Anticancer Effects of Kimchi Fermented for Different Times and with Added Ingredients in Human HT-29 Colon Cancer Cells

김보경,Jiale Song,주재현,강순아,박건영 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.2

Anticancer effects of kimchi fermented for different times and containing added ingredients in HT-29 human colon carcinoma cells were studied. Optimally ripened kimchi showed higher anti-proliferation activities than fresh and over-ripened kimchi. Anticancer-ingredientsadded kimchi exhibited higher activities than standardizedrecipe kimchi in HT-29 cells. Optimally-ripened anticancer kimchi suppressed expression of Bcl-2 and promoted expression of Bax, caspase-9, and caspase-3 to promote apoptosis, and reduced mRNA expressions of proinflammatory factors, exhibiting the strongest anticancer effect. Fermentation and ingredients are important factors to increase in vitro anticancer functionalities.

Nullifying Tumor Efflux by Prolonged Endolysosome Vesicles: Development of Low Dose Anticancer-Carbon Nanotube Drug

Lee, Yeon Kyung,Choi, Jungil,Wang, Wenping,Lee, Soyoung,Nam, Tae-Hyun,Choi, Wan Sung,Kim, Chang-Joon,Lee, Jong Kwon,Kim, Sang-Hyun,Kang, Sang Soo,Khang, Dongwoo American Chemical Society 2013 ACS NANO Vol.7 No.10

<P>As the majority of side effects of current chemotherapies stems from toxicity due to excessive dosing of anticancer drugs, minimizing the amount of drug while maximizing drug efficacy is essential to increase the life-quality of chemotherapy patients. This study demonstrated that the intracellular delivery of amide linked doxorubicin on carbon nanotube can nullify the efflux of cancer cells by achieving prolonged endolysosome delivery and can induce burst release of doxorubicin in an acidic hydrolase environment and, ultimately, can reduce the amount of anticancer drug by 10-fold compared to conventional effective drug dose. The clearance of accumulated carbon nanotubes in the liver was observed after 4 weeks, and analysis of liver toxicity markers showed no significant changes in GOT and GPT levels and release of pro-inflammatory cytokines across both short- and long-term periods.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-10/nn4041206/production/images/medium/nn-2013-041206_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn4041206'>ACS Electronic Supporting Info</A></P>

The phyto-oestrogens: its anticarcinogenic and antioxidant activity-a review

Widyarini, Sitarina,Reeve, Vivienne E. Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.2

The isoflavonoids comprise a group of phyto-oestrogens that have useful biological activities including oestrogenic, antioxidant and anticancer. As dietary components for humans, they are bioavailable from leguminous vegetables (such as genistein from soybean), and have been well-documented to have numerous health benefits. A wide range of epidemiological studies in humans and limited studies in animals have identified isoflavonoids as potential chemopreventive agents against hormone-dependent cancers. Therefore, an attempt has been made through this review to summarise the information in the mechanisms aspect of isoflavonoid phyto-oestrogens in inhibiting cancer in vitro and in vivo in the models of human cancers.

간호사에서 항암제 취급양상과 건강증상

신혜숙,이세훈 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

To evaluate the subjective symptoms among nurses handling anticancer drugs, we investigated symptom prevalence in 487 nurses exposed to anticancer drugs and 242 control nurses, who are working at 14 university hospitals in Korea by self-administered questionnaire. Safety regulations for handling anticancer drugs in these hospitals as well as the level of knowledge on safety rules of them among nurses were also evaluated. The results were as follows: 1. Only 1.5% of nurses used the biological safety cabinet always, 32.7% could not use it during evening time and on holidays, and 65.8% could not use at all since lack of it. When nurses prepared anticancer drugs, they were gloves(49.7%), gown(7.2%), goggle(1.6%), and mask(11.5%). And 46.1% of them answered that they ate and drank in the anticancer drugs preparation room. 2. The level of knowledge on safety rules of anticancer drugs were generally low in both exposed(12.7/17 items) and control(12.7/17 items) group. The questions which nurses answered wrong exceeded fifty percent were : the possibility of exposing to anticancer drugs when they correct their make-ups; and when they handled body fluids of cancer patients. Only 20.3% of the nurses were acknowledged with the hours for the cancer patients' body fluids being considered to be contaminated after receiving chemotherapy. 3. The prevalence of allergic disease was higher in exposed group than in control group. Among 43 symptoms of total, the prevalence of 10 symptoms (nausea, skin rash, itching, chronic throat irritation, tachycardia, alopecia, skin hyper pigmentation, loss of libido, leukopenia, thrombocytopenia) were higher in exposed group than in control group. 4. The prevalence of ten symptoms which showed higher prevalence in exposed group was significantly correlated with eating and drinking in the preparation room for anticancer drugs, the degree of skin contact with anticancer drugs, and the amount of anticancer handling them, and BMI. It was shown that eating and drinking in anticancer drug preparation room, and the amount of handling them, significantly affected the prevalence of 10 symptoms among nurses exposed after stepwise multiple regression analysis. The results of this study suggest that nurses handling anticancer drugs have potential risk of exposure to anticancer drugs, and the preventive measures for the protection of nurses' health be needed by education, and improvement of their working environment.

