비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할

도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

黃連湯이 CCl4로 유도된 간중독 흰쥐에 미치는 영향

高元島,朴賢俊,尹炳局,鄭成伊,朴宣東 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2

The purpose of this study is to observe the effects of Hwanglyuntang on serum reactions of CCI₄ treated rats. In this study the experimental rats were divided five groups(Normal, Control, Sample A, Sample B and Sample C). Under the same condition Normal group was fed basal diet and water, the Control group was injected with carbon tetrachloride(CCI₄, 0.5㎖/㎏) and fed a basal diet for 2 weeks, the Sample A group was injected with carbon tetrachloride(CCI₄, 0.5㎖/㎏) and fed the Hwanglyuntang extract(10㎖/㎏) for 2 weeks, the Sample B group was fed the Hwanglyuntang extract(10㎖/㎏) for 2 weeks and injected with carbon tetrachloride(CCI₄, 0.5㎖/㎏), the Sample C group was fed on the Hwanglyuntang extract(10㎖/㎏) for 2 weeks. The change in GOT, GPT, γ-GPT, ALP, LDH activity and Bilirubin level in blood serum were preasured. The obtained results are summarized as follows : It was found that GOT, GPT, γ-GPT, ALP LDH activity and Bilirubin levels in the blood serum of the sample groups, as compared with control group, sample group was significantly decreased.

유착성 관절낭염 치료에 있어서 한방 치료와 양방 치료의 임상적 고찰 : 동서협진 모델 개발을 위한 기초 연구를 중심으로

남동우,정인태,김주희,박유선,임사비나,이두익,이재동,이윤호,최도영 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : To observe the effect of acupuncture treatment and western medical treatment on frozen shoulder patients. Methods : 39 voluntary patients were randomly assigned to the Eastern treatment group(E group, n=22) and the Western treatment group(W group, n=17). The E group received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for 4 weeks. The W group received suprascapular nerve block, subacromial injection and trigger point injection, twice a week for 4 weeks. Both groups were instructed to practice self exercise during their daily lives. Evaluations were made before treatment and after treatment using Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). The obtained data were analyzed and compared. Results : The E group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 5.67 on a scale of 10. The W group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 7.73. But the difference between the two groups were insignificant according to CSA and SPADI. Conclusion : Both acupuncture and nerve block treatment significantly improved frozen shoulder. But the difference of the two treatments was insignificant.

Poly-periodic hole arrays for angle-invariant plasmonic filters.

Do, Yun Seon,Choi, Kyung Cheol Optical Society of America 2015 Optics letters Vol.40 No.16

<P>We suggest a plasmonic filter with novel hole arrays for an angle-invariant optical response. The suggested patterns consist of randomly distributed polycrystalline domains in which nano sized holes are arranged with the same period. While the microscopic area of periodicity determines the center wavelength and transmission intensity, the broken periodicity of each domain contributes to restrain the angle dependency. The results increase the possible use of nanohole-based filters in practical area.</P>

Korean Association for Clinical Oncology : Slide Session ; OP4-4 : Others ; Prognostic Signifl cance of Ki-67 Labeling Index in Who Grade Ⅱ Meningioma

