Congenital Peribronchial Myofibroblastic Tumor: A Case Study and Literature Review

김유일,조은윤,박하영,조준훈,한정호 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.2

Congenital peribronchial myofibroblastic tumor (CPMT) is a benign pulmonary spindle cell neoplasm of intrauterine and perinatal period, which is thought to arise from primitive peribronchial mesenchyme. We present a case detected incidentally in a one-month-old infant. The solid and partially necrotic tumor involved the right middle and lower lobes of the lung with extension to the diaphragm. Histologically, the tumor was composed of fasciculated monotonous spindle cells, proliferating peribronchiolar cartilage and round cells with rich vasculature, and high mitotic activity was identified in the round cell area. Immunohistochemical and electron microscopic studies showed that the spindle cells were myofibroblastic in phenotype. Although the tumor showed several malignant pathological features, recurrence was not observed in the two-year follow-up period, consistent with the benign clinical behavior of CPMT.

Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas

김유일,주영훈,김민식,이연수 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.5

Background: High-risk (HR) human papillomavirus (HPV) is found in a subset of head and neck (HN) squamous cell carcinomas (SCCs). For oropharyngeal SCCs, HR HPV positivity is known to be associated with good prognosis, and a separate staging system for HPV-associated carcinomas using p16 immunohistochemistry (IHC) as a surrogate test has been adopted in the 8th American Joint Committee on Cancer staging system. We examined the HR HPV status and the genotype distribution in five HN subsites. Methods: Formalin-fixed paraffin-embedded tissue sections were used for p16 IHC and DNA extraction. HPV DNA detection and genotyping were done employing either a DNA chip-based or real-time polymerase chain reaction–based method. Results: During 2011–2019, a total of 466 SCCs were tested for HPV DNA with 34.1% positivity for HR HPV. Among HN subsites, the oropharynx showed the highest HR HPV prevalence (149/205, 75.1%), followed by the sinonasal tract (3/14, 21.4%), larynx (5/43, 11.6%), hypopharynx (1/38, 2.6%), and oral cavity (1/166, 0.6%). The most common HPV genotype was HPV16 (84.3%) followed by HPV35 (6.9%) and HPV33 (4.4%). Compared with HR HPV status, the sensitivity and specificity of p16 IHC were 98.6% and 94.3% for the oropharynx, and 99.2% and 93.8% for the tonsil, respectively. Conclusions: Using a Korean dataset, we confirmed that HR HPV is most frequently detected in oropharyngeal SCCs. p16 positivity showed a good concordance with HR HPV DNA for oropharyngeal and especially tonsillar carcinomas. The use of p16 IHC may further be extended to predict HR HPV positivity in sinonasal tract SCCs.

Quadratic Volterra 모델을 이용한 자유지지 라이저의 동적 응답 시계열 예측

김유일(Yooil Kim) 대한조선학회 2014 大韓造船學會 論文集 Vol.51 No.4

F-78 : Free Paper Presentation ; Clinical Efficacy of Corticosteroid for the Control of Lung Cancer Treatment-Related Pulmonary Toxicities

김선,오인재,박서연,선현주,윤성훈,유진영,이보람,반희정,권용수,김규식,김유일,임성철,김영철 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Background: Since more patients are being treated with anti-tumor agents and radiation, associated pulmonary toxicities are more commonly being recognized and treated. The aim of this study is to evaluate the characteristics of pulmonary toxicities and the efficacy of corticosteroid therapy. Methods: Clinical information was retrospectively assembled from 398 patients who received systemic steroid for the control of pulmonary toxicities over the past 5 years. The patients were divided into 4 groups under clinical diagnosis and we compared the steroid responses between groups. Results: Among total of 398 patients, drug-induced interstitial lung disease (ILD) was 88 (22%), radiation pneumonitis 189 (47%), acute exacerbation of chronic obstructive pulmonary disease (AECOPD) 47 (12%), and others 74 (19%). The response rates of steroid of each group were 65%, 87%, 81%, and 62%, respectively (p<0.001). Pulse dose (hazard ratio [HR] 26.24, 95% confidence interval [CI] 8.50-81.05) and high-dose steroid (HR 14.28, 95% CI 6.70-30.47) had higher fatality comparing with low-dose therapy (p<0.001). In ILD group, diffuse alveolar damage pattern on chest radiography showed higher 2-month mortality (100%) than non-specific interstitial pneumonia (NSIP, 62%) and bronchiolitis obliterans with organizing pneumonia (BOOP, 42%, p=0.032) pattern. Conclusions: Radiation pneumonitis and AECOPD showed better response to corticosteroid than drug-induced ILD. In subgroup analysis of ILD, BOOP and NSIP radiographic patterns showed more favorable outcome.Background: Since more patients are being treated with anti-tumor agents and radiation, associated pulmonary toxicities are more commonly being recognized and treated. The aim of this study is to evaluate the characteristics of pulmonary toxicities and the efficacy of corticosteroid therapy. Methods: Clinical information was retrospectively assembled from 398 patients who received systemic steroid for the control of pulmonary toxicities over the past 5 years. The patients were divided into 4 groups under clinical diagnosis and we compared the steroid responses between groups. Results: Among total of 398 patients, drug-induced interstitial lung disease (ILD) was 88 (22%), radiation pneumonitis 189 (47%), acute exacerbation of chronic obstructive pulmonary disease (AECOPD) 47 (12%), and others 74 (19%). The response rates of steroid of each group were 65%, 87%, 81%, and 62%, respectively (p<0.001). Pulse dose (hazard ratio [HR] 26.24, 95% confidence interval [CI] 8.50-81.05) and high-dose steroid (HR 14.28, 95% CI 6.70-30.47) had higher fatality comparing with low-dose therapy (p<0.001). In ILD group, diffuse alveolar damage pattern on chest radiography showed higher 2-month mortality (100%) than non-specific interstitial pneumonia (NSIP, 62%) and bronchiolitis obliterans with organizing pneumonia (BOOP, 42%, p=0.032) pattern. Conclusions: Radiation pneumonitis and AECOPD showed better response to corticosteroid than drug-induced ILD. In subgroup analysis of ILD, BOOP and NSIP radiographic patterns showed more favorable outcome.