항암제와 한약재의 병용투여 시 암세포 증식억제 효과에 대한 국내 실험연구 문헌고찰

이지은,최진용,한창우,최준용,박성하,김소연,Lee, Ji Eun,Choi, Jin Yong,Han, Chang Woo,Choi, Jun Yong,Park, Seong Ha,Kim, So Yeon 대한한의학방제학회 2017 大韓韓醫學方劑學會誌 Vol.25 No.3

Objective : In this study, we searched the experimental research about combined treatment of anticancer drug and herbal medicine for killing or inhibiting proliferation of Cancer cells searched in OASIS and KISS. This study aimed to analyze the experimental research paper about anticancer drug combined treatment with herbal medicine. Methods : We collected the research paper including killing or inhibiting proliferation of Cancer cells in OASIS and KISS using keyword anticancer drug with herbal medicine, tumor suppressor with herbal medicine, inhibition of Cancer with herbal medicine and combined treatment with herbal medicine. Assorting by cancer cells, we analyzed experimental results cancer cell viability, anticancer drug dosage, tumor weight and survival rate. Also, we checked the effects of herbal medicine on cancer and additive effect reducing side effect of anticancer drug. Results : Total 45 studies were selected. 38 studies reported combined treatment of anticancer drug and herbal medicine was more effective than only anticancer drug. The death of cancer cells was synergistically induced by the cotreatment of anticancer drug and herb extracts. The studies suggest that the cotreatment of anticancer drug and herb extracts could reduce side effect of anticancer drug. In addition, some studies reported cotreatment mechanism like apoptotic death signal processes. In combined treatment of anticancer drug and herb extracts, The expression of Fas/Fas L, Bax, Bcl2, Caspase-3 etc.. was markedly increased in cancer cells. Conclusions : Our results suggest that anticancer drug combined treatment with herbal medicine could be efficient for killing or inhibiting proliferation of cancer cells. However, this paper had some limitation as follows: First, collected studies have been published only for korean journal. Second, results of research and effects of combined treatment are not collected objectively. To solve these problems, more objective and balanced studies should be performed.

일 종합병원의 항암제 취급 간호사의 항암제 안전관리 교육요구도

하부영,이인숙 (사)위기관리이론과실천 2023 Crisisonomy Vol.19 No.3

This research investigated clinical nurses’ educational needs for safe anticancer drug management. A cross-sectional descriptive study involving 225 clinical nurses who responded to self-reporting questionnaires was conducted from May 26 to June 20, 2021. Descriptive statistics, a paired t-test, and demand analysis utilizing Borich analysis and the Locus for Focus model were used to evaluate the data. As a results, the categories with the highest priority were “coping with exposure to anticancer drugs,” “environmental control of the handling of anticancer drugs,” “safe administration of an anticancer drug,” “handling of patients’ blood, body fluids, and excretion,” “fulfilling education on the safe management of anticancer drugs,” and “using personal protective equipment.” These findings will help develop educational programs for clinical nurses who deal with anticancer drugs. Future studies should concentrate on developing and evaluating a program for the safe management of anticancer drugs.

Anticancer Activity of Undecapeptide Analogues Derived from Antimicrobial Peptide, Brevinin-1EMa

강수진,이봉진,Hye-Young Ji 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5

In spite of great advances in cancer therapy, cancer remains the major cause of death throughout the world. The increasing resistance of cancer cells towards current anticancer drugs requires development of anticancer agents with a new mode of action. Some antimicrobial peptides have become therapeutic candidates as new anticancer agents. As part of an effort to develop new antimicrobial and/or anticancer agents from natural peptides with low molecular weights, we have investigated the shortest bioactive analogues, which were derived from a 24-residue antimicrobial peptide, Brevinin-1EMa. Recently, we found four bioactive undecapeptides derived from a cationic, amphipathic α-helical, 11-residue peptide (named herein GA-W2: FLGWLFKWASK-NH2) (Won et al., 2011). In order to identify the potential of these peptides as anticancer agents, we investigated the anticancer activity of four undecapeptides against seven tumor cell lines such as A498 (kidney), A549 (lung), HCT116 (colon), MKN45 (stomach), PC-3 (prostate), SK-MEL-2 (skin) and SK-OV-3 (ovary). GA-K4 (FLKWLFKWAKK-NH2), which had the most potent antimicrobial activity of the four undecapeptides, also exhibited the most potent anticancer activity and synergistic effect in combination with doxorubicin. Therefore, GA-K4 peptide may be a potentially useful candidate as an anticancer peptide agent.

