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S-276 : Nodular lymphoid hyperplasia of the lung
( Geon Wook Kang ),( Cheol Hyeon Kim ),( Seung Sook Lee ),( Du Hwan Choe ),( Hye Ryoun Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
We report a rare case of nodular lymphoid hyperplasia in the lung. A 56-year-old man was admitted to our hospital for examination of an abnormal chest radiography images. Computed tomography showed an ovoid-shaped mass in the left upper lobe of the lung, measuring 3 cm in diameter. In addition, CT also showed multifocal nodular opacities in the bilateral lung fields. Transthoracic needle aspiration was performed, but it was non-diagnostic. Then, open lung biopsy was performed. Histopathological examination of the resected lung revealed polyclonal proliferation of lymphoid tissue, leading to a diagnosis of nodular lymphoid hyperplasia. Multiple residual nodules were no change during a year of follow-up.
Kang, Keon-Wook,Kim, Yoon-Gyoon,Kim, Choon-Won,Kim, Sang-Geon The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
Liver fibrosis is a prepathological state wherein damaged liver tissues in chronic liver diseases, such as hepatitis, are not repaired to normal tissues, but converted to fibrous tissue. 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz), a cancer chemopreventive agent, is effective against a wide variety of chemical carcinogens. Recently, we reported that oltipraz inhibits liver fibrogenesis (Kang et al., 2002). In the present study, the effects of oltipraz in combination with dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDb) on dimethylnitrosamine (DMN)-induced liver fibrogenesis were assessed in rats. Oltipraz (30 mg/kg body weight, po, 3 times per week for 4 weeks) was found to inhibit the increases in plasma ALT, AST and bilirubin by DMN, whereas DDB (30 mg/kg body weight, po, 3 times per week for 4 weeks) attenuated the increases in the plasma ALT and bilirubin. The lowered plasma protein and albumin contents in DMN-treated rats were completely restored by oltipraz, but not by DDB. DDB decreases liver cell injury and inflammation through inhibition of nuclear factor-kB. DMN increased the accumulation of liver collagen, as indicated by the increase in the 4-hydroxyproline content in liver homogenates, which was reduced by treatment with oltipraz, but not by DDB. Given the differential effect between oltipraz and DDB, the potential enhancement of antifibrotic efficacy by the drugs was assessed in the animal model. Despite the minimal effect of DDB on DMN-induced fibrogenesis, DDB (5-25 mg/kg), administered together with oltipraz (25-5 mg/kg), showed an additive protective effect against hepatotoxicity and fibrosis induced by DMN, which was shown by the blood chemistry parameters and histopathological analysis. The adequate composition ratio of oltipraz to DDB was 5:1. These results provide information on the pharmaceutical composition, comprising of oltipraz and DDB as the active components, for the treatment and/or prevention of liver fibrosis and cirrhosis.
Nephrotoxic Potential and Toxicokinetics of Tetrabromobisphenol a in Rat for Risk Assessment
Kang, Mi Jeong,Kim, Ju Hyun,Shin, Sil,Choi, Jae Ho,Lee, Sang Kyu,Kim, Hyung Sik,Kim, Nam Deuk,Kang, Geon Wook,Jeong, Hye Gwang,Kang, Wonku,Chun, Young Jin,Jeong, Tae Cheon Informa UK (TaylorFrancis) 2009 Journal of toxicology and environmental health. Pa Vol.72 No.21
<P>Tetrabromobisphenol A (TBBPA), one of the most widely used global brominated flame retardants, is used to improve fire safety of laminates in electrical and electronic equipment. To investigate the nephrotoxic potential of TBBPA and its toxicokinetic profile in rats, single-dose and daily 14-d repeated-dose toxicity studies at 200, 500, or 1000 mg/kg were performed. Several biochemical parameters were analyzed to evaluate nephrotoxicity of TBBPA. High-dose 1000 mg/kg TBBPA significantly elevated renal thiobarbituric acid-reactive substance (TBARS) levels, and superoxide dismutase (SOD) activity was increased at all 3 doses administered. This was associated with no change in the activity of catalase (CAT). Our results suggest that acute 1-d high-dose administration of TBBPA produced transient renal changes at 5 h. Subsequently, TBBPA in serum, urine, and kidney was determined by liquid chromatography-mass spectroscopy (LC/MS). Toxicokinetic studies indicated that TBBPA shows relatively a short half-life (7-9 h) and was eliminated almost completely in feces by 2 d. Based on the results from the 14-d repeated-dose study, TBBPA did not accumulate in the rat, and was eliminated in feces. The present results suggested that TBBPA may not be toxic to kidney, as the chemical is not bioavailable and is not present in renal tissue.</P>
강건욱 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.6
PACS (Picture Archiving and Communication System) is being rapidly spread and installed in many hospitals, but most of the system do not include nuclear medicine field. Although additional costs of hardware for nuclear medicine PACS is low, the complexity in developing viewing software and little market have made the nuclear medicine PACS not popular. Most PACS utilize DICOM 3.0 as standard format, but standard format in nuclear medicine has been Interfile. Interfile should be converted into DICOM format if nuclear images are to be stored and visualized in most PACS. Nowadays, many vendors supply the DICOM option in gamma camera and PET. Several hospitals in Korea have already installed nuclear PACS with DICOM, but only the screen captured images are supplied. Software for visualizing pseudo-color with color lookup tables and expressing with volume view should be developed to fulfill the demand of referring physicians and nuclear medicine physicians. PACS is going to integrate not only radiologic images but also endoscopic and pathologic images. Web and PC based PACS is now a trend and is much compatible with nuclear medicine PACS. Most important barrier for nuclear medicine PACS that we encounter is not a technical problem, but indifference of investor such as administrator of hospital or PACS. Now it is time to support and invest for the development of nuclear medicine PACS.
천강민(Kang-Min Cheon),신백천(Baek-Cheon Shin),신건호(Geon-Ho Shin),고정일(Jeong-Il Go),이준혁(Jun-Hyeok Lee),허장욱(Jang-Wook Hur) 한국기계가공학회 2022 한국기계가공학회지 Vol.21 No.5
Although pipe performs various functions in industrial sites and residential spaces, if it is damaged due to corrosion caused by the external environment, it may cause equipment failure or a major accident. For this reason, various studies for safety management are being conducted, but studies on detecting corrosion or cracks on the pipe surface using a laser displacement sensor have hardly been conducted. Therefore, in this study, the corrosion degree of the pipe surface was compared and classified into 4 corrosion conditions, and inspection equipment using a laser scanner was manufactured. The corrosion height was calculated from the four surface data obtained from the measuring equipment and applied to various CNN algorithms, and 91% accuracy was obtained during training using the Modified VGGNet16 code with reduced number of parameters.