Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

An Investigation on the Life of Master Won Guk Lee, the Creator of Chung-Do-Kwan

( Seon Young Jung ),( Jun Ho Lee ),( Seung Woo Shin ),( Chun Hwan Cho ),( Seung Hyun Jang ),( Won Shin ) 경남대학교 기초과학연구소 2014 기초과학지 Vol.31 No.-

The purpose of this study is to review (or, investigate) the life of Won Guk Lee. He is the creator of Chung-Do-Kwan, which is one of the five original Taekwondo kwans. Data was gathered from advanced research, newspapers, documentaries, the Internet, magazines, and journals etc. Thus, we were able to create a sequence of events based on the research data. First, we can say that in Won Guk Lee``s career, he created Chung-Do-Kwan and brought Dangsoodo to Korea. These events have had a significant development on Taekwondo. Second, Taekwondo curriculum, which was published by Won Guk Lee, established the foundation of Taekwondo poomsae, as well as giving us the pure spirit of Korean martial arts.

Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

Superconducting MgB2 Wire Drawing Considering Anisotropic Hardening Behavior and Hydrostatic Effect

Young‑Seok Oh,Ho Won Lee,Kook‑Chae Chung,Duck‑Young Hwang,Seong‑Hoon Kang,Jeong Whan Yoon 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

Numerical modeling was conducted to investigate the deformation behavior of powder mixture during multi-pass drawingprocesses for multi-filamentary MgB2wire. A modified Drucker-Prager Cap (DPC) model with an elliptical cap surface usingthe new material characterization method was developed to capture the anisotropic hardening behavior and hydrostatic effectof the powder mixture. A number of uniaxial die compaction, cold isostatic pressing, diametrical compression, and uniaxialcompression tests were conducted using different powder densities to characterize the modified DPC model. A commercialfinite element software ABAQUS with a user subroutine was used to simulate the drawing of the MgB2wire. The densityand area fraction of the powder mixture during the wire-drawing process were verified with experimental results. The differencein packing density at the inner and outer filaments of the MgB2wire was successfully captured by simulation. Inaddition, the effect of the initial packing density on the superconducting properties of MgB2wire was numerically studied. It is shown that the increase in the superconducting area, which results from a high initial packing density, should be moreeffective compared to the increase in the grain connectivity in enhancing the critical current properties for the MgB2wirewhen the final packing density is saturated after a number of drawing processes.

조기발현 치매(초로기 치매)의 특징과 비약물적 접근법에 관한 연구동향 조사

원경아(Won, Kyung-A),이민아(Lee, Min-A),심주영(Sim, Ju-Young) 한국노인작업치료학회 2020 한국노인작업치료학회지 Vol.2 No.1

목적 : 본 연구의 목적은 조기발현(초로기) 치매의 행동심리·인지적 특징과 더불어 일상생활활동 수행능력을 알아보고, 이들을 대상으로 한 비약물적 중재법들을 체계적으로 분석하여 제시하고자 한다. 연구방법 : 국내외 데이터베이스 중 NDSL, RISS, Google Scholar를 통해 조기발현(초로기) 치매와 관련된 문헌을 수집하였다. 수집된 문헌들의 제목·초록·전문 순으로 검토하여 조기발현(초로기) 치매환자의 특징과 비약물적 중재법에 대한 내용을 추출한 후 결과를 체계적으로 제시하고자 하였다. 결과 : 조기발현 치매 유형에는 알츠하이머형 치매, 혈관성 치매, 전측두엽 치매 등이 있으며, 노인성 치매와는 다른 양상을 보이며 비전형적인 경우가 많은 것으로 나타났다. 행동심리·인지적 증상뿐만 아니라 수단적 일상생활활동 수행능력의 감소가 두드러지며, 증상 완화 또는 악화 지연을 위해 인지활동, 신체활동, 사회활동 등과 관련된 다양한 비약물적 중재법들이 적용되고 있는 것으로 확인되었다. 결론 : 본 논문은 노인성 치매가 아닌 조기발현 치매의 특징과 비약물적 중재법에 대해 일목요연하게 기술하였다. 본 연구는 국내 조기발현 치매 관련 연구가 적은 상황에서 조기발현 치매의 원인, 증상, 비약물적 중재법 등에 대해 체계적으로 정리하고자 했다. 본 연구결과는 향후 병원뿐만 아니라 지역사회와 가정에서 활용될 수 있을 것으로 기대된다. Objective : This study aimed to investigate the behavioral·psychological and cognitive characteristics of early-onset dementia, as well as patients ability to perform activities of daily living, and to systematically analyze and introduce non-pharmacological interventions. Methods : Literature related to early-onset dementia was collected through NDSL, RISS, and Google Scholar. We reviewed the articles in order of title, abstract and full text, and tried to show systematically the results after extracting the contents from non-pharmacological intervention methods and characteristics of patients with early-onset dementia. Results : Types of early-onset dementia include Alzheimer s dementia, vascular dementia, and frontotemporal dementia. Patients with early-onset dementia are different from senile dementia and are often non-typical. In patients with early-onset dementia, behavioral·psychological and cognitive symptoms, as well as a decreased ability to perform instrumental activities of daily living are noticeable. It was confirmed that various non-pharmacological interventions related to cognitive, physical, and social activity are applied to relieve symptoms. Conclusion : This paper clearly describes the characteristics of early-onset dementia and non-pharmacological interventions for patients with early-onset dementia. This study is meaningful in that it systematically summarizes the causes, symptoms, and non-pharmacological interventions of early-onset dementia as studies related to early-onset dementia in Korea are scarce. Thus, the results of this study are expected to be helpful not only for hospitals, but also for communities and families dealing with early-onset dementia.

