http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
반흔 2기 십이지장궤양 환자에서 Helicobacter pylori 제균이 소화성 궤양의 재발에 미치는 영향 -중간 보고-
이준행,이풍렬,현재근,최원혁,임윤정,안병훈,이용욱,김영호,김재준,고광철,백승운,이종철,최규완 대한소화기내시경학회 2002 Clinical Endoscopy Vol.24 No.2
Background/Aims: It is recommended that duodenal ulcer patients who are infected with H. pylori should be treated with eradication therapy, whether the ulcer is active or in remission. However, there has been no report on the effect of eradication treatment in patients with incidentally found S-2 stage duodenal ulcer scar. Methods: We prospectively enrolled 80 H. pylori-positive patients with S-2 stage duodenal ulcer scar who have no past history of ulcer treatment. Treatment group received triple therapy consisted of omeprazole, amoxicillin, and clarithromycin for 2 weeks, whereas control group received no treatment. The follow-up endoscopy was performed every 1 year and when the patients have symptoms of ulcer disease. Fifty-three patients were followed up for more than 1 year. Results: The eradication rate of the treatment group was 92.9%. During the follow-up period of 14.7 months, 20% (5/25) of patients in the control group (2 gastric ulcers and 3 duodenal ulcers) and 3.6% (1/28) of patients in the treatment group (1 duodenal ulcer) developed active or healing stage peptic ulcers (p=0.089). Conclusions: Our results suggest that H. pylori eradication may be effective in preventing peptic ulcers in patients with S-2 stage duodenal ulcer scar. (Korean J Gastrointest Endosc 2002;24:71-75) 목적: H. pylori에 감염되어 있는 활동기, 치유기 및 반흔기를 포함한 모든 소화성 궤양 환자에서 H. pylori의 박멸을 추천하고 있다. H. pylori에 감염되어 있는 십이지장궤양 환자에서 제균 후 재발률이 현저히 낮아지는 것은 잘 알려져 있으나 증상이 없는 반흔 2기의 십이지장궤양 환자에서도 H. pylori의 제균이 질병의 경과, 특히 소화성 궤양의 재발에 영향을 미치는지에 대해서는 잘 알려져 있지 않다. 대상 및 방법: 건강검진의 일환으로 상부위장관 내시경검사를 시행하여 H. pylori에 감염이 확인되고 십이지장 구부에서 반흔 2기의 십이지장궤양이 발견된 환자 80명을 대상으로 하였다. CLO 검사나 조직검사 중 어느 하나에서라도 양성인 경우에 H. pylori에 감염된 것으로 판단하였다. 환자를 무작위로 치료군과 대조군으로 분류하여 치료군에서는 하루에 omeprazole 20 mg, amoxicillin 2,000 mg, clarithromycin 1,000 mg을 2주간 투여하였다. H. pylori 제균 치료 1년 후 추적내시경 검사를 시행하여 소화성 궤양의 재발 유무를 확인하였다. 결과: 치료군 중 28명과 대조군 중 25명에서 1년 이상 추적관찰이 가능하였다. 치료군에서 H. pylori의 제균율은 92.9%였다. 평균 14.7개월의 추적관찰 기간에 십이지장궤양의 재발은 치료군에서 1예(3.6%), 대조군에서 3예(12.0%)가 관찰되었으며 모두 활동기였다. 대조군의 2명(8.0%)에서는 추적 내시경검사에서 치유기의 양성 위궤양이 발견되었다. 위궤양과 십이지장궤양을 포함한 소화성 궤양의 재발률은 대조군에 비하여 치료군에서 감소하는 경향을 보였다(20.0% 대 3.6%, p=0.089) 결론: 본 연구의 결과는 H. pylori에 감염되어 있는 반흔 2기의 십이지장궤양 환자에서 제균요법이 소화성 궤양의 재발을 감소시키는 데 기여함을 시사한다.
김춘관,안석진,하경원,현재근,김성민,백경란,이남용,송재훈 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 비호지킨씨 림프종으로 항암 치료를 받고 있는 환자에게, 감수성있는 항균제 투여와 중심정맥 카테터를 제거함으로써, 중심정맥 카테터와 관련된 O.anthropi 패혈증을 성공적으로 치료한 1예를 경험하였다. O. anthropi 감염이 세계적으로 드물고, 국내에서는 그 보고가 없었으나, 이 균이 Pseudomonas와 유사해서 동정이 잘못될 수 있으며, 중심정맥 카테터를 가지고 있는 면역 억제된 환자에서 호발됨을 고려해 볼 때, 향후 더 많은 관심을 가져야 할 것이다. Ochrobactrum anthropi is a gram-negative, oxidase producing, non-lactose fermenting bacilli. It was formerly known as CDC Group Vd with confusions in taxonomical classification. Although there have been few reports of O. anthropi infection in English literatures, it may be related to central venous catheter infections, especially in the immunocompromised hosts. We report a case with sepsis due to O. anthropi, who had a central venous catheter and chemotherapy for non--Hodgkin's lymphoma, with review of the literatures. O. anthropi was isolated from blood culture and identified with biochemical tests. We successfully treated the patient with removal of Hickman catheter and antibiotics. To our knowledge, this is the first case of O. anthropi infection in Korea.
