칼슘과 아연으로 치환된 Y0.8 Pr0.₂ Ba₂ Cu₃ O7_δ 의 전기 및 자기적 성질에 관한 연구

김성재,전인,박영민,강재필,노태호,박현진,최숙자,송승기 명지대학교 자연과학연구소 1996 자연과학논문집 Vol.14 No.-

전이온도가 72K인 고온초전도체 Y?P?B?Cu?O?에서 초전도성을 감소시키는 Pr원소자리에 Ca과 Zn를 적당히 치환시켜 자기적 성질을 연구하였다. 초전도 전이온도(Tc)는 Ca이 치환된 시료의 경우 80~85k의 범위에서 측정되었으며, Zn가 치환된 경우에는 35~49K의 값을 보였다. 비저항의 온도 변화로부터 결정된 전기적 전이온도는 온도에 대한 자기모우먼트으 변화에서 구한 자기적 전이온도와 비슷한 값을 보였다. 자기이력곡선으로부터 Bean의 모델을 이용하여 Hcl(저임계자기장), Hc?(고임계자기장), 반자성정도, 임계전류밀도를 측정하였다. 이러한 성질들은 시료 내에 Ca의 치환량이 많아질수록 증가하였으며, Zn가 많아질수록 급격히 감소하였다. 특히 임계전류밀도는 x=0.0인 시료는 1.60x10?A/㎠이었으며 Ca이 치환된 시료는 1.30~1.98x10? A/㎠, Zn가 첨가된 시료는 3.5x10?~1.3x10?A/㎠의 값으로 계산되었다. 이것은 시료 내에서 Ca은 초전도성을 증가시키고, Zn는 초전도성을 감소시키는 것을 의미한다. We have studied magnetic properties as a appropriate substitute of Ca and Zn element for Prelement which reduces superconducting properties in the high-temperature superconductor Y?Pr?Ba?Cu?O? of transition temperature 72K. When Ca is put into, the critical temperature(Tc)showed the value of measurement at the range of 80~85K while for Zn the Tc had the range of 35~49K. The electric critical temperature determined by the temperature dependence of resistivity had a similar data to the magnetic field), Hc?(high critical magnetic field), diamagnetic ratio and critical current density have observed by Bean's model from the magnetic hysterisis curve. These properties were increased with adding Ca and abruptly decreased with adding Zn in the samples. Especially, the critical current density of x=0.0 sample was calculated at 1.60x10?A/㎠ and those of the other Ca-added samples at the range of 1.30~1.98xA/㎠and those of Zn-added samples at the range of 3.50x10?~1.30x10?A/㎠. These mean that Ca increases supercondecting properties in the sample and Zn element decreases them.

Risk factors associated with idiopathic sudden sensorineural hearing loss during pregnancy in South Korea: a nationwide population-based study

( Hyoun-sook Song ),( Hee-sun Kim ),( Kyu-min Lee ),( Sung Won Han ),( Geum Joon Cho ),( Han-sung Hwang ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Sudden sensorineural hearing loss (SSNHL) in pregnancy is rare. It is believed that the changes of hormone levels may increase thrombogenic risk and interrupt cochlear microcirculation, causing the development of sudden deafness in pregnancy. This study aimed to investigate the incidence and to evaluate the risk factors associated with SSNHL during pregnancy. Methods: We enrolled 401,470 Korean women who had delivery between January 1, 2010, and December 31, 2014 including 459 women with SSNHL. And we had undergone a national health screening examination through the National Health Insurance Corporation. Results: We evaluated the risk factors between 459 women with SSNHL in pregnancy and 401,011 without SSNHL. There were no statistically significant differences in the maternal age, parity, method of delivery, and gestational age at delivery. There were no differences in BMI, blood pressure, fasting blood sugar, and cholesterol level between the two groups. After the adjustment of maternal age on multivariate analysis, SSNHL in pregnancy did not increase the risk for gestational hypertension, preterm birth less than 37 weeks gestation, small-for-gestational age, large-for-gestational age, postpartum hemorrhage, placental previa, and placental abruption. Conclusion: SSNHL can occur throughout the pregnancy and is not associated with maternal identified systemic diseases. It also does not increase risks during delivery or adverse perinatal outcome.

