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      • KCI등재

        유방암 치료에 대한 한의 임상 가이드라인 개발을 위한 기초연구

        이강욱,유화승,이진선,이남헌,Lee, Kang-Wook,Yoo, Hwa-Seung,Lee, Jin-Sun,Lee, Nam-Hun 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.2

        Objectives : The purpose of this study was to present the clinical practice guidelines for breast cancer through the analysis of existing clinical practice guidelines in Western and Chinese medicine. Methods : The literature search was performed regarding conventional and integrative medical treatment of breast cancer using Google Scholar, KIOM OASIS, PUBMED and Jisan library of Daejeon university. Results : Breast cancer is the fifth most common cancer in Korea. Recent studies revealed that combining conventional and integrative medical treatment can reduce the sequela of surgical operation and improve survival rate. However there isn’t still a systemic clinical guideline for breast cancer in korean medicine. This study will be a preliminary study to establish clinical practice guidelines of Korean Medicine for breast cancer.Conclusions : Further objective and systemic clinical studies related to Korean Medicine are needed to develope more advanced clinical practice guidelines of breast cancer.

      • KCI등재

        한인진(韓茵蔯), 울금(鬱金), 산사(山査), 단삼(丹蔘) 발효복합추출물이 RAW264.7 및 HUVEC 세포에서 나타나는 이상지질혈증 관련 염증인자 발현 및 항산화에 미치는 영향

        이강욱,조현경,유호룡,설인찬,김윤식,Lee, Kang-wook,Cho, Hyun-kyoung,Yoo, Ho-ryong,Seol, In-chan,Kim, Yoon-sik 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

        Objectives: To investigate the effect of fermented extract of Artemisiae Iwayomogii Herba, Curcumae Longae, Crataegi Fructus and Salviae Miltiorrhizae Radix (FMH) on anti-inflammation associated with dyslipidemia and anti-oxidation in RAW264.7 and HUVEC cells. Methods: The total polyphenols, total flavonoids, DPPH radical scavenging activity, ABTS radical scavenging activity, and cytotoxicity of FMH were measured. RAW264.7 cells treated with FMH were tested for production of NO, and for cytokine and LTB4 levels and HUVEC cells treated with FMH were examined for production of cDNA of genes related to inflammation. Results: 1. FMH contained polyphenols and flavonoids. The DPPH and ABTS radical scavenging activity of FMH increased in a concentration-dependent manner. 2. FMH treatment inhibited the production of nitric oxide (NO), cytokines, and LTB4 in RAW264.7 cell when compared to the untreated control group. 3. FMH decreased the transcription of pro-inflammatory genes, whereas it increased transcription of anti-inflammatory genes, in HUVEC cells. Conclusion: FMH is effective as an antioxidant and for treatment and prevention of dyslipidemia, atherosclerosis, ischemic heart disease, stroke, and other cardiocerebrovascular diseases.

      • KCI등재

        조선후기 東西 兩班 官職의 분류

        이강욱 서울대학교 규장각한국학연구원 2020 한국문화 Vol.0 No.89

        Siljik was a regular post given based on Munsan-gye rank system and Musan-gye rank system with actual tasks receiving regular stipend. It embraced the characteristics of bonjik, nokjik, functional post, and regular post while their opposite gyeomjik, murokgwan, nominal post as gunjik, and temporary post gagwan was not included in siljik. Sanjik operated only in military posts, which was mostly gyeomjik with actual duties. Sanjik differed from siljik in that most of them were gyeomjik, and differed from gunjik in that they had actual tasks. However, in a sense that sanjik was also given according to Musan-gye rank system, it also belonged to jeongjik. Therefore, sanjik was one of the military post’s jeongjik, distinct from japjik․siljik․gunjik․heojik. In a broad sense, jeongjik was an opposite concept to japjik, referring to every civil and military post given by Munsan-gye and Musan-gye rank system. This definition of jeongjik encompassed gyeomjik, gunjik, murokgwan, and gagwan as well as siljik. In a narrow sense, jeongjik shared the same notion with siljik where gyeomjik, gunjik, murokgwan, and gagwan were not included. Cheajik was a post where several officials held one vacant position in turn and received their stipend only when they were at work. This was implemented in order to distribute limited amount of posts to the increasing number of public official candidates as much as possible. Cheajik was not separate from jeongjik or siljik but any posts regardless of siljik, gunjik, jeongjik or japjik, as far as it possessed official stipend, could be operated as cheajik. Gaseoljik was an additionally established post besides the limited number of civil and military posts. It took up the same official title stated by law. Gaseoljik operated in several ways: it was established when necessary and thereafter abolished; it was additionally established besides the limited number of posts and became a regular one; it was assigned to a temporary post. Depending on where it would be additionally established, it was possible for any posts including silgwan, gyeomgwan, and gagwan. Gwonseoljik was a temporary post established to perform certain tasks for the time being. Unlike gaseoljik, therefore, it did not take up the existing title stated by law but made their own title, which would naturally disappear after the task was done. Gwonseoljik could either be established with the gwonseol public office or without it only as a post. Every gwonseoljik operated as a gyeomjik. In sum, civil and military yangban posts in late Joseon largely consisted of jeongjik given by Munsan-gye and Musan-gye rank system, japjik given by Japjik-gye rank system, and togwanjik given by Togwanjik-gye rank system. Among them, jeongjik included siljik, a regular post with stipend; stipendless posts as gyeomjik and murokgwan; additionally established posts as gaseoljik and gwonseoljik. Gunjik and sanjik was also included in the military post’s jeongjik. Cheajik was established to pay stipend to those unsalaried officials and thus any posts with enough finances, regardless of siljik, gunjik, or japjik, were able to be operated as cheajik. Since cheajik was an idea for the operation of posts, it could not be used as a comparative concept to jeongjik.