기능성 소화불량증에서 13C - 요소호기검사의 DOB30 와 위근위부 운동기능과의 상관관계
심상군(Sang Goon Shim),이풍렬(Poong Lyul Rhee),현재근(Jae Gun Hyun),김지은(Jee Eun Kim),성인경(In Kyung Sung),장재권(Jae Kwon Jang),류광현(Kwang Hyun Ryu),김영호(Young Ho Kim),김재준(Jae J . Kim),고광철(Kwang Cheol Koh),백승운(Seung 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: 13C-urea breath test (UBT) is accepted as an accurate test to detect Helicobacter pylori (H. pylori) infection. The results of UBT could be correlated with the extent of H. pylori colonization density or the severity of the gastric mucosal inflammation. We examined whether UBT values correlated with some parameters for proximal gastric motor functions in functional dyspepsia (FD). Methods: Twelve patients with FD and H. pylori infection confirmed by UBT were included. Breath samples were taken before and 30 min after 75 mg 13C-urea ingestion and analyzed by isotope mass spectrometry. The results of UBT were expressed as the difference between value at 30 min and value at baseline (DOB30). Gastric emptying scintigraphy and gastric barostat study were performed to measure the proximal gastric motor functions. Results: No significant correlation was found between DOB30 and proximal half-emptying time (r=-0.34, p=0.28), DOB30 and proximal gastric distribution of meal at 1 min images (r=0.03, p=0.93). According to the gastric barostat study, basal tone (r=0.53, p=0.07), compliance (r=-0.05, p=0.86), and gastric accommodation (r=-0.08, p=0.79) were not associated with DOB30. Conclusion: DOB30 does not correlate with proximal gastric motor parameters in patients with FD. (Korean J Gastroenterol 2001;38:405-410)
이준행 ( Jun Haeng Lee ),김영호 ( Young Ho Kim ),현재근,성인경 ( In Kyung Sung ),손희정 ( Hee Jung Son ),이풍렬 ( Poong Lyul Rhee ),김재준 ( Jae J. Kim ),고광철 ( Kwang Cheol Koh ),백승운 ( Seung Woon Paik ),이종철 ( Jong Chul Rhe 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 대장선종에서 대장암으로서 진행과정에서 아포토시스는 감소되고 세포증식은 증가한다고 알려져 있다. 그런데 대장암에서 아포토시스와 세포증식의 상호관계나 병기에 따른 아포토시스나 세포증식의 변화양상에 대해서는 논란이 있어왔다. 본 연구에서는 각 병기에 따른 직장암 조직에서의 아포토시스와 세포증식의 정도를 정량적으로 관찰하고, 기존에 알려진 예후인자와 bcl-2 및 p53 의 발현과의 상관관계를 조사하였다. <방법> 수술로 절제된 57예의 직장암 조직을
류민규(Min Kyu Ryu),김영호(Young Ho Kim),현재근(Jae Geun Hyun),문원(Won Moon),이경수(Kyung Su Lee),이상수(Sang Soo Lee),이준행(Jun Haeng Lee),손희정(Hee Jung Son),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),백 대한내과학회 2001 대한내과학회지 Vol.60 No.1
N/A Backgound : Crohn's disease (CD) is a chronic inflammatory disease that has difficulty in treatment due to various complications and frequent recurrence. There have been many studies on the clinical aspects of CD in western countries, however there have been few studies in Korea. We try to perform this study to elucidate the clinical features of CD in Korea. Methods : We retrospectively reviewed the medical records of 62 patients diagnosed as CD in Samsung Medical Center from October 1994 to July 1999 and investigated their clinical features. Results : Male to female ratio was 1.7:1 and the mean age at diagnosis was 29.6 years. The most common symptom was abdominal pain (58%), followed by diarrhea. Perianal lesions were observed in 27 cases (44%) of 62 patients. Fistula was the most common (60%) among the perianal lesions, followed by abscess, fissure, and stricture. Extraintestinal manifestations were observed in 23 cases (37%) of 62 patients. Arthritis was the most common (44%), followed by oral, skin, and ocular lesions. All patients were classified into three groups on the basis of disease extent by the radiologic and endoscopic findings; combined type (66%), colitis alone (23%), and small bowel disease alone (11%). Empirical anti-tuberculous medications were administered to 28 cases (45%) of 62 patients before CD was diagnosed. The presenting features were classified into inflammatory (71%), fistulizing (14.5%), and fibrostenotic (14.5%) type. Operation was performed in 31 cases (50%) of 62 patients during clinical course. The causes of operation were fistulizing complication (48%), fibrostenotic obstruction (32%), and indefinite diagnosis (20%). Conclusion : We noticed little difference in the clinical features of CD in Korea compared to those of western countries. And, intestinal tuberculosis should be considered in differential diagnosis of CD in endemic areas of tuberculosis like Korea.(Korean J Med 60:46-50, 2001)
활동성 크론병에서 초기 스테로이드 치료 반응에 따른 임상적, 생화학적, 병리학적 인자들에 관한 연구
김영호,장재권,김지은,최규완,박동일,도재혁,백승운,고광철,이풍렬,이종철,현재근,안병훈,김재준,류민규 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6
Background/Aims: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory faetor of the response to initial steroid therapy in active Crohn`s disease patients, Methods: The medical records of 32 patients with active Crohn`s disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. Results: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68.8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. Conclusions: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group.