복잡한 염색체 결함을 보인 치료 관련성 급성 골수성 백혈병(Therapy-Related AML) 1 례

송숙희,빈중선,김종혁,방영석,박근칠,선덕재,박찬정,조현찬 大韓血液學會 1992 大韓血液學會誌 Vol.27 No.1

덕유산국립공원의 식생에 관한 연구 -남덕유지역 낙엽활엽수림을 중심으로-

김현숙 ( Hyoun Sook Kim ),이상명 ( Sang Myong Lee ),정흥락 ( Heung Lak Chung ),송호경 ( Ho Kyung Song ) 한국환경생태학회 2009 한국환경생태학회지 Vol.23 No.5

본 연구는 덕유산국립공원 남덕유지역 낙엽활엽수림의 식생구조를 분석하기 위하여 2007년 5월부터 2008년 9월까지 식물사회학적 방법과 구배분석을 실시하여 임분의 구조와 특성을 비교하였다. 남덕유지역의 낙엽활엽수림을 분석한 결과, 신갈나무군락(전형하위군락, 철쭉꽂하위군락, 그늘사초하위군락), 졸참나무군락(전형하위군락, 굴참나무하위군락, 서어나무하위군락), 서어나무군락, 들메나무군락 및 층층나무군락으로 구분되었으며 군락 간에는 종조성, 계층구조 및 식피율 등 생태적 특정에 많은 차이가 있는 것으로 조사되었다. 전체 군락에서 나타난 중요치는 신갈나무가 가장 높고(67.8) 다음으로 들메나무(44.8), 졸참나무(24.5), 당단풍(17.0), 층층나무(15.9), 쇠물푸레(11.5), 철쭉꽃(11.0), 까치박달(11.0), 쪽동백나무(10.9), 함박꽃나무(10.4), 서어나무(9.8) 등의 순으로 나타났다. 흉고직경급을 분석한 결과 신갈나무는 정규분포형의 밀도를 나타내고 있어 당분간은 이들 수종의 우점 상태가 계속될 것으로 보이며, 들메나무는 계곡부에 한정적으로 출현하며 어린 개제의 밀도가 높아 지형적인 극상림으로 발달될 것으로 판단된다. 졸참나무는 어린 개체와 중간 개체의 밀도가 높아 앞으로 계속 높은 우점도를 나타낼 것으로 사료된다. 남닥유지역의 낙엽활엽수림 식생을 식물사회학적 방법에 의하여 분류된 5개 군락과 11개의 환경 요인으로 DCCA ordination 분석한 결과 신갈나무 군락은 해발고가 높고 양이온치환용량과 전질소(C.E.C, T-N)가 많은 지역에 분포하였다. 들메나무군락은 해발고가 높고 수분과 치환성양이온(Ca, Mg, K)이 많은 곳에 분포하였으며, 졸참나무군락과 서어나무군락은 해발고가 낮고 양이온치환용량과 전질소가 적은 지역에 분포하였다. 층층나무군락은 타 군락과 비교해 볼 때 중간지역에 분포하였다. This study was carried out to classify vegetation structure on the deciduous forest at Namdeogyu area in Deogyusan National Park from May 2007 to September 2008 using the gradient analyses and phytosociological method. The vegetation was classified into Quercus mongolica community(Typical subcommunity, Rhododendron schlippenbachii-Q. mongolica subcommunity, Carex lanceolata-Q. mongolica subcommunity), Q. Serrata community(Typical subcommunity, Q. variabilis-Q. serrata subcommunity, Carpinus laxiflora-Q. serrata subcommunity), C. laxiflora community, Fraxinus mandshurica community and Corn us controversa community. Ecological characteristics such as species composition, layer structure, vegetation ratio, and the distribution of individual trees by DBH(diameter at breast height) were significantly different among communities. The order of important value of the forest community with DBH 2cm above plants was Q. mongolica(67.8), F. mandshurica(44.8), Q. serrata(27.5), Acer pseudo-sieboldianum(l7.0), C. controversa(15.9), F. sieboldiana(11.5), R. schlippenbachii(11.0), C. cordata(11.0), Styrax obassia(10.9), Magnolia sieboldii(10.4) and C. laxiflora(9.8). Distribution of DBH of Q. mongolica had a formality distribution, suggesting a continuous domination of these species over the other species for the time being. In contrast, F. mandshurica appeared limited to the valley of the sheet and a higher frequency of young individuals, suggesting a continuous domination of these species the development of a climax forest terrain. Q. serrata had a higher frequency of young individuals and middle individuals, suggesting a continuous domination of these species over the other species for the time being in contrast. This study examined the correlation between each community and the environment according to DCCA ordination. The Q. mongolica community predominated in the highest elevation habitats which had many C.E.C and T-N. F. mandshurica community predominated in the highest elevation habitats which had many Moisture and EX-Cation. The Q. serrata community and C. laxiflora community mainly occurred in the low elevation habitats which had few C.E.C and T-N. The C. controversa community appeared on the park in the middle habitats.

