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유전자 재조합 VIIa 투여로 회복된 후천성 혈우병 환자의 급성출혈 1예
이나리아,임원,김미현,김효정,박진섭,설영미,송무곤,정주섭,조군제,최영진,윤성훈,김선경 대한혈액학회 2009 Blood Research Vol.44 No.3
Acquired hemophilia is a rare but potentially life-threatening hemorrhagic disorder caused by the development of autoantibodies against coagulation factor VIII. Concentrates of human factor VIII, desmopressin, activated prothrombin complex concentrates, recombinant activated factor VII can all be used to control episodes of acute bleeding. The recent availability of bypassing agents like recombinant activated factor VII has been shown to be clinically safe and effective as treatment for acute bleeding. In this case report, a 67 year-old male patient with Rh negative blood type developed gross hematuria and bleeding after transurethral resection due to prostatic hypertrophy. After vesicocutaneous fistular reduction operation, post-operative bleeding was presented. The acute bleeding was controlled successfully by the combined treatment with recombinant activated factor VII (Novo sevenⓇ) and prednisone.
A Case of Severe Acute Kidney Injury by Near-Drowning
성은영,이하린,이나리아,이성준,송상헌,이동원,이수봉,설미영,곽임수 대한의학회 2012 Journal of Korean medical science Vol.27 No.2
Acute kidney injury (AKI) secondary to near-drowning is rarely described and poorly understood. Only few cases of severe isolated AKI resulting from near-drowning exist in the literature. We report a case of near-drowning who developed to isolated AKI due to acute tubular necrosis (ATN) requiring dialysis. A 21-yr-old man who recovered from neardrowning in freshwater 3 days earlier was admitted to our hospital with anuria and elevated level of serum creatinine. He needed five sessions of hemodialysis and then renal function recovered spontaneously. Renal biopsy confirmed ATN. We review the existing literature on near-drowning-induced AKI and discuss the possible pathogenesis.
김선경,김미현,이나리아,차동혁,김효정,최영진,정주섭,조군제 대한혈액학회 2009 Blood Research Vol.44 No.2
Primary malignant lymphoma of the urinary bladder is a rare disease, and it accounts for only 0.2% of all the cases of extranodal lymphoma. The prognosis of primary bladder lymphoma has been favorable, with many patients being alive and well several years after treatment. We report here on a case of primary diffuse large B cell lymphoma of the urinary bladder in a 75-year-old man patient who presented with a one-month history of persistent dysuria. The abdominal CT revealed a mass at the posterior wall of the urinary bladder. The tissue obtained by transurethral cystoscopy showed an atypical lymphoid proliferation, which was consistent with diffuse large B cell lymphoma. The patient received systemic chemotherapy of rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) and he achieved a significant partial remission.
차동혁,김효정,이나리아,남형석,최보광,이혜원,김성근,정주섭,조군제,최영진,김선경 대한혈액학회 2009 Blood Research Vol.44 No.3
Behçet’s disease is a relapsing inflammatory disorder characterized by vasculitis of unknown cause and has been reported rarely in association with malignant diseases. In most cases the autoimmune nature of Behçet’s disease and the long-term immunosuppressive therapy for disease control have been proposed to be responsible for malignant transformation. Although a few cases of various solid tumor and myelodysplastic syndrome have been reported in association with Behçet’s disease, acute leukemia has seldom been associated with Behçet’s disease in Korea. We report a case of 38-year-old man with acute myeloblastic leukemia association with a Behçet’s disease who had not received long-term treatment.