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윤서빈,최의환,김정웅,Keun P. Kim 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
An important event enabling meiotic prophase I to proceed is the close juxtaposition of conjoined chromosome axes of homologs and their assembly via an array of transverse filaments and meiosis-specific axial elements into the synaptonemal complex (SC). During meiosis, recombination requires the establishment of a platform for recombinational interactions between the chromosome axes and their subsequent stabilization. This is essential for ensuring crossover recombination and proper segregation of homologous chromosomes. Thus, well-established SCs are essential for supporting these processes. The regulation of recombination intermediates on the chromosome axis/ SC and dynamic positioning of double-strand breaks are not well understood. Here, using super-resolution microscopy (structured illumination microscopy), we determined the localization of the replication protein A (RPA) complex on the chromosome axes in the early phase of leptonema/zygonema and within the CEs of SC in the pachynema during meiotic prophase in mouse spermatocytes. RPA, which marks the intermediate steps of pairing and recombination, appears in large numbers and is positioned on the chromosome axes at the zygonema. In the pachynema, RPA foci are reduced but do not completely disappear; instead, they are placed between lateral elements. Our results reveal the precise structure of SC and localization dynamics of recombination intermediates on meiocyte chromosomes undergoing homolog pairing and meiotic recombination.
오토인코더 기반 키워드 임베딩을 통한 문서 분류 방법론
윤서빈,김남규 한국컴퓨터정보학회 2023 韓國컴퓨터情報學會論文誌 Vol.28 No.9
In this study, we propose a Dual Approach methodology to enhance the accuracy of document classifiers by utilizing both contextual and keyword information. Firstly, contextual information is extracted using Google's BERT, a pre-trained language model known for its outstanding performance in various natural language understanding tasks. Specifically, we employ KoBERT, a pre-trained model on the Korean corpus, to extract contextual information in the form of the CLS token. Secondly, keyword information is generated for each document by encoding the set of keywords into a single vector using an Autoencoder. We applied the proposed approach to 40,130 documents related to healthcare and medicine from the National R&D Projects database of the National Science and Technology Information Service (NTIS). The experimental results demonstrate that the proposed methodology outperforms existing methods that rely solely on document or word information in terms of accuracy for document classification.
휴먼 위치인식과 Pan-Tilt모듈을 이용한 객체 응시추적 시스템 구현
윤서빈(Seo-bin Yun),윤상석(Sang-Seok Yun) 한국정보통신학회 2019 한국정보통신학회 종합학술대회 논문집 Vol.23 No.2
본 논문은 실내공간에 장착된 RGB-D 센서를 이용하여 사용자의 위치를 추정한 후 Pan-Tilt모듈이 장착된 모바일 로봇을 이용하여 추적 대상자에게 접근하면서 대상자를 지속적으로 응시할 수 있는 객체 응시추적 시스템을 제안한다. RGB-D 센서로부터 추출된 이미지 정보에 Haar-cascade알고리즘을 사용하여 객체를 검출한 후 Depth 정보로부터 3차원 공간 내에서의 위치를 추정하게 되며, 기준좌표를 통한 3차원 좌표변환을 통하여 로봇은 휴먼객체의 상대적인 공간위치를 인식하게 된다. 4x3(m)의 실내공간에서 추적실험을 수행한 결과 움직이는 로봇에 설치된 Pan-Tilt모듈을 이용하여 휴먼 객체를 지속적인 응시가 가능하며, 안정적으로 추적이 가능함을 확인하였다. This paper uses RGB-D sensors mounted in interior space to estimate the user"s position, and then propose an object Examining Estimation System system that can continuously stare at the target while approaching the target using mobile robots equipped with Pan-Tilt modules. After detecting the object using the Haar-cascade algorithm on the image information extracted from the RGB-D sensor, the position of the object in the 3D space is estimated from the depth information. Through 3D coordinate transformation through reference coordinates, the robot recognizes the relative spatial position of the human object. As a result of experiment in the indoor space of 4x3(m), it was confirmed that the Pan-Tilt module installed in the mobile robot can stably track while continuously staring at the human object.