석재 또는 외장타일 건식 알루미늄 트러스 설치공법의 시공에 관한 연구

이영래 ( Young Lae Lee ),홍성욱 ( Seong Wook Hong ),도선붕 ( Sun Boong Doh ),김상원 ( Sang Won Kim ),안용선 ( Yong Sun Ahn ) 한국건축시공학회 2012 한국건축시공학회 학술발표대회 논문집 Vol.12 No.1

Steel method compared with conventional aluminum truss construction materials as the biggest difference, aluminum truss method by using an aluminum material construction of the existing steel truss compared with the welding operation is omitted, as the air operations will be reduced by about 40% do not need skilled workers in the existing portion of each tube and cost 11,233 to 13,173 won/㎡ cheap it was found.

Structures, Nanomechanics, and Disintegration of Single-Wall GaN Nanotubes: Atomistic Simulations

Jeong Won Kang,황호정,Jun-Ha Lee,Ki OH Song,Ki Ryang Byun,Oh-Keun Kwon,Won Young Choi 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.I

We have investigated the structural, mechanical, and thermal properties of single-walled GaN nanotubes by using atomistic simulations and a Tersoff-type potential. The Tersoff potential for GaN eectively describes the properties of GaN nanotubes. The nanomechanics of GaN nanotubes under tensile and compressive loadings have also been investigated, and Young's modulus has been calculated. The caloric curves of single-walled GaN nanotubes can be divided into three regions corresponding to nanotubes, the disintegrating range, and vapor. Since the stability or the stiness of a tube decreases with increasing curving sheet-to-tube strain energy, the disintegration temperatures of GaN nanotubes are closely related to the curving sheet-to-tube strain energy.

Polypropylene Nanocomposites with Graphene Oxide Containing Flame Retardant Moieties

Seung Won Lee(이승원),Huiseob Shin(신휘섭),Yong Hun Lee(이용훈),Jong-Chan Lee(이종찬),Jae Young Jho(조재영) 한국고분자학회 2020 폴리머 Vol.44 No.5

폴리프로필렌(polypropylene, PP)/산화그래핀(graphene oxide, GO) 복합재료의 난연성과 기계적 성질을 향상시키기 위해 GO를 인계 난연제로 개질시켰다. 복합재료는 무수말레인산이 수식된 PP(maleic anhydride-grafted PP, MAPP)를 상용화제로 사용하여 용융 혼합 방식으로 제작되었다. 푸리에 적외선 분광학(Fourier transform infrared, FTIR), 광전자분광법(X-ray photoelectron spectroscopy, XPS)을 통해 난연제와 GO 사이에 공유 결합이 형성된 것을 확인할 수 있었다. GO의 기능화와 상용화제 사용이 PP/GO 복합재료의 형태학, 난연성, 기계적 성질에 미치는 영향을 평가하였다. 주사전자현미경(SEM)을 이용한 형태학 분석 결과, MAPP를 첨가함으로써 충전제와 기지재 사이의 계면 상호작용이 증가되어 GO의 박리 및 분산성이 향상되었다. PP/기능화된 GO 복합재료의 한계산소지수, 영 탄성률, 인장 강도가 PP/GO 복합재료에 비해 증가된 결과를 나타냈다. Graphene oxide (GO) was functionalized with phosphorus-containing groups to give the flame retardancy to the polypropylene (PP)/GO nanocomposites. The composites were prepared via melt mixing with maleic anhydride-grafted PP (MAPP) as a compatibilizer. Through the Fourier transform infrared (FTIR) spectroscopy, and X-ray photoelectron spectroscopy (XPS), covalently-bonded flame retardant moieties on GO were characterized. The effect of the functionalization of GO and the use of compatibilizer on the morphology, flame retardancy, and mechanical properties of the PP/GO composites were investigated. SEM observation of the composites showed that the addition of MAPP improved the exfoliation and dispersion state of the GO sheets by improving the interfacial interaction between the filler and the matrix. For PP/functionalized GO composites, the limiting oxygen index (LOI), Young’s modulus, and tensile strength were increased compared with PP/GO composites.

Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

해양온도차발전 Closed and Regeneration Cycle의 기본 정특성

차상원(Sang1Won Cha),김유택(You1Taek Kim),이영호(Young1Ho Lee) 한국유체기계학회 2011 한국유체기계학회 학술대회 논문집 Vol.2011 No.11