무릎관절 각도가 발목 근육의 근전도 활동에 미치는 영향

유경석,김택연 대한정형도수치료학회 2006 대한정형도수물리치료학회지 Vol.12 No.1

The purpose of this study was to investigate the influence of the various knee angles and ground state on the muscular activities and fatigue of the ankle muscles by integrated electromyograms (iEMG) and median frequency of tibialis anterior (TA), peroneus longus (PL), flexor digitorum longus (FDL) and gastrocnemius (GC). Ten healthy male subjects were participated into stable and balance ball sessions at four angles of knee joint. The surface electromyograms (sEMG) were recorded from the TA, PL, FDL and GC on stable and balance ball with full weight bearing at four knee angles of 0˚, 15˚, 30˚ and 45˚. The time serial data of the surface electromyographic signals were transformed into integrated and frequency serial data by fast fourier transformation. On the stable ground, the iEMG signals of the TA, PL, FDL and GC were significantly higher at 45˚ and 30˚ of knee angles than 0˚ and 15˚ of knee flexion (p<0.05). On the balance ball, the iEMG of the TA, PL, FDL and GC were significantly higher at 45˚ and 30˚ of knee angles than 0˚ and 15˚of knee flexion (p<0.05). The median frequency of the TA, PL, FDL and GC were significantly lower at 45˚ and 30˚ of knee angles than 0˚ and 15˚ of knee on the stable ground (p<0.05). On the balance ball, also the median frequency of the TA, PL, FDL and GC were significantly lower at 45˚ and 30˚ of knee angles than 0˚ and 15˚ of knee flexion (p<0.05). The iEMG of the TA, PL, FDL and GC were significantly higher on the balance ball at 0˚, 15˚, 30˚ and 45˚ of knee angles compared with stable ground. The median frequency of the TA, PL, FDL and GC were significantly lower on the balance ball at 0˚, 15˚, 30˚ and 45˚ of knee angles compared with stable ground. These results indicate that the ground conditions and angles of the knee joint involved to muscular activities and fatigue of ankles muscles, may performed at first on stable ground and then balance ball in order to 0˚, 15˚, 30˚ and 45˚ of knee flexion.

Dysfunction Syndrome을 가진 만성 요통환자의 요천골도수교정에 의한 자세의 변화 : 증례 보고 2

전차선,유경석,김택연 대한정형물리치료학회 2003 대한정형도수물리치료학회지 Vol.9 No.2

본 case study는 척추 관절에 변화를 일으켜 근육의 변화와 통증에 변화가 있는 지를 알아보기 위하여 dysfunction syndrome을 가진 5명의 만성 여성 요통환자의 single group에 Geenman의 impulse technique(glade5)을 1회 적용 후 Pain Scale와 IBS -2000를 사용하여 검사 하였다. - Pain Scale는 0 ~ 100 단계로 나누어 환자에게 직접 아픈 정도를 기입하게 하고 치료 후 재검사와 통증의 변화 정도를 기입하게 하였다. -lBS-2000는 체형 진단기로써 레이저를 이용하여 인체 근육의 경사도를 등고선으로 나타내는 측정기로서 주로 근 Balance와 체형의 균형을 알아보는 기구이다. 측정 방법은 후두-견봉의 각도, C7-견봉의 각도, L4 -S2의 각도, 전 후만의 비, 척추의 기울기를 측정하였다. 자료 분석은 Pained T - test을 하였다. 이 측정치의 결과로 Dysfunction syndrome을 가진 요통환자의 척추 및 근 평형성의 다음과 같은 결과를 얻었다. 1. 주관적인 통증 변화는 교정 전 407.07 였고, 교정 후 309.24로 p<0.05를 보여 유의한 차이가 있었다. 2. 객관적인 측정으로써 후두 -견봉의 각도 변화는 교정 전 왼쪽 362.60, 오른쪽 373.16 였다. 교정 후 왼쪽 33.704.31, 오른쪽 353.05로 p>0.05를 보여 각도의 변화는 보이나 유의한 차이를 보이지 못 하였다. 3. C7 -견봉 각도의 변화는 교정 전 왼쪽 173.73, 오른쪽 175.30 였다. 교정 후 왼쪽 162.55, 오른쪽 172.07로 p>0.05를 보여 각도의 변화는 보이나 유의한 차이를 보이지 못 하였다. 4. 요추 골반의 각도 변화는 왼쪽 19.58 2.75, 오른쪽 20.13 2.75 였다. 교정 후 왼쪽 19.793.33, 오른쪽 21.094.51로 p >0.05를 보여 각도의 변화는 보이나 유의한 차이를 보이지 못하였다. 5. 척추의 전·후만 깊이의 변화는 교정 전 TTD는 2.20 1.44cm , TLD는 2.070.53cm 였고 교정 후 TTD는 2.19 0.49cm , TLD는 1.880.11cm 로 수치의 변화를 보이나 p>0.05로 유의한 차이는 없었다. 6. 척추의 전·후만 비의 변화는 교정 전 TTDR은 0.560.20, TTDR은 0.430.02 였고 교정 후 TTDR은 0.630.02, TLDR은 0.350.02로 변화를 보이나 유의한 차이는 없었다. 7. 척추의 기울기의 변화는 교정전 XD/YD는1.720.77, 교정 후 0.900.41로 수치의 변화는 보이나 유의한 차이를 보이지 못하였다. 전체적인 평형성의 수치를 보이나 유의한 차이는 보이지 못 하였다.

