동물(젖소)건강 Monitoring system 모델 개발 V. 임상학적 위해요소 분석

최민철,김종수,김곤섭,김용환,이효종,손우진,원현희 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.2

An animal health monitoring system in Gyeongnam area (near-Chinju) was studied to evaluate the environmental risk factors, physical examinations and 4 disease entities(abomasal displacement, traumatic reticulopericarditis & -peritonitis, milk fever and lameness) in 40(34 in second year)dairy herds (total 1253 dairy cattle). In feeding environments, we examined housing system, forage percentage in ration, stall types, playground, cleanness of stall. In housing system, most of herds (60%) have tie-stall types and 36 herds are open-type housing. The forage ratio of ration was less than 50% in most of herds (67%). 39 herds had their own playgrounds and the frequency of playground cleanness was irregular, Physical examinations included the T(temperature), P (pulse), R (respiration), abnormalities of superficial lymph nodes, claw examination and total CBC with blood from tail veins. T, P, R are within normal limits (T : 38.1$\pm$0.6$^{\circ}C$, P : 84.6$\pm$12.9/min., R : 24.0$\pm$7.6/min. ,respectively), the swelling of lymph nodes were shown in 13 cattle and overall claw trimming was required in 3 herds. In blood examination, 23 cattle showed leuko-cytosis and 7 cattle showed low RBC and hemoglobin level, the other cattle were within normal limits (WBC : 8.90$\pm$2.06 10$^3$/ul., RBC : 6.36$\pm$1.02 10$^{6}$ ul, Hb : 9.83$\pm$ 1.20 g/dl PCV : 27.43$\pm$5.67 %, respectively). In 4 disease entities, we found some metallic foreign bodies in men of 13 cattle, which had predisposing factors of traumatic reticulopericarditis and reticuloperitonitis, 13 abomasal displacement, 51 milk fever and lameness in 39 cattle.

Ivermectin에 의한 개 심장사상충증의 치료1례

최민철,Choi Min-chul 대한수의사회 1990 대한수의사회지 Vol.26 No.1

A dog which Showed dry muzzle, coughing, dyspnea, weight loss and exercise intolerance was clinically examined. Dirofilaria immitis infection was determined by hematological findings, radiographic evaluation and detection of microfilaria with modified Kno

Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma

최민철,황소현,김세화,정상근,박현,주원덕,송승훈,이찬,김태헌,강혜윤,안희정 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose In this study, we investigated the frequencies of mutations in DNA damage repair genes including BRCA1, BRCA2, homologous recombination genes and TP53 gene in ovarian highgrade serous carcinoma, alongside those of germline and somatic BRCA mutations, with the aim of improving the identification of patients suitable for treatment with poly(ADPribose) polymerase inhibitors. Materials and Methods Tissue samples from 77 Korean patients with ovarian high-grade serous carcinoma were subjected to next-generation sequencing. Pathogenic alterations of 38 DNA damage repair genes and TP53 gene and their relationships with patient survival were examined. Additionally, we analyzed BRCA germline variants in blood samples from 47 of the patients for comparison. Results BRCA1, BRCA2, and TP53 mutations were detected in 28.6%, 5.2%, and 80.5% of the 77 patients, respectively. Alterations in RAD50, ATR, MSH6, MSH2, and FANCA were also identified. At least one mutation in a DNA damage repair gene was detected in 40.3% of patients (31/77). Germline and somatic BRCA mutations were found in 20 of 47 patients (42.6%), and four patients had only somatic mutations without germline mutations (8.5%, 4/47). Patients with DNA damage repair gene alterations with or without TP53mutation, exhibited better disease-free survival than those with TP53 mutation alone. Conclusion DNA damage repair genes were mutated in 40.3% of patients with high-grade serous carcinoma, with somatic BRCAmutations in the absence of germline mutation in 8.5%. Somatic variant examination, along with germline testing of DNA damage repair genes, has potential to detect additional candidates for PARP inhibitor treatment.