덕유산국립공원 남사면과 북사면의 식생 비교

김현숙 ( Hyoun Sook Kim ),이상명 ( Sang Myong Lee ),송호경 ( Ho Kyung Song ) 한국환경생태학회 2010 한국환경생태학회지 Vol.24 No.5

본 연구는 덕유산국립공원 남·북사면 산림 식생을 TWINSPAN으로 분류하고 DCCA ordination으로 분석한 결과, 남사면에서는 신갈나무군락, 졸참나무군락, 굴참나무군락, 소나무군락, 서어나무군락, 층층나무군락 및 들메나무군락으로 구분되었으며, 북사면에서는 신갈나무군락, 졸참나무군락, 소나무군락, 서어나무군락, 물박달나무군락, 층층나무군락, 들메나무군락, 거제수나무군락, 구상나무군락 및 주목군락으로 구분되었다. 사면별 중요치를 남사면에서는 103개 조사구를 대상으로, 북사면에서는 137개 조사구를 대상으로 분석한 결과 신갈나무가 남·북사면 모두에서 높은 중요치를 보였고 남사면에서는 신갈나무 다음으로 소나무, 졸참나무, 굴참나무, 쪽동백나무, 당단풍 순으로 나타났다. 북사면에서는 신갈나무 다음으로 들메나무가 높은 값을 나타냈고, 당단풍, 졸참나무, 서어나무, 층층나무, 까치박달, 철쭉꽃 순으로 나타났다. 남·북사면에서 군락 간에는 종조성 및 생태적 특징에 다소 차이가 있는 것으로 조사되었다. DCCA ordination 분석한 결과 해발고도와 수분요소가 남·북사면에서 모두 군락의 분포와 상관이 높은 것으로 나타났고 그 외에 남사면에서는 T-N, O.M., Ca 양료와 pH가 비교적 높은 상관관계를 보였으며, 북사면에서는 Ca 양료와 pH도 비교적 높은 상관관계를 보였다. This study was carried out to classify vegetation structure of the southern and northern slopes in the Deogyusan National Park using TWINSPAN classification and DCCA ordination analysis. The vegetation on the southern slope was classified into Quercus mongolica community, Q. serrata community, Q. variabillis community, Pinus densiflora community, Carpinus laxiflora community, Cornus controversa community and Fraxinus mandshurica community. The vegetation on the northern slope was classified into Q. mongolica community, Q. serrata community, P. densiflora community, C. laxiflora community, Betula davurica community, C. controversa community, F. mandshurica community, B. costata community, Abies koreana community and Taxus cuspidata community. To find out important value in each slope, we took 103 districts on the southern slope and 137 districts on the northern slope. As the result, Q. mongolica was highest value in the southern and northern slopes, followed by P. densiflora, Q. serrata, Q. variabillis, Styrax obassia, Acer pseudosieboldianum in the southern slope, F. mandshurica, A. pseudosieboldianum, Q. serrata, C. laxiflora, C. controversa, C. cordata, Rhododendron schlippenbachii in the northern slope. Species distribution and ecological features had differences between the southern and northern slopes communities. As the result of DCCA ordination analysis, sea level and water availability had high correlation with community distribution. Besides, T-N, O.M., exchangeable Ca and pH did in the southern slope. And exchangeable Ca, pH also did in the northern slope.