초고속 비행체용 소모성 터빈엔진 사전연구

김유일(YouIl Kim),황기영(KiYoung Hwang) 한국추진공학회 2011 한국추진공학회 학술대회논문집 Vol.2011 No.11

초고속 비행체에 적용 가능한 소모성 터빈엔진 개발을 위한 사전연구를 수행하였다. 엔진 요구도 및 설계점 결정을 위한 가상 운용임무형상을 선정하고, 유사급 엔진과 참고문헌 등을 통해 확보된 데이터를 활용하여 설계점 해석을 수행하였는데, 해면고도, 마하수 1.2 조건에서 터빈입구온도 3,600R에 대한 설계점 계산결과, 비추력 2599.4 ft/s, 비연료소모율 1.483 lb/(lb*h)이 예측되었다. 설계점 계산결과를 기준으로 두 가지 임무형상에 대한 엔진 성능해석결과, 엔진 최대 순추력을 결정하는 설계변수는 천음속 및 낮은 초음속영역에서는 터빈입구온도, 높은 초음속 영역에서는 압축기 출구온도임을 확인하였다. 이밖에도 단순, 저가, 경량의 엔진형상으로 축류형 다단압축기와 직류형 연소기, 1단 축류터빈, 고정 수축팽창 노즐이 적용된 단순터보제트엔진을 제시하였다. A prestudy on expendable turbine engine for high-speed vehicle was conducted. The two possible mission profiles were established to decide the engine requirements and Design Point, and Design Point analysis was performed with the values of design parameter which were obtained from similar class engines and technical references. The results showed that Specific Net Thrust is 2599.4 ft/s and Specific Fuel Consumption is 1.483 lb/(lb*h) at the flight condition of Sea Level, Mach 1.2. It was also found through the performance analysis on the two possible mission profiles that major design parameters for determining Net Thrust were Turbine Inlet Temperature for low supersonic flight speed and Compressor Exit Temperature for high supersonic flight speed. In addition, simple turbojet engine with axial compressor, straight annular combustor, axial turbine and fixed throat area converge-diverge exhaust nozzle was proposed as the configuration of simple low cost light engine.

Chronic Obstructive Pulmonary Disease: Respiratory Review of 2013

김유일 대한결핵및호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.2

Chronic obstructive pulmonary disease (COPD) is a common airway disease that has considerable impact on disease burdens and mortality rates. A large number of articles on COPD are published within the last few years. Many aspects on COPD ranging from risk factors to management have continued to be fertile fields of investigation. This review summarizes 6 clinical articles with regards to the risk factors, phenotype, assessment, exacerbation, management and prognosis of patients with COPD which were being published last year in major medical journals.

