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폐암에 의한 기관지 폐쇄의 레이저 Phototherapy 1 예
한준열,백남종,박성학,박석영,김석영,임계순 대한내과학회 1987 대한내과학회지 Vol.33 No.4
Major bronchial obstruction by lung cancer is troublesome. Radiation therapy has been the choice of treatment, but it may take long time until relieving bronchial obstruction and has some complications. Recently, laser phototherapy is applied to treatment of malignant obstruction by lung cancer and esophageal cancer, and with increasing frequency and with promising short-term results and acceptable complication rates. We experienced a case of laser phototherapy of malignant airway obstruction of left main bronchus due to squamous cell carcinoma. A 60-year old woman was admitted to the hospital because of dyspnea. Three times of laser phototherapy with Nd-YAG laser was performed with intervals more than three days. The bronchial obstruction was relieved and the procedure was very tolerable.
B형 급성 및 만성간염이 간경변으로 이행하는 병리조직학적 양상
한준열,정환국 대한간학회 1996 Clinical and Molecular Hepatology(대한간학회지) Vol.2 No.2
The chronic active or aggressive hepatitis B, in which periportal inflammation(piecemeal necrosis) is conventionally accepted as the pattern of progression to cirrhosis', implies little concern with intralobular necroinflammation as a process responsible for aggravation and progression. Some published observations, however, refer to episodes of acute necrotizing bouts(subacute hepatic necrosis) have been reported$quot;. For technical reasons, relatively few sequential biopsy studies of chronic hepatitis B are available and particularly, initial acute hepatitis B is barely documented since biopsies are now rarely perfomed in acute stages of hepatitis4. Moreover, most published sequential studies are complicated by therapeutic intervention . The availability of Korean sequential biopsy specimens and the increasing interest in parenchymal changes in the evolution of hepatitis B encouraged the description of the progression of acute and chronic hepatitis B to cirrhosis. During the long-term follow-up study, acute bouts of intralobular parenchymal necroinflammation are observed whenever the stage of aggravation is caught and the biopsy is possible. Whatever the result of these studies, the observation presented suggests a major role of parenchymal changes in the evolution of chronic hepatitis B and this experience focuses on the important lesions of the lobular parenchyma in classification and evaluation of chronic hepatitis'. Seven patients are selected on the basis of elevated S-ALT level, and submit to repated needle biopsies during a 6-month period$quot;. Of these, 2 cases show chronic active hepatitis with early cirhosis constantly, and in 5 cases CAH appear 1 or 2 times in each case during the follow-up period. In clinical follow-up after the sequential biopsies, these 7 patients were all healthy at least for an average of 18.6 years ranging from 14 to 27 years, except for one who developed into HCC without complication of cirrhosis. Thus, while the sample size of this study is small, continuous piecemeal necrosis seems not to be a pattern of progression to cirrhosis. In conclusion, acute and chronic hepatitis B experienced in Korea appear to progress to cirrhosis by means of repeated acute episodic bouts of intralobular necroinflammation, and the conventional concept that continuous progress by piecemeal necrosis seems not to hold true.