Hardware-in-the-loop Simulation Method for a Wind Farm Controller Using Real Time Digital Simulator

Gyeong-Hun Kim,Jong-Yul Kim,Jin-Hong Jeon,Seul-Ki Kim,Eung-Sang Kim,Ju-Han Lee,Minwon Park,In-Keun Yu 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

A hardware-in-the-loop simulation (HILS) method for a wind farm controller using a real time digital simulator (RTDS) is presented, and performance of the wind farm controller is analyzed. A 100 MW wind farm which includes 5 MW wind power generation systems (WPGS) is modeled and analyzed in RSCAD/RTDS. The wind farm controller is implemented by using a computer, which is connected to the RTDS through transmission control protocol/internet protocol (TCP/IP). The HILS results show the active power and power factor of the wind farm, which are controlled by the wind farm controller. The proposed HILS method in this paper can be effectively utilized to validate and test a wind farm controller under the environment in practice without a real wind farm.

Induction of reactive oxygen species–mediated apoptosis by purified Schisandrae semen essential oil in human leukemia U937 cells through activation of the caspase cascades and nuclear relocation of mitochondrial apoptogenic factors

Yu, Gyeong Jin,Choi, Il-Whan,Kim, Gi-Young,Hwang, Hye Jin,Kim, Byung Woo,Kim, Cheol Min,Kim, Wun-Jae,Yoo, Young Hyun,Choi, Yung Hyun Elsevier 2015 Nutrition research Vol.35 No.10

<P><B>Abstract</B></P> <P>The aim of this study was to evaluate the beneficial effects of Schisandrae semen essential oil (SSeo) on apoptosis events and the mechanisms associated with these effects in human leukemia U937 cells. The treatment of U937 cells with SSeo significantly inhibited survival and induced apoptosis. Schisandrae semen essential oil treatment increased the levels of death receptors and Fas, and activated caspases accompanied by proteolytic degradation of poly(ADP-ribose)-polymerase, which was associated with the downregulation of members of the inhibitor of apoptosis protein family protein expression; however, a pan-caspase inhibitor reversed SSeo-induced apoptosis. Treating the cells with SSeo also caused truncation of Bid, translocation of proapoptotic Bax to the mitochondria, and loss of mitochondrial membrane permeabilization, thereby inducing the release of cytochrome <I>c</I> into the cytosol. Subsequently, SSeo upregulated the translocation of mitochondrial apoptogenic factors, such as endonuclease G and apoptosis-inducing factor, into the nucleus during the apoptotic process. Notably, SSeo immediately increased the generation of intracellular reactive oxygen species (ROS); however, pretreatment with <I>N</I>-acetylcysteine, a common ROS quencher, almost completely blocked SSeo-induced apoptosis. Taken together, these findings indicate that SSeo caused ROS- and caspase-dependent cell death involving mitochondrial dysfunction and nuclear translocation of mitochondrial proapoptosis proteins. Based on our data, the consumption of Schisandrae semen or its essential oil is a good natural therapeutic agent for anticancer activity and regression.</P>

The C allele of synonymous SNP (rs1142636, Asn170Asn) in <i>SYN1</i> is a risk factor for the susceptibility of Korean female schizophrenia

Yu, Gyeong Im,Kim, Su Kang,Park, Hae Jeong,Kim, Jong Woo,Chung, Joo‐,Ho,Shin, Dong Hoon Wiley Subscription Services, Inc., A Wiley Company 2012 Synapse Vol.66 No.11