덕유산국립공원 향적봉 일대 식생구조 연구

김현숙 ( Hyoun Sook Kim ),이상명 ( Sang Myong Lee ),송호경 ( Ho Kyung Song ) 한국환경생태학회 2010 한국환경생태학회지 Vol.24 No.6

본 연구는 덕유산국립공원 향적봉일대 산림 식생을 식물사회학적 방법과 구배분석을 실시하여 분석한 결과, 신갈나무군락(철쭉하위군락, 전형하위군락), 졸참나무군락, 굴참나무군락, 소나무군락, 층층나무군락, 들메나우군락 및 주목 군락으로 구분되었으며 군락 간에는 종조성, 계층구조 및 식피율 등 생태적 특징에 많은 차이가 있는 것으로 조사되었다. 전체 군락에서 나타난 중요치는 신갈나무가 가장 높고(81.2) 다음으로 들메나무, 졸참나무, 소나무, 당단풍, 굴참나무, 철쭉, 층층나무, 주목 등의 순이었다. 중요치가 높은 주요종에 대한 흉고직경급을 분석한 결과 신갈나무와 졸참나무는 계속적으로 우점도가 높아질 것이며, 들메나무는 계곡부에 군락을 형성하고 역J자형에 가까운 분포로 나타나 지형적 극상림으로 발달할 것으로 생각된다. 소나무와 주목은 당분간 우점도 상태를 유지 할 것으로 예상되며, 굴참나무와 층층나무는 정규분포형을 나타내고 있어 현상태로 계속 우점도를 유지할 것으로 생각된다. 식물사회학적 방법에 의하여 분류된 7개 군락과 l2개의 환경 요인으로 DCCA ordination 분석한 결과 신갈나무군락과 주목군락은 해발고가 높고 건조하고 Ca의 양료가 적으며 pH가 비교적 낮은 곳에 분포하였으며, 졸참나무군락은 해발고가 낮고 수분이 비교적 많은 지역에 분포하였다. 소나무군락은 남사면의 해발고가 중간 정도이고 pH가 낮고 Ca 등의 양료가 적은 건조한 지역에 분포하였다. 들메나무군락은 해발고가 낮고 수분이 많은 계곡부에 분포하고 있으며, Ca의 양료가 많으며 pH가 높은 지역에 분포하였다. This study was carried out to classify vegetation structure of the Hyangjeokbong in the Deogyusan National Park using the gradient analysis and phytosociological method. The vegetation was classified into Quercus mongolica community(Rhododendron schlippenbachii subcommunity, typical subcommunity), Q. serrata community, Q. variabillis community, Pinus densflora community, Cornus controversa community, Fraxinus mandshurica community and Taxus cuspidata community. Ecological characteristics such as species composition, layer structure, vegetation ratio, and the distribution of individual frees by DBH(diameter at breast height) were significantly different among communities. The order of important value of the forest community with DBH 2cm above plants was Q. mongolica(81.2), F. mandshurica, Q. serrata, P. densflora, Acer pseudosieboldianum, Q. variabillis, Rhododendron schlippenbachii, C. controversa, T. cuspidata. Distribution of DBH of Q. mongolica and Q. serrata had suggesting a continuous domination of these species over the other species for the time being. In contrast, F. mandshurica appeared limited to the valley of the sheet and a higher frequency of young individuals, suggesting a continuous domination of these species the development of a climax forest terrain. P. densiflora and T. cuspidata had suggesting a continuous domination of these species over the other species for the time being in maintain. Q. variabilis and C. controversa had a formality distribution, suggesting a continuous domination of these species over the other species for the time being. This study examined the correlation between each community and the environment according to DCCA ordination. The Q. mongolica community and T. cuspidata community predominated in the highest elevation habitats which had few moisture, Ca and in the low pH. The Q. serrata community mainly occurred in the low elevation habitats which had many moisture. P. densiflora community predominated in the middle elevation and south-facing slope habitats which had few moisture, Ca and in the low pH. F. mandshurica community predominated in the low elevation habitats which had many moisture, Ca and pH.

