접근법으로 수술한 종골 골절에서 술 후 조기 합병증의 발생률이 높으므로 개방성 골절에서는 개방창을 철저하게 치료하고, 술 전 계획과 계획된 술기를 통하여 수술 시간을 90분 이내로 단축하고, 비복신경의 해부학적 위치를 고려하여 절개함으로 술 후 조기 합병증의 발생률을 감소시킬 수 있을 것으로 사료된다. Purpose : To analyze early postoperative complications of calcaneal fractures operated by a lateral extensile approach and to identify risk factors for would complications. Materials and Methods : From July 1990 to February 2003, 116 calcaneal fractures in 104 patients were treated by open reduction and internal fixation through a lateral extensile approach. The patient's records were reviewed for early postoperative complications. Statistical analysis was performed to determine significant relationships between predicted variables and the development of would complications. Results: Fourteen fractures (12.0%) developed infection. Ten of them were superficial infection and four were deep infection that required surgical treatment. Eight fractures (6.9%) developed skin necrosis. Six of them were marginal skin necrosis and two were flap necrosis that required surgical treatment. Seven fractures (6.0%) developed sural nerve injury, but their symptoms were improved without additional treatment. Open fracture (p=0.003) and prolonged operating time (p=0.049) increased significantly the rate of wound complications. Conclusion: The rate of early postoperative complications of calcaneal fractures operated by a lateral extensile approach is high. These complications can be reduced by meticulous treatment of an open wound, reduced operating time within 90minutes through preoperative planning and skillful technique, and correct incision to avoid damage of the sural nerve.

정신재활 치료가 정신분열병 환자의 재발율, 입원횟수, 입원일수 그리고 치료 경비에 미치는 효과 : 2년 추적조사 연구

조진석,공지현,김진원,심경순,하준선,김철권,강동호,장정희,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 사회기술훈련, 환자교육, 가족교육, 집단치료, 예술치료, 작업치료와 같은 포괄적인 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 정신분열병 환자의 재발율, 입원횟수, 입원일수, 직접 치료경비 등에 어떤 효과가 있는 지를 알아보기 위함이다. 연구방법 : 1993년 9월부터 1995년 2월까지 양산 신경정신병원의 폐쇄병동에서 퇴원한 20∼35세 사이의 정신분열병 환자 173명을 대상으로 46명에게는 6개월동안 정신재활 치료를 시행하였고 127명에게는 통상적인 외래치료만 시행한 후 연구시작 시점을 포함하여 2년동안 양군에 속한 환자들을 대상으로 재발율, 입원횟수, 입원일수, 직접 치료경비 등을 1년 단위로 추적 조사하였으며, 연구시작 시점을 기준으로 전과 후의 매년 평균 입원횟수, 입원일수, 직접 치료경비도 서로 비교하였다. 결 과 : 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 재발율, 입원횟수, 입원일수, 직접 치료비용이 현저히 감소되었다. 그리고 정신재활 치료를 받은 군에서는 치료 전에 비해 치료 후에 재발율, 입원횟수, 입원일수, 직접 치료비용이 유의하게 감소하였지만 통상적인 외래치료만 받은 군에서는 치료 전과 후간에 유의한 변화를 보이지 않았다. 결 론 : 정신분열병 환자들에게 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 환자의 임상적 경과를 호전시킬 뿐 아니라 가족의 경제적 부담도 줄일 수 있다. Objective : We evaluated the clinical efficacy of a comprehensive psychiatric rehabilitation of schizophrenia, including family psychoeducation, patient education, social skills training, group psychotherapy, art therapy, and occupational therapy. Method : From September 1993 to February 1995, 173 chronic schizophrenics who met DSM-IV criteria and were discharged from a locked ward were assigned into the psychiatric rehabilitation service group(psychiatric rehabilitation group, n=46) or the customary out-patient service group(out-patient group, n=127) prospectively, but not randomly. Assignment was based on preferences of patients and their relatives, Each subject included in the psychiatric rehabilitation group received twice weekly patient education, social skills training, family psychoeducation, group psychotherapy, art therapy, occupational therapy and maintenance chemotherapy during a 6-month period. Those in the out-patient group received individual supportive psychotherapy and maintenance chemotherapy according to their clinical needs for 10-20 minutes once per week. After entry into the study, all subjects were assessed for the number of readmission, days of hospitalization, and the direct treatment costs through the first and second year of follow-ups. These outcome variables were also compared pre-and post-2 years at the time point of entry into the study. Aftercare chemotherapy on a weekly to monthly basis continued for the remainder of the two year follow-up period. Results : With regard to the mean number of hospital admissions per year, the mean days of hospitalization per year, and the direct treatment costs per year, the psychiatric rehabilitation group had significantly decreased all clinical outcomes 2 years after compared with before receiving psychiatric rehabilitation. But there were no significant differences in the all clinical outcomes between before and after study intake in the out-patient group. For the number of relapse regardless of drug compliance, 4 patients(9%) during first year and 14 patients(30%) during second year were relapsed in the 46 subjects of the psychiatric rehabilitation group. In contrast, 75 patients(59%) during first year and 90 patients (71%) during second year relapsed in the out-patient group. When considering the effect of drug noncompliance to relapse, 4(9%) and 14 patients(30%) were relapsed while on medication respectively during the first and second year in the 46 of the psychiatric rehabilitation group, vs. 27(34%) of 79 patients on medication during the first year and 31(46%) of 68 patients on medication during the second year were relapsed in the out-patient group. Conclusions : These results indicate that the comprehensive psychiatric rehabilitation can be useful therapeutic intervention both to improve the clinical outcomes of schizophrenic patients and to reduce the economical burden of their relatives.

