우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

음악프로그램이 치매노인의 인지기능과 문제행동에 미치는 효과

홍영규,강영실 노인간호학회 2009 노인간호학회지 Vol.11 No.1

Purpose: This study was done to identify the effects of a music program on cognitive function and disturbing behavior in elders with dementia. The program consisted of listening to, percussion accompaniment, and singing along with popular music, and folk and children's songs. Method: The design was a nonequivalent control group pretest-posttest study. Participants were 32 elders with dementia (experimental: 17, control: 15). The program took place for fifty minutes, six times a week for four weeks. Cognitive function was assessed using the MMSE-K (Mini Mental State Examination- Korean Version) and disturbing behavior, using a disturbing behavior measurement tool developed by Kang. Descriptive statistics, Chi-square and t-test were used to analyze the data. Results: Scores for cognitive function (orientation, attention and calculation) for the experimentalgroup increased significantly (t=5.616, p=.000) and scores for disturbing behavior (aggressive psychomotor behavior, passive behavior and nonaggressive psychomotor behavior) decreased significantly (t=-3.348, p=.002), especially, decreased. Conclusion: The results indicate that the music program was an effective intervention for cognitive function and disturbing behavior in elderly people with dementia admitted to hospital. Therefore, the music program is recommended for use in clinical practice as a nursing intervention for the patients with dementia.

아토피피부염 소아 청소년에서의 정신병리와 양육태도 연구

홍강의,정재석,김규한 대한소아ㆍ청소년정신의학회 1999 소아청소년정신의학 Vol.10 No.1

버텍스에 의한 숫자패턴 인식

辛烘圭,姜英鎭,朴鍾旭 圓光大學校 1987 論文集 Vol.21 No.2

본 논문에서는 도형 패턴의 윤곽선에 대한 버텍스 결정 방법을 도입하여 필기체 숫자 패턴을 인식하는 방법을 보였다. 본 방법은 입력 패턴의 윤곽선에 대한 버텍스의 관계로 부터 연결 링크와 접촉 링크를 추출하고, 패턴의 디스크립터를 유도하여 인식하는 방법이다. 그 결과 필기자의 관습에 의한 변형에 영향이 적고 인식 파라메타 수가 감소되었다. 또한 실험 결과 인식율이 대단히 높고 처리 시간도 세선화 방법에 비하여 30(%) 정도 빠르다는 것을 확인한다. In this paper, it is showed to recognize the Arabic numeral patterns by vertices decision from the contour line. This method is extracted links by vertices relation for input pattern and is recognized by inducing description function from the links. In this results, the affection of deformation due to the way of writters and the number of parameter for recognition are reduced, and experimental results show that recognition for hardwritten numeral patterns are effected and access time is reduced about 30 (%) compared with the conventional method using thinning process.

공동주택단지의 양복도 및 중복도 아파트의 조도실험을 통한 설계 개선방안 연구

김홍규,김강수,박철수 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2

This study suggested the several design reformations through the illumination experiment by using the model of twin and internal corridor apartment in multi-family housing. For this study, the illumination experiment of 3 types of twin & internal corridor apartment (1/30 scale model) was used. Twin corridor apartment models include Typical, Vertical Opening, and Horizontal Opening types. And internal corridor apartment models are as follows : Typical, Type(I) : exemption of I unit in core area, Type(II) : opening of corridor-end. The result was revealed that vertical opening type received the more lighting in lower level of apartment than horizontal opening type in the corridor apartment model. Secondly, it was necessary to expand the window size of core areas of 1 unit and to enlarge the opening areas of internal corridor-end.