Anticancer Activity of Undecapeptide Analogues Derived from Antimicrobial Peptide, Brevinin-1EMa

Kang, Su-Jin,Ji, Hye-Young,Lee, Bong-Jin 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5

In spite of great advances in cancer therapy, cancer remains the major cause of death throughout the world. The increasing resistance of cancer cells towards current anticancer drugs requires development of anticancer agents with a new mode of action. Some antimicrobial peptides have become therapeutic candidates as new anticancer agents. As part of an effort to develop new antimicrobial and/or anticancer agents from natural peptides with low molecular weights, we have investigated the shortest bioactive analogues, which were derived from a 24-residue antimicrobial peptide, Brevinin-1EMa. Recently, we found four bioactive undecapeptides derived from a cationic, amphipathic ${\alpha}$-helical, 11-residue peptide (named herein GA-W2: FLGWLFKWASK-$NH_2$) (Won et al., 2011). In order to identify the potential of these peptides as anticancer agents, we investigated the anticancer activity of four undecapeptides against seven tumor cell lines such as A498 (kidney), A549 (lung), HCT116 (colon), MKN45 (stomach), PC-3 (prostate), SK-MEL-2 (skin) and SK-OV-3 (ovary). GA-K4 (FLKWLFKWAKK-$NH_2$), which had the most potent antimicrobial activity of the four undecapeptides, also exhibited the most potent anticancer activity and synergistic effect in combination with doxorubicin. Therefore, GA-K4 peptide may be a potentially useful candidate as an anticancer peptide agent.

한약(韓藥)을 이용(利用)한 항암(抗癌) 실험연구(實驗硏究)의 경향(傾向)에 관(關)한 고찰(考察)

김현아,임성우,이원철,Kim, Hyung-A,Lim, Sung-Woo,Lee, Won-Chul 대한암한의학회 1998 大韓癌韓醫學會誌 Vol.4 No.1

Because there were lots of side effects and tolerances to the existing anticancer therapeutics, the experiment extracting the anticancer effect from medicinal herbs is in progress liviely. Therefore the purpose of this study were to research the tendency and the course of anticancer studies. To research the tendency of anticancer studies, medicinal herbs of fifty three experimental papers were analyzed and to examine the course of studies, anticancer papers in the medical world were used. The obtained results were as follows: Methods of herbal medicinal treatments were elimination the pathogenic factor(祛邪) and supporting healthy energy(扶正) method used. In this study, immediately tumor bearing and immune response were the most important point. The subject of immediately tumor bearing was not in the specific cancer but in the influence on the life span of general cencerous cells. In the experimental study of immune response, the effect on NK cell activity of medicinal herbs most studied. The combined usage of medicinal herbs and anticancer agent mostly intended to know whether it inhibits the tumor cell growth. The serum test and blood cell number test show if medicinal herbs inhibit side effect of anticancer agent. More than 80 percents of used medicinal herbs, there were anticancer activities. However anticancer experimental studies using medicinal herbs two weak points. The one, it was difficult to choose a prescription according to differentiation of symptoms and signs(辨證論) of the Oriental Medicine, because we put to the test not a man but a mouse. The other, as we observed the indirect effect of the whole physiological regulation caused by synergic effects of the complex prescription, we don't understand the detailed mechanism of the herb. Therefore, if the anticancer effect of the herb is proved the experiment, we should research the concrete medical action of medicinal herbs and immunological analysis of herbal medicines to the body.

백혈병 세포주에 대한 Biological Response Modifiers의 항암제 세포독성 증강효과

이윤영,전의건,길준영,윤일국,유관희,안병준,김삼용 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

To investigate the possibility of increased cytotoxicity of anticancer drugs, we treated human leukemia cells with combinations of anticancer drugs and biological response modifiers(BRMs). Using the colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay, we evaluated the chemosensitivity of 8 anticancer drugs (vincristine, vinblastine, adriamycin, cisplatin, etoposide, cytosine arabinoside, bleomycin, and cyclophosphamide), and the anticancer effects of 3 BRMs(interleukin-2, alpha interferon, and gamma interferon) combined with these anticancer drugs against human leukemia HL-60 and KG-l cells. The results were as follows; in the chemosensitivity of 8 anticancer drugs, VCR, VBL, ADR, and CPDD were effective, while VP-l6, ara-C, Bleo, and CYC produced less than 50% inhibition of HL-60 and KG-l cells lines. Among 3 BRMs investigated, all of them showed less than 20% inhibition of KG-l cell lines and none were effective against HL-60 cells. In the anticancer effects of 3 BRMs, all of them showed about 20% inhibitory effects against KG-l cells, but there were not any effects against HL-60 cells. All of the anticancer drugs markedly increased cytotoxic effects when they were combined with BRM. Especially, the ID_50 values of VCR, VBL and ADR when combined with BRMs decreased to 67~3%. These results demonstrate that some BRMs can markedly increase the cytotoxicity of VCR, VBL, ADR, CPDD, VP-l6, ara-C, Bleo, and CYC and suggest possible clinical usefulwess.