쥐에서 Carboxymethylcellulose 및 Ibuprofen을 이용한 유착형성 방지에 관한 연구

최민철,이효종,김곤섭,Choi Min-Cheol,Lee Hyo-Jong,Kim Gon-Sup 한국임상수의학회 1993 한국임상수의학회지 Vol.10 No.2

With the use of a rat surgical model, the ability of carboxymethylcellulose and ibuprofen in the reduction of abdominal adhesion was examined. Seventy seven female rats were randomly divided into 7 groups : (1) control, (2) 2% CMC, (3) 3% CMC, (4) ibuprofen 25mg, (5) ibuprofen 50mg, (6) combination of ibuprofen 25mg and 2% CMC and(7) combination of ibuprofen 50mg and 3%, CMC. Following induction of abrasion injuries on ileum, colon and both uterine horns with a surgical blads, the rats in groups (2), (6) were infused with 2% CMC solution singly or in combined Infection of 25 mg/kg of ibuprofen for three consecutive days, the rats In groups (3), (7) were infused with 3% CMC solution singly or In combined Injection of 50mg/kg of ibuprofen for three consecutive days. The rats in groups (4), (5) were injected only with 25 mg or 50 mg/kg of ibuprofen for three consecutive days. After 10 days the abdominal cavities were opened and the appearance of formed adhesion were graded. The changes of body weight, CBC and blood chemicals were also evaluated at 3, 6 and 10 days after operation. In ileum, the rats in the groups (2), (6) and (7) showed less adhesion formation. In colon, there were significant differences(p<0.05) in adhesion formation in all treated groups as compared to control. In both uterine horns, there were significant decrease(p<0.05) of adhesion formation in groups(2), (6) and (7) in comparison with other groups. The increasing rate of body weight was evident in group (3) and fibrinogen concentrations at 6 and 10 days revealed significant decrease (p<0.01) in group (7), whereas there was no consistent change in CBC and blood chemicals. Therefore, it can be sugested that the infusion of 2% CMC solution with or without the injection of 25 mg/kg of ibuprofen and 3% CMC solution with the injection of 50 mg/kg of ibuprofen are effective and safe following abdominal surgery,

Aloe vera투여가 Cobalt-60 감마선 조사를 받은 마우스의 생존율과 조혈간세포에 미치는 영향

최민철,성재기,Choi Min-cheol,Sung Jai-Ki 한국임상수의학회 1990 한국임상수의학회지 Vol.7 No.2

The present study was carried out to investigate whether the aloe had a radioprotective effect in mice exposed to cobalt-60 gamma radiation or not. The survival ratio of mice for 30 days, hematopoiesis of blood-forming stem cells by spleen colony assay, chromosomal aberration frequency of bone marrow cells and histopathological findings of bone marrow were investigated. The survival ratios of aloe administered groups with concentration of 250, 500, 1,000 and 1,500mg for 3 days before irradiation and control group in cobalt-60 gamma irradiated mice(700rads whole body irradiation, dose rate of 50rads/min.) were 77.4, 79.3, 80.6, 90.0 and 53.1%, respectively. The survival ratios of pre-irradiation aloe administered groups were superior to those of post-irradiation aloe groups and control group. In spleen colony assay, Aloe vera administration before irradiation enhanced the recoveries of numbers of blood-forming stem cells of bone marrow of irradiated mice. There were decreased chromosomal aberrations of bone marrow cells at the first day after irradiation in aloe administered groups compared to that of control group. Histopathological findings in the bone marrow of irradiated mice were hypocellularity due to the depletion of myelocytes, abundant of fat vacuoles and these changes were weakened in aloe administered groups compared to that of control group.

엘리트 골프 선수의 X-Factor와 X-Factor stretch의 차이

최민철,이기광,손지훈,임영태 한국골프학회 2010 골프연구 Vol.4 No.2

The purpose of this study was to investigate X-factor and X-factor stretch from elite golfers in Korea. Sixteen college male elite golf players participated in this study. Subjects used their own driver and swing five trials and 3-D motion analysis system was used to determine X-factor, X-factor stretch, effective X- factor, and the duration during the back swing phase. The results indicated that mean X-factor was 61.24o and mean X- Factor stretch was 65.60o. Mean effective X-factor was found as 4.36 and the average time difference was 0.09 second. These results were similar to the data of previous research in Korea but still below to the data of world top ranked professional golfers. Overall, it is indicated that the lead of low extremity can cause X-Factor stretch and it is functioned to produce late hitting at impact. This may affect to increase head speed and total ball flight distance.

