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강건욱,김상겸,Kang, Keon-Wook,Kim, Sang-Kyum 대한약학회 2007 약학회지 Vol.51 No.6
It has been reported that sulfur-containing intermediates or products in the transsulfuration pathway including S-adenosylmethionine, 5'-methylthioadenosine, glutathione and taurine can prevent liver injury mediated by inflammation response induced by lipopolysaccharide (LPS) treatment. The present study examines the modulation of hepatic metabolism of sulfur amino acid in a model of acute sepsis induced by LPS treatment (5 mg/kg, iv). Serum TNF-alpha and hepatotoxic parameters were significantly increased in rats treated with LPS, indicating that LPS results in sepsis at the doses used in this study. LPS also induced oxidative stress determined by increases in malondialdehyde levels and decreases in total oxy-radical scavenging capacities. Hepatic methionine and glutathione concentrations were decreased, but S-adenosylho-mocysteine, cystathionine, cysteine, hypotaurine and taurine concentrations were increased. Hepatic protein expression of methionine adenosyltransferase, cystathionine beta-synthase and cysteine dioxygenase were induced, but gamma-glutamylcysteine ligase catalytic subunit levels were decreased. The results show that sepsis activates transsulfuration pathway from methionine to cysteine, suggesting an increased requirement for methionine during sepsis.
강건욱,정준기,이동수,이인기,Hendra Budiawan,천기정,김용철,팽진철,문지윤 대한의학회 2014 Journal of Korean medical science Vol.12 No.12
In many circumstances, causing sites of low back pain (LBP) cannot be determined only byanatomical imaging. Combined functional and morphological imaging such as bone scanwith single-photon emission computed tomography/computed tomography (SPECT/CT)may be helpful in identifying active lesions. The purpose of this study was to evaluate theusefulness of bone SPECT/CT in localizing the pain site and the treatment of chronic LBP. One hundred seventy-five patients suffering from chronic LBP who underwent SPECT/CTwere included, retrospectively. All of the patients received multiple general treatmentsaccording to the symptoms, and some of them underwent additional target-specifictreatment based on SPECT/CT. Numerical rating scale (NRS) pain score was used to assessthe pain intensity. Of 175 patients, 127 showed good response to the given therapies,while the rest did not. Overall, 79.4% of patients with definite active lesions showed goodresponse. Patients with mild active or no lesions on SPECT/CT had relatively lower responserate of 63.0%. Good response was observed by the treatment with the guidance of activelesions identified on SPECT/CT. SPECT/CT could be useful in identifying active lesions inpatients with chronic LBP and guiding the clinicians to use adequate treatment.
경도의 안구건조증 환자에서 굴절교정수술 전후 0.05% 사이클로스포린 사용의 효과
강건욱,김홍균,Kun Wook Kang,Hong Kyun Kim 대한안과학회 2014 대한안과학회지 Vol.55 No.12
Purpose: To evaluate the efficacy of pre- and post-operative use of topical 0.05% cyclosporine A (CsA) in mild dry eye patients having refractive surgery. Methods: This randomized prospective study included 40 patients with mild dry eye syndrome who were scheduled for laser in situ keratomileusis (LASIK). All patients were divided into 2 groups. Patients in the CsA group used both 0.1% sodium hyaluronate (HA) and 0.05% CsA from 2 weeks before to 8 weeks after the surgery, while patients in the control group used 0.1% HA only. Ocular surface disease index (OSDI), tear film break-up time (TF-BUT), Oxford Stain Score (OSS), and tear osmolarity were evaluated before surgery and 1, 4, and 8 weeks after surgery. Results: TF-BUT was significantly longer in the CsA group at 1 and 4 weeks post-operatively (<EM>p </EM>= 0.024, <EM>p </EM>= 0.036) compared to the control group. Tear osmolarity was significantly lower in the CsA group at 1 week post-operatively (<EM>p </EM>= 0.004) compared to the control group. Conclusions: The pre- and post-operative use of topical 0.05% CsA is effective in alleviating dry eye symptom after LASIK in patients with dry eye syndrome. J Korean Ophthalmol Soc 2014;55(12):1752-1757