      • KCI우수등재
      • 동측 상환골 및 전완부 양골 골절에 대한 임상적 고찰

        이강욱,노철규 의과학연구소 1991 全北醫大論文集 Vol.15 No.4

        There has been only some guidelines for treatnents of concomitant ipsilateral fractures of the humerus and forearm both bone, so-called floating elbow. The authors reviewed 11 patients of floating elbow who were treated at Chonbuk National University Hospital between January 1984 and June 1991. The results were as follows: 1. Average age was 28 years old and the most common cause of injury was belt injury 2. The most common combined injury was nerve paralysis and we treated it with relatively good result by conservative treatment. 3. The method of internal fixation using plate & screws showed better result than other method of treatments. 4. In younger patients, the better results were obtained than older patients.

      • 韓牛와 乳牡牛 精液性狀에 關한 比較 硏究

        李康郁 건국대학교 1971 學術誌 Vol.12 No.1

        Obervation were made on the semen value of clinicaly healthy korean native and darts bulls for the purpose of determination of mean semen value and its seasonal variations during one year period. The semen sampling were scheduled by random in four different seasons and the sample size were appointed from 150 samples korean native bulls and 213 dairy bulls. The range or mean values of the amount of ejaculation semen, color, smell, concentration, PH, number of sperms, and malformation rate were determined in this and their respective standard deviation of means, and seasonal variations were as follows ; 1.The amount of ejaculation in the korean native bulls showed a range of 3cc to 7.5cc and with a mean of 4.99±0.52cc. Dairy bulls showed a range of 3.9cc to 13cc with a mean of 7.18±0.36cc. Ejaculation amount on semen of korean native bulls is less than those of the dairy bulls. There was no significant difference amount of semen in different seasones, ages and months. 2.The semen concentration value of korean native bulls and dairy bulls showed a range of (-) to (□), were found to .be same value and with a mean of 1.49±0.02(+) and dairy bulls with a mean of 0.91±0.39(+). There was a highly concentration in the korean native bulls, (P <0. 01). There was a seasonal variation and ages difference which was not found to be not significant of the statistics. 3.The Semen of He Korean native bull who high in Concertation. (P) 6.2 to 6.6 that designated to be a same value. The PH value of semen from korean native bulls was less acid than those of dairy bulls with a mean of 6.25±0.02, dairy bulls with a mean of 6.37±0.06 (p<0.01) 4.The number of sperms korean native bulls showed a range of 75.5×104/cmm to 198.7×104/cmm with a mean of 115.8×104/cmm. Dairy bulls showed a range of 42.3×104/cam to 132.5×104/cmm with a mean of 68.96±4.60×104/cnlm. There was highly number of sperms korean native bulls than dairy bulls. 5.The motility of sperms of korean native bulls showed a range of 80% to 95% and with a mean of 94.12±0.19%. Dairy bulls showed a range of 75% to 95% with a mean of 93.12±2.31%. There was a active motillity of sperms in korean native bulls better than dairy bulls. 6.The Semen malformation rate of korean native bulls showed a range of 6.5% to 16.2%, with a mean of 10.54±0.39%. Dairy bulls showed a range of 1.7% to 8.1% with a mean of 4.94±0.42%. there was highly incidence of malformation rate in korean native bulls more than dairy bulls.

      • KCI등재

        완전삽입형 인공망막 구현을 위한 인공망막모듈 개발

        이강욱,카이호 요시유키,후쿠시마 타카후미,타나까 테츠,고야나기 미쯔마사,Lee, Kang-Wook,Kaiho, Yoshiyuki,Fukushima, Takafumi,Tanaka, Tetsu,Koyanagi, Mitsumasa 대한의용생체공학회 2010 의공학회지 Vol.31 No.4

        To restore visual sensation of blind patients, we have proposed a fully implantable retinal prosthesis comprising an three dimensionally (3D) stacked retinal chip for transforming optical signal to electrical signal, a flexible cable with stimulus electrode array for stimulating retina cells, and coupling coils for power transmission. The 3D stacked retinal chip is consisted of several LSI chips such as photodetector, signal processing circuit, and stimulus current generator. They are vertically stacked and electrically connected using 3D integration technology. Our retinal prosthesis has a small size and lightweight with high resolution, therefore it could increase the patients` quality of life (QOL). For realizing the fully implantable retinal prosthesis, we developed a retinal prosthesis module comprising a retinal prosthesis chip and a flexible cable with stimulus electrode array for generating optimal stimulus current. In this study, we used a 2D retinal chip as a prototype retinal prosthesis chip. We fabricated the polymide-based flexible cable of $20{\mu}m$ thickness where 16 channels Pt stimulus electrode array was formed in the cable. Pt electrode has an impedance of $9.9k{\Omega}$ at 400Hz frequency. The retinal prosthesis chip was mounted on the flexible cable by an epoxy and electrically connected by Au wire. The retinal prosthesis chip was cappted by a silicone to pretect from corrosive environments in an eyeball. Then, the fabricated retinal prosthesis module was implanted into an eyeball of a rabbit. We successfully recorded electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module. EEP amplitude was increased linearly with illumination intensity and irradiation time of incident light. The retinal prosthesis chip was well functioned after implanting into the eyeball of the rabbit.

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