윤서빈(Seo-Bin Yun),천정호(Jung-Ho Cheon),윤상석(Sang-Seok Yun) 대한인간공학회 2020 대한인간공학회 학술대회논문집 Vol.2020 No.10
Objective: The aim of this study is to allow the mobile robot to react quickly to make face-to-face interaction and to keep a distance between humans and robots. Background: Since the emergence of social robots that enable social behavior such as interacting with people and sharing daily communication and communion, social interaction between humans and robots has emerged as the most active area of research in robot technology. Method: It recognizes the human body joint and estimates the human body pose in space by calculating the relative coordinates of the body joint information. Based on the estimated human location, an omnidirectional robot is used to move to a target point that maintains a certain distance while facing the user. Results: In the user"s pose estimation, the angle error within 5 degrees was confirmed. In the experiment of moving the robot"s destination position, it was confirmed that the error was large at a position of 3m or more. Conclusion: The robot can move to a position where face-to-face interaction is possible by estimating the user"s pose by extracting the user"s joint coordinates based on the RGB-D sensor and calculating the geometric transfer function. Application: The proposed method can be utilized to perform triggering for dialogue between the user and the robot or to control the robot"s posture when the user moves.
최의환,윤서빈,한윤수,김근필 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.2
Homologous recombination (HR) is necessary for maintenance of genomic integrity and prevention of various mutations in tumor suppressor genes and proto-oncogenes. Rad51 and Rad54 are key HR factors that cope with replication stress and DNA breaks in eukaryotes. Rad51 binds to single-stranded DNA (ssDNA) to form the presynaptic filament that promotes a homology search and DNA strand exchange, and Rad54 stimulates the strand-pairing function of Rad51. Here, we studied the molecular dynamics of Rad51 and Rad54 during the cell cycle of HeLa cells. These cells constitutively express Rad51 and Rad54 throughout the entire cell cycle, and the formation of foci immediately increased in response to various types of DNA damage and replication stress, except for caffeine, which suppressed the Rad51-dependent HR pathway. Depletion of Rad51 caused severe defects in re-sponse to postreplicative stress. Accordingly, HeLa cells were arrested at the G2–M transition although a small amount of Rad51 was steadily maintained in HeLa cells. Our results suggest that cell cycle progression and proliferation of HeLa cells can be tightly controlled by the abundance of HR proteins, which are essential for the rapid response to postreplicative stress and DNA damage stress.
Maintenance of genome integrity and active homologous recombination in embryonic stem cells
최의환,윤서빈,Koh Young Eun,서영진,김근필 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Embryonic stem cells (ESCs) possess specific gene expression patterns that confer the ability to proliferate indefinitely and enable pluripotency, which allows ESCs to differentiate into diverse cell types in response to developmental signals. Compared to differentiated cells, ESCs harbor an elevated level of homologous recombination (HR)-related proteins and exhibit exceptional cell cycle control, characterized by a high proliferation rate and a prolonged S phase. HR is involved in several aspects of chromosome maintenance. For instance, HR repairs impaired chromosomes and prevents the collapse of DNA replication forks during cell proliferation. Thus, HR is essential for the maintenance of genomic integrity and prevents cellular dysregulation and lethal events. In addition, abundant HR proteins in the prolonged S phase can efficiently protect ESCs from external damages and protect against genomic instability caused by DNA breaks, facilitating rapid and accurate DNA break repair following chromosome duplication. The maintenance of genome integrity is key to preserving the functions of ESCs and reducing the risks of cancer development, cell cycle arrest, and abnormal replication. Here, we review the fundamental links between the stem cell-specific HR process and DNA damage response as well as the different strategies employed by ESCs to maintain genomic integrity.
실시간 모니터링 및 생체정보 수집 환자 케어시스템 구현
김세정 ( Sea-jung Kim ),윤서빈 ( Seo-bin Yoon ),변정훈 ( Jung-hun Byeon ),오예은 ( Ye-eun O ),유종현 ( Jong Hyun Ryu ),전홍영 ( Hong Young Jun ),정길환 ( Kil Hwan Jeong ),김규겸 ( Kou Gyeom Kim ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.1
환자의 생체신호 측정 및 관찰, 영상 위생 등을 포함하는 직접간호는 간호사들의 총 간호활동 시간 중 내과는 48%, 외과는 40% 로 간호사들의 업무 부담이 되고 있다. 또한 의료기관에서 사용되는 의료기기들은 여러 회사에서 구매하여 사용되기 때문에 각 회사마다 상이한 프로토콜을 가지고 있어 하나의 시스템으로 생체신호를 모으기가 쉽지 않다. 따라서 여러 장비에서 생체신호를 실시간으로 취득하여 통합 관리할 수 있는 시스템 개발을 통해 간호사의 직접간호 업무량을 줄여 간호사의 근무환경 개선뿐만 아니라 중증환자의 경우 환자 생체신호에 대한 실시간 원격감시가 가능하고 환자에게서 발생된 모든 생체신호가 데이터베이스 시스템으로 기록관리 됨으로 인해 환자의 생체 신호에 대한 이력 추적관리가 가능함으로써, 양질의 의료 서비스가 가능한 환자케어시스템을 개발하고자 한다.