정신분열병 환자에서의 한국어판 사회적응 척도의 개발 : 신뢰도 및 타당도 연구

김철권,서지민,김상수,조진석,하준선,김정옥,변원탄 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신분열병 환자의 사회적응 정도를 측정하는데 사용되는 사회적응 척도의 한국어판을 개발하기 위함이다. 방 법: 사회적응 척도를 번역한 후 정신분열병 환자 67명과 정상인 78명을 대상으로 신뢰도와 타당도를 검증하였다. 결 과: 자료분석 결과 검사-재검사 신뢰도는 0.85, 검사자간 신뢰도는 0.89, 내적 일치도는 0.87로 높은 수치였다. 변별 타당도를 검증하기 위하여 정신분열병 환자군과 정상 대조군을 비교한 결과 정신분열병 환자군에서 사회적응 정도가 유의하게 낮았다. 구성 타당도를 알아보기 위하여 10개 영역간의 상관관계를 측정한 결과 성적적응 영역을 제외한 모든 영역들에서 유의한 상관관계를 보였다. 본 척도의 전반적 평가 영역 결과와 GAF 결과간의 상관성을 통해 간접적으로 검증한 공존 타당도 역시 유의하였다. 결 론: 한국판 사회적응 척도는 우수한 신뢰도와 타당도가 입증되었고 나아가 정신분열병 환자의 사회적응 정도를 평가하는데 유용하게 사용되어질 수 있을 것이다. Objectives: The purpose of this study was to develop the Korean version of the Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) in the schizophrenics. Methods: KSAS Ⅱ-RV was administered to 67 schizophrenic patients and 78 matched normal controls for examining the reliability and validity. Results: Data analysis showed statistically significant reliabilities and validities of KSAS Ⅱ-RV. The test-retest reliability, inter-rater reliability, and internal consistency for total scores of KSAS Ⅱ-RV were 0.85, 0.89. and 0.87, respectively. Evidence for discriminant validity of KSAS Ⅱ-RV comes from the results that the mean scores of schizophrenic patients were significantly high than those of normal controls. Construct validity was assessed by calculating the 10 inter-subareas correlations of the KSAS Ⅱ-RV, and all except the sexual adjustment area were statistically significant. Significant correlations between the global area scores of KSAS Ⅱ-RV and those of Global Assessment of Functioning Scale lend support for the concurrent validity of this instrument indirectly. Conclusions: KSAS Ⅱ-RV was found to be a valid and reliable instrument which can be used to evaluate the degree of social adjustment in the schizophrenic patients.