( Yun Seon Choi ),( Do Hoon Lim ),( Jeong Il Yu ),( Kyung Il Jo ),( Do Hyun Nam ),( Ho Jun Seo ),( Jung Il Lee ),( Doo Sik Kong ),( Yeon Lim Suh ),( Yun Han Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Purpose: This study was performed to determine the clinical signifi cance of the Ki-67 labeling index (LI) for local control in patients with WHO grade Ⅱ meningioma. Methods: The medical records and values of Ki-67 LI`s were retrospectively reviewed for 50 patients who underwent surgical resection of intracranial WHO grade Ⅱ meningiomas at Samsung Medical Center from May 2001 to Dec 2012. Simpson grade Ⅰ, Ⅱ, Ⅲ, and Ⅳ resections were performed in 16, 23, 5, and 6 patients, respectively.Forty-three patients (86%) were treated with immediate postoperative radiotherapy (PORT). The median total radiation dose was 60 Gy (range 54-60). Results: The median follow-up was 47.4 months. The mean Ki-67 LI was 13% (range 1-47%). Twelve patients (24.0%) showed local failure, and 8 patients (16.0%) experienced local failure even after PORT. The mean Ki-67 LI was 15% in patients with local failure (n=12) and 12% in patients without local failure (n=38). The 3-year actuarial local control was 80.5%. The 3-year overall survival was 89.5%. Ki-67 LI > 13% and PORT were significant prognostic factors for local control (p=0.015 and p=0.009, respectively). In patients with Ki-67 LI > 13% (n=17), PORT (n=14) improved local control (p<0.001). However, PORT (n=29) did not affect local control (p=0.412) for patients with Ki-67 LI = 13% (n=33). Conclusions: Ki-67 LI can be a useful prognostic factor for local control in WHO grade Ⅱ meningioma. In patients with Ki-67 LI > 13%, PORT may be recommended in order to improve local control.

Matching Surface Plasmon Modes in Symmetry-Broken Structures for Nanohole-Based Color Filter

Yun Seon Do,Kyung Cheol Choi IEEE 2013 Photonics Technology Letters Vol.25 No.24

<P>Metallic nanoholes have been highlighted by their possible use as plasmonic color filters (PCFs). However, previous results have demonstrated the functions of the PCFs as stand-alone components and have provided few explanations about the optimization of these structures. We provide a design method of the PCFs that offers unique analytic insights about extraordinary optical transmission (EOT) in a systematic manner. The dielectric environment in the cylindrical hole has an important role to match the surface plasmon (SP) modes in holes and subsequently to enhance the EOT. Efficient EOT was achieved with finite dimensions less than the penetration depth of the SPs. This letter will provide more realistic guidelines for designing nanohole-based applications.</P>

P552 : Mycoplasma pneumoniae infection-associated erythema multiform

( Yun Sun Moon ),( Do Seon Jeong ),( Seok Rim Kim ),( Chi Yeon Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

Sweet-like syndrome induced by bortezomib

( Do Seon Jeong ),( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Sweet syndrome is characterized by fever, tender, erythematous skin lesions, neutrophilia, high levels of serum inflammatory markers, and diffuse mature neutrophil infiltration typically localized to the upper dermis. Many drugs have been found to be associated with Sweet’s syndrome. Various drugs used in hematology and oncology such as immunomodulating drugs, differentiation-inducing agents, and anti-neoplastic agents have been found to be associated. Bortezomib is a proteasome inhibitor, which was approved in 2008 to treat progressive multiple myeloma. Bortezomib can cause cutaneous side effects such as erythema, pruritus, periorbital edema, eczemas and rarely erythema multiforme-like skin changes or vasculitis. A 65-year old man used bortezomib for multiple myeloma. Using about 3 cycles and the multiple nodular lesion was repeated three times for a period of relief and aggravation of the symptoms. The diagnosis was reported Sweet syndrome by incisional biopsy. Symptoms improved after the bortezomib was discontinued. In conclusion, even though there are not many reports, we have to be aware of the possibility of sweet-like syndrome due to bortezomib.

Endoscopically Observed Lower Esophageal Capillary Patterns

( Do Won Choi ),( Seong Nam Oh ),( Soo Jung Baek ),( Soo Hyun Ahn ),( Yun Jung Chang ),( Won Seok Jeong ),( Hyo Jung Kim ),( Jong Eun Yeon ),( Jong Jae Park ),( Jae Seon Kim ),( Kwan Soo Byun 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.4

Background: It has been reported that there are four zones of distinct venous patterns around the gastroesophageal junction (GEJ); i.e. truncal, perforating, palisade (PZ) and gastric zones. Using the distal end of PZ as a marker for GEJ, this study was d