<P><B>Abstract</B></P><P><B>Objective:</B> The aim of this study was to investigate the association between the exonic single nucleotide polymorphisms (SNPs) of <I>synapsin I</I> (<I>SYN1</I>) (rs1142636, Asn170Asn, Xp11.23) and <I>SYN2</I> (rs2289708, 3′‐untranslated region, 3p25) in schizopherenia. <B>Methods:</B> Two hundred eighty six schizophrenia patients and 304 control subjects were recruited. SNPs with a know heterozygosity and minor allele frequency (MAF) > 0.1 in Asian populations were selected and genotyped by direct sequencing. <B>Results:</B> The allelic frequencies of rs1142636 (<I>SYN1</I>) were associated with schizophrenia (<I>P</I> < 0.05), respectively. The allelic frequency of rs1142636 in all subjects was associated with schizophrenia [<I>P</I> = 0.000059, OR = 2.17 (95% CI = 1.47–3.18)]. The C allele frequency of rs1142636 was higher in schizophrenia (20.8%) than that in controls (10.8%). In the analysis of gender, the allelic frequency of rs1142636 was also strongly associated with female schizophrenia [<I>P</I> = 0.0001, OR = 2.65 (95% CI = 1.61–4.36)], but not with male schizophrenia. The C allele frequency of rs1142636 was higher in female schizophrenia (22.2%) than that in female controls (9.7%). The rs2289708 SNP (<I>SYN2</I>) did not show any association between schizophrenia and controls. <B>Conclusions:</B> These results suggest that the C allele of a synonymous SNP (rs1142636, Asn170Asn, Xp11.23) in <I>SYN1</I> may be a risk factor for the susceptibility of Koreran female schizophrenia. Synapse 66:979–983, 2012. © 2012 Wiley Periodicals, Inc.</P>

Dictyostelium discoideum Ax2 as an Assay System for Screening of Pharmacological Chaperones for Phenylketonuria Mutations

Kim, Yu-Min,Yang, Yun Gyeong,Kim, Hye-Lim,Park, Young Shik The Korean Society for Microbiology and Biotechnol 2015 Journal of microbiology and biotechnology Vol.25 No.6

In this study, we developed an assay system for missense mutations in human phenylalanine hydroxylases (hPAHs). To demonstrate the reliability of the system, eight mutant proteins (F39L, K42I, L48S, I65T, R252Q, L255V, S349L, and R408W) were expressed in a mutant strain (pah^-) of Dictyostelium discoideum Ax2 disrupted in the indigenous gene encoding PAH. The transformed pah - cells grown in FM minimal medium were measured for growth rate and PAH activity to reveal a positive correlation between them. The protein level of hPAH was also determined by western blotting to show the impact of each mutation on protein stability and catalytic activity. The result was highly compatible with the previous ones obtained from other expression systems, suggesting that Dictyostelium is a dependable alternative to other expression systems. Furthermore, we found that both the protein level and activity of S349L and R408W, which were impaired severely in protein stability, were rescued in HL5 nutrient medium. Although the responsible component(s) remains unidentified, this unexpected finding showed an important advantage of our expression system for studying unstable proteins. As an economic and stable cell-based expression system, our development will contribute to mass-screening of pharmacological chaperones for missense PAH mutations as well as to the in-depth characterization of individual mutations.

Design assessment of triangular support bracket for manufacturability

Kim, Yu-Gyeong,Jung, Yung-Jin,Kim, Hyun-Soo,Ahn, Hee-Jae Elsevier 2015 Fusion engineering and design Vol.98 No.-

<P><B>Abstract</B></P> <P>The triangular support is connected structurally and hydraulically with the inner shell of the vacuum vessel and its main role is to keep plasma vertical stability during operational disruptions. Korea is responsible for the procurement of sectors 1 and 6 of the main vessel including triangular support. At present, design review for its fabrication by ITER Korea and Hyundai Heavy Industries, Co., Ltd. is in progress. This paper presents the results on various designs for triangular support bracket in terms of manufacturability considering both easiness of non-destructive evaluation and fabrication efficiency. The several designs are proposed and evaluated under the most critical loading condition using elastic and limit analysis with fatigue evaluation. Consequently, an optimized design for structural safety is determined in accordance with RCC-MR. This result is reconfirmed by cross-checking in comparison with the baseline of integrity that already had been determined by ITER Organization. The design deviation requests of triangular support bracket have been submitted to ITER Organization and Agreed Notified Body for approval, and their verification is currently under discussion.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Various designs for ITER triangular support bracket are proposed in terms of efficient manufacturability. </LI> <LI> An optimized design for structural safety is determined in accordance with RCC-MR. </LI> <LI> This result is reconfirmed by cross-checking in comparison with the IO baseline of integrity. </LI> </UL> </P>

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

Kim, Mi-Gyeong,Shon, Yuna,Kim, Jinyoung,Oh, Yu-Kyoung U.S. Dept. of Health, Education, and Welfare, Publ 2017 Journal of the National Cancer Institute Vol.109 No.1

Predicting the Binding Residues of UHRF1 in the PROTAC Complex using NMR Chemical Shift Analysis

Yu Gyeong Kim,Sung Jean Park 한국분석과학회 2023 학술대회논문집 Vol.2023 No.5

Improving the Subcritical Water Extraction of the Tea Catechins from Green Tea (Camellia sinensis) by Pulsed Electric Field and Intense Pulsed Light

Yu-Gyeong Kim,Bo-Yeong Seok,Han-Sol Kim,Hye-Won Mok,Ye-Ji Kim,Hee-Jeong Hwang,Min-Jung Ko,Myong-Soo Chung 한국산업식품공학회 2019 학술대회 및 심포지엄 Vol.2019 No.10