[Poster] Great saphenous vein aneurysm : uncommon experience of vascular anomaly

Jun Suk Byun,Ju Ik Moon,Yu Mi Ra,Sang Eok Lee,In Seok Choi,Won Jun Choi,Dae Sung Yoon,Hyun Sik Min 대한외과학회 2011 대한외과학회 학술대회 초록집 Vol.2011 No.11

노인 가족에 있어서 주택연금 노후소득보장 효과

변준석 ( Jun-seok Byun ),홍희정 ( Hee-jeong Hong ) 한국가족복지학회 2017 한국가족복지학 Vol.22 No.1

In this study, we developed a new methodology to measure the degree of guarantee of old-age earnings of public pension. In addition, this method was used to compare the effect of securing the old-age income between the public reverse mortgage and the public pension. In this study, the proposed new methodology is the "contribution to guarantee of old-age income," which is a comprehensive single index covering both income replacement rate and eligibility. Based on this methodology, we estimated the income guarantee effect of national pension, basic pension, and public reverse mortgage, all of which are representative public pensions in Korea. The results of the estimation of the contribution of the old-age income guarantee show that the contribution of the public reverse mortgage was 31.3%, which was about two times higher than the basic pension at 15.0% and the national pension at 14.5%. This means that if the public reverse mortgage is additionally applied to the public pension system, the current senior citizen family generation can increase the contribution of the old-age income guarantee up to 60.8%.

논문 : 도시환경정비사업의 집행 지연요인 도출 및 관리적 시사점 분석

변준석 ( Jun Seok Byun ),이주형 ( Joo Hyung Lee ) 디자인융복합학회 2013 디자인융복합연구 Vol.12 No.5

본 연구는 도시환경정비사업을 대상으로 사업의 지연에 영향을 미치는 여러 요인들 가운데 사업지연에 보다 큰 영향을 미치는 주요 요인들을 분석하였으며, 관리적 시사점을 제시하였다. 연구방법은 도시환경정비사업 집행 지연요인 도출 및 계층화 분류, AHP방법을 활용한 지연요인들 간 중요도 분석을 수행하였다. 분석결과, 총 21개의 사업 지연요인이 도출되었으며, 그 중 ‘행정절차 오류’, ‘조합의 정치적 분쟁’, ‘사업계획 변동’, ‘소유자 이해부족 갈등’, ‘세입자 보상가 불만족’, ‘사업성에 대한 불확실성’, ‘주민의견 반영 미흡’, ‘부정행위’, ‘정비계획 수립 지연’, ‘세입자 이주대책 미흡’, ‘주택경기 침체에 따른 사업성 저하’, ‘과도한 기반시설’ 의 12개의 요인이 주요 지연요인으로 분석되었다. This study analyzed main factors affecting project delay among the several factors and suggest managerial implications about urban renewal project. The method of study is as in the following. First of all, we deducted action delay factors of urban renewal project and classified hierarchy. And then, we carried out Analysis of Importance among factors of delay using the AHP (Analytic Hierarchy Process). As a result of this study, total twenty-one factors of project delay are deducted and twelve factors(administrative procedures mistake, political conflict of association, change of project plan, conflict of owner, dissatisfaction of compensation price for tenant, business value, insufficiency of resident opinion reflect, cheating, delay of maintenance plan establishment, insufficiency of migration measure, feasibility decline of depression housing economy, excessive infrastructure) are analyzed that it is important to delay project.