국내 AI 기술 경쟁력 분석과 정책적 시사점 : AI 특허를 중심으로

최민철,조재한 산업연구원 2022 연구자료 Vol.- No.-

국내 연구개발 효율성 하락 요인 분석 : 제조기업의 특허출원을 중심으로

최민철 산업연구원 2021 연구자료 Vol.- No.-

유전성 부인암의 예방, 조기검진 및 치료

최민철 대한산부인과학회 2017 대한산부인과학회 학술대회 Vol.103 No.-

Comparative evaluation of renal size on radiography and ultrasonography in rabbits

최민철,윤희준,이효종,강태영,Choi, Min-cheol,Yin, Xi-jun,Lee, Hyo-jong,Kang, Tae-young The Korean Society of Veterinary Science 1996 大韓獸醫學會誌 Vol.36 No.4

토끼에서 신장의 크기(길이, 폭 및 높이)를 측정하고 이에 대한 기본자료로 삼고자 53마리의 토끼(Newzealand White)의 신장을 방사선 촬영과 초음파 신장촬영 그리고 신장을 적출하여 실제 길이를 재고 이들간의 측정치를 비교하였다. 방사선 촬영에서는 우측신장은 T13-L2에서 관찰되었고 좌측신장은 L2-L4에서 관찰되었다. 초음파 신장촬영상에서는 신장 피질은 작고 균등하며 주변조직에 비하여 저에코상을 보였고 신장의 신우는 무에코 내지는 약간의 저에코상을 보였다. 토끼의 좌측신장에서 길이, 폭 및 높이는 각각 $35.84{\pm}3.12(mean{\pm}SD)$, $23.52{\pm}3.21$ 및 $15.11{\pm}2.58cm$ 였으며 우측신장에서는 $36.02{\pm}3.42$, $23.69{\pm}3.50$ 및 $14.13{\pm}3.55cm$ 이었다. 방사선 사진상에서 양쪽 신장의 길이와 폭은 실제 크기에 비하여 약간 확대되었으며(102~104%), 초음파신장 촬영상에서 양쪽 신장의 길이, 폭 및 높이는 실제 크기에 비하여 적게 축소된 상을 보였다(70~96%). 복배상 방사선 사진에서 신장의 길이와 폭의 제2요추 길이의 대비에서 1.85와 1.25배로 나타났다. 체중과 신장의 각 측정치와의 상관관계에서는 서로간에 유의치 있는 상관관계가 있었다. Renal size(length, width and height) of rabbits was measured by radiographs and nephrosonograms and compared with actual size. After measuring on the radiographs and nephrograms, both kidneys were removed from the body and actual size was also measured. On radiographs, right kidney was observed at the T13-L2 vertebrae and left kidney was at L2-L4 vertebrae. On nephrosonograms, the renal cortex was visible as small, homogenous echoes that were hypoechoic relative to the surrounding tissues, whereas the renal medulla was anechoic to slightly hypoechoic. The actual length, width and height of the left kidney were $35.84{\pm}3.12(mean{\pm}SD)$, $23.52{\pm}3.21$, $15.11{\pm}2.58cm$, respectively, whereas those of the right kidney were $36.02{\pm}3.42$, $23.69{\pm}3.50$ and $14.13{\pm}3.55cm$, respectively. On radiographs, the length and width of both kidneys were a little magnified(102-104%) when compared to actual size. On nephrosonograms, the length, width and height of bothkidneys were lessened(70-96 %) when compared to actual size. The length and width of kidney were 1.85 and 1.25 times the length of the second lumbar vertebrae on the ventrodorsal view. In correlation and correlation coefficient of body weight with the renal size, the body weight and renal size were significantly correlated with each other other(p<0.01) and the correlation coefficents of body weight with left, right and both Kindneys were 0.748, 0.794 and 0.859, respectively.