비알콜성 지방간과 대사성 질환들과의 연관성

김홍규,서찬종,윤효중,황용하,이기영,박혜영,김갑환,강문호 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: 비알콜성 지방간은 일반적으로 비만, 제2형 당뇨병 및 고지혈증과 연관성이 있는 것으로 알려져 있으나, 인슐린 저항성과의 독립적인 연관성여부나, 대사 증후군과의 연관성에 관해서는 아직 연구가 많지 않다. 한편, 최근 건강검진센터를 중심으로, 초음파를 이용한 지방간의 진단이 흔하게 되었는데, 이런 대상에서의 지방간의 임상적인 의미에 대해서는 잘 알려져 있지 않았다. 따라서, 본 연구에서는 초음파로 진단된 비알콜성 지방간과 비만, 당대사이상, 이상지질혈증 및 인슐린 저항성과의 연관성을 알아보고, 대사성 증후군과 비알콜성 지방간의 동반정도를 알아보고자 하였다. 방법: 2000년도 4월부터 6월까지 종합건강진단을 위해 가천의대 길병원 건강증진센터에 내원한 262명 중 음주력과 바이러스성 간염, 심한 간기능 또는 신기능이상 및 현성 갑상선기능이상을 보인 147명을 제외한 115명을 대상으로 하였다. 지방간의 진단은 경험 있는 1명의 방사선과의사에 의해 복부 초음파로 진단하였다. 대사성 증후군의 정의는 당대사이상이 있으면서 비만, 이상지질혈증, 그리고 고혈압 중 두 가지 이상의 이상이 있는 경우로 하였다. 결과: 대상자 115명중 비알콜성 지방간이 있는 경우는 30명, 대조군은 85명이었다. 1) 수축기 및 이완기 혈압, 체중, 체질량지수, 체지방량 및 체지방률, 총콜레스테롤과 중성지방, 공복 혈중 인슐린 및 HOMA 인슐린저항성지표는 비알콜성 지방간군에서 의미 있기 높았다. 2) 나이, 성별, 체질량지수, 허리-둔부 둘레비, 체지방량, 체지방률, 공복혈당, 총콜레스테롤, 중성지방, HLD-콜레스테롤, 인슐린, HOMA 인슐린 저항성지표, 그리고 고혈압유무를 포함하여 로지스틱 회귀분석을 실시하였을 때, 체질량지수, 총 콜레스테롤 및 HOMA 인슐린저항성지표가 비알콜성 지방간과 독립적인 연관성이 있었다. 3) 비알콜성 지방간과 대사성 증후군의 연관성을 조사하였는데, 비알콜성 지방간을 가진 사람의 27%에서 대사성 증후군을 동반하였고, 대사성 증후군의 가진 사람의 53%에서 비알콜성 지방간을 동반하였다. 4) 대조군과 비알콜성 지방간군에서 대사성 증후군의 각 구성 인자인 당대사이상, 비만, 이상지질혈증 및 고혈압 중 2개 이상의 인자를 갖는 경우는 각각 28%와 73%로 비알콜성 지방간군에서 현저하게 높았다. 결론: 본 연구의 결과는 비알콜성 지방간이 인슐린 저항성과 독립적인 연관성을 가질 가능성을 시사하였고, 비알콜성 지방간이 있는 경우에 당대사이상, 비만, 이상지질혈증 및 고혈압 중 두 가지 이상의 대사성 질환을 가질 확률이 대조군에 비해 약 3배나 높음을 보여주었다. 따라서, 비알콜성 지방간으로 진단된 환자들에서 이러한 대사성 질환들에 대한 적절한 평가와 이를 호전시키기 위한 노력 및 주의 깊은 경과관찰이 필요할 것으로 생각되었다. Background: Non-alcoholic fatty lever disease (NAFLD) is known to be frequently associated with obesity, type 2 diabetes and dyslipidemia. Recently, the diagnosis of fatty lever disease, based on ultrasonographic findings, has increased. Therefore, we examined the association between NAFLD and various metabolic disease, such as obesity, glucose intolerance, dyslipidemia, and hypertension or metabolic syndrome, and tried to find out whether NAFLD was independently related to insulin resistance. Methods: From April to June 2000, 262 subjects, attending for routine physical check-ups, were screened. Of these, 115 one hundred fifteen subjects were studied, with the other 147 excluded due to significant alcohol consumption, evidence of viral or toxic hepatits, significant liver or renal dysfunction, and overt thyroid disease. Fatty lever was diagnosed if the subject had a 'bright' liver on ultrasonographic examination. All diagnoses were made by a singled experienced radiologist. Results: of the 115 subjects. 30(26%) showed NAFLD. 1. Systolic and diastolic blood pressures, body weight, serum total cholesterol, triglyceride, fasting insulin levels, and HOMA IR (homeostasis model assessment insulin resistance index) were higher in the subjects with NAFLD than in the controls. 2. Multiple logistic regression analysis, including age, sex, BMI, waist to hip ratio, fasting serum, glucose, lipids and insulin levels, HOMA IR, and hypertension showed that BMI, total cholesterol and HOMA IR were independently related with NAFLD. 3. 27% of the subjects with NAFLD showed metabolic syndrome, and 53% of subjects with metabolic syndrome had NAFLD. 4. The percentage of subjects who had more than two factors of metabolic syndrome was three times higher in the subjects with NAFLD compared to the controls. Conclusion: These results suggest that NAFLD may be independently related with insulin resistance. Metabolic diseases, such as glucose intolerance, obesity, dyslipidemia and hypertension, were more prevalent in the subjects with NAFLD than in the controls. Therefore, we should try to assess the status of the metabolic disease, and treat them in patients with NAFLD (J Kor Soc Endocrinol 17:526∼534, 2002).

생소한 HBsAg 선별검사키트 bioelisa와 IEMA Well의 평가

김덕언,김홍석,김신규,이혜림,박일규,강정옥,최태열 대한임상검사정도관리학회 1997 臨床檢査와 精度管理 Vol.19 No.2

Rhinocerebral Mucormycosis 2예

오명돈,최강원,김병국,김재중,이홍규,김상윤 대한감염학회 1986 감염 Vol.18 No.2

Mucormycosis is an acute suppurative opportunistic mycosis that produce predominantly rhinocerebral disease in patient with diabetic ketoacidosis and immunosuppressed patient. We experienced two cases of rhinocerebral mucormycosis recently. The one occurred in patient with diabetic ketoacidosis and the other in acute leukemia. They showed nasal discharge, orbital cellulitis and proptosis. Their condition rapidly deteriorated. Biopsy from palate and sinus revealed broad, nonseptate, right-angled branching hyphae, a finding compatible with mucormycosis.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.