도시환경정비사업 집행 지연요인의 인과구조 분석-토지등소유자방식을 중심으로-

변준석(Byun Jun Seok),송호창(Song, Ho Chang) 한국부동산학회 2016 不動産學報 Vol.64 No.-

본 연구는 도시환경정비사업을 대상으로 사업 집행을 지연시키는 주요 요인들 가운데 사업지연에 보다 큰 영향을 미치는 요인 및 인과관계에 대해 분석하였다. 10개의 주요 지연요인들을 대상으로 DEMATEL분석을 통해 인과성 분석을 실시하였으며, 그 결과, 도시환경정비사업의 집행 지연요인으로써 가장 주요한 원인이 되는 요인은 경기 침체에 따른 사업성 저하로 나타났으며, 그 다음으로 관련 수립계획 및 인가오류, 소유자 이해부족 갈등, 사업시행자의 불투명한 사업 추진, 소유자, 보상가 불만족 등의 순으로 분석되었다. 최종적으로 사업 지연요인의 인과성 분석결과, 도시환경정비사업의 집행 지연구조는 관련계획 수립 오류, 사업시행자의 불투명한 사업추진, 소유자 보상가 불만족, 경기 침체에 따른 사업성 저하, 소유자 이해부족 갈등, 사업시행자의 미약한 공신력이 원인이 되어, 사업성에 대한 불확실성, 사업계획 변동, 세입자 갈등, 수요변화 등의 또 다른 지연요인을 발생시키는 형태로 나타나는 것을 알 수 있었다. 1. CONTENTS (1) RESEARCH OBJECTIVES The major purpose of this research is investigating the delay factors of the project process focused on urban environmental improvement project out of the renewal plans and then it attempted to find causation between them. (2) RESEARCH METHOD It was evaluated the causal relationship with the major delay factors by DEMATEL (Decision Making Trial and Evaluation Laboratory). (3) RESEARCH FINDINGS First of all, the most essential cause as the delay factor was the decline of project implementation associated with economic recession and then the following factors in order were authorization errors and the linked improvement framework, problems as poor understanding of property owners, feeble public confidence of the executives and property occupiers’ compensation payment dissatisfaction. 2. RESULTS There was the causational relationship between the delay factors within the enforcement structure of the urban environment renewal project. Hence the project feasibility, changing project plans, problems with their tenants and fluctuated demand trend occurred because it was effected by authorization and improvement framework errors, project feasibility, compensation payment dissatisfaction, less possibility of the scheme due to economic slump, poor consideration of property occupiers and lack of public confidence as the executives.

Change of Crystallinity and Surface Roughness of Tin Oxide Film in Hybrid Ion Beam Deposition(HIBD)

Jun-Sik Cho,Won-Kook Choi,Ki Byun Yoon,Hyung-Jin Jung,Seok-Keun Koh 한국진공학회 1995 한국진공학회 학술발표회초록집 Vol.- No.-

Multicenter retrospective analysis of patients with chronic lymphocytic leukemia in Korea

Jun Ho Yi,이경원,이지현,Kwai Han Yoo,Chul Won Jung,Dae Sik Kim,Jeong-Ok Lee,Hyeon Seok Eom,Ja Min Byun,Youngil Koh,Sung Soo Yoon,Jin Seok Kim,Jee Hyun Kong,Ho-Young Yhim,Deok Hwan Yang,Dok Hyun Yoon,Do Hyou 대한혈액학회 2021 Blood Research Vol.56 No.4

Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack of feasible novel agents and laboratory prognostic tools, there are limited data on the clinical outcomes of this disease in Asia. To clarify the current treatment status, we performed a multicenter retrospective analysis of patients with CLL in Korea. Methods The medical records of 192 eligible patients between 2008 and 2019 were reviewed for clinical characteristics, treatment courses, and outcomes. The first-line treatment regimens of the patients included in this analysis were as follows: fludarabine/cyclophosphamide/ rituximab (FCR) (N=117, 52.7%), obinutuzumab plus chlorambucil (GC) (N=30, 13.5%), and chlorambucil monotherapy (N=24, 10.8%). Results The median progression-free survival (PFS) was 55.6 months, and the average 2-year PFS rate was 80.3%. PFS was not significantly different between the patients receiving FCR and those receiving GC; however, chlorambucil treatment was associated with significantly inferior PFS (P <0.001). The median overall survival was 136.3 months, and the average 5- and 10-year OS rates were 82.0% and 57.4%, respectively. Conclusion This is one of the largest studies involving Korean patients with CLL. Although the patients had been treated with less favored treatment regimens, the outcomes were not different from those reported in Western studies.