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Thioacetamide 에 의한 간경변에서 Pentoxifylline 투여가 흰쥐의 간 섬유화와 세포주기조절 단백질에 미치는 영향
장자준,장기택,김미란,정인평,이미숙 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.3
Background: Thioacetamide is a classic hepatotoxic reagent which leads to the reproducible hepatic fibrosis in rats. Thioacetamide-induced fibrosis is an appropriate model for cirrhosis in humans due to the long duration of course and similiar histology. Thioacetamide produces hepatotoxicity through lipid peroxidation but it is unclear whether lipid peroxidation directly correlated with hepatic fibrosis. Pentoxifylline, a derivative of the methylxanthine, showed an antifibrogenic effect in cell cultures of human fibroblasts and some animal models. But this antifibrogenic effect is controversial. Pentoxifylline revealed a hepatoprotective effect in some toxic hepatitis. This hepatoprotective effect seems to influence cell cycle regulatory protein during regeneration. This study aimed to evaluate an effect of pentoxifylline on fibrosis and cell cycle regulatory protein during liver regeneration in thioacetamide-induced rat cirrhosis. Lipid peroxidation assay was compared with collagen content so as to evaluate the correlation with fibrosis. Mothed: Liver cirrhosis was induced by 0.03% oral administration of thioacetamide. Pentoxifylline was administered simultaneously with thioacetamide, The semiquantitative fibrosis index was measured based on histologic finding. Collagen content was estimated by spectrophotometric assay. Activated hepatic stellate cells were counted using α-SMA immunohistochemistry. Malondialdehyde, lipid peroxidation metabolite, was estimated by thiobarbituric acid reactive substance assay. Cell cycle regulatory protein was evaluated by western blot. Results- There was no difference in semiquantitative fibrosis index, collagen content and hepatic stellate cell count between thioacetamide treated rats and simultaneous pentoxifylline treated rats. Lipid peroxidation product was not correlated with collagen content. Western blot showed no difference in cell cycle regulatory protein. Conclusion- Pentoxifylline does not show an antifibrogenic effect in thioacetamide-induced rat cirrhosis, in which thioacetamide induced hepatocellular damage and fibrosis. Lipid peroxidation may be a secondary effect rather than primary mediating mechanism in hepatic fibrosis. (Korean J Hepatol 20017:281-291)
건축용 외장재와 접착제 연소가스의 독성분석에 관한 연구
김원종 ( Won Jong Kim ),박영주 ( Young Ju Park ),이해평 ( Hae Pyeong Lee ),임석환 ( Suk Hwan Lim ),김정인 ( Jung In Kim ) 한국안전학회(구 한국산업안전학회) 2013 한국안전학회지 Vol.28 No.4
This study was carried out, using toxicity test apparatus, to analyze toxic gases of heat insulation material and adhesives of composite panels used for the architectural surface material when a fire occurs. The findings of this study show that CO, CO2, HCOH, CH2CHCN and NOx were detected from styrofoam, reinforced styrofoam, polyurethane foam and glass fiber, but in the case of the polyurethane foam, HCl and HCN were detected as well. All the architectural adhesives released CO, CO2 and NOx, but HCHO was only detected from the adhesives for styrofoam, wood, tile, windows and doors; CH2CHCN was only from those for wood and stone; C6H5OH was only from those for wood. The toxicity index was also measured for architectural surface material and adhesives. Polyurethane foam showed the highest index, 11.7, and glass fiber was followed as 6.8. Reinforced styrofoam showed 5.7 and styrofoam revealed the least 4.9. In the case of architectural adhesives, the highest ranking was those for stone 7.4, windows and doors 6.1, wood 5.3, tile 3.8, and styrofoam 3.7 were followed, respectively.