덕유산국립공원 현존식생 분포현황 및 천이 연구

김현숙 ( Hyoun Sook Kim ),이상명 ( Sang Myong Lee ),송호경 ( Ho Kyung Song ) 한국환경생태학회 2011 한국환경생태학회지 Vol.25 No.1

본 연구는 덕유산국립공원 산림 식생을 상관조사와 현지식생조사를 토대로 덕유산국립공원 현존식생도를 작성하였다. 상관에 의한 현존식생은 42개 유형으로 구분되었으며, 조사지역 전체의 산림 식생 중에서 신갈나무림이 39.08%로 가장 넓게 분포하였다. 다음으로 굴참나무림, 소나무림, 들메나무림의 순으로 차지하여 덕유산국립공원은 타 국립공원의 산림과 비교할 때 들메나무림이 많이 분포되어 있는 것이 특징이다. 덕유산국립공원 식생을 환경구배에 따라 구분하면 낙엽활엽수림(참나무류림, 계곡림), 침엽수림(소나무림), 아고산림(주목림, 구상나무림, 철쭉관목림, 초원) 등 7개의 유형으로 나누어졌다. 중요치가 높은 주요종에 대한 흉고직경급을 분석한 결과 신갈나무와 굴참나무는 어린 개체와 중간 개체의 밀도가 높고 졸참나무, 서어나무는 어린개체의 밀도가 높아 계속적으로 우점도가 높아질 것이며, 들메나무는 계곡부에 군락을 형성하고 어린개체의 밀도가 높은 역J자형에 가까운 분포로 나타나 지형적 극상림으로 발달할 것으로 추정된다. 소나무, 물박달나무, 층층나무, 거제수나무, 구상나무, 주목은 어린개체와 큰개체의 밀도는 낮고 중간개체의 밀도가 높은 정규분포형을 나타내고 있어 현상태로 계속 우점도를 유지할 것으로 사료된다. This study was written about the actual vegetation map by researchig current vegetation and on-site vegetation in the Deogyusan National Park. Current vegetation patterns were classified into 42 types according to correlation. And Quercus mongolica forest was 39.08% out of the total forest vegetation, and was dispersed the most widely. Next were Q. variabilis, Pinus densiflora, and Fraxinus mandshurica forests in order, so that the forests of Deogyusan are different from those of another national parks in that F. mandshurica forest is more widely dispersed. Forest vegetation of Deogyusan national park is broadly classified into three types: deciduous broad-leaved forest (Quercus forest and valley forest), coniferous forest(P. densiflora forest), and sub-alpine forest(Taxus cuspidata forest, Abies koreana, Rhododendron schlippenbachii shrub-forest, and prairie). Distribution of DBH of Q. mongolica and Q. variabillis had a higher frequency of young individuals and middle individuals, Q. serrata and Carpinus laxiflora had a higher frequency of young individuals, suggesting a continuous domination of these species over the other species for the time being. In contrast, F. mandshurica appeared limited to the valley of the sheet and a higher frequency of young individuals, suggesting a continuous domination of these species the development of a climax forest terrain. P. densiflora, Betula davurica, Cornus controversa, B. costata, A. koreana and T. cuspidata had a formality distribution, suggesting a continuous domination of these species over the other species for the time being.