터빈엔진시험을 통한 제트연료 변경에 따른 엔진성능 변화 연구

김유일(Youil Kim),민성기(Seongki Min) 한국추진공학회 2010 한국추진공학회 학술대회논문집 Vol.2010 No.11

제트연료변경에 따른 엔진 운용 특성 변화를 살펴보기 위해 JP-8 연료와 JP-S 연료를 사용하여 소형터보제트엔진의 지상시험 및 고도시험을 수행하였다. 비중이 18% 높은 JP-S 연료에 대한 연료조절 시스템 특성은 동일 연료공급명령에 대한 실 연료공급량이 JP-8 연료보다 8% 많이 공급되었다. 시동 특성은 연료조절시스템의 명령 대비 공급량의 차이로 인한 점화시점 및 엔진 회전수 가속율 등의 변화를 제외하고는 유사한 특성을 보였다. 정상상태 성능 특성은 순 추력의 일부 구간을 제외하고는 순추력과 공기유량, 배기가스온도 등 대부분의 엔진 성능 변수가 1% 이내로 유사하였으나 연료소모량만은 연료의 발열량 차이로 인해 최대 5 %이상 차이가 발생하였다. 이를 동일 추력 대비 비 연료소모율로 비교할 때 지상시험에서는 약 1.1~2.6 %, 고공환경시험에서는 5 % 이상 차이가 발생하였다. The engine ground and altitude tests were carried out to investigate the effect of jet fuel alteration on the performance of a small turbojet engine. JP-S was supplied 8% higher than JP-8 by fuel metering system at the same command. The employment of JP-S showed the similar starting characteristic to that of JP-8, however, difference in the ignition time and acceleration rate of engine speed due to the difference of fuel flow rate by fuel metering system was observed. In spite of jet fuel alteration, the test results yield the similar Steady-State engine performance in Net thrust, Air flow, Exhaust Gas Temperature, etc. On the other hand, the Fuel consumption of JP-S increased by 5 % compared with that of JP-8. In point of Specific Fuel Consumption (SFC), SFC of JP-S was approximately 1.1~2.6 %, 5 % higher than that of JP-8 in ground and altitude tests respectively at the same thrust.

Nerve injury in an undiagnosed adult tethered cord syndrome patients following spinal anesthesia -A case report-

김유일,송재욱,임진훈,김용석,권영은,이준학 대한마취통증의학회 2015 Anesthesia and pain medicine Vol.10 No.3

Spinal anesthesia is a safe and widely used procedure. Spinal cord injury is a rare but serious complication from spinal anesthesia occurs, unexpectedly. Risks of direct neural injury from spinal anesthesia increase in tethered cord syndrome that the spinal cord is tethered by the inelastic structure and is, also, extended to the lower lumbar vertebra. A 52-years-old female patient undergoing anti-incontinence surgery developed neurologic symptoms following spinal anesthesia. The low-lying conus (L5 body level) and tethered cord were found during the assessment of neurological symptoms.

이동단말기 환경에서 응용프로그램 로더와 동적 링커 개발

김유일(Youil Kim),이원재(Wonjae Lee),한환수(Hwansoo Han),이재호(Jaeho Lee),김선자(Sunja Kim) 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.31 No.1B

응용프로그램 로더와 동적 링커는 응용프로그램이 실제로 실행되기까지의 준비 과정을 담당하는 프로그램들이다. 최근의 WIPI 표준은 휴대폰에 새로운 응용프로그램을 전송 받아 수행할 수 있는 환경을 제안하고 있지만, 휴대폰과 같은 제한된 이동단말기에서 사용할 만한 로더와 동적 링커는 공개되어 있지 않다. 본 논문에서는 이동단말기 환경에서 응용프로그램 로더와 동적 링커를 개발하는 과정을 설명한다. 개발에 참가한 연구진의 경험을 소개함으로써 이후의 비슷한 환경에서 로더와 링커를 개발하려는 연구자들에게 중요한 참고자료로 활용될 수 있을 것이다.

Extraction of the mode shapes of a segmented ship model with a hydroelastic response

김유일,안인규,박성곤 대한조선학회 2015 International Journal of Naval Architecture and Oc Vol.7 No.6

The mode shapes of a segmented hull model towed in a model basin were predicted using both the Proper Orthogonal Decomposition (POD) and cross random decrement technique. The proper orthogonal decomposition, which is also known as Karhunen-Loeve decomposition, is an emerging technology as a useful signal processing technique in structural dynamics. The technique is based on the fact that the eigenvectors of a spatial coherence matrix become the mode shapes of the system under free and randomly excited forced vibration conditions. Taking advantage of the simplicity of POD, efforts have been made to reveal the mode shapes of vibrating flexible hull under random wave excitation. First, the segmented hull model of a 400 K ore carrier with 3 flexible connections was towed in a model basin under different sea states and the time histories of the vertical bending moment at three different locations were measured. The measured response time histories were processed using the proper orthogonal decomposition, eventually to obtain both the first and second vertical vibration modes of the flexible hull. A comparison of the obtained mode shapes with those obtained using the cross random decrement technique showed excellent correspondence between the two results.