Transformations of 2,4,6-Trinitrotoluene in Various Conditions by Klebsiella sp. Strain C1 Isolated from Activated Sludge

Chang, Chong-Suk,Kim, Hyoun-Young,Kang, Yang-Mi,Bae, Kyung-Sook,Song, Hong-Gyu The Microbiological Society of Korea 2002 The journal of microbiology Vol.40 No.3

Several 2,4,6-trinitrotoluene (TNT) degrading bacteria were isolated from an activated sludge by an enrichment culture technique, and their TNT removal activities were examined. Among the isolates, strain C1 showed the highest degrading capability, and completely removed 100 or 200 mg I$\^$-1/ of TNT within 6 hours of incubation. This bacterium was identified as Klebsiella sp. The effects of different carbon sources on the removal of the parent TNT by Klebsiella sp. C1 were negligible, but the transformation rates of TNT metabolites such as amino-dinitrotoluenes and diamino-nitrotoluenes were higher with fructose addition compared to glucose addition. When nitrate was used as the nitrogen source, the degradation rates of TNT and hydroxylamino-dinitrotoluenes were higher than those with the ammonium addition. Although the TNT removal rate of Klebsiella sp. C1 was slightly higher in anaerobic conditions, the further transformations of TNT metabolites were more favorable in aerobic conditions.

Analysis of Gene Expression in Arginine Biosynthetic Gene Cluster of Corynebacterium glutamicum

Sei Hyun Yim,Su Hyoun Kim,Mee Young Park,Sam Il Jung,Heung Shick Lee,Chung Il Cheon,Eun Sook Song,Soo Suk Lee,Myeong Sok Lee 한국유전학회 2008 Genes & Genomics Vol.30 No.3

Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for industrial amino acid production. We have cloned and analyzed arginine gene cluster in this organism. Although, many other bacteria have ArgA ( N-acetylglutamate synthase, NAGS), the gene is not found in chromosomal DNA of C. glutamicum. Interestingly, significant identity was found between C. glutamicum ArgB and N-terminal domain of E. coli ArgA in a comparison of amino acid sequences. Moreover, C. glutamicum argB gene encoding N-acetylglutamate kinase (NAGK) was able to complement E. coli argA auxotroph as well as argB mutant, suggesting C. glutamicum ArgB is a bifunctional enzyme with both NAGS and NAGK activities. The analysis of Northern hybridization and RT-PCR showed that the arginine biosynthesis gene cluster synthesizes two transcripts corresponding to argCJBDFR and argGH in C. glutamicum. The respective transcriptions were started at A and T residues which are located 30bp or 44bp upstream from translation start codon for argC and argG genes respectively. The promoter regions were also analyzed in the region preceding the respective transcription initiate sites. Interestingly, we found that arginine, end product of arginine biosynthesis pathway, regulates the gene expression of argCJBDFR but not argGH.

Comparative effectiveness of JAK inhibitors and biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis

Soo-Kyung Cho,Hyoungyoung Kim,Yeo-Jin Song,Hye Won Kim,Eunwoo Nam,Shin-Seok Lee,Hye-Soon Lee,Sung-Hoon Park,Yeon-Ah Lee,Min-Chan Park,Sung Hae Chang,Hyoun-Ah Kim,Seung-Ki Kwok,Hae-Rim Kim,Hyun-Sook Ki 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.4

Background/Aims: We aimed to compare the effectiveness and safety of Janus kinase inhibitors (JAKi) vs. biologic disease-modifying antirheumatic drugs (bDMARD) in Korean patients with rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic DMARDs. Methods: A quasi-experimental, multi-center, prospective, non-randomized study was conducted to compare response rates between JAKi and bDMARDs in patients with RA naïve to targeted therapy. An interim analysis was performed to estimate the proportion of patients achieving low disease activity (LDA) based on disease activity score (DAS)–28– erythroid sedimentation rate (ESR) (DAS28-ESR) at 24 weeks after treatment initiation and to evaluate the development of adverse events (AEs). Results: Among 506 patients enrolled from 17 institutions between April 2020 and August 2022, 346 (196 JAKi group and 150 bDMARD group) were included in the analysis. After 24 weeks of treatment, 49.0% of JAKi users and 48.7% of bDMARD users achieved LDA (p = 0.954). DAS28-ESR remission rates were also comparable between JAKi and bDMARD users (30.1% and 31.3%, respectively; p = 0.806). The frequency of AEs reported in the JAKi group was numerically higher than that in the bDMARDs group, but the frequencies of serious and severe AEs were comparable between the groups. Conclusions: Our interim findings reveal JAKi have comparable effectiveness and safety to bDMARDs at 24